Abstract:
:Olanzapine, an atypical antipsychotic medication, has been associated with weight gain and metabolic toxicity, especially in long term usage. Carnosic acid (CA), a major constituent of rosemary extract, has been shown to improve metabolic abnormalities. In this experiment, the effect of CA on olanzapine-induced obesity and metabolic toxicity has been evaluated. Female Wistar rats were divided into six groups. (1) control; (2) olanzapine (5 mg/kg/day, IP); (3, 4 and 5) olanzapine (5 mg/kg/day, IP) plus CA (5, 10 and 20 mg/kg/day, gavage) and (6) CA (20 mg/kg/day, gavage). Bodyweight and food intake were measured during the study. After 14 days, mean systolic blood pressure (MSBP), glycemia, serum lipid profile, the serum concentration of leptin, insulin, AMPK, P-AMPK, and P-ACC liver protein levels were evaluated. The mean weight in the group received olanzapine increased by 4.8 g at the end of the study. The average food intake was increased by olanzapine. Olanzapine increased triglyceride, fasting blood glucose (FBG), and leptin levels. It increased MSBP and down-regulated P-AMPK/AMPK ratio and P-ACC protein levels. CA (three doses) decreased body weight gain and reduced average food intake at 10 and 20 mg/kg. CA especially at the highest dose decreased the changes in lipid profile, FBG, leptin level, and MSBP. P-AMPK/AMPK and P-ACC protein levels were increased by carnosic acid. In conclusion, the activation of AMPK by CA can be proposed as a key mechanism against olanzapine-induced metabolic toxicity where the activation of AMPK increases fat consumption and regulates glucose hemostasis in the liver.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Razavi BM,Abazari AR,Rameshrad M,Hosseinzadeh Hdoi
10.1007/s11033-020-05825-5subject
Has Abstractpub_date
2020-10-01 00:00:00pages
7583-7592issue
10eissn
0301-4851issn
1573-4978pii
10.1007/s11033-020-05825-5journal_volume
47pub_type
杂志文章abstract::The two predominant forms of arginase, cytosolic Arginase-I and mitochondrial Arginase-II, catalyze hydrolysis of arginine into ornithine and urea. Based on presence of arginase activity in extracts using potassium chloride (KCl), mitochondrial membrane-bound arginase has also been suggested. However, the activity of ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-016-3965-3
更新日期:2016-05-01 00:00:00
abstract::This study investigated the role of the mevalonate pyrophosphate decarboxylase gene in the triterpene biosynthetic pathway of Ganoderma lucidum. The mevalonate pyrophosphate decarboxylase gene (mvd) was isolated using a degenerate primer-PCR technique. An analysis of the Gl-mvd transcription profile revealed a positiv...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1431-9
更新日期:2012-05-01 00:00:00
abstract::AP2/ERF transcription factors play an important role in regulation of the cross-talk between ethylene and jasmonate signaling pathways mediating defense responses of plants to biotic and abiotic stresses. In this study, an AP2/ERF transcription factor gene was isolated and characterized from laticifers of rubber tree ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1146-y
更新日期:2012-04-01 00:00:00
abstract::Fluorescent proteins related to and derived from green fluorescent protein (GFP) are widely used as tools for investigating a wide range of biological processes. In particular, GFP and its relatives have been used extensively as qualitative reporters of gene expression in many different organisms, but relatively few s...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-008-9285-5
更新日期:2009-05-01 00:00:00
abstract::DNA-, RNA- and protein synthesis have been studied in Mycobacterium smegmatis cells infected with phage I3. The macromolecular synthesis continued until the end of latent period. Early RNA and protein synthesis were necessary prior to the commencement of DNA replication. The infecting phage DNA sedimented as larger th...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00798378
更新日期:1981-11-30 00:00:00
abstract::The aim of this work was to sequence the promoter region of β-lactoglobulin (BLG) gene in four sheep breeds, in order to identify polymorphisms, infer and analyze haplotypes, and phylogenetic relationship among the Valle del Belice breed and the other three breeds considered as ancestors. Sequencing analysis and align...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0794-2
更新日期:2012-01-01 00:00:00
abstract::Late-embryogenesis abundant (LEA) proteins have been reported to be closely correlated with the acquisition of desiccation tolerance during seed development and response of plant to drought, salinity, and freezing, etc. In this study, a LEA gene, CarLEA4 (GenBank accession no. GU247511), was isolated from chickpea bas...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1130-6
