Abstract:
:In vivo and in vitro expressed N-terminal sequence of EWS (EAD) and hsRPB7 (subunit of human RNA polymerase II) were probed for protein-protein interactions using pull-down assays. In result, it was found that the proteins 57Z (residues 1-57 of EAD) and hsRPB7 interact in vitro forming a stable complex. The direct interaction between 57z and hsRPB7 indicate that DHR-related peptides and other small molecules, targeted to N-terminus of EWS might possess therapeutic potentialities as anti-cancer agents to function as inhibitors of EAD-mediated transactivation.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Todorova Rdoi
10.1007/s11033-008-9308-2subject
Has Abstractpub_date
2009-07-01 00:00:00pages
1269-74issue
6eissn
0301-4851issn
1573-4978journal_volume
36pub_type
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