High-risk non-melanoma skin cancer of the head and neck.

abstract：:Dysregulation of the cell cycle is a classic hallmark of cancer growth and metastatic potential. Re-establishing cell cycle control through CDK inhibition has emerged as an attractive option in the development of targeted cancer therapy. Three oral agents selectively targeting CDK4/6 have been developed: palbociclib, ...

journal_title：Current oncology reports

authors： Mayer EL

更新日期：2015-01-01 00:00:00

abstract：:Malignant pleural effusions (MPEs) are a significant source of cancer-related morbidity. Over 150,000 patients in the United States suffer from breathlessness and diminished quality of life due to MPE each year. Current management strategies are of mostly palliative value and focus on symptom control; they do not addr...

journal_title：Current oncology reports

authors： Bradshaw M,Mansfield A,Peikert T

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Surgical management of locally advanced oral cavity squamous cell carcinomas (OCSCC) has long been recognized as a primary treatment modality. Technological advances have led to significant improvements in our surgical approach, from improvement in the visualization of tumors to more efficient and pre...

journal_title：Current oncology reports

authors： Yao CMKL,Chang EI,Lai SY

更新日期：2019-11-07 00:00:00

abstract：PURPOSE OF REVIEW:Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the setting of earlier stage surgically resectable lung cancer. RECENT FINDI...

journal_title：Current oncology reports

authors： Gentzler RD,Riley DO,Martin LW

更新日期：2020-08-15 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the intestinal tract, are characterized by the expression of KIT, also known as CD117. Increasingly, primary tumors from novel sites are being described. The KIT gene is commonly mutated, causing constitutive activation of the protein and a...

journal_title：Current oncology reports

authors： von Mehren M

更新日期：2003-07-01 00:00:00

abstract：:Most of the experience with second-line chemotherapy for non-small-cell lung cancer (NSCLC) comes from small phase II trials, which have shown disappointing or inconsistent results. The notable exception has been docetaxel, which has been extensively studied as a second-line therapy for NSCLC. On the basis of consiste...

journal_title：Current oncology reports

authors： Fossella FV

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The concept of value-based health care (VBHC) was articulated more than a decade ago. However, its clinical implementation remains an on-going process and a particularly demanding one for the domain of head and neck cancer (HNC). These cancers often present with fast growing tumors in functionally and...

journal_title：Current oncology reports

authors： Takes RP,Halmos GB,Ridge JA,Bossi P,Merkx MAW,Rinaldo A,Sanabria A,Smeele LE,Mäkitie AA,Ferlito A

更新日期：2020-07-10 00:00:00

abstract：:Neuroblastoma is the most common extracranial tumor of childhood, with about 650 new cases each year in the United States. The clinical course of neuroblastoma is variable and depends on age at diagnosis, staging, histology, and specific genetic abnormalities, such as MYCN oncogene amplification or aberrations of chro...

journal_title：Current oncology reports

authors： Mueller S,Matthay KK

更新日期：2009-11-01 00:00:00

abstract：:Cyclin-dependent kinases (CDKs) and their related pathways represent some of the most attractive targets in the development of anticancer therapeutics. Among a variety of CDK inhibitors under development, flavopiridol, UCN-01, CYC202, and BMS-387032 are undergoing clinical evaluation based on evidence of preclinical a...

journal_title：Current oncology reports

authors： Dai Y,Grant S

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Skull base reirradiation is challenging due to complex anatomy, enrichment of treatment-resistant clonogens, and increased risk of severe treatment complications. Without local therapy, early mortality is certain and tumor progression can result in debilitating symptoms. Modern radiotherapy advancemen...

journal_title：Current oncology reports

authors： Ho JC,Phan J

更新日期：2017-10-28 00:00:00

abstract：:Health-related quality of life (QOL) outcomes are frequently used by clinicians, patients, and researchers for assessing the effectiveness of an intervention. Small differences in QOL may be statistically significant but their clinical relevance remains undefined. The smallest changes in QOL scores of the anterior sku...

journal_title：Current oncology reports

authors： Amit M,Abergel A,Fliss DM,Gil Z

更新日期：2012-04-01 00:00:00

abstract：:The establishment of the Intergroup Rhabdomyosarcoma Study (IRS) Committee in 1972 by three extant American pediatric cooperative groups initiated five generations of studies in the multidisciplinary treatment of soft-tissue sarcomas. Taking the lead from the use of vincristine, actinomycin-D, and cyclophosphamide (VA...

journal_title：Current oncology reports

authors： Ruymann FB

更新日期：2003-11-01 00:00:00

abstract：:Cancer risk has become a significant research topic due to an increase in statistical risk models built to predict cancer incidence or mortality. Over the past 3 years, 15 models on the development of different types of cancer, including breast, colorectal, prostate, gastric, lung, ovarian, pancreatic, testicular, and...

journal_title：Current oncology reports

authors： Johnson CM,Smolenski D

更新日期：2007-11-01 00:00:00

abstract：:The search is on for biomarkers for use in the diagnosis, staging, prognosis, and management of patients with melanoma. As with many types of cancer, the hematogenous spread of melanoma is a bad prognostic sign, and many groups have attempted to detect circulating melanoma cells in patients with different stages of me...

journal_title：Current oncology reports

authors： Kounalakis N,Goydos JS

更新日期：2005-09-01 00:00:00

abstract：:This review briefly summarizes the results of previous systemic (chemotherapy) and local (surgery and radiotherapy) treatment attempted to date for malignant mesothelioma. The prospects for newer modalities, ie molecular and biologic therapies, are also highlighted, including results of both preclinical and early clin...

