Combined effects of niacin and chromium treatment on vascular endothelial dysfunction in hyperlipidemic rats.

abstract：:As an essential signaling modulator, Src gene appears to be necessary for increased expression of the prolactin receptor, normal downstream signaling, and alveolar cell organization. In this study, we detected the polymorphism of Src gene by polymerase chain reaction-restriction fragment length polymorphism assay (PCR...

journal_title：Molecular biology reports

authors： Liu W,Wang J,Li Q,Ju Z,Huang J,Wang H,Liu S,Li J,Zhong J,Wang C

更新日期：2010-12-01 00:00:00

abstract：:Genetic susceptibility and environment exposures are associated risk factors in carcinogenesis. Gene polymorphisms that decrease the activity of detoxifying carcinogen substances may modify the effect of exposures. We investigated whether the polymorphisms PON1 rs662 (Q192R), and PON1 rs854560 (L55M) would be associat...

journal_title：Molecular biology reports

authors： Vasconcelos GM,Gonçalves BA,Montalvão-de-Azevedo R,Thuler LC,Braga FH,Pombo-de-Oliveira MS,de Camargo B,Brazilian Embryonal Tumor Group.

更新日期：2014-09-01 00:00:00

abstract：:Serotonin receptor (5-HT) is a biogenic amine acting as a neurotransmitter and neuromodulator that mediates various aspects of reproduction and gametogenesis. The full-length nucleotide sequence of Haliotis discus hannai encodes a protein of 417 amino acids with a predicted molecular mass of 46.54 kDa and isoelectric ...

journal_title：Molecular biology reports

authors： Sharker MR,Sukhan ZP,Kim SC,Lee WK,Kho KH

更新日期：2020-01-01 00:00:00

abstract：:We report here a cDNA and its deduced amino acid sequence encoding a cathepsin D-like, aspartic protease from Chlamys farreri (denoted as CfCD) by expressed sequence tag and rapid amplification of cDNA ends techniques. The cDNA of CfCD consisted of 1,810 nucleotides with a canonical polyadenylation signal sequence AAT...

journal_title：Molecular biology reports

authors： Li C,Zhang H,Li L,Song L

更新日期：2010-03-01 00:00:00

abstract：:High Mobility Group Box 1 (HMGB1) is a nuclear protein participating in chromatin architecture and transcriptional regulation. Recently, there is increasing evidence that HMGB1 contributes to the pathogenesis of chronic inflammatory and autoimmune diseases due to its pro-inflammatory and immunostimulatory properties. ...

journal_title：Molecular biology reports

authors： Pan HF,Wu GC,Li WP,Li XP,Ye DQ

更新日期：2010-03-01 00:00:00

abstract：:Phage display procedure was applied to the N-terminal domain of human topoisomerase I. The consensus sequence identified for clones binding to the N-terminal domain was found in 35 human proteins that are either permanently or temporarily located in the nucleus. They are in majority involved in the DNA repair, transcr...

journal_title：Molecular biology reports

authors： Trzcińska AM,Girstun A,Piekiełko A,Kowalska-Loth B,Staroń K

更新日期：2002-12-01 00:00:00

abstract：:α-Synuclein is a presynaptic neuronal protein that is abundant in the human brain and is linked genetically and neuropathologically to Parkinson's disease (PD). The E46K mutation of the α-synuclein gene has been linked to autosomal dominant early-onset of PD. Crocin is a carotenoid chemical compound of saffron that ha...

journal_title：Molecular biology reports

authors： Ghasemi Tigan M,Ghahghaei A,Lagzian M

更新日期：2019-08-01 00:00:00

abstract：:The present meta-analysis of relevant case-control studies was conducted to investigate the possible relationships between genetic variations in the killer cell immunoglobulin-like receptor (KIR) gene clusters of the human KIR gene family and susceptibility to ankylosing spondylitis (AS). The following electronic data...

journal_title：Molecular biology reports

authors： Zuo HN,Wang ZL,Cui DR,Xin DJ

更新日期：2014-08-01 00:00:00

abstract：:Uterine leiomyomas (UL) are prevalent benign tumors, especially among women of African ancestry. The disease also has genetic liability and is influenced by risk factors such as hormones and obesity. This study investigates the haplotypes of the Cytochrome P450 1B1 gene (CYP1B1) related to hormones and coiled-coil dom...

journal_title：Molecular biology reports

authors： Alleyne AT,Bideau VS

更新日期：2019-06-01 00:00:00

abstract：:ColE1 DNA replication is initiated by RNA II and inhibited by RNA I. Control of the replication occurs through the interaction between RNA I and RNA II. Therefore, RNases involved in the metabolism of RNA I and RNA II are expected to play a key role in the control of the ColE1 plasmid replication. RNase H, RNase E, RN...

