Abstract：
:Imprinted genes play important roles in mammalian growth, development and behavior. In this study, we obtained 1568 bp mRNA sequence of porcine DIO3 (deiodinase, iodothyronine, type III), and also identified its imprinting status during porcine fetal development. The complete open reading frame (ORF) encoding 278 amino acids. The porcine DIO3 mRNA was expressed predominantly in backfat, mildly in liver, uterus, kidney, heart, small intestine, muscle and stomach, and almost absent in spleen and lung. A single nucleotide polymorphism in exon (A/C (687)) was used to investigate the allele frequencies in different pig breeds and the imprinting status in porcine embryonic tissues. The results indicate that DIO3 was imprinted in all the tested tissues. Statistical analysis showed the DIO3 gene polymorphism was significantly associated with almost all the fat deposition and carcass traits, including lean meat percentage (LMP), fat meat percentage (FMP), ratio of lean to fat (RLF), shoulder fat thickness (SFT), sixth-seventh rib fat thickness (RFT), buttock fat thickness (BFT), loin eye area (LEA), and intramuscular fat (IMF).
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Qiao M,Wu HY,Guo L,Mei SQ,Zhang PP,Li FE,Zheng R,Deng CYdoi
10.1007/s11033-011-0983-zsubject
Has Abstractpub_date
2012-03-01 00:00:00pages
2329-35issue
3eissn
0301-4851issn
1573-4978journal_volume
39pub_type
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pub_type： 杂志文章
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journal_title：Molecular biology reports
pub_type： 已发布勘误,撤回出版物
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更新日期：2019-10-01 00:00:00
