Abstract：
:Chordomas and chondrosarcomas of the skull base are rare, indolent tumors with a natural history of locally invading their surroundings. Safe, maximal resection is the mainstay of treatment, followed by adjuvant radiation therapy. Even with multimodality therapy, local recurrence remains the most common failure pattern, translating to an adverse overall survival. Compared with other forms of radiation therapy, proton beam therapy has been used to increase the dose delivered to the tumor while elegantly sparing dosing to adjacent critical normal structures.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Nguyen QN,Chang ELdoi
10.1007/s11912-008-0052-5subject
Has Abstractpub_date
2008-07-01 00:00:00pages
338-43issue
4eissn
1523-3790issn
1534-6269journal_volume
10pub_type
杂志文章,评审abstract：:Variant forms of bladder cancer are non-urothelial neoplasms or urothelial carcinomas mixed with other histologies. Compared to pure urothelial carcinoma, they all present with a high stage and grade. Prognosis is variable and there is a lack of evidence regarding the ideal treatment approach, because of their relativ...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-011-0161-4
更新日期：2011-06-01 00:00:00
abstract：:Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is constant clinical study involving modifications of chemoradiotherapy...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-011-0166-z
更新日期：2011-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The aim of this article is to discuss the current role of radiotherapy (RT) for early-stage Hodgkin's lymphoma (HL) in the context of risk-adapted and response-adapted treatment strategy, and describe changes in RT technical approach. RECENT FINDINGS:In low-risk patients, RT could be omitted but, at ...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-017-0592-7
更新日期：2017-05-01 00:00:00
abstract：:Gamma-(γ)-herpes virus lymphomas comprise a heterogenous group of B-cell and T-cell neoplasms most commonly associated with Epstein-Barr virus and rarely human herpes virus-8 infection. Adult T-cell leukemia/lymphoma (ATLL) is a unique disease entity caused by the human T-cell lymphotrophic virus, type 1 (HTLV-I), the...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-011-0186-8
更新日期：2011-10-01 00:00:00
abstract：:New combinations of chemotherapy with radiotherapy for gastrointestinal cancers are showing evidence that improved outcomes may result from toxicity profiles associated with "targeted" systemic radiosensitizing agents. These new agents are also clinically attractive owing to such factors as oral bioavailability and pa...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-005-0073-2
更新日期：2005-05-01 00:00:00
abstract：:Pediatric medicine is moving toward a greater appreciation that the delivery of quality medical care involves a partnership including the health care team, the child, and the family. Pediatric medicine now emphasizes the importance of information exchange among these groups. This paper discusses two models for communi...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-007-0061-9
更新日期：2007-11-01 00:00:00
abstract：:Cancer risk has become a significant research topic due to an increase in statistical risk models built to predict cancer incidence or mortality. Over the past 3 years, 15 models on the development of different types of cancer, including breast, colorectal, prostate, gastric, lung, ovarian, pancreatic, testicular, and...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-007-0071-7
更新日期：2007-11-01 00:00:00
abstract：:HER2 is a member of the epidermal growth factor receptor (EGFR) family of tyrosine kinases and is involved in the growth, invasion, metastasis, and prognosis of breast cancer. The rationale for prospective trials evaluating the role of anti-HER2 monoclonal antibody therapy for patients with high-risk HER2-positive res...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-001-0073-9
更新日期：2001-11-01 00:00:00
abstract：PURPOSE OF REVIEW:We aim to summarise the available evidence on systemic therapies for advanced anal cancer. RECENT FINDINGS:There is no universal consensus on the management of this condition and the prognosis remains poor. Nevertheless, significant progress has been recently made including completion of the first, e...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-018-0698-6
更新日期：2018-05-04 00:00:00
abstract：:The utility of lymphatic mapping and sentinel lymph node biopsy in malignancies of the female lower genital tract-- vulvar, vaginal, and cervical cancers--is being explored in multiple centers internationally. For patients with these tumors, lymphatic mapping with sentinel lymph node biopsy holds the promise of increa...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-005-0008-y
更新日期：2005-11-01 00:00:00
abstract：:Neuroblastoma is the most common extracranial tumor of childhood, with about 650 new cases each year in the United States. The clinical course of neuroblastoma is variable and depends on age at diagnosis, staging, histology, and specific genetic abnormalities, such as MYCN oncogene amplification or aberrations of chro...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-009-0059-6
更新日期：2009-11-01 00:00:00
abstract：:Management of early endometrial cancer is contentious these days with little agreement between oncologists as well as across MDTs or tumour boards and indeed across countries. This is because of the state of knowledge with regards to risk factors in early endometrial cancer; although we recognise risk factors affect o...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-016-0505-1
更新日期：2016-04-01 00:00:00
abstract：:Results of treatment for patients with non-Hodgkin's lymphomas have significantly improved over the last decade, especially following the discovery that anti-CD20 antibody therapy can significantly change the outlook for patients with both aggressive and indolent lymphomas. Although investigators have previously attem...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-010-0128-x
更新日期：2010-11-01 00:00:00
abstract：:The majority of patients with ovarian cancer will relapse after initial chemotherapy and will be candidates for salvage treatment. Currently, five agents show clear activity in patients with platinum- and paclitaxel-resistant disease: topotecan, oral etoposide, liposomal doxorubicin, gemcitabine, and, possibly, doceta...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-999-0012-8
更新日期：1999-09-01 00:00:00
