Abstract：
:Cordyceps sinensis (CS) is an entomogenous fungus used as a tonic food and Chinese medicine to replenish health. This study investigated the protective effects of CS in rats post-renal ischemia-reperfusion (I/R) sequence by analyzing the influence on stromal cell-derived factor-1α (SDF-1α and chemokine (C-X-C motif) receptor 4 (CXCR4) expressions and senescence during recovery. Chemokine SDF-1 [now called chemokine C-X-C motif ligand 12 (CXCL12)] and its receptor CXCR4 are crucial in kidney repair after ischemic acute renal failure. CS treatment significantly alleviated I/R-induced renal damage assessed by creatinine levels (p < 0.05) and abated renal tubular damages assessed by periodic acid-Schiff with diastase (PASD) staining. CS induced early SDF-1α expression and increased CXCR4 expression 1-6 h post-reperfusion. Histology studies have revealed that CS induced SDF-1α in squamous cells of Bowman's capsule, mesangial cells, distal convoluted tubules (DCT), and proximal convoluted tubules (PCT). CS also improved renal repair in I/R-induced injury by increasing Ki-67 staining. I/R induced renal senescence after 3 and 6 h of reperfusion. However, CS alleviated I/R-induced senescence at early stage (1 and 3 h). We conclude that CS protects against I/R injury via the SDF-1/CXCR4-signaling axis and alleviates senescence.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Wang HP,Liu CW,Chang HW,Tsai JW,Sung YZ,Chang LCdoi
10.1007/s11033-012-2316-2subject
Has Abstractpub_date
2013-03-01 00:00:00pages
2347-55issue
3eissn
0301-4851issn
1573-4978journal_volume
40pub_type
杂志文章abstract：:A full-length cDNA encoding wheat peroxisomal ascorbate peroxidase (pAPX) was cloned by Suppression Subtractive Hybridization (SSH) and in silico approach. The cDNA was 1027 bp in length and contained a complete ORF of 876 bp, which encodes a protein of 292 amino acid residues. Its deduced amino acids sequence had 84%...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-005-4536-1
更新日期：2006-09-01 00:00:00
abstract：:The two predominant forms of arginase, cytosolic Arginase-I and mitochondrial Arginase-II, catalyze hydrolysis of arginine into ornithine and urea. Based on presence of arginase activity in extracts using potassium chloride (KCl), mitochondrial membrane-bound arginase has also been suggested. However, the activity of ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-016-3965-3
更新日期：2016-05-01 00:00:00
abstract：:It has been about nine decades since the proposal of Otto Warburg on the metabolism of cancer cells. Unlike normal cells which undergo glycolysis and oxidative phosphorylation in the presence of oxygen, proliferating and cancer cells exhibit an increased uptake of glucose and increased rate of glycolysis and predomina...
journal_title：Molecular biology reports
pub_type： 杂志文章,评审
doi：10.1007/s11033-014-3764-7
更新日期：2015-04-01 00:00:00
abstract：:A culture-independent molecular phylogenetic analysis was carried out to study for the first time the diversity of bacterial ammonia monooxygenase subunit A (amoA) and nitrogenase reductase subunit H (nifH) genes from Urca inlet at Guanabara Bay in Rio de Janeiro, Brazil. Most bacterial amoA and nifH sequences exhibit...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-1111-9
更新日期：2012-04-01 00:00:00
abstract：:Expressed sequence tags (ESTs) provide valuable tools that can be used to predict the genes involved in primary and secondary metabolite synthesis. To the best of our knowledge, ESTs have not yet been developed for Codonopsis. lanceolata, and therefore, the EST referenced in this report is the first transcript for C. ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-0464-9
更新日期：2011-06-01 00:00:00
abstract：:Adriamycin is one of the most effective and useful antineoplastic agents. Acute doxorubicin cardiotoxicity involved cardiomyocyte apoptosis. In this study, we investigated whether adriamycin induced myocardium apoptosis through activation of nuclear factor kappaB in rat. Forty male Wistar rats were randomly divided in...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-007-9112-4
更新日期：2008-12-01 00:00:00
abstract：:Laparoscopic surgery techniques have been increasingly preferred to classic laparotomy by surgeons since 1987. However, this method may have some side effects on different intraabdominal organs including kidneys. The aim of this study is to evaluate the effects of different pressures of CO2 on p53 related apoptosis in...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-014-3519-5
更新日期：2014-10-01 00:00:00
abstract：:Adipose differentiation-related protein gene (ADP) plays an important role in controlling lipid accumulation in mammals. It may also affect lipid deposition in birds. However, the molecular mechanism of its actions in birds remains unknown. In the present study, the coding sequence of ADP cDNA for Chinese native breed...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-009-9836-4
