Abstract:
:Obesity is for many scholars the most important starting status that gives rise to Metabolic Syndrome (MS) and Type 2 Diabetes (T2D). In the present paper, a genetically homogeneous Amerindian population, as defined by HLA genes, has been genotyped for one of the MS and T2D predisposing genes: PPAR-γ Ala12 and Pro 12 variants. Ala12 has been negatively associated with obesity, but other authors do not find such an association. Notwithstanding, a meta-analysis that used many subjects clearly demonstrated that PPAR-γ Ala12 bearing ones had a reduced risk for T2D. Our results show that Amerindians do not have association of PPAR-γ2 Ala12 and obesity; the latter was measured by waist circumference values after taken specific Amerindian normal waist parameters. Also, a population genetics study indicates that Pro12 allele was the wild allele, which must have occurred before modern humans left Africa. Ala12 may have appeared in Caucasoids later on, according to our comparisons. Negroids tend to show low or null Ala 12 allele frequencies, while most other populations have a significant frequency, particularly European Caucasoids. This may suggest that appearance of Ala12 allele occurred after populations adapted to an agricultural feeding.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Arnaiz-Villena A,Fernández-Honrado M,Areces C,Enríquez-de-Salamanca M,Abd-El-Fatah-Khalil S,Coca C,Arribas I,Algora M,Rey Ddoi
10.1007/s11033-012-2230-7subject
Has Abstractpub_date
2013-02-01 00:00:00pages
1767-74issue
2eissn
0301-4851issn
1573-4978journal_volume
40pub_type
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