Abstract:
:The relationship between genetic polymorphisms of glutathione S-transferase (GST) and the development of glioma has been investigated in several epidemiologic studies. However these studies report inconsistent results. In order to quantitatively summarise the evidence for such a relationship, a meta-analysis is conducted. The PubMed database was searched from inception to January 2012 to identify relevant studies that met pre-stated inclusion criteria. We also reviewed reference lists from retrieved articles. Two researchers evaluated study eligibility and extracted the data independently, and disagreements were resolved by discussion. The principal outcome measure was the odds ratio (OR) with 95 % confidence interval (CI) for the risk of glioma associated with GSTM1, GSTT1, GSTP1 I105V or GSTP1 A114V. This meta-analysis included 11 case-control studies, which included 2,404 glioma cases and 6,379 controls. The combined results based on all studies showed that there was no association between any of the GST variants and the risk of glioma (for GSTM1: pooled OR = 1.03; 95 % CI, 0.92-1.15; for GSTT1: pooled OR = 1.12; 95 % CI, 0.90-1.40; for GSTP1 I105V: pooled OR = 0.92; 95 % CI, 0.64-1.31 and for GSTP1 A114V: pooled OR = 1.14; 95 % CI, 0.97-1.34). Subgroup analyses showed that GSTP1 A114V genotype was associated with an increased risk of other histopathologic glioma except glioblastoma multiforme (GBM) (pooled OR = 1.30; 95 % CI = 1.06-1.60); no relationship was found between other GST variants and histopathologic groups. In conclusion, our meta-analysis suggests no association between GST variants and the risk of glioma. However, the significant risk elevation is present between GSTP1 A114V genotype and other histopathologic glioma except GBM.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Fan Z,Wu Y,Shen J,Zhan Rdoi
10.1007/s11033-012-2213-8subject
Has Abstractpub_date
2013-02-01 00:00:00pages
1641-50issue
2eissn
0301-4851issn
1573-4978journal_volume
40pub_type
杂志文章,meta分析abstract::Steroid administration, which is commonly performed for the treatment of autoimmune inflammatory diseases, cancers or organ transplantation, has been a leading cause of nontraumatic osteonecrosis of the femoral head (ONFH). Single nucleotide polymorphisms (SNPs) of the adenosine triphosphate-binding cassette B1 (ABCB1...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3173-y
更新日期:2014-05-01 00:00:00
abstract::Cotton fiber cells elongate without dividing to form economically valuable spinnable fiber. Reports of the ploidy level of fiber cells are variable. Early reports indicated an increase in nuclear DNA content in young fibers; however, subsequent reports failed to observe such a significant increase in ploidy level. Eva...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9496-4
更新日期:2010-02-01 00:00:00
abstract::There is an increasing body of evidence that a brief exposure to anesthesia induces ischemic tolerance in rat brain (anesthetic preconditioning). However, it is unknown whether preconditioning with sevoflurane, a commonly used volatile anesthetic in current clinical practice, produces a delayed window of neuroprotecti...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1290-4
更新日期:2012-05-01 00:00:00
abstract::Osteoporosis is a degenerative disease of the skeletal system, and its major complication is fracture that severely influences the living quality of the middle-aged and the aged. The purpose of this study was to investigate the significance of sex hormones and some biochemical indicators related to bone metabolism in ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0187-y
更新日期:2011-02-01 00:00:00
abstract::Kawasaki disease (KD) is a multi-systemic vasculitis which preferentially affects infants and children. A single nucleotide polymorphism (rs28493229) in the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) was identified to be associated with the increased risk of KD; however, in more recent studies associations have b...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-012-2022-0
更新日期:2012-12-01 00:00:00
abstract::Histone H1 is know to play a role in the formation and maintenance of higher-order chromatin structure. It has been recently suggested that the linker histone might be also involved in the regulation of the activity of individual genes. If H1 is a regulatory factor in eukaryotic gene transcription, it should possess s...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1007/BF00369901
更新日期:1991-02-01 00:00:00
abstract::Tall fescue is a perennial cool-season grass with economic importance especially in temperate regions of the northern hemisphere. This study was done to assess the genetic diversity and population structure of 90 tall fescue populations and cultivars using ISSR and EST-SSR markers in order to categorize valuable popul...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05173-z
