Abstract：
:Infection with mycobacterium tuberculosis (MTB) can cause different outcomes in hosts with variant genetic backgrounds. Previously, we identified an intracellular pathogen resistance 1 (Ipr1) gene with the role of resistance of MTB infection in mice model. However, until now, its binding proteins have been little known even for its human homology, SP110. In this study, the homology for mouse Ipr1 in canines was found to have an extra domain structure, h.1.5.1. And 30 potential candidate proteins were predicted to bind canine Ipr1, which were characterized of the interacting structure with the h.1.5.1. Among them, MYBBP1A was verified to bind with both Ipr1 and eGFP-Ipr1 in mouse macrophage J774A.1 clone 21 cells using co-immunoprecipitation method. And with the constructed high-confidence Ipr1-involved network, we suggested that Ipr1 might be involved in apoptosis pathway via MYBBP1A.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Cai L,Pan H,Trzciński K,Thompson CM,Wu Q,Kramnik Idoi
10.1007/s11033-010-0042-1subject
Has Abstractpub_date
2010-12-01 00:00:00pages
3863-8issue
8eissn
0301-4851issn
1573-4978journal_volume
37pub_type
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