更新日期:2012-04-01 00:00:00
abstract::High Mobility Group Box 1 (HMGB1) is a nuclear protein participating in chromatin architecture and transcriptional regulation. Recently, there is increasing evidence that HMGB1 contributes to the pathogenesis of chronic inflammatory and autoimmune diseases due to its pro-inflammatory and immunostimulatory properties. ...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1007/s11033-009-9485-7
更新日期:2010-03-01 00:00:00
abstract::Imprinted genes play important roles in mammalian growth, development and behavior. In this study, we obtained 1568 bp mRNA sequence of porcine DIO3 (deiodinase, iodothyronine, type III), and also identified its imprinting status during porcine fetal development. The complete open reading frame (ORF) encoding 278 amin...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0983-z
更新日期:2012-03-01 00:00:00
abstract::The occurrence of PFD is closely related with elasticity, toughness, and functional changes of the connective tissue of the pelvic support tissue. This study aims to evaluate the effect of mechanical stretch on the differentiation of BMSCs with a co-culture with pelvic ligament fibroblasts. BMSCs was isolated and iden...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1422-x
更新日期:2012-05-01 00:00:00
abstract::Large-scale random cDNA sequencing projects have been started for several organisms and are a valuable tool for the analysis of quantitative and qualitative aspects of gene expression. However, the reliability of the obtained data is limited as most of the clones are only partially analysed on one strand. As a consequ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00424432
更新日期:1996-01-01 00:00:00
abstract::Syndecan-1 has been implicated in tumorigenesis and progression of various human malignancies. Recent studies have demonstrated that syndecan-1 may have a different function and biological activity depending on the specific tumor type. Therefore, the aim of this study was to investigate the clinical significance of sy...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1767-9
更新日期:2012-09-01 00:00:00
abstract::Differential display (DD) is a novel PCR-based technique, very commonly used to study differentially expressed genes at the mRNA level. In this paper we report a modified version of this technique that we have used to study the differences between the mRNA population from brain tissue of adult and old rats. We have mo...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-006-9010-1
更新日期:2007-03-01 00:00:00
abstract::Chemerin, as a new member of adipokines family, is highly expressed in adipose tissue in rodent and its expression increases with obesity. Moreover, chemerin has been reported to have significant relationship with metabolic syndrome and insulin sensitivity. Here, the gene encoding chemerin from Xiang pig was cloned. T...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0934-8
更新日期:2012-02-01 00:00:00
abstract::Correct classification of genomic variants causing potentially aberrant splicing is of utmost importance for patient management, especially in clinically actionable genes such as BRCA1/2. In this article, we report molecular evaluation of the BRCA1 c.439T>C (rs794727800, p.Leu147=) variant based on RNA of a patient su...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05199-3
更新日期:2020-02-01 00:00:00
abstract::Apolipoprotein AV (apoAV) modulates plasma triglyceride levels, which is an independent risk factor for cardiovascular disease. ApoAV is also involved in atherosclerosis lesion formation. In order to systematically evaluate the apolipoprotein-related gene profile in tree shrew, a model for its insusceptibility to athe...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2641-0
更新日期:2013-09-01 00:00:00
abstract::The full length cDNA sequence of the Tpt1/TCTP (Tumor protein, Translationally-controlled1) gene was identified from Common Carp (Cyprinus carpio, Cyprinidae), and was designated as CcTpt1 gene. The CDS is 510 bp and encodes a 170-amino acid peptide with a typical Tpt1 signature 2 domain, and is a typical Tpt1 protein...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2806-x
更新日期:2013-10-13 00:00:00
abstract::Spata34 is a testis-specific-expressed gene which exerts diverse functions in testis development. This study intends to examine the expression profiles of Spata34 in postnatal rat testis, and explore its potential roles in cell proliferation in vitro. We found that the mRNA and protein expression levels of Spata34 wer...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4439-6
更新日期:2018-12-01 00:00:00
abstract::Circular RNA (circRNA), a novel type of non-coding RNA that consists of a circular loop, has been demonstrated to act as a "sponge" for microRNAs (miRNAs). However, the role of circRNAs in keloid remains unknown. In this study, we investigated circRNA expression profiles in keloid to identify potential diagnostic and ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05120-y
更新日期:2020-01-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are implicated in atherosclerosis evolution into a coronary artery disease (CAD). They could be used as biomarkers for a predictive approach when they are studied simultaneously. We aim in our study to demonstrate prospectively in patients with history of CAD that MMPs level is linked ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04914-4
更新日期:2019-10-01 00:00:00
abstract::Severe malaria (SM) caused by Plasmodium falciparum (Pf) infection has been associated with life-threatening anemia, metabolic acidosis, cerebral malaria and multiorgan dysfunction. It may lead to death if not treated promptly. RNASE 3 has been linked to Pf growth inhibition and its polymorphisms found associated with...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05934-1
更新日期:2020-11-01 00:00:00
abstract::The leaf primordium derives from the peripheral zone of shoot apical meristem. During the formation of leaf primordia, they need to establish the proximodistal, mediolateral, and ab/adaxial axes. Among these axes, the ab/adaxial axis might be the most important. ASYMMETRIC LEAVES2 (AS2) gene is a member of AS2/LATERAL...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1288-y
更新日期:2012-04-01 00:00:00
abstract::We report complete mitochondrial genome of Northern Indian red muntjac, Muntiacus vaginalis, and its phylogenetic inferences. Mitogenome composition was 16,352 bp in length and its overall base composition in the circular genome was A = 33.2%, T = 29.0%, C = 24.50% and G = 13.30%. It exhibited a typical mitogenome str...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4486-z
更新日期:2019-02-01 00:00:00
abstract::The Cichlid fish Sarotherodon melanotheron is typically found in West and Central African estuaries and lagoons. It represents a good candidate for promoting tilapia farming in brackish waters. Understanding the genetic diversity in its populations from the hydrographical basins of Southern Benin is primordial before ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4354-x
更新日期:2018-12-01 00:00:00
abstract::FK-506 binding proteins (FKBPs) belong to the peptidyl-prolyl cis/trans isomerase superfamily (PPIases, EC: 5.2.1.8) which catalyzes the interconversion of peptidyl-prolyl bonds while they can also act on polypeptides, as folding helper enzymes. Here, we biochemically characterize two recombinant FKBPs, AvfkbA1 and Av...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1869-4
更新日期:2012-12-01 00:00:00
abstract::Laparoscopic surgery techniques have been increasingly preferred to classic laparotomy by surgeons since 1987. However, this method may have some side effects on different intraabdominal organs including kidneys. The aim of this study is to evaluate the effects of different pressures of CO2 on p53 related apoptosis in...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3519-5
更新日期:2014-10-01 00:00:00
abstract::Cytokinin oxidases are involved in the regulation of plant cytokinin levels, which are important in regulating plant growth and development, and may affect the yield of cereals. Here, we report the isolation and characterization of two putative cytokinin oxidase genes, TaCKX2.1 and TaCKX2.2, from wheat. Both TaCKX2.1 ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0367-9
更新日期:2011-04-01 00:00:00
abstract::The Cdx-2 polymorphism in VDR gene has been extensively investigated for association with cancer risk, however, results of different studies have been inconsistent. The objective of this study is to assess the relationship of the Cdx-2 polymorphism in VDR and cancer risk by meta-analysis. All eligible case-control stu...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-013-2503-9
更新日期:2013-07-01 00:00:00
abstract::The aim of this study was to determine whether the Fcγ receptors (FCGRs) polymorphisms confer susceptibility to periodontitis in ethnically different populations. We did a literature search using PubMed and Embase, and conducted a meta-analysis on the associations between the FCGR2A H131R (rs1801274), FCGR3A F158V (rs...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-013-2599-y
更新日期:2013-08-01 00:00:00
abstract::Haemoglobin meseenger RNA was isolated from spleen erythroïd cells of anaemic rabbits. The mRNA fraction looks quite homogeneous when analyzed by sucrose gradient centrifugation; it sediments in the 9S region. When added to an ascites cell free system, spleen 9S RNA stimulates the incorporation of radioactive leucine ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00357405
更新日期:1973-06-01 00:00:00