A homozygous nonsense variant in DYM underlies Dyggve-Melchior-Clausen syndrome associated with ectodermal features.

abstract：:Sperm-mediated gene transfer (SMGT) has been long heralded as a faster and cheaper alternative to more commonly used methods of producing transgenic animals. In this study, the capra semen ejaculates were pooled together and then incubated in vitro with DIG-labeled DNA. The binding and internalizing rates were observe...

journal_title：Molecular biology reports

authors： Zhao Y,Yu M,Wang L,Li Y,Fan J,Yang Q,Jin Y

更新日期：2012-03-01 00:00:00

abstract：:Current study was conducted to investigation of effect of magnetic field on cell dedifferentiation and follow it callus induction derived from mature embryo culture in bread wheat genotypes. For this purpose, a factorial experiment based on completely randomized design was carried out with two wheat genotypes and thre...

journal_title：Molecular biology reports

authors： Kahrizi D,Cheghamirza K,Akbari L,Rostami-Ahmadvandi H

更新日期：2013-02-01 00:00:00

abstract：:It is widely accepted that protein phosphorylation is a major control event in regulating cell cycle. In the present study, a novel M-phase phosphoprotein 6 (MPP6) was identified from black tiger shrimp Penaeus monodon (designated as PmMPP6) by cDNA library and RACE approaches. The full-length cDNA of PmMPP6 was of 69...

journal_title：Molecular biology reports

authors： Zhou J,Qiu L,Jiang S,Zhou F,Huang J,Yang L,Su T,Zhang D

更新日期：2013-02-01 00:00:00

abstract：:In this study we are presenting the development of technetium-99m (99mTc) labeled ibuprofen for the imaging of aseptic inflammation. 99mTc-Ibuprofen complex was developed by optimizing the radiolabeling conditions such as reaction time, ligand and reducing agent concentration, pH, reaction time and temperature. Follow...

journal_title：Molecular biology reports

authors： Khan NU,Naqvi SAR,Sohail H,Roohi S,Jamal MA

更新日期：2019-06-01 00:00:00

abstract：:Because of the importance of androgens to prostate cancer (PCa) development, several candidate genes along androgen pathway have been under intensive study. Given the role of the molecular chaperone HSP70 in the regulation of the androgen receptor (AR) transactivation function, we first chose to explore the associatio...

journal_title：Molecular biology reports

authors： Sfar S,Saad H,Mosbah F,Chouchane L

更新日期：2008-09-01 00:00:00

abstract：:Bud dormancy in perennial plants adapts to environmental and seasonal changes. Bud dormancy is of ecological interest because it affects forest population growth characteristics and is of economical interest because it impacts wood production levels. To understand Pinus sylvestris L. var. mongolica litv. bud-dormancy ...

journal_title：Molecular biology reports

authors： Bi YD,Wei ZG,Shen Z,Lu TC,Cheng YX,Wang BC,Yang CP

更新日期：2011-02-01 00:00:00

abstract：:India has a rich heritage of rearing cattle where farmers selected native cattle suitable to their local agro-ecological conditions for centuries. It is reflected in 50 indigenous breeds of cattle, besides many lesser known populations not explored so far. It is the need of the hour to characterize such populations to...

journal_title：Molecular biology reports

authors： Sharma R,Ahlawat S,Sharma H,Bhagat RL,Singh PK,Tantia MS

更新日期：2020-08-01 00:00:00

abstract：:Two GATC specific methylases together with Sau3AI isoschizomeric restriction endonuclease were partially characterized in Mitsuokella multiacida 46/5. This is the first report on the presence of solitary Dam methyltransferase alongside GATC specific restriction-modification system resulting in the unusual two-fold met...

journal_title：Molecular biology reports

authors： Piknova M,Filova M,Javorsky P,Pristas P

更新日期：2005-12-01 00:00:00

abstract：:The two predominant forms of arginase, cytosolic Arginase-I and mitochondrial Arginase-II, catalyze hydrolysis of arginine into ornithine and urea. Based on presence of arginase activity in extracts using potassium chloride (KCl), mitochondrial membrane-bound arginase has also been suggested. However, the activity of ...

journal_title：Molecular biology reports

authors： Mishra S,Mishra R

更新日期：2016-05-01 00:00:00

abstract：:Fusarium head blight (FHB), predominantly caused by Fusarium graminearum, is a destructive disease that poses a serious threat to wheat (Triticum aestivum L.) production around the world. A suppression subtractive hybridization (SSH) cDNA library was constructed from F. graminearum infected spikes of a resistant Belgi...