更新日期:2020-01-01 00:00:00
abstract::The two predominant forms of arginase, cytosolic Arginase-I and mitochondrial Arginase-II, catalyze hydrolysis of arginine into ornithine and urea. Based on presence of arginase activity in extracts using potassium chloride (KCl), mitochondrial membrane-bound arginase has also been suggested. However, the activity of ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-016-3965-3
更新日期:2016-05-01 00:00:00
abstract::The association between vitamin D receptor (VDR) gene polymorphisms and risk of benign prostatic hyperplasia (BPH) has been investigated in numerous publications, but published results remain inconclusive. Hence, we conducted this meta-analysis to derive a more precise conclusion. Four polymorphisms (Taq-I, Bsm-I, Apa...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-014-3554-2
更新日期:2014-10-01 00:00:00
abstract::Bud dormancy in perennial plants adapts to environmental and seasonal changes. Bud dormancy is of ecological interest because it affects forest population growth characteristics and is of economical interest because it impacts wood production levels. To understand Pinus sylvestris L. var. mongolica litv. bud-dormancy ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0159-2
更新日期:2011-02-01 00:00:00
abstract::BACs-on-Beads (BoBs™) assay is a rapid aneuploidy test (RAT) that detects numerical chromosomal aneuploidies and multiple microdeletion/microduplication syndromes. This study was conducted to appraise the usefulness of the BoB™ assay as a complementary diagnostic tool to conventional karyotyping for the rapid detectio...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05117-7
更新日期:2020-01-01 00:00:00
abstract::Several studies have examined the effects of the tumor necrosis factor-α (TNF-α) -308 A/G and lymphotoxin-α (LT-α) +252 A/G polymorphisms on susceptibility to sarcoidosis, showing mixed results. The purpose of this study was to examine whether the TNF-α -308 A/G and LT-α +252 A/G polymorphisms confer susceptibility to...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-013-2859-x
更新日期:2014-01-01 00:00:00
abstract::The MinION is a miniaturized high-throughput next generation sequencing platform of novel conception. The use of nucleic acids derived from formalin-fixed paraffin-embedded samples is highly desirable, but their adoption for molecular assays is hurdled by the high degree of fragmentation and by the chemical-induced mu...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-017-4133-0
更新日期:2018-02-01 00:00:00
abstract::ATP-binding cassette transporter A1 (ABCA1) modulates plasma levels of high density lipoprotein (HDL), a cardiovascular protecting factor. Tree shrew was considered to be an animal protected from atherosclerosis characterized by high proportion of HDL in plasma. The cDNA clones and expression of tree shrew ABCA1 was i...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-007-9199-7
更新日期:2009-03-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-α) and interleukin 1 beta (IL-1β) genetic variants which resulting in TNF-α and IL-1 overproduction may increase susceptibility to autoimmune diseases such as atherosclerosis. We have studied the association of TNF-α G308A and IL-1β (+3953) C/T polymorphism with myocardial infarction i...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0701-x
更新日期:2011-11-01 00:00:00
abstract::The oligochaete earthworm, Eudrilus eugeniae is capable of regenerating both anterior and posterior segments. The present study focuses on the transcriptome analysis of earthworm E. eugeniae to identify and functionally annotate the key genes supporting the anterior blastema formation and regulating the anterior regen...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-06044-8
更新日期:2020-12-11 00:00:00
abstract::Protein phosphorylation is one of the most fundamental types of post-translational modifications and it plays a vital role in various cellular processes of eukaryotes. Among three types of phosphorylation i.e. serine, threonine and tyrosine phosphorylation, tyrosine phosphorylation is one of the most frequent and it i...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4417-z
更新日期:2018-12-01 00:00:00
abstract::Xenin is a regulatory peptide first isolated from the human gastric mucosa. Using an open-access protein database MEDLINE (33 million molecules; 11 billion amino acid residues) and our original computer program, we conducted a search for the xenin motifs in the primary structure of proteins across almost the entire ta...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4147-2
更新日期:2018-04-01 00:00:00