journal_title：Molecular biology reports

authors： Jung YH,Lee Y

更新日期：1995-01-01 00:00:00

abstract：:Actins are ubiquitous and highly conserved proteins that play key roles in cell formation and cellular activities. In this study, an actin gene was isolated from chickpea for the first time and designated as CarACT1 (for Cicer arietinum L. actin gene 1; Genbank accession no. EU529707). It encoded a putative protein wi...

journal_title：Molecular biology reports

authors： Peng H,Cheng H,Yu X,Shi Q,Zhang H,Li J,Ma H

更新日期：2010-02-01 00:00:00

abstract：:In view of high mortality associated with coronary artery disease (CAD), development of an early predicting tool will be beneficial in reducing the burden of the disease. The database comprising demographic, conventional, folate/xenobiotic genetic risk factors of 648 subjects (364 cases of CAD and 284 healthy controls...

journal_title：Molecular biology reports

authors： Naushad SM,Hussain T,Indumathi B,Samreen K,Alrokayan SA,Kutala VK

更新日期：2018-10-01 00:00:00

abstract：:In the present work, Site-directed mutagenesis to insert the Glu50Lys amino acid substitution was achieved by PCR using plasmid pBluescript-OPTN. Mutated human OPTN(E50K) gene-driven mouse c-kit promoter was constructed and confirmed by endonuclease digestion and sequence analysis. Transgenic mice were generated via t...

journal_title：Molecular biology reports

authors： Meng Q,Xiao Z,Yuan H,Xue F,Zhu Y,Zhou X,Yang B,Sun J,Meng B,Sun X,Cheng F

更新日期：2012-02-01 00:00:00

abstract：:Regulation of the sumoylation system at the level of gene expression has not yet been explored. To begin to define transcriptional regulatory features, the promoter region for the SUMO1 gene was cloned from human genomic DNA and characterized. Initially, a 532 base pair fragment upstream of and including the predicted...

journal_title：Molecular biology reports

authors： Nanos-Webb A,Deyrieux A,Bian XL,Rosas-Acosta G,Wilson VG

更新日期：2010-03-01 00:00:00

abstract：:Relying on the regulation of transcription factors, plants resist to various abiotic and biotic stresses. NAC (NAM, ATAF1/2, CUC2) are one of the largest families of plant-specific transcription factors and known to play important roles in plant development and response to environmental stresses. A new NAC gene was cl...

journal_title：Molecular biology reports

authors： Wang YX

更新日期：2013-11-01 00:00:00

abstract：:The modified base queuine is a nutrient factor for lower and higher eukaryotes except yeast. It is synthesized in eubacteria and inserted into the wobble position of specific tRNAs (tRNA(GUN)) in exchange of guanine at position 34. The tRNAs of Q family are completely modified in terminally differentiated somatic cell...

journal_title：Molecular biology reports

authors： Pathak C,Vinayak M

更新日期：2005-09-01 00:00:00

abstract：:Insect molting is an important developmental process of metamorphosis, which is initiated by molting hormone. The molting process includes the activation of dermal cells, epidermal cells separation, molting fluid secretion, the formation of new epidermis and old epidermis excoriation etc. Polyphenol oxidases (PPOs), d...

journal_title：Molecular biology reports

authors： Wang MX,Lu Y,Cai ZZ,Liang S,Niu YS,Miao YG

更新日期：2013-05-01 00:00:00

abstract：:Sensitivity to phenylthiocarbamide (PTC) has a bimodal distribution pattern and the genotype of the TAS2R38 gene, which is composed of combinations of three coding single nucleotide polymorphisms (SNPs), p.A49P (c.145G>C), p.V262A (c.785T>C) and p.I296 V (c.886A>G), determines the ability or inability to taste PTC. In...

journal_title：Molecular biology reports

authors： Sagong B,Bae JW,Rhyu MR,Kim UK,Ye MK

更新日期：2014-03-01 00:00:00

abstract：:PCR low ionic strength single-strand conformation polymorphism (PCR-LIS-SSCP) and DNA sequencing methods were used to analyze the polymorphisms within the coding region of bovine ATP1A1 gene. A novel C/A mutation was identified at the nucleotide position 2789 of the ATP1A1 mRNA, but it was silent with respect to the a...

journal_title：Molecular biology reports

authors： Liu Y,Li D,Li H,Zhou X,Wang G

更新日期：2011-01-01 00:00:00

abstract：:The present study brings out the preventive role of (-)-epigallocatechin-gallate (EGCG) on cardiac mitochondrial metabolism and apoptosis in cigarette smoke (CS)-exposed rats. The CS-exposed rats showed significantly decreased activities of TCA cycle enzymes and mitochondrial enzymatic antioxidants, on the other hand,...

journal_title：Molecular biology reports

authors： Adikesavan G,Vinayagam MM,Abdulrahman LA,Chinnasamy T

更新日期：2013-12-01 00:00:00

abstract：:Rice production in recent years is highly affected by rapidly increasing temperatures in the tropical and sub-tropical countries, which threatens the sustainable production in near future. Hence, understanding the heat tolerance mechanism and evolving tolerant varieties is an immense need in the staple crop rice. An e...

journal_title：Molecular biology reports

authors： Wahab MMS,Akkareddy S,Shanthi P,Latha P

更新日期：2020-03-01 00:00:00

abstract：:The circular dichroism spectra of poly(dG). poly(dC) have been studied as a function of pH in 0.15 M NaCl solution. Acid titration to pH 2.5 showed two transitions, one around pH 5, the second below pH 3. These transitions are disproportionation reactions and are not due to the dissociation of the complexes. Alkaline ...

journal_title：Molecular biology reports

authors： Thiele D,Sarocchi MT,Guschlbauer W,Marck C

更新日期：1973-10-01 00:00:00

abstract：:Recently genetics and epigenetics alterations have been found to be characteristic of malignancy and hence can be used as targets for detection of neoplasia. RAS association domain family protein 1A (RASSF1A) gene hypermethylation has been a subject of interest in recent researches on cancer breast patients. The aim o...

journal_title：Molecular biology reports

authors： Hagrass HA,Pasha HF,Shaheen MA,Abdel Bary EH,Kassem R

更新日期：2014-01-01 00:00:00

abstract：:In the present study, we characterized an evolutionarily conserved non-transmembrane ATP-binding cassette protein: hABCF3. Subcellular immunofluorescence staining demonstrated that hABCF3 localizes preferentially in cytoplasm, unlike its paralog protein hABCF1, which localizes in both cytoplasm and nucleus. Quantitati...

journal_title：Molecular biology reports

authors： Zhou J,Lin Y,Shi H,Huo K,Li Y

更新日期：2013-10-01 00:00:00

abstract：:As a kind of binding protein, the type 1 Na(+)/H(+) exchanger (NHE1) is a receptor for the highly pathogenic Avian leukosis viruses-J subgroup (ALV-J) in chicken. In order to investigate the potential effect of chicken NHE1 gene on leukosis, we compared its expression between ALV-J-affected and -unaffected chicken, sc...

journal_title：Molecular biology reports

authors： Chen B,Pan W,Zhang L,Liu J,Ouyang H,Nie Q,Zhang X

更新日期：2014-10-01 00:00:00

abstract：:Dyggve melchior clausen syndrome (DMC, MIM 223800) is a very rare autosomal recessive form of skeletal dysplasia associated with various degrees of mental retardation. It is characterized by a progressive spondyloepimetaphyseal dysplasia (SEMD) with disproportionate short stature, generalized platyspondyly and lacy il...

journal_title：Molecular biology reports

authors： Abdullah,Shah PW,Nawaz S,Hussain S,Ullah A,Basit S,Ahmad W

更新日期：2020-09-01 00:00:00

abstract：:Many environmental and genetic factors have been contributed to the development of systemic sclerosis (SSc). To determine whether IL-10 gene polymorphisms are associated with SSc, we conducted a meta-analysis approach. A total of eight studies involving 1,034 SSc cases and 1,815 controls were obtained by electronic da...

journal_title：Molecular biology reports

authors： Peng WJ,Wang BX,Pan HF,Tao JH,Zhang JQ,He Q,Xiao CC,Wang J

更新日期：2012-06-01 00:00:00

abstract：:FK-506 binding proteins (FKBPs) belong to the peptidyl-prolyl cis/trans isomerase superfamily (PPIases, EC: 5.2.1.8) which catalyzes the interconversion of peptidyl-prolyl bonds while they can also act on polypeptides, as folding helper enzymes. Here, we biochemically characterize two recombinant FKBPs, AvfkbA1 and Av...

journal_title：Molecular biology reports

authors： Dimou M,Zografou C,Venieraki A,Katinakis P

更新日期：2012-12-01 00:00:00

abstract：:Our previous studies have shown that miR-125b-5p was highly expressed and significantly upregulated during abdominal fat deposition in chickens. However, the role of miR-125b in the regulation of adipogenesis is not clear in chickens. Therefore, we evaluated the effects of miR-125b-5p on preadipocyte proliferation and...

journal_title：Molecular biology reports

authors： Li G,Chen Y,Jin W,Zhai B,Li Y,Sun G,Li H,Kang X,Tian Y

更新日期：2021-01-04 00:00:00

abstract：:Hepatitis C virus (HCV) can be classified into six major genotypes. The HCV genotypes variability accounts for its geographical distribution, its responses to treatments and the clinical outcomes. The aim of this study was to determine the distribution of HCV genotypes among volunteer blood donors in Thailand. Samples...

journal_title：Molecular biology reports

authors： Sistayanarain A,Kunthalert D,Vipsoongnern Y

更新日期：2011-10-01 00:00:00