journal_title：Molecular biology reports

authors： Muhovski Y,Batoko H,Jacquemin JM

更新日期：2012-10-01 00:00:00

abstract：:Identifying patients at high risk of metastasis is a major challenge in lung adenocarcinoma (ADC) therapy, therefore discovery of noninvasive biomarkers and therapeutic targets is urgent. We found significant differences between the secretomes of differentially expressed proteins in lung ADC cell lines, clinical tissu...

journal_title：Molecular biology reports

authors： Liu Z,Gao Y,Hao F,Lou X,Zhang X,Li Y,Wu D,Xiao T,Yang L,Li Q,Qiu X,Wang E

更新日期：2014-11-01 00:00:00

abstract：:Infection with mycobacterium tuberculosis (MTB) can cause different outcomes in hosts with variant genetic backgrounds. Previously, we identified an intracellular pathogen resistance 1 (Ipr1) gene with the role of resistance of MTB infection in mice model. However, until now, its binding proteins have been little know...

journal_title：Molecular biology reports

authors： Cai L,Pan H,Trzciński K,Thompson CM,Wu Q,Kramnik I

更新日期：2010-12-01 00:00:00

abstract：:Circulating long noncoding RNAs as biomarkers of diseases have attracted increasing attention recently. However, circulating lncRNAs in hypertension is still unexplored niche. The levels of lncRNAs GAS5, NR024118, MRAK134679, AX765700 and MRNR026574 were measured in the serum and myocardium of hypertensive rats and no...

journal_title：Molecular biology reports

authors： Wu Y,Zhang Z,Ren S,Li K,Ning Q,Jiang X

更新日期：2019-12-01 00:00:00

abstract：:Many case-control studies have investigated the role of TGF-β1 gene +869C/T promoter polymorphism in autoimmune diseases, but the results are inconsistent. To clarify this point, we performed a meta-analysis based on all available studies in Pubmed, Elsevier Science Direct, Google Searching, Chinese Biomedical Literat...

journal_title：Molecular biology reports

authors： Zhang L,Yan JW,Wang YX,Wan YN,Li JP,Liu P,Xu B,Wang BX,Peng WJ,Pan FM,Wang J

更新日期：2013-08-01 00:00:00

abstract：:Rat liver chromatin activated by partial hepatectomy is more susceptible to the action of DNAse I than control chromatin isolated from intact liver. The study on the transfer of chromatin material to the acid-soluble fraction reveals a higher rate of activated chromatin degradation. Activated chromatin shows also an i...

journal_title：Molecular biology reports

authors： Batova IN,Fedoseeva GE,Zelenin AV

更新日期：1979-12-31 00:00:00

abstract：:A copper(II) complex containing aspartame (APM) as ligand, Cu(APM)2Cl2·2H2O, was synthesized and characterized. In vitro binding interaction of this complex with human serum albumin (HSA) was studied at physiological pH. Binding studies of this complex with HSA are useful for understanding the Cu(APM)2Cl2·2H2O-HSA int...

journal_title：Molecular biology reports

authors： Shahabadi N,Khodaei MM,Kashanian S,Kheirdoosh F,Filli SM

更新日期：2014-05-01 00:00:00

abstract：:Hypertension is the most widespread disease in the world affecting humans and imparts a significant cardiovascular and renal risk to patients, and extensive research over the past few decades has enhanced our understanding of the underlying pathogenesis of hypertension. A growing number of studies have shown that miRN...

journal_title：Molecular biology reports

authors： Miao C,Chang J,Zhang G

更新日期：2018-12-01 00:00:00

abstract：:Substantial evidence has demonstrated that platelet-derived growth factor-D (PDGF-D) is tightly associated with the development and progression of tumors. However, its biological functions in esophageal squamous cell carcinoma (ESCC) remain to be delineated. In this study, we found that expressions of PDGF-D mRNA and ...

journal_title：Molecular biology reports

authors： Han Y,Guo XH,Zheng QF,Zhu YL,Fan YY,Zhang XY

更新日期：2013-03-01 00:00:00

abstract：:Studies investigating the association between glutathione S-transferase M1 (GSTM1) polymorphism and bladder cancer risk report conflicting results. The objective of this study was to quantitatively summarize the evidence for such a relationship. We performed a systematic search of the National Library of Medline and E...

journal_title：Molecular biology reports

authors： Zhang R,Xu G,Chen W,Zhang W

更新日期：2011-04-01 00:00:00

abstract：:Ran is a multifunctional small GTPase involved in important cellular activities like nucleocytoplasmic transport, mitotic spindle assembly, nuclear envelope formation, etc., but is also known to be differentially expressed in response to abiotic stress, particularly low temperature. We have over-expressed Lepidium lat...