abstract::Recently a GWAS study had identified 38 genomic variants commonly found in humans that influence migraine risk. For further replicate these findings, we selected two SNPs; rs2651899 on chromosome 1p36.32 in PRDM16 gene and rs10166942 on chromosome 2q37.1 close to TRPM8 gene for their associations with migraine in the ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04593-1
更新日期:2019-02-01 00:00:00
abstract::Proteasomes (prosomes) are large multiprotein complexes. They are involved in protein degradation of ubiquitin-conjugated proteins and in the generation of MHC class I peptides. We gave further evidence that they interfere with in vitro protein synthesis. Proteasomes inhibit the translation of Tobacco mosaic virus RNA...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00996354
更新日期:1994-01-01 00:00:00
abstract::C2H2 proteins belong to a group of transcription factors (TFs) existing as a superfamily that plays important roles in defense responses and various other physiological processes in plants. The present study aimed to screen for and identify C2H2 proteins associated with defense responses to abiotic and biotic stresses...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1542-y
更新日期:2012-06-01 00:00:00
abstract::Growth-regulating factor (GRF) is an important protein in GA-mediated response, with key roles in plant growth and development. However, it is not known whether or how the GRF proteins in citrus to regulate organ size. In this study, nine citrus GRF genes (CsGRF1-9) were validated from the 'Anliu' sweet orange (AL, Ci...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-016-4048-1
更新日期:2016-10-01 00:00:00
abstract::The response of glycolysis to exposure of glucose in non-growing S. cerevisiae cells from diauxic shift was monitored. The result was compared to a kinetic model of glycolysis with branches to glycogen, trehalose, glycerol, and succinate. Experimental data at steady-state concentrations of metabolites in the upper par...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/a:1020349023158
更新日期:2002-01-01 00:00:00
abstract::Previous data on association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk were controversial. To investigate the association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk. We performed a meta-analysis to assess the relationship between oral cancer and genotype with English language until...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-011-0777-3
更新日期:2012-01-01 00:00:00
abstract::Nonspecific lipid transfer protein (nsLTP) is usually basic and secreted low-molecular-mass protein in plants. The 3-D structure of nsLTP1 resembles that of elicitin produced by the plant pathogen Phytophthora cryptogea, which can bind to the plant plasma membrane putative receptor and activate the downstream response...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-008-9238-z
更新日期:2009-04-01 00:00:00
abstract::The small molecules already existing on the earth can be assembled to biological macromolecules in the presence of the suitable tool. A workman must sharpen his tools if he is to do his work well. The tool must be specific, delicate and automatic. Obviously, it is enzyme. Therefore, to explore the origin of life we mu...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-007-9189-9
更新日期:2009-02-01 00:00:00
abstract::Interindividual variability exists in statin lipid-lowering response, partially attributed to genetic factors. Organic anion-transporting polypeptide 1B1 (OATP1B1) encoded by SLCO1B1 gene (solute carrier organic anion transporter family member 1B1) facilitates hepatic uptake of simvastatin and atorvastatin. SLCO1B1 po...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3334-z
更新日期:2014-07-01 00:00:00
abstract::Diabetes affects a variety of tissues including the central nervous system; moreover, some evidence indicates that memory and learning processes are disrupted. Also, oxidative stress triggers alterations in different tissues including the brain. Recent studies indicate mitochondria dysfunction is a pivotal factor for ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4233-5
更新日期:2018-10-01 00:00:00
abstract::To investigate mechanisms of rat glutathione S-transferase P1 gene (rGSTP1) expression regulation during chemical carcinogenesis. we studied enhancer elements located in the region between -2.5 kb to -2.2 kb. The region was upstream from the start site of transcription and was divided into two major fragments, GPEI an...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/a:1011993604051
更新日期:2001-03-01 00:00:00
abstract::Heterogeneous nuclear ribonucleoprotein particles (HnRNP) were separated in metrizamide density gradients, into two fractions migrating to 1.31 g ml-1 and 1.18 g ml-1, respectively. Proteins associated with each of these fractions were analysed by SDS-acrylamide gel electrophoresis. It is shown that the whole proteins...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00643481
更新日期:1977-03-01 00:00:00