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Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display.

Abstract：

:Phage display procedure was applied to the N-terminal domain of human topoisomerase I. The consensus sequence identified for clones binding to the N-terminal domain was found in 35 human proteins that are either permanently or temporarily located in the nucleus. They are in majority involved in the DNA repair, transcription, RNA metabolism or cell cycle control. Four of identified proteins: Bub3 protein, Cockayne syndrome protein A, damaged DNA binding protein 2 and GRWD protein belong to WD-repeat proteins and their sequences recognized by the N-terminal domain are identically localized.

journal_name

Mol Biol Rep

journal_title

Molecular biology reports

authors

Trzcińska AM,Girstun A,Piekiełko A,Kowalska-Loth B,Staroń K

doi

10.1023/a:1021237021338

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

347-52

issue

4

eissn

0301-4851

issn

1573-4978

journal_volume

29

pub_type

杂志文章

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