journal_title：Molecular biology reports

authors： Sinha VB,Grover A,Singh S,Pande V,Ahmed Z

更新日期：2014-09-01 00:00:00

abstract：:Hepatitis B virus X protein (HBx) is closely involved in the development of hepatocellular carcinoma (HCC). Tumor suppressor p53 was reported to induce HBx degradation and repress its oncogenic function recently, but the molecular mechanism is unknown. In this study, we attempted to identify the underlying mechanism. ...

journal_title：Molecular biology reports

authors： Xian L,Zhao J,Wang J,Fang Z,Peng B,Wang W,Ji X,Yu L

更新日期：2010-07-01 00:00:00

abstract：:Biochemical networks comprise many diverse components and interactions between them. It has intracellular signaling, metabolic and gene regulatory pathways which are highly integrated and whose responses are elicited by extracellular actions. Previous modeling techniques mostly consider each pathway independently with...

journal_title：Molecular biology reports

authors： Tomar N,Choudhury O,Chakrabarty A,De RK

更新日期：2013-02-01 00:00:00

abstract：:Myocilin (MYOC) gene is expressed in many ocular tissues, including the trabecular meshwork, a specialized eye tissue essential in regulating intraocular pressure. Many mutations in MYOC have been detected in primary open-angle glaucoma (POAG). We investigated whether MYOC mutations contributed to the susceptibility t...

journal_title：Molecular biology reports

authors： Qu X,Zhou X,Zhou K,Xie X,Tian Y

更新日期：2010-01-01 00:00:00

abstract：:The lily-of-the-valley Convallaria (Asparagaceae) consists of three herbaceous perennial species. The plants are commonly found in northern hemisphere, and are best-known for their ornamental and pharmaceutical value. In order to assess the genetic structure, diversity and demographic history of Convallaria species, 1...

journal_title：Molecular biology reports

authors： Lu QX,Gao J,Wu JJ,Zhou X,Wu X,Li MD,Wei YK,Wang RH,Qi ZC,Li P

更新日期：2020-04-01 00:00:00

abstract：:We performed PCR of many DNA fragments of 6-32 nucleotides in length. Some of the fragments expanded into kilobase lengths even in the absence of the complementary strand. The dramatic expansion was observed for (CA)8, (TG)8, (CA)4, (CA)6, (CA)12, (TG)4, (TG)6, (TG)12, (TC)10, (GA)10 and other single strands. Similar ...

journal_title：Molecular biology reports

authors： Reichová N,Kypr J

更新日期：2003-09-01 00:00:00

abstract：:Fatty acid-binding proteins (FABPs), small cytosolic proteins that function in the uptake and utilization of fatty acids, have been extensively studied in higher vertebrates while invertebrates have received little attention despite similar nutritional requirements during periods of reproductive activity. Therefore, a...

journal_title：Molecular biology reports

authors： Li WW,Jin XK,He L,Gong YN,Jiang H,Wang Q

更新日期：2011-11-01 00:00:00

abstract：:Combined treatment with niacin and chromium has been found to have a protective effect against oxidative damage to different tissues of hyperlipidemic rats. But its effects on vascular endothelial dysfunction are less clear. This study was performed to investigate the effect of combined treatment with niacin and chrom...

journal_title：Molecular biology reports

authors： Niu N,Yu YH,Wang Y,Wang LJ,Li Q,Guo LM

更新日期：2009-07-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) has been investigated extensively at the molecular level. Nevertheless, genome wide study on the temporal and spatial dynamics of the virus is non-existed. To explore this topic, we determined complete coding genome sequences for four PRRSV isolates and analy...

journal_title：Molecular biology reports

authors： Yoon SH,Kim H,Kim J,Lee HK,Park B,Kim H

更新日期：2013-10-12 00:00:00

abstract：:Iron may be implicated in the generation of oxidative stress by the catalyzing the Haber-Weiss or Fenton reaction. On the other hand, oxidative stress has been implicated in the pathogenesis of age-related macular degeneration (AMD) and heme oxygenase-1 (HO-1), encoded by the HMOX1 gene and heme oxygenase-2 (HO-2), en...

journal_title：Molecular biology reports

authors： Synowiec E,Szaflik J,Chmielewska M,Wozniak K,Sklodowska A,Waszczyk M,Dorecka M,Blasiak J,Szaflik JP

更新日期：2012-03-01 00:00:00

abstract：:Dipeptidyl peptidase III (DPP III) is an emerging biomarker of human cancers. Expression, specificity, and function of human DPP III (hDPP III) mRNA variant I (V-I), II (V-II), and III (V-III) are poorly understood. Here, we investigated expression of these variants in multiple human tumor derived cell lines. DNA sequ...

journal_title：Molecular biology reports

authors： Prajapati SC,Chauhan SS

更新日期：2016-06-01 00:00:00