Abstract：
:Diabetes affects a variety of tissues including the central nervous system; moreover, some evidence indicates that memory and learning processes are disrupted. Also, oxidative stress triggers alterations in different tissues including the brain. Recent studies indicate mitochondria dysfunction is a pivotal factor for neuron damage. Therefore, we studied mitochondrial activity in three brain regions at early type I-diabetes induction. Isolated mitochondria from normal hippocampus, cortex and cerebellum revealed different rates of oxygen consumption, but similar respiratory controls. Oxygen consumption in basal state 4 significantly increased in the mitochondria from all three brain regions from diabetic rats. No relevant differences were observed in the activity of respiratory complexes, but hippocampal mitochondrial membrane potential was reduced. However, ATP content, mitochondrial cytochrome c, and protein levels of β-tubulin III, synaptophysin, and glutamine synthase were similar in brain regions from normal and diabetic rats. In addition, no differences in total glutathione levels were observed between normal and diabetic rat brain regions. Our results indicated that different regions of the brain have specific metabolic responses. The changes in mitochondrial activity we observed at early diabetes induction did not appear to cause metabolic alterations, but they might appear at later stages. Longer-term streptozotocin treatment studies must be done to elucidate the impact of hyperglycemia in brain metabolism and the function of specific brain regions.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Osorio-Paz I,Ramírez-Pérez G,Hernández-Ramírez JE,Uribe-Carvajal S,Salceda Rdoi
10.1007/s11033-018-4233-5subject
Has Abstractpub_date
2018-10-01 00:00:00pages
871-879issue
5eissn
0301-4851issn
1573-4978pii
10.1007/s11033-018-4233-5journal_volume
45pub_type
杂志文章abstract：:The association between vitamin D receptor (VDR) gene polymorphisms and risk of benign prostatic hyperplasia (BPH) has been investigated in numerous publications, but published results remain inconclusive. Hence, we conducted this meta-analysis to derive a more precise conclusion. Four polymorphisms (Taq-I, Bsm-I, Apa...
journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11033-014-3554-2
更新日期：2014-10-01 00:00:00
abstract：:The two predominant forms of arginase, cytosolic Arginase-I and mitochondrial Arginase-II, catalyze hydrolysis of arginine into ornithine and urea. Based on presence of arginase activity in extracts using potassium chloride (KCl), mitochondrial membrane-bound arginase has also been suggested. However, the activity of ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-016-3965-3
更新日期：2016-05-01 00:00:00
abstract：:The aim of this study was to develop microsatellite markers as a tool to study population structure, genetic diversity and effective population size of Echinopsis chiloensis, an endemic cactus from arid and semiarid regions of Central Chile. We developed 12 polymorphic microsatellite markers for E. chiloensis using ne...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-016-4069-9
更新日期：2016-12-01 00:00:00
abstract：:Macrophage activation is modulated by both environmental cues and endogenous programs. In the present study, we investigated the role of a PAQR family protein, monocyte to macrophage differentiation-associated (MMD), in macrophage activation and unveiled its underlying molecular mechanism. Our results showed that whil...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-1370-5
更新日期：2012-05-01 00:00:00
abstract：:Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are autoimmune, inflammatory diseases with substantial genetic contributions. Matrix metalloproteinase (MMP)-2, tumor necrosis factor (TNF)-α and NLR family pyrin domain-containing 1 (NLRP1) play important roles in the immune response. We studied the MMP-2 rs24...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2743-8
更新日期：2013-11-01 00:00:00
abstract：:In the published original version, the complete list of authors was omitted. The complete list of contributing authors is updated with this Correction. ...