journal_title：Current oncology reports

authors： Smythe WR

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to provide clinicians and pathologists with an understanding of the aetiopathology, pathogenesis and classification of vulval neoplasia and their molecular correlates. RECENT FINDINGS:There is an increased understanding of subcellular changes in vulvar malignancies. These p...

journal_title：Current oncology reports

authors： Williams A,Syed S,Velangi S,Ganesan R

更新日期：2019-08-15 00:00:00

abstract：PURPOSE OF REVIEW:This review was undertaken to analyze the main reasons behind the limited development of hospice care in China, and to put forward some suggestions. RECENT FINDINGS:Although the Chinese government has increased its support for hospice care in recent years, however, owing to the lack of education arou...

journal_title：Current oncology reports

authors： Ling M,Wang X,Ma Y,Long Y

更新日期：2020-07-28 00:00:00

abstract：:Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is constant clinical study involving modifications of chemoradiotherapy...

journal_title：Current oncology reports

authors： Meyer J,Balch G,Willett C,Czito B

更新日期：2011-06-01 00:00:00

abstract：:Squamous cell carcinoma of the anal canal historically has been treated with abdominoperineal resection, resulting in high rates of morbidity and local recurrence. Pioneering work led to the finding that radiation therapy (RT) combined with 5-fluorouracil (5-FU) and mitomycin results in high rates of local control and...

journal_title：Current oncology reports

authors： Czito BG,Willett CG

更新日期：2009-05-01 00:00:00

abstract：:Adjuvant treatment of patients with endometrial cancer is tailored to clinical-pathological prognostic factors. Pelvic radiation therapy for stage I endometrial cancer (EC) provides a highly significant improvement of local control, but without survival advantage. Low-risk EC patients have a very favorable prognosis, ...

journal_title：Current oncology reports

authors： Creutzberg CL,Nout RA

更新日期：2011-12-01 00:00:00

abstract：:Results of treatment for patients with non-Hodgkin's lymphomas have significantly improved over the last decade, especially following the discovery that anti-CD20 antibody therapy can significantly change the outlook for patients with both aggressive and indolent lymphomas. Although investigators have previously attem...

journal_title：Current oncology reports

authors： Hagemeister FB

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past two decades, advances have been made in understanding the pathophysiology of cancer-associated weight loss, termed "cachexia." To date, there is no proven effective intervention to completely reverse cachexia and there are no approved drug therapies to treat it. This paper will review re...

journal_title：Current oncology reports

authors： Reid J,McKeaveney C,Martin P

更新日期：2019-02-04 00:00:00

abstract：:Recent advances in molecular biology have enhanced our understanding of the pathogenesis of brain tumors, particularly in children. The use of molecular diagnostic tools is quickly becoming a standard component in the diagnosis and classification of brain tumors in children, in addition to providing insight leading to...

journal_title：Current oncology reports

authors： Ullrich NJ,Pomeroy SL

更新日期：2006-11-01 00:00:00

abstract：PURPOSE REVIEW:B cell signaling agents, including ibrutinib, idelalisib, and the BCL-2 inhibitor venetoclax have become an integral part of therapy for patients with non-Hodgkin's lymphomas. The toxicity profiles of these medications is distinct from chemoimmunotherapy. Here, we will review the mechanism of action of t...

journal_title：Current oncology reports

authors： Rhodes J,Mato A,Sharman JP

更新日期：2018-04-11 00:00:00

abstract：:Intensity-modulated radiotherapy (IMRT) is the next evolutionary step of three-dimensional conformal radiotherapy (3-DCRT). IMRT plans are generated with computer-optimized nonuniform radiation beam intensities incident on a target or patient. The dose distributions in IMRT show significantly higher conformality compa...

journal_title：Current oncology reports

authors： Peñagarícano JA,Papanikolaou N

更新日期：2003-03-01 00:00:00

abstract：:There is no clear consensus regarding the most effective management of poor responders to neoadjuvant chemotherapy. Intensifying or changing primary systemic treatment has not been shown to offer any benefit. There is a paucity of trials testing the utility of adjuvant chemotherapy in this setting. Adjuvant hormonal t...

journal_title：Current oncology reports

authors： Wesolowski R,Budd GT

更新日期：2009-01-01 00:00:00

abstract：:Epidemiologic studies supported by molecular technology have provided sufficient evidence of the causal role of some human papillomavirus (HPV) infections in the development of cervical cancer. The finding is consistent universally, and HPV has been proposed as the first identified necessary cause of cervical cancer. ...

journal_title：Current oncology reports

authors： Bosch FX,de Sanjosé S

更新日期：2002-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to discuss the current role of radiotherapy (RT) for early-stage Hodgkin's lymphoma (HL) in the context of risk-adapted and response-adapted treatment strategy, and describe changes in RT technical approach. RECENT FINDINGS:In low-risk patients, RT could be omitted but, at ...

journal_title：Current oncology reports

authors： Filippi AR,Levis M,Parikh R,Hoppe B

更新日期：2017-05-01 00:00:00

abstract：:Osteoporosis is a disease that causes substantial morbidity and mortality for which preventive therapy is available. Women with breast cancer are at increased risk for osteoporosis for several reasons, including premature ovarian failure as a result of treatment, direct effects of chemotherapy, and effects of the brea...

journal_title：Current oncology reports

authors： Mincey BA

更新日期：2003-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with cancer have an elevated risk of cardiovascular disease. This review describes the cardiovascular risks of different cancer therapies and the evidence for cardioprotective strategies. RECENT FINDINGS:Recent studies have provided additional support for the safety and efficacy of dexrazoxa...

journal_title：Current oncology reports

authors： Upshaw JN

更新日期：2020-06-20 00:00:00