Abstract：
:Vitiligo is an acquired pigmentary disorder characterized by loss of epidermal melanocytes. A strong association at a single nucleotide polymorphism (SNP) rs11966200 within MHC region had been identified in a recent genome-wide association study of generalized vitiligo in Chinese Han population. This study aims to investigate the relationships between SNP rs11966200 and the clinical features of generalized vitiligo in Chinese Han population. We compared the allele and genotype frequency among different vitiligo subphenotypes including age onset, extent of disease, clinical subtypes, family history of vitiligo and history of autoimmune disease. Our data showed SNP rs11966200 was associated with early-onset vitiligo (onset age ≤ 20 years) (odds ratio [OR], 1.54; p = 2.01 × 10(-13)), moderate-severe vitiligo (involved body surface ≥ 5 %) (OR, 1.17; p = 0.025), vitiligo vulgaris (OR, 1.13; p = 0.043), and focal vitiligo (OR, 0.86; p = 0.018). The study suggested that the underlying risk causal allele tagged by SNP rs11966200 might not only play important roles in the development of vitiligo, but also contribute to the diverse clinical characteristics of generalized vitiligo at least in Chinese Han population.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Tang J,Liu JL,Zhang C,Hu DY,He SM,Zuo XB,Wang PG,Sun LD,Zhang XJ,Yang Sdoi
10.1007/s11033-013-2491-9subject
Has Abstractpub_date
2013-06-01 00:00:00pages
4097-100issue
6eissn
0301-4851issn
1573-4978journal_volume
40pub_type
杂志文章abstract：:Safe harbor loci allow predicable integration of a transgene into the genome without perturbing endogenous gene activity and for decades have been exploited in the mouse to investigate gene function, generate humanised models and create tissue specific reporter and Cre recombinase expressing lines. Herein, we show tha...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-019-05204-9
更新日期：2020-02-01 00:00:00
abstract：:In the present study, we investigated the differentially expressed proteins associated with ulcerative colitis (UC) using proteomic methods. Two-dimensional electrophoresis (2-DE) technology was performed to separate the total proteins of ulcerative tissues from those of the normal tissues of UC patients. PDQuest soft...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-1373-2
更新日期：2012-05-01 00:00:00
abstract：:Three members of Brassica napus TRANSPARENT TESTA 2 (BnTT2) gene family encoding potential R2R3-MYB regulatory proteins of proanthocyanidin biosynthesis were isolated. BnTT2-1, BnTT2-2, and BnTT2-3 are 1102 bp with two introns, and have a 938-bp full-length cDNA with a 260 amino acid open reading frame. They share 98....
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-006-9024-8
更新日期：2007-06-01 00:00:00
abstract：:We report complete mitochondrial genome of Northern Indian red muntjac, Muntiacus vaginalis, and its phylogenetic inferences. Mitogenome composition was 16,352 bp in length and its overall base composition in the circular genome was A = 33.2%, T = 29.0%, C = 24.50% and G = 13.30%. It exhibited a typical mitogenome str...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-018-4486-z
更新日期：2019-02-01 00:00:00
abstract：:Increasing numbers of reports show that imprinted genes play a crucial role in fetal development, and uniparental embryos, which possess two paternally or two maternally derived pronuclei, are excellent tools for investigating the biological significance of imprinted genes. In the present study, to examine the in vitr...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-014-3774-5
更新日期：2015-02-01 00:00:00
abstract：:In plants, pathogenesis-related 1 protein (PR1) is considered as important defense protein. The production and accumulation of PR proteins in plants are one of the important responses to several biotic and abiotic stresses. In this regard, PR1 gene was isolated from Triticum turgidum ssp durum and was named as TdPR1.2...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-06053-7
更新日期：2020-12-13 00:00:00
abstract：:Yellow lupin seeds (Lupinus luteus) cytoplasmic tRNAGlu was isolated and the primary structure was determined to be: (sequence in text) AGU CCCGGCGACGGAACCAOH. It is 76 nucleotides long and contains 8 modified nucleosides: 2 residues of pseudouridine, ribothymidine, 3 dihydrouridines, 5-methylcytosine and 1-methyladen...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/BF00805633
更新日期：1988-01-01 00:00:00
abstract：:Birch (Betula platyphylla), an eminent tree species in Northeast and Inner Mongolia of China, has been widely used in architecture, furniture, and paper making in recent years. In order to retrieve genes involved in early development of B. platyphylla male inflorescence, RNA populations extracted from early and late d...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-0818-y
更新日期：2012-02-01 00:00:00
abstract：:Long term intake of high-glucose diet (HGD) may induce many diseases such as dyslipidemia, fatty liver and diabetes disease. Most of the research for molecular mechanisms of the association between HGD and the above diseases focus on the metabolism of glucose and lipid. However, there are few studies on molecular mech...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-009-9622-3
更新日期：2010-04-01 00:00:00
abstract：:The researches on yak genetics and breeding were extremely restricted due to lacking of reliable DNA molecular markers. The microsatellites with repeat motif (AC)n/(GT)n in yak genome were enriched by Dynal magnetic beads and the gene libraries containing (AC)n/(GT)n were constructed. Among the 92 identified and seque...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-014-3249-8
更新日期：2014-06-01 00:00:00
abstract：:The human COX-2 promoter contains a direct repeat 1 (DR1) which was shown to confer responsiveness to PPARs. We found that in AN(3)CA and F9 cells, this hCOX-2 DR1 mediates responsiveness to all-trans-retinoic acid (tRA) or 9-cis-retinoic acid (9cRA), but this effect was suppressed by PPARδ. Truncated PPARδ lacking th...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-0173-4
更新日期：2011-02-01 00:00:00
abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) could infect porcine alveolar macrophages (PAM), and the CD169 and CD163 are identified as critical receptors on the surface of PAM, but whether the single nucleotide polymorphisms (SNPs) of these genes could influence the infection is remain unclear. In this...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1857-8
更新日期：2012-11-01 00:00:00
abstract：:The aim of this study was to explore candidate single nucleotide polymorphisms (SNPs) and candidate mechanisms of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Two SLE genome-wide association studies (GWASs) datasets were included in this study. Meta-analysis was conducted using 737,984 SNPs in 1,5...
journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11033-012-1952-x
更新日期：2012-12-01 00:00:00
abstract：:Cordyceps sinensis (CS) is an entomogenous fungus used as a tonic food and Chinese medicine to replenish health. This study investigated the protective effects of CS in rats post-renal ischemia-reperfusion (I/R) sequence by analyzing the influence on stromal cell-derived factor-1α (SDF-1α and chemokine (C-X-C motif) r...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-2316-2
更新日期：2013-03-01 00:00:00
abstract：:Bacterial artificial chromosome (BAC) library is an important genomic resource useful in targeted marker development, positional cloning, physical mapping and a substrate for genome sequencing for better understanding the genome organization of a species. The present manuscript elucidates the improvement in protocols ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05283-z
更新日期：2020-03-01 00:00:00
abstract：:Whole-exome sequencing (WES) is an ideal method for the diagnosis of autosomal recessive diseases. The aim of this study was to evaluate the diagnostic power of WES in patients with autosomal recessive inheritance and to determine the relationship between genotype and phenotype. Retrospective screenings of 24 patients...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-018-4470-7
更新日期：2019-02-01 00:00:00
abstract：:Interleukin-8 (IL8) polymorphisms have been implicated in several cancers, but their roles in the pathogenesis of hepatocellular carcinoma (HCC) are largely unknown. The present study was designed to explore the association between IL8 polymorphism and the risk of HCC in a Chinese population. Four single nucleotide po...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2993-5
更新日期：2014-03-01 00:00:00
abstract：:Methicillin resistant Staphylococcus aureus (MRSA) is one of the challenging bacterial pathogen due to its acquired resistance to the β lactam antibiotics. The Sortase A is an enzyme of Gram-positive bacteria including S. aureus to anchor surface proteins to the cell wall. Sortase A is well studied enzyme and consider...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-014-3384-2
更新日期：2014-08-01 00:00:00
abstract：:Insulin-like growth factor (IGF) expression plays a critical role in the endocrine regulation of proliferation, differentiation, and growth in shellfish as well as in fish. The Pacific oyster, Crassostrea gigas, is a significant aquaculture species that comprises a large percentage of the Korean shellfish industry; mo...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-018-4559-z
更新日期：2019-02-01 00:00:00
abstract：:The study was done to identify the candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms that contribute to Parkinson's disease (PD) susceptibility and to generate a SNP to ene to pathway hypothesis using an analytical pathway-based approach. We used a PD genome-wide association study...
journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11033-012-2346-9
更新日期：2013-03-01 00:00:00
abstract：:Radiotherapy is an effective treatment for some esophageal cancers, but the molecular mechanisms of radiosensitivity remain unknown. Ubiquitin-like with PHD and ring finger domains 1 (UHRF1) is a novel nuclear protein which is overexpressed in various cancers but not yet examined in esophageal squamous cell carcinoma ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2559-6
更新日期：2013-09-01 00:00:00
abstract：:The mouse double minute 2 (MDM2) gene encodes a phosphoprotein that interacts with P53 and negatively regulates its activity. SNP309 polymorphism (T-G) in the promoter of MDM2 gene has been reported to be associated with enhanced MDM2 expression and tumor development. Many published studies have evaluated the associat...
journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11033-011-1119-1
更新日期：2012-04-01 00:00:00
abstract：:Etiological factors for coronary artery disease (CAD) involve a wide range of gene and environmental interactions. One of the systems being implicated in the pathophysiology of CAD is the renin-angiotensin system (RAS). However, the genetic polymorphisms of this system have not been widely studied in Iranian patients ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2596-1
更新日期：2013-08-01 00:00:00
abstract：:Recently, circulating miRNAs have been reported as promising biomarkers for various pathologic conditions including cancer. Certain microRNAs (miRNAs) have been shown early diagnostic potential for many types of cancer. The objective of this study was to investigate the potential of certain serum/plasma miRNAs as nove...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-014-3322-3
更新日期：2014-07-01 00:00:00
abstract：:Although there are many studies on the role of PI3K/AKT/mTOR pathway and autophagy genes in the mechanism of head and neck cancer formation and prognostic significance, there is no study investigating the role of the genes in paranasal sinus carcinomas. The aim of the study was to assess the role of the PI3K/AKT/mTOR ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05458-8
更新日期：2020-05-01 00:00:00
abstract：:The circular dichroism spectra of poly(dG). poly(dC) have been studied as a function of pH in 0.15 M NaCl solution. Acid titration to pH 2.5 showed two transitions, one around pH 5, the second below pH 3. These transitions are disproportionation reactions and are not due to the dissociation of the complexes. Alkaline ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/BF00357155
更新日期：1973-10-01 00:00:00
abstract：:Two DREB-like genes, designated as DmDREBa and DmDREBb, were isolated from chrysanthemum by RACE approach. The DmDREBa and DmDREBb genes encoded proteins of 191 and 185 amino acid residues with the predicted molecular mass of 21.66 and 20.99 kDa, respectively. Both DmDREBs proteins comprised a typical EREBP/AP2 domain...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-007-9153-8
更新日期：2009-01-01 00:00:00
abstract：:Vascular endothelial growth factor B (VEGF-B) was reported to be angiogenic, and it was considered as a neuroprotective agent in mouse retinal ganglion cells following optic nerve crush. Thus, it was necessary to investigate whether VEGF-B contributes to the process of retinal and choroidal neovascularization. We aime...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2917-4
更新日期：2014-02-01 00:00:00
abstract：:It has been demonstrated that ACSL3 and ACSL5 play important roles in fat metabolism. To investigate the primary functions of ACSL3 and ACSL5 and to evaluate their expression levels during goose fatty liver development, we cloned the ACSL3 and ACSL5 coding domain sequences (CDSs) of geese using RT-PCR and analyzed the...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-014-3053-5
更新日期：2014-01-01 00:00:00
abstract：:In the present study, root cell suspension cultures of W. somnifera were elicited with mycelial extract (1% w/v) and culture filtrate (5% v/v) of their native endophytic fungus Aspergillus terreus 2aWF in shake flask. Culture filtrate of A. terreus 2aWF significantly elicits withanolide A at 6H (12.20 ± 0.52 µg/g FCB)...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-019-04641-w
更新日期：2019-04-01 00:00:00