journal_title：Molecular biology reports
pub_type： 已发布勘误
doi：10.1007/s11033-018-4454-7
更新日期：2018-12-01 00:00:00
abstract：:The Cichlid fish Sarotherodon melanotheron is typically found in West and Central African estuaries and lagoons. It represents a good candidate for promoting tilapia farming in brackish waters. Understanding the genetic diversity in its populations from the hydrographical basins of Southern Benin is primordial before ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-018-4354-x
更新日期：2018-12-01 00:00:00
abstract：:Development of a rapid and accurate quantification method for the detection of microRNAs (miRNAs) has been desired, in particular, when they are differently expressed in normal and pathological conditions. However, various methods for the quantification of small non-coding RNAs as well as miRNAs have been described. T...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-2442-x
更新日期：2013-05-01 00:00:00
abstract：:De novo assemblies of transcriptome sequence of F(1) interspecies hybrids between Mandarin fish Siniperca chuatsi (Basilewsky) (♀) and Golden mandarin fish Siniperca scherzeri Steindachner (♂) were generated using Illumina sequencing. In the present study, 64 microsatellite primer pairs were designed on basis of the t...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1958-4
更新日期：2013-02-01 00:00:00
abstract：:Circadian rhythms are endogenous and self-sustained oscillations of multiple biological processes with approximately 24-h rhythmicity. Circadian genes and their protein products constitute the molecular components of the circadian oscillator that form positive/negative feedback loops and generate circadian rhythms. Th...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2841-7
更新日期：2014-01-01 00:00:00
abstract：:Due to being stable in the circulatory system plasma miRNAs have been detected in various diseases including coronary artery disease (CAD) which is the major cause of mortality and morbidity worldwide. Atherosclerosis is the major cause of CAD. The first and most important event in the progression of atherosclerosis i...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-018-4547-3
更新日期：2019-02-01 00:00:00
abstract：:The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of head and neck cancer (HNC) were investigated in many published studies; however, the currently available results are inconclusive. Therefore, we conducted this meta-analysis for deriving a more precise estimation of associ...
journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11033-013-2708-y
更新日期：2013-10-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease, with multiple genetic and environmental factors involving in its etiology. Angiotensin converting enzyme (ACE) gene was reported to have important roles in the development and progression of SLE. In this study, a case-control study was carried out to investi...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1813-7
更新日期：2012-10-01 00:00:00
abstract：:Current study was conducted to investigation of effect of magnetic field on cell dedifferentiation and follow it callus induction derived from mature embryo culture in bread wheat genotypes. For this purpose, a factorial experiment based on completely randomized design was carried out with two wheat genotypes and thre...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-2214-7
更新日期：2013-02-01 00:00:00
abstract：:Cartilage has a limited self-repair capability and the repair of large cartilage defects remains a challenge in clinic. This study aimed to investigate the effect of mesenchymal stem cells (MSCs) loaded three-dimensional bilayer collagen scaffold for cartilage repair. Cross-linked three-dimensional bilayer collagen sc...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-0853-8
更新日期：2012-02-01 00:00:00
abstract：:Abiotic stresses such as salinity and drought have adverse effects on plants. In the present study, a Na(+)/H(+) antiporter gene homologue (LfNHX1) has been cloned from a local halophyte grass (Leptochloa fusca). The LfNHX1 cDNA contains an open reading frame of 1,623 bp that encodes a polypeptide chain of 540 amino a...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-3015-3
更新日期：2014-03-01 00:00:00
abstract：:MicroRNAs (miRNAs) may play important roles in SLE, but genetic polymorphisms of miRNAs and their relationships with various autoantibodies present in SLE patients remain unclear. Here, we report that 213 SLE patients and 209 healthy individuals of Chinese had been taken into this case-control studies, which had been ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-0252-6
更新日期：2011-03-01 00:00:00
abstract：:Previous report showed that Estrogen related receptor α (ERRα) knockout mice had a significant reduction in adipose tissue deposition. Although it was reported that ERRα could promote adipogenesis in several immortalized preadipocytes cell lines, the mechanism behind which is still unclear to date. Besides, the expres...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-1104-8