abstract：:The use of anti-angiogenic agents as part of the therapeutic armamentarium for advanced stage solid tumors has become the standard of care in several instances, particularly for renal cell carcinoma, non-small cell lung carcinoma, colorectal carcinoma, and gastrointestinal stromal tumors. These agents primarily target...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-012-0242-z
更新日期：2012-08-01 00:00:00
abstract：:Adjuvant treatment of patients with endometrial cancer is tailored to clinical-pathological prognostic factors. Pelvic radiation therapy for stage I endometrial cancer (EC) provides a highly significant improvement of local control, but without survival advantage. Low-risk EC patients have a very favorable prognosis, ...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-011-0191-y
更新日期：2011-12-01 00:00:00
abstract：:Mutations in the cancer susceptibility genes BRCA1 and BRCA2 are associated with significantly increased risks of breast and ovarian cancer. Fortunately, effective strategies are available to reduce these risks, including genetic testing, which is an important consideration in determining management of patients with a...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-008-0008-9
更新日期：2008-01-01 00:00:00
abstract：:The search is on for biomarkers for use in the diagnosis, staging, prognosis, and management of patients with melanoma. As with many types of cancer, the hematogenous spread of melanoma is a bad prognostic sign, and many groups have attempted to detect circulating melanoma cells in patients with different stages of me...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-005-0065-2
更新日期：2005-09-01 00:00:00
abstract：:Dysregulation of the cell cycle is a classic hallmark of cancer growth and metastatic potential. Re-establishing cell cycle control through CDK inhibition has emerged as an attractive option in the development of targeted cancer therapy. Three oral agents selectively targeting CDK4/6 have been developed: palbociclib, ...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-015-0443-3
更新日期：2015-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Mantle cell lymphoma (MCL) prognosis is strictly related to the characteristics of the disease, which can range from very indolent cases to highly aggressive and refractory ones. Here we will review the current knowledge on MCL biomarkers. RECENT FINDINGS:Biomarker-informed diagnosis is essential for...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-018-0728-4
更新日期：2018-08-22 00:00:00
abstract：:Successful immune targeting of malignancies hinges upon the ability to activate specific T-cell populations to recognize and attack tumor but spare normal vital tissues. Investigators in the field of tumor immunology are currently utilizing at least three distinct approaches toward this goal. In the first approach, mo...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-000-0108-7
更新日期：2000-11-01 00:00:00
abstract：:Malignant pleural effusions (MPEs) are a significant source of cancer-related morbidity. Over 150,000 patients in the United States suffer from breathlessness and diminished quality of life due to MPE each year. Current management strategies are of mostly palliative value and focus on symptom control; they do not addr...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-013-0315-7
更新日期：2013-06-01 00:00:00
abstract：:High-risk non-melanoma skin cancer (NMSC) of the head and neck is difficult to manage, given its propensity for regional metastasis, perineural invasion, direct parotid invasion, and bony destruction. Management of these tumors demands awareness of the characteristics contributing to their recurrence. Recent studies e...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-005-0042-9
更新日期：2005-03-01 00:00:00
abstract：:The number of patients given neoadjuvant chemotherapy (NAC) followed by fertility-sparing surgery in cervical cancer is still scarce. Only a few centres perform these procedures, and thus, such procedures remain largely in the experimental stage. Patients that do not fulfil the criteria for standard fertility-sparing ...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-015-0446-0
更新日期：2015-01-01 00:00:00
abstract：PURPOSE OF REVIEW:The aim of this review is to sum up the state of the art of urachal carcinoma (UC) in order to easily guide clinicians. RECENT FINDINGS:UC is a rare and aggressive disease with consequent few data about diagnosis and treatment. Dates are mainly based on retrospective trial and case reports with limit...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-020-0878-z
更新日期：2020-01-27 00:00:00
abstract：PURPOSE OF REVIEW:Opioids are the only class of drug with the proven ability to control severe pain. The introduction of stringent opioid prescribing restrictions has inevitably impacted upon the ability of those prescribing opioids for advanced life-limited disease to practice as previously and could limit the supply ...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-020-0900-5
更新日期：2020-03-13 00:00:00
abstract：:In the past, the treatment options for patients with metastatic prostate cancer that progressed despite castrate levels of testosterone was limited, and no therapies provided an improvement in survival. The majority of these patients had extensive osseous disease, multiple comorbidities, and poor performance status. W...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-000-0058-0
更新日期：2000-09-01 00:00:00
abstract：:While there is an ongoing debate regarding the timing of the maximal surgical effort in epithelial ovarian cancer, it is well established that patients with suboptimal tumor debulking derive no benefit from the surgical procedure. The amount of residual disease after cytoreductive surgery has been repeatedly identifie...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-015-0439-z
更新日期：2015-04-01 00:00:00
abstract：:Although gastric cancer is still a worldwide major public health concern, it remains relatively uncommon in the Western countries. Despite improvement in surgical morbidity and mortality, as well as significant advancement of chemotherapy and radiotherapy options, the survival for gastric cancer has not significantly ...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-004-0049-7
更新日期：2004-05-01 00:00:00
abstract：:Radiation-induced mucositis is an important dose-limiting acute side effect associated with the treatment of tumors of the upper aerodigestive tract. The toxicity of radiation therapy increases with prior or concurrent administration of some chemotherapeutic agents. Pretreatment eradication of infection, maintenance o...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-001-0043-2
更新日期：2001-01-01 00:00:00
