Abstract：
:Successful immune targeting of malignancies hinges upon the ability to activate specific T-cell populations to recognize and attack tumor but spare normal vital tissues. Investigators in the field of tumor immunology are currently utilizing at least three distinct approaches toward this goal. In the first approach, molecular targets of cytolytic T cells which spontaneously develop in tumor-bearing patients have been identified and are subsequently used as immunogens in immunotherapy trials. Whereas this approach originally focused upon the identification of tumor antigens in the immune-responsive tumors malignant melanoma and renal cell carcinoma, it surprisingly led to the identification of a variety of molecules that are now known to be expressed in other common pediatric and adult tumors. In the second approach, tumor-specific molecules (eg, mutant p53 and chromosomal translocations) that have been identified in individual tumors during the study of neoplastic transformation are used as immunogens. Because chromosomal translocations are common in pediatric tumors, such targets may be of particular interest in pediatric oncology. In the third approach, immunization with whole tumor cell components is undertaken with the assumption that the most immunogenic molecules within the tumor will dominate the immune response induced. The benefits and limitations for each approach, particularly as it pertains to the development of immunotherapy for pediatric tumors, are discussed in this article.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Mackall CL,Helman LJdoi
10.1007/s11912-000-0108-7keywords:
subject
Has Abstractpub_date
2000-11-01 00:00:00pages
539-46issue
6eissn
1523-3790issn
1534-6269journal_volume
2pub_type
杂志文章,评审abstract：:The identification of somatic driver mutations in human samples has allowed for the development of a molecular classification for melanoma. Recent breakthroughs in the treatment of metastatic melanoma have arisen as a result of these significant new insights into the molecular biology of the disease, particularly the ...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-012-0249-5
更新日期：2012-10-01 00:00:00
abstract：:The original version of this article, which published in Current Oncology Reports, Volume 21, Issue 6, June 2019, contained an error in addressing the indication for use of neratinib in early stage breast cancer. ...
journal_title：Current oncology reports
pub_type： 已发布勘误
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-012-0270-8
更新日期：2012-12-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-020-00952-5
更新日期：2020-07-10 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-018-0698-6
更新日期：2018-05-04 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章
doi：10.1007/s11912-012-0271-7
更新日期：2012-12-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-003-0068-9
更新日期：2003-07-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2014-02-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2003-05-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2003-11-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-018-0693-y
更新日期：2018-04-11 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2011-02-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-001-0007-6
更新日期：2001-03-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2018-04-11 00:00:00
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journal_title：Current oncology reports
pub_type： 历史文章,杂志文章,评审
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更新日期：2018-11-13 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-002-0039-6
更新日期：2002-09-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-017-0574-9
更新日期：2017-03-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2015-04-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-010-0089-0
更新日期：2010-05-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2016-06-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2008-07-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-018-0673-2
更新日期：2018-04-10 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-996-0008-6
更新日期：2004-01-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-005-0073-2
更新日期：2005-05-01 00:00:00
abstract：:Acute promyelocytic leukemia (APL) is a disease associated with fusion oncoproteins invariably involving the retinoic acid receptor (Raralpha). Retinoic acid induces differentiation in APL cells and is successfully used in conjunction with chemotherapy to treat and cure a significant percentage of patients with APL. A...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-001-0052-1
更新日期：2001-05-01 00:00:00
abstract：:Anaplastic oligodendrogliomas are rare primary brain tumors. However, they respond more effectively to treatment and have a better prognosis than commoner varieties. About 25 year ago, reports emerged that oligodendrogliomas can respond robustly and durably to chemotherapy with procarbazine, lomustine (CCNU), and vinc...
journal_title：Current oncology reports
pub_type： 杂志文章
doi：10.1007/s11912-012-0281-5
更新日期：2013-02-01 00:00:00
abstract：:Siltuximab is a chimeric monoclonal antibody targeting interleukin-6 (IL-6), which in the fall of 2014 became the first FDA-approved treatment of the rare disease idiopathic multicentric Castleman's disease (MCD). MCD is a non-clonal lymphoproliferative disorder in which common symptoms include fever, night sweats, we...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2015-07-01 00:00:00
abstract：:Skin cancer is the most common type of cancer in the United States. US incidence of malignant melanoma is increasing faster than any other type of cancer. To minimize increasing morbidity and mortality rates, it is imperative that appropriate screening and early detection of skin cancer become more widespread. All phy...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-004-0082-6
更新日期：2004-11-01 00:00:00
abstract：:Although gastric cancer is still a worldwide major public health concern, it remains relatively uncommon in the Western countries. Despite improvement in surgical morbidity and mortality, as well as significant advancement of chemotherapy and radiotherapy options, the survival for gastric cancer has not significantly ...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-004-0049-7
更新日期：2004-05-01 00:00:00