更新日期：2010-07-01 00:00:00
abstract：:In view of high mortality associated with coronary artery disease (CAD), development of an early predicting tool will be beneficial in reducing the burden of the disease. The database comprising demographic, conventional, folate/xenobiotic genetic risk factors of 648 subjects (364 cases of CAD and 284 healthy controls...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-018-4236-2
更新日期：2018-10-01 00:00:00
abstract：:Echinococcus granulosus is a parasitic helminth which affects both man and animals. During infection with larval stage of the organism secretory and membrane-bound (S/M) proteins play a meaningful role for evasion of immune system. Antigen B (AgB) is one of them. Present investigation has defined sequence diversity of...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-0332-7
更新日期：2011-03-01 00:00:00
abstract：:Start codon targeted (SCoT) polymorphic markers were used to assess genetic relationships among 64 grape varieties. Seventeen informative primers were selected from 36 SCoT primers based on their ability to produce clear and repeatable polymorphic and unambiguous bands among the varieties. A total of 131 bands were pr...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-1329-6
更新日期：2012-05-01 00:00:00
abstract：:The aim of this study is to evaluate which dysregulated angiomiRs compose the specific proangiogenic microRNA signature of advanced laryngeal cancer and review the literature. Thirty-six samples from twelve patients with advanced laryngeal carcinoma were collected. Total RNA was extracted and microRNA global profiling...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05250-8
更新日期：2020-07-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is a common, complex disorder associated with substantial morbidity and mortality, influenced by both environmental factor and genetic factor. ADAM33 gene was found to be associated with asthma, declined lung function and COPD. The purpose of the study was to test whether S...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-0637-6
更新日期：2011-11-01 00:00:00
abstract：:MicroRNAs (miRNAs) may play important roles in SLE, but genetic polymorphisms of miRNAs and their relationships with various autoantibodies present in SLE patients remain unclear. Here, we report that 213 SLE patients and 209 healthy individuals of Chinese had been taken into this case-control studies, which had been ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-0252-6
更新日期：2011-03-01 00:00:00
abstract：:Heavy metals pollution affects the nutritive value of fish. This study examined if the inclusion of dietary hempseed (HS) and hempseed oil (HO) in the diet of the fish could revert the copper-induced toxic effects on muscle fatty acid profile of rohu (Labeo rohita) and mrigal (Cirrhinus mrigala). Fingerlings of both s...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-018-4483-2
更新日期：2019-02-01 00:00:00
abstract：:Rice production in recent years is highly affected by rapidly increasing temperatures in the tropical and sub-tropical countries, which threatens the sustainable production in near future. Hence, understanding the heat tolerance mechanism and evolving tolerant varieties is an immense need in the staple crop rice. An e...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05291-z
更新日期：2020-03-01 00:00:00
abstract：:A double-stranded RNA-specific nuclease (ds RNase) has been isolated and partially purified from human placenta by DEAE-cellulose and DNA-cellulose column chromatography. Denatured DNA-cellulose retained most of the single-stranded RNA-specific nuclease (ss RNase) activity, whereas the ds RNase came out in the void vo...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/BF00775365
更新日期：1983-08-01 00:00:00
abstract：:Members of the methyl binding domain (MBD) protein family are known for binding to methylated DNA by recognizing methylated cytosines. Their original function is to regulate protein biosynthesis by recruitment of transcriptional repression complexes to silence gene expression. The aim of the presented work was to dete...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-008-9391-4
更新日期：2009-09-01 00:00:00
abstract：:MADS-box genes encode important transcription factors in plants that are involved in many processes during plant growth and development. An investigation of the soybean genome revealed 106 putative MADS-box genes. These genes were classified into two classes, type I and type II, based on phylogenetic analysis. The soy...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-2438-6
更新日期：2013-06-01 00:00:00
abstract：:To explore the relationship of Notch1 mutation in T-ALL with the survival rate of T-ALL patients. The PubMed database, the Cochrane Library, conference proceedings, EMBASE databases, and references of published trials and review articles were searched. Two reviewers independently assessed the quality of the trials and...
journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s11033-011-1424-8
更新日期：2012-05-01 00:00:00
abstract：:Metabolic syndrome is an agglomeration of disorders including obesity, diabetes and cardiovascular diseases and characterized as chronic mild inflammation which elevates the circulatory inflammatory markers. This could be due to mitochondrial dysfunction, oxidative stress and hypoxia as a consequence of high fat diet ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-019-04623-y
更新日期：2019-04-01 00:00:00
abstract：:The phosphoenolpyruvate (PEP) carboxylase is regulated at the levels of transcription and post-translation in C4 plants in light and abundantly accumulates in leaf mesophyll cells. We report here developmental and photosynthetic regulation of stably accumulated Bacillus thuringiensis δ-endotoxin under the control of P...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-0369-7
更新日期：2011-04-01 00:00:00
abstract：:Dihydroflavonol 4-reductase (DFR), which catalyzes the reduction of dihydroflavonols to leucoanthocyanins, is a key enzyme in the biosynthesis of anthocyanidins, proanthocyanidins, and other flavonoids of importance in plant development and human nutrition. This study isolated a full length cDNA encoding DFR, designat...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-1061-2
更新日期：2012-03-01 00:00:00
abstract：:Free cytoplasmic 40S mRNP particles from rat liver were treated with EDTA and separated into two populations of RNP particles with sedimentation maxima of 20S and 35S, respectively. A characteristic set of distinct scRNAs is found for 20S and 35S RNP particles. The sequences of two of the most abundant scRNAs from 20S...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/BF00777475
更新日期：1983-05-01 00:00:00
abstract：:HSG1 (Heat shock-induced gene 1) is one of the high-temperature-induced proteins in grapevine. Sequence analysis has demonstrated that HSG1 is a grape Bcl-2-associated athanogene (BAG) that contains IQ and BAG domains in its sequence. HSG1 expression was not detected in leaves without heat treatment, while tendrils, s...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-1224-1
更新日期：2012-04-01 00:00:00
abstract：:Adipocyte death is important in obesity development. Understanding and prevention of adipocyte deaths may be a molecular approach in the treatment. In the study, we aimed to understand role of Niban gene, which acts as an anti-apoptotic molecule as a response to stress conditions, in adipocytes. 3T3-L1 adipocytes were...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05992-5
更新日期：2020-12-01 00:00:00
abstract：:Alterations in expression of the DFF40 gene have been reported in some cancers. This study is an in vitro study of the therapeutic effects of gene transfer that lead to elevation in DFF40 expression within T-47D cells in the presence of sulfonamide drugs. In this study, we have constructed a eukaryotic expression vect...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-014-3626-3
更新日期：2014-11-01 00:00:00
abstract：:Variants of the transcription factor 7-like 2 gene (TCF7L2) have been associated with type 2 diabetes and cardiovascular disease in different populations. Here we investigated the potential association of the rs7903146 polymorphism in the TCF7L2 gene with clinical profile of end-stage renal disease (ESRD) patients. We...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-014-3275-6
更新日期：2014-06-01 00:00:00
abstract：:The relationship between genetic polymorphisms of glutathione S-transferase (GST) and the development of glioma has been investigated in several epidemiologic studies. However these studies report inconsistent results. In order to quantitatively summarise the evidence for such a relationship, a meta-analysis is conduc...
journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11033-012-2213-8
更新日期：2013-02-01 00:00:00
abstract：:Insect molting is an important developmental process of metamorphosis, which is initiated by molting hormone. The molting process includes the activation of dermal cells, epidermal cells separation, molting fluid secretion, the formation of new epidermis and old epidermis excoriation etc. Polyphenol oxidases (PPOs), d...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-2428-8
更新日期：2013-05-01 00:00:00
