Abstract:
:We characterized a panel of human RNase MRP/RNase P autoantibodies by immunoprecipitation, immunodepletion, immunoaffinity purification and immunoblotting. We report on the protein spectrum that is recognized by RNase MRP/RNase P autoantibodies. We also describe another, related patient serum that based on these assays does not immunoprecipitate RNase P/MRP/Th40. This autoantibody 'KC', however, coimmunoprecipitates the RNase MRP/RNase P associated RNAs from HeLa and La9 cell extracts as shown by nuclease protection experiments.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Karwan RMdoi
10.1023/a:1006878511162subject
Has Abstractpub_date
1998-03-01 00:00:00pages
95-101issue
2eissn
0301-4851issn
1573-4978journal_volume
25pub_type
杂志文章abstract::Killer cell immunoglobulin like receptor genes expressed by the natural killer cells and T cells of some subclasses are one of the very diversity and complex gene families on chromosome 19q13.4 which play key developmental role in the fight against viral infections, malignantly transformed cells and so on in the first...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4563-3
更新日期:2019-02-01 00:00:00
abstract::Epidemiological studies found inconsistent results on the association of two variants on TGFBR1 (TGFBR1*6A and Int7G24A) with colorectal cancer (CRC) risk. The present study was aimed to evaluate the association of these two variants with CRC susceptibility via the meta-analysis methods. For variant TGFBR1*6A, nine re...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-011-1009-6
更新日期:2012-03-01 00:00:00
abstract::Geranylgeranyl diphosphate synthase (GGPPS) [EC 2.5.1.29] catalyzes the biosynthesis of geranylgeranyl diphosphate (GGPP), which is a key precursor for diterpenes such as taxol. Herein, a full-length cDNA encoding GGPPS (designated as CgGGPPS) was cloned and characterized from hazel (Corylus avellana L. Gasaway), a ta...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9935-2
更新日期:2010-10-01 00:00:00
abstract::The Rv3203 (LipV) of Mycobacterium tuberculosis (Mