Abstract:
:Study of retina specific genes would offer insights into retinal diseases and treatment. Based on the information from the gene expression profiles of mouse retinas, we here identified a mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) as one of the highly expressed proteins in retina. Sequence analysis revealed that mouse and rat MGARPs have an extra insertion of four consecutive amino acid repeats at the C-terminus, while other homologues do not. MGARP was demonstrated to be localized to the mitochondria and overexpression of MGARP missing N-terminal region causes severe mitochondrial aggregation, implying an important role of MGARP in maintaining mitochondrial morphology. MGARP is highly expressed in mitochondria-rich layers, including inner segment of the photoreceptor, outer plexiform layer and ganglion cell layers of mouse retina. Far-UV CD spectrum analysis suggested that MGARP exhibits a large area of intrinsic disorder and the unusual position of its Tyr fluorescence suggested that Tyr residues in MGARP might form excimer and exist in an ionized state. These findings implied that MGARP be a good candidate for assembling certain ion channels on mitochondria membrane and have great potential to be involved in retinal energetic metabolism through mitochondria related pathway.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Qi S,Wang Y,Zhou M,Ge Y,Yan Y,Wang J,Zhang SS,Zhang Sdoi
10.1007/s11033-010-9948-xsubject
Has Abstractpub_date
2011-06-01 00:00:00pages
2869-77issue
5eissn
0301-4851issn
1573-4978journal_volume
38pub_type
杂志文章abstract::Rheumatoid arthritis (RA) is a chronic inflammatory disease in which numerous cells and mediators affect inflammatory conditions and disease severity. To compare the serum levels of adiponectin, vitamin D, copper, and zinc in patients with RA and to investigate the relationship between these parameters and RA severity...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04682-1
更新日期:2019-04-01 00:00:00
abstract::The mechanism by which external Bax releases cytochrome c is still controversial and may also depend on the type of mitochondria and the actual localisation of cytochrome c. Outer membrane porin acquires high binding affinity for hexokinase by interacting with the adenine nucleotide translocator (ANT) in the contact s...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/a:1020383108620
更新日期:2002-01-01 00:00:00
abstract::Birch (Betula platyphylla), an eminent tree species in Northeast and Inner Mongolia of China, has been widely used in architecture, furniture, and paper making in recent years. In order to retrieve genes involved in early development of B. platyphylla male inflorescence, RNA populations extracted from early and late d...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0818-y
更新日期:2012-02-01 00:00:00
abstract::CREB-regulated transcription coactivator 3 (CRTC3) was a recently identified protein which played an important role in glucose and lipid metabolism. Previous research showed that the polymorphisms of CRTC3 were associated with obesity in Mexican-Americans. Data on that relationship in Chinese was unavailable so far. S...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2844-4
更新日期:2014-01-01 00:00:00
abstract::Antimicrobial resistance is increasing around the world and the search for effective treatment options, such as new antibiotics and combination therapy is urgently needed. The present study evaluates oregano essential oil (OEO) antibacterial activities against reference and multidrug-resistant clinical isolates of Aci...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05989-0
更新日期:2020-12-01 00:00:00
abstract::Mitochondrial dysfunction plays a crucial role in the central pathogenesis of insulin resistance and type 2 diabetes mellitus. Macrophages play important roles in the pathogenesis of insulin resistance. Lauric acid is a 12-carbon medium chain fatty acid (MCFA) found abundantly in coconut oil or palm kernel oil and it ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-06019-9
更新日期:2020-12-01 00:00:00
abstract::Interleukin 15 (IL-15) is a Th1-related cytokine that triggers inflammatory cell recruitment with implications for pathogenesis in ulcerative colitis. The IL-15 gene is located within a 35 kb region of the q28-31 locus of chromosome 4. In the present work, the role of IL-15 gene polymorphisms as susceptibility markers...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3067-z
更新日期:2014-01-01 00:00:00
abstract::Imprinted genes play important roles in mammalian growth, development and behavior. In this study, we obtained 1568 bp mRNA sequence of porcine DIO3 (deiodinase, iodothyronine, type III), and also identified its imprinting status during porcine fetal development. The complete open reading frame (ORF) encoding 278 amin...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0983-z
更新日期:2012-03-01 00:00:00
abstract::Transcriptome from high throughput sequencing-by-synthesis is a good resource of molecular markers. In this study, we present utility of massively parallel sequencing by synthesis for profiling the transcriptome of red pepper (Capsicum annuum L. TF68) using 454 GS-FLX pyrosequencing. Through the generation of approxim...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1102-x
更新日期:2012-03-01 00:00:00
abstract::The conserved M2 protein of influenza A virus is considered as a promising candidate target for a broad-spectrum, recombinant influenza A vaccine. In the present study, the open reading frame (ORF) of avian influenza A/chicken/Iran/101/1998 (H9N2) M2 gene was amplified then cloned in pAED4, prokaryotic expression vect...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9851-5
更新日期:2010-07-01 00:00:00
abstract::The molecular composition of macromolecular assemblies engaged in transcription and splicing influences biogenesis of mRNA transcripts. Preference for one over the other interactive protein partner within those complexes is expected to change the gene expression pattern and to affect subsequent cellular events. We rep...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3128-3
更新日期:2014-01-01 00:00:00
abstract::Molecular abnormalities in the 11p15.5 imprinted gene cluster lead to two different growth diseases: Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS). They are mainly caused by epigenetic alterations in one of the two imprinting 11p15 control regions (ICR1 and ICR2). These CpG-rich regions are diffe...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2057-2
更新日期:2013-01-01 00:00:00
abstract::Toll-like receptors (TLRs) constitute a multi-gene family, which plays a pivotal role in sensing invading pathogens by virtue of conserved microbial patterns. TLR repertoire of chicken and zebra finch has been well studied. However TLR family of other avian species is yet to be characterized. In the present study, we ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1709-6
更新日期:2012-08-01 00:00:00
abstract::F-box proteins are key components of the ubiquitin (Ub)/26S proteasome pathway that mediates selective degradation of regulatory proteins involved in a wide variety of cellular processes affecting eukaryotic cells. In plants, F-box genes form one of the largest multigene superfamilies and control many important biolog...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0438-y
更新日期:2011-06-01 00:00:00
abstract::Transcriptional activity is closely associated with DNA methylation and chromatin remodelling. Evidence is emerging that a family of methylation specific (methyl-CpG binding domain, MBD) proteins have the capacity to bind to methylated sequences and repress transcription. Recent advances in this area reveal that many ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/a:1015744625049
更新日期:2001-01-01 00:00:00
abstract::Development of a rapid and accurate quantification method for the detection of microRNAs (miRNAs) has been desired, in particular, when they are differently expressed in normal and pathological conditions. However, various methods for the quantification of small non-coding RNAs as well as miRNAs have been described. T...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2442-x
更新日期:2013-05-01 00:00:00
abstract::Eukaryotic 20S proteasomes are complex oligomeric proteins. The maturation process of the 14 different alpha- and beta-subunits has to occur in a highly coordinate manner. In addition beta-subunits are synthesized as proproteins and correct processing has to be guaranteed during complex maturation. The structure forma...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1023/a:1006826725056
更新日期:1997-03-01 00:00:00
abstract::We studied the distribution of the D/D, I/D, and I/I genotypes of the angiotensin-converting enzyme (ACE) in a sample of healthy Lebanese individuals to assess their prevalence and compare them with other populations. ACE genotypes were determined using the Cardiovascular Disease (CVD) StripAssay, which is based on a ...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1007/s11033-006-9013-y
更新日期:2007-03-01 00:00:00
abstract::As a paired class homeodomain transcription factor, mutations of PROP1 (Prophet of POU1F1) are responsible for deficiencies of GH, PRL, TSH, LH and FSH. Regarding mutations of GH, PRL, and POU1F1 genes significantly associating with different production traits, PROP1 gene is a novel important candidate gene for detect...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-008-9418-x
更新日期:2009-11-01 00:00:00
abstract::Late blight caused by Phytophthora infestans is the most important disease of potato. Many efforts have been made to understand molecular mechanism of the durable resistance to address the challenge raised by rapid evolution of the pathogen. A pathogenesis related protein (PR) gene StPRp27 was previously isolated from...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0937-5
更新日期:2012-02-01 00:00:00
abstract::Safe harbor loci allow predicable integration of a transgene into the genome without perturbing endogenous gene activity and for decades have been exploited in the mouse to investigate gene function, generate humanised models and create tissue specific reporter and Cre recombinase expressing lines. Herein, we show tha...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05204-9
更新日期:2020-02-01 00:00:00
abstract::By measuring the permeability across the lipid bilayer in the presence and absence of membrane-bound protein or glycoprotein it should be possible to get an impression concerning their ability to penetrate into the membrane bilayer. Proteins such as phospholipase A2 and acetylcholinesterase markedly increase the perme...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00777245
更新日期:1982-04-16 00:00:00
abstract::Vitiligo is an acquired pigmentary disorder characterized by loss of epidermal melanocytes. A strong association at a single nucleotide polymorphism (SNP) rs11966200 within MHC region had been identified in a recent genome-wide association study of generalized vitiligo in Chinese Han population. This study aims to inv...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2491-9
更新日期:2013-06-01 00:00:00
abstract::The aim of this study was to explore the association between alpha-thalassemia, fetal hemoglobin, hematological indices, and clinical adverse events in Angolan sickle cell disease pediatric patients. A total of 200 sickle cell disease (SCD) children were sampled in Luanda and Caxito. A venous blood sample was collecte...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05628-8
更新日期:2020-07-01 00:00:00
abstract::Abiotic stresses such as salinity and drought have adverse effects on plants. In the present study, a Na(+)/H(+) antiporter gene homologue (LfNHX1) has been cloned from a local halophyte grass (Leptochloa fusca). The LfNHX1 cDNA contains an open reading frame of 1,623 bp that encodes a polypeptide chain of 540 amino a...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-3015-3
更新日期:2014-03-01 00:00:00
abstract::The human COX-2 promoter contains a direct repeat 1 (DR1) which was shown to confer responsiveness to PPARs. We found that in AN(3)CA and F9 cells, this hCOX-2 DR1 mediates responsiveness to all-trans-retinoic acid (tRA) or 9-cis-retinoic acid (9cRA), but this effect was suppressed by PPARδ. Truncated PPARδ lacking th...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0173-4
更新日期:2011-02-01 00:00:00
abstract::The present was carried out to evaluate the toxicity of methanolic leaf extract of Rhizophora mucronata (MERM) under in vivo and in vitro conditions. Mutagenicity of MERM (up to 4,000 μg/plate) evaluated by Salmonella/microsome assay (TA98, TA100, TA1535 and TA1538 strains), with or without metabolic activation showed...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2981-9
更新日期:2014-03-01 00:00:00
abstract::Wild Solanum species are the important resources for potato improvement. With the availability of potato genome and sequencing progress, knowledge about genomic resources is essential for novel genes discovery. Hence, the aim of this study was to decipher draft genome sequences of unique potato genotypes i.e. somatic ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-06106-x
更新日期:2021-01-13 00:00:00
abstract::The relationship between genetic polymorphisms of glutathione S-transferase (GST) and the development of glioma has been investigated in several epidemiologic studies. However these studies report inconsistent results. In order to quantitatively summarise the evidence for such a relationship, a meta-analysis is conduc...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-012-2213-8
更新日期:2013-02-01 00:00:00
abstract::As-ClC (chloride channels protein from Artemia sinica), a member from the chloride channels protein family, is a α-helical membrane protein predicted to traverse the cell membrane 11 times. It is important for several physiological functions such as cell volume regulation, cell proliferation, growth and differentiatio...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2441-y
更新日期:2013-05-01 00:00:00