更新日期：2012-03-01 00:00:00
abstract：:Dyggve melchior clausen syndrome (DMC, MIM 223800) is a very rare autosomal recessive form of skeletal dysplasia associated with various degrees of mental retardation. It is characterized by a progressive spondyloepimetaphyseal dysplasia (SEMD) with disproportionate short stature, generalized platyspondyly and lacy il...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05774-z
更新日期：2020-09-01 00:00:00
abstract：:The tertiary structure of nucleic acids results from an equilibrium between electrostatic interactions of phosphates, stacking interactions of bases, hydrogen bonds between polar atoms and water molecules. Water interactions with ribonucleic acid play a key role in its structure formation, stabilization and dynamics. ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1452-z
更新日期：2012-05-01 00:00:00
abstract：:We performed PCR of many DNA fragments of 6-32 nucleotides in length. Some of the fragments expanded into kilobase lengths even in the absence of the complementary strand. The dramatic expansion was observed for (CA)8, (TG)8, (CA)4, (CA)6, (CA)12, (TG)4, (TG)6, (TG)12, (TC)10, (GA)10 and other single strands. Similar ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1023/a:1024916602218
更新日期：2003-09-01 00:00:00
abstract：:CD40 signaling plays a critical role in the survival rate of gastric cancer patients. Tumour samples were collected from 73 patients with who were diagnosed as gastric cancer in general surgery department in the 1st affiliated hospital of Suzhou University between September 2002 and July 2003. All patients had not rec...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1734-5
更新日期：2012-09-01 00:00:00
abstract：:The objective of present study was to screen the effect of methyl jasmonate (MJ) in lipopolysaccharide (LPS) induced in vivo and in vitro arthritis. Arthritis was induced in wistar rats by intraplantar administration of LPS (1 mg/Kg) and effect of MJ was screened in two doses (20, 40 mg/Kg, IP), indomethacin (30 mg/Kg...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-018-4520-1
更新日期：2019-02-01 00:00:00
abstract：:Several lines of evidence indicate that inflammatory processes play pivotal role in the development of intracranial aneurysm (IA). Recently, polymorphisms in the interleukin-12 (IL-12) gene were shown to be associated with immune-mediated inflammatory disease. The aim of this study was to investigate the interactions ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-2031-z
更新日期：2012-12-01 00:00:00
abstract：:In plants, stomata play a pivotal role in the regulation of gas exchange and are distributed throughout the aerial epidermis. SDD1, a gene isolated from Arabidopsis thaliana has been demonstrated to specialize in stomatal density and distribution. In our present study, a comprehensive survey of global gene expression ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-009-9776-z
更新日期：2010-02-01 00:00:00
abstract：:Two GATC specific methylases together with Sau3AI isoschizomeric restriction endonuclease were partially characterized in Mitsuokella multiacida 46/5. This is the first report on the presence of solitary Dam methyltransferase alongside GATC specific restriction-modification system resulting in the unusual two-fold met...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-005-2310-z
更新日期：2005-12-01 00:00:00
abstract：:Rice production in recent years is highly affected by rapidly increasing temperatures in the tropical and sub-tropical countries, which threatens the sustainable production in near future. Hence, understanding the heat tolerance mechanism and evolving tolerant varieties is an immense need in the staple crop rice. An e...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05291-z
更新日期：2020-03-01 00:00:00
abstract：:Quercus acutissima is native to eastern Asia. It has a wide distribution in China and China is an important component in understanding the ecology and genetic structure of this species. Q. acutissima attained high economic value for hardwood product and can be managed as an energy tree species. To investigate the gene...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2486-6
更新日期：2013-06-01 00:00:00
abstract：:FK-506 binding proteins (FKBPs) belong to the peptidyl-prolyl cis/trans isomerase superfamily (PPIases, EC: 5.2.1.8) which catalyzes the interconversion of peptidyl-prolyl bonds while they can also act on polypeptides, as folding helper enzymes. Here, we biochemically characterize two recombinant FKBPs, AvfkbA1 and Av...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1869-4
更新日期：2012-12-01 00:00:00
abstract：:The mouse double minute 2 (MDM2) gene encodes a phosphoprotein that interacts with P53 and negatively regulates its activity. SNP309 polymorphism (T-G) in the promoter of MDM2 gene has been reported to be associated with enhanced MDM2 expression and tumor development. Many published studies have evaluated the associat...
journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11033-011-1119-1
更新日期：2012-04-01 00:00:00
