High Mobility Group Box 1: a potential therapeutic target for systemic lupus erythematosus.

abstract：:The CRISPR/Cas9 system now allows for unprecedented possibilities of genome editing. However, there are some limitations, including achieving efficient one-step multiple genome targeting to save costs, time, and ensure high quality. In the present study, we investigated the efficiency of one-step multiple gene modific...

journal_title：Molecular biology reports

authors： Hirata M,Wittayarat M,Namula Z,Le QA,Lin Q,Nguyen NT,Takebayashi K,Sato Y,Tanihara F,Otoi T

更新日期：2020-07-01 00:00:00

abstract：:The studies conducted aimed at evaluating the genetic diversity within and between varieties of conservative flocks of geese, using the polymorphism of 14 microsatellite sequences. The experimental material included conservative flocks of geese the following indigenous breeds and varieties kept in Poland: Kielecka (Ki...

journal_title：Molecular biology reports

authors： Parada R,Książkiewicz J,Kawka M,Jaszczak K

更新日期：2012-05-01 00:00:00

abstract：:HSG1 (Heat shock-induced gene 1) is one of the high-temperature-induced proteins in grapevine. Sequence analysis has demonstrated that HSG1 is a grape Bcl-2-associated athanogene (BAG) that contains IQ and BAG domains in its sequence. HSG1 expression was not detected in leaves without heat treatment, while tendrils, s...

journal_title：Molecular biology reports

authors： Kobayashi M,Takato H,Fujita K,Suzuki S

更新日期：2012-04-01 00:00:00

abstract：:This study was aimed to evaluate the regulation mechanism of cortactin (CTTN) on matrix metalloproteinases 9 (MMP-9) and its relations with Exo70 in invasion of hepatoma carcinoma (HCC) cells. The expression levels of CTTN, Exo70 and MMP-9 were detected in normal hepatocytes and various HCC cells by real-time PCR. The...

journal_title：Molecular biology reports

authors： Zhao G,Zhang H,Huang Z,Lv L,Yan F

更新日期：2016-05-01 00:00:00

abstract：:1-Deoxynojirimycin (DNJ), the main alkaloid in mulberry leaves, was recognized to treat patients with type 2 diabetes mellitus (T2DM). However, the regulatory mechanism of DNJ on glucose homeostasis was still unclear. In the present study, a safe concentration of 0.1-10 μmol/L for DNJ was incubated with mature 3T3-L1 ...

journal_title：Molecular biology reports

authors： Li Q,Wang Y,Dai Y,Shen W,Liao S,Zou Y

更新日期：2019-12-01 00:00:00

abstract：:Irritable bowel syndrome (IBS) is one of the most common gastrointestinal diagnoses seen by primary care providers and gastroenterologists. Proinflammatory cytokines interleukin (IL)-6 and IL-8 have been found increased in IBS patients. Cytokine gene single nucleotide polymorphisms (SNPs) of IL-8 and IL-10 have not be...

journal_title：Molecular biology reports

authors： Romero-Valdovinos M,Gudiño-Ramírez A,Reyes-Gordillo J,Martínez-Flores WA,Ramírez-Miranda ME,Maravilla P,Olivo-Díaz A

更新日期：2012-09-01 00:00:00

abstract：:β-Catenin plays a crucial role in embryonic development and responds to the activation of several signal transduction pathways. In this paper, in order to understand the functions of β-catenin gene in early embryonic development of Artemia sinica, the complete cDNA sequence was cloned for the first time using RACE tec...

journal_title：Molecular biology reports

authors： Li X,Hou L,Ma J,Liu Y,Zheng L,Zou X

更新日期：2012-01-01 00:00:00

abstract：:The protease activity of gp63 from L. major was studied in relation to tunicamycin induced N-deglycosylation. It was found that after tunicamycin treatment, a N-deglycosylated product of gp63 with protease activity is present at the cell surface of Leishmania promastigote. ...

journal_title：Molecular biology reports

authors： Hernandez C,Manenti S,Hernandez AG

更新日期：1992-05-01 00:00:00

abstract：:The interleukin (IL)-1β-511 C/T polymorphism has been shown to be functional and to contribute to the risk of gastric cancer. However, the relationship between the IL-1β-511 C/T polymorphism and gastric carcinogenesis remains inconclusive. A systematical electronic search was conducted of the MEDLINE, EMBASE, and CENT...

journal_title：Molecular biology reports

authors： Park MJ,Hyun MH,Yang JP,Yoon JM,Park S

更新日期：2015-01-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) is an essential cofactor for aromatic acid hydroxylases, which control the levels of monoamine neurotransmitters. BH4 deficiency has been associated with many neuropsychological disorders. Dihydrofolate reductase (DHFR) can catalyze 7,8-dihydrobiopterin to 5,6,7,8-tetrahydrobiopterin (BH4) in...

journal_title：Molecular biology reports

authors： Wang W,Gao J,Wang J,Liu C,Meng Y

更新日期：2012-12-01 00:00:00

abstract：:Substantial epidemiological studies have shown an association of obesity with the common gynecological malignancy, endometrial cancer. The relevant interactions and contribution of estradiol and the adipose cytokine, leptin, in endometrial lesions are not completely understood. Suitable animal models to understand the...

journal_title：Molecular biology reports

authors： Shetty A,Venkatesh T,Tsutsumi R,Suresh PS

更新日期：2020-01-01 00:00:00

abstract：:Dyggve melchior clausen syndrome (DMC, MIM 223800) is a very rare autosomal recessive form of skeletal dysplasia associated with various degrees of mental retardation. It is characterized by a progressive spondyloepimetaphyseal dysplasia (SEMD) with disproportionate short stature, generalized platyspondyly and lacy il...

journal_title：Molecular biology reports

authors： Abdullah,Shah PW,Nawaz S,Hussain S,Ullah A,Basit S,Ahmad W

更新日期：2020-09-01 00:00:00

abstract：:Melanotransferrin (MTf), a member of the transferrin families, plays an important role in immune response. But the research about MTf in sea cucumber is limited till now. In this study, the Melanotransferrin (Aj-MTf) gene was firstly cloned and characterized from the sea cucumber Apostichoupus japonicus by reverse tra...

journal_title：Molecular biology reports

authors： Qiu X,Li D,Cui J,Liu Y,Wang X

更新日期：2014-06-01 00:00:00

abstract：:Oryza rufipogon L. (O. rufipogon) or a common wild rice, showed considerable aluminum (Al) tolerance. In this study, we examined the physiologic and genetic response of wild rice short term and long term to Al toxicity, respectively. In the short term study, morin staining, DAPI staining and aniline blue staining were...

journal_title：Molecular biology reports

authors： Cao Y,Lou Y,Han Y,Shi J,Wang Y,Wang W,Ming F

更新日期：2011-11-01 00:00:00

abstract：:Membrane-bound ribosomes were isolated from a post-mitochondrial supernatant fraction of mouse liver homogenate by sedimentation in a sucrose density gradient, Loose ribosomes were released from the membrane fragments with 0.5 M KCl, while tight bound ribosomes were not released. After purification of the loose and ti...

journal_title：Molecular biology reports

authors： Hoffman WL,Dowben RM

更新日期：1980-07-31 00:00:00

abstract：:This experiment was conducted to explore the biological functions of myogenin (MyoG) gene. MyoG gene was cloned from genome of Hu sheep by overlap extension PCR. Then, pEGFP-C1-MyoG and pcDNA3.0-MyoG fusion expression vectors was constructed and pEGFP-C1-MyoG vector had been transfected into NIH-3T3 cells by liposomes...

journal_title：Molecular biology reports

authors： Zhang Z,Xu F,Zhang Y,Li W,Yin Y,Zhu C,Du L,Elsayed AK,Li B

更新日期：2014-02-01 00:00:00

abstract：:F-box proteins play important roles in the regulation of various developmental processes in plants. Approximately 1796 F-box genes have been identified in the wheat genome, but details of their functions remain unknown. Moreover, not much was known about the roles of kelch repeat domain-containing F-box genes (TaKFBs)...

journal_title：Molecular biology reports

authors： Hong MJ,Kim DY,Choi HI,Seo YW,Kim JB

更新日期：2020-02-01 00:00:00

abstract：:Cotton fiber cells elongate without dividing to form economically valuable spinnable fiber. Reports of the ploidy level of fiber cells are variable. Early reports indicated an increase in nuclear DNA content in young fibers; however, subsequent reports failed to observe such a significant increase in ploidy level. Eva...

journal_title：Molecular biology reports

authors： Taliercio E,Ray J,Scheffler J

更新日期：2010-02-01 00:00:00

abstract：:Two GATC specific methylases together with Sau3AI isoschizomeric restriction endonuclease were partially characterized in Mitsuokella multiacida 46/5. This is the first report on the presence of solitary Dam methyltransferase alongside GATC specific restriction-modification system resulting in the unusual two-fold met...

journal_title：Molecular biology reports

authors： Piknova M,Filova M,Javorsky P,Pristas P

更新日期：2005-12-01 00:00:00

abstract：:The purpose of this study was to identify genomic regions, quantitative trait loci (QTL), affecting carcass traits on chromosome 1 in an F2 population of Japanese quail. For this purpose, two white and wild strains of Japanese quail (16 birds) were crossed reciprocally and F1 generation (34 birds) was created. The F2 ...

journal_title：Molecular biology reports

authors： Moradian H,Esmailizadeh AK,Sohrabi SS,Nasirifar E,Askari N,Mohammadabadi MR,Baghizadeh A

更新日期：2014-07-01 00:00:00

abstract：:Many environmental and genetic factors have been contributed to the development of systemic sclerosis (SSc). To determine whether IL-10 gene polymorphisms are associated with SSc, we conducted a meta-analysis approach. A total of eight studies involving 1,034 SSc cases and 1,815 controls were obtained by electronic da...

journal_title：Molecular biology reports

authors： Peng WJ,Wang BX,Pan HF,Tao JH,Zhang JQ,He Q,Xiao CC,Wang J

更新日期：2012-06-01 00:00:00

abstract：:Spermiogenesis is a developmental process undergoing continuous differentiation to drive a diploid spermatogonium towards a haploid sperm cell. This striking transformation from spermatogonium to spermatozoa is made possible by the stage-specific adaption of cytoskeleton and associated molecular motor proteins. KIFC1 ...

journal_title：Molecular biology reports

authors： Wang YT,Mao H,Hou CC,Sun X,Wang DH,Zhou H,Yang WX

更新日期：2012-07-01 00:00:00

abstract：:The mechanism by which external Bax releases cytochrome c is still controversial and may also depend on the type of mitochondria and the actual localisation of cytochrome c. Outer membrane porin acquires high binding affinity for hexokinase by interacting with the adenine nucleotide translocator (ANT) in the contact s...

journal_title：Molecular biology reports

authors： Vyssokikh MY,Zorova L,Zorov D,Heimlich G,Jürgensmeier JJ,Brdiczka D

更新日期：2002-01-01 00:00:00

abstract：:To determine the plasma lipid and lipoprotein profiles and their possible association with the type of β-thalassemia mutation we studied 103 major β-thalassemia patients including 71 children and 32 young adults compared to 102 healthy subjects consisted of 90 children and 12 young healthy adults. The plasma lipid and...

journal_title：Molecular biology reports

authors： Madani H,Rahimi Z,Manavi-Shad M,Mozafari H,Akramipour R,Vaisi-Raygani A,Rezaei M,Malek-Khosravi S,Shakiba E,Parsian A

更新日期：2011-04-01 00:00:00

abstract：:Blood and liver from curimbata (Prochilodus lineatus) acclimated at pH 4.5, 7.0 and 8.0 and at 20 and 30 °C were exposed in vitro to different concentrations of copper (Cu): 98 ± 0.8 μg Cu L-1 at pH 4.5 and 16 ± 0.2 μg Cu L-1 at pH 8.0 at 20 °C; 88 ± 0.8 μg Cu L-1 at pH 4.5 and 14 ± 0.5 μg Cu L-1 at pH 8.0 at 30 °C an...

journal_title：Molecular biology reports

authors： Dos Santos Carvalho C,Fernandes MN

更新日期：2019-10-01 00:00:00

abstract：:Apolipoprotein AV (apoAV) modulates plasma triglyceride levels, which is an independent risk factor for cardiovascular disease. ApoAV is also involved in atherosclerosis lesion formation. In order to systematically evaluate the apolipoprotein-related gene profile in tree shrew, a model for its insusceptibility to athe...

journal_title：Molecular biology reports

authors： Li G,Luo H,Sun G,Wu G,Wu G,Wang Y,Man Y,Wang S,Li J,Chen B

更新日期：2013-09-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) located at the cell surface and in the extracellular matrix of most animal tissues are proteoglycan coreceptors that carry heparan sulfate chains, and play a vital role in infections of many diseases. HSPGs are classified as glypican, syndecan, perlecan and agrin according to diff...

journal_title：Molecular biology reports

authors： Wang W,Tao C,Zhou P,Zhou X,Zhang Q,Liu B

更新日期：2013-03-01 00:00:00

abstract：:Maize (Zea mays L.) is an important model plant with an important role in agriculture and national economies all over the world. The optimum growth temperature of maize is between 25 and 28 °C. At temperatures below 12 °C, maize is vulnerable to damage by chilling stress. MYB transcription factors play important roles...

journal_title：Molecular biology reports

authors： Li M,Lin L,Zhang Y,Sui N

更新日期：2019-08-01 00:00:00

abstract：:Combined treatment with niacin and chromium has been found to have a protective effect against oxidative damage to different tissues of hyperlipidemic rats. But its effects on vascular endothelial dysfunction are less clear. This study was performed to investigate the effect of combined treatment with niacin and chrom...

journal_title：Molecular biology reports

authors： Niu N,Yu YH,Wang Y,Wang LJ,Li Q,Guo LM

更新日期：2009-07-01 00:00:00

abstract：:The present meta-analysis of relevant case-control studies was conducted to investigate the possible relationships between genetic variations in the killer cell immunoglobulin-like receptor (KIR) gene clusters of the human KIR gene family and susceptibility to ankylosing spondylitis (AS). The following electronic data...

journal_title：Molecular biology reports

authors： Zuo HN,Wang ZL,Cui DR,Xin DJ

更新日期：2014-08-01 00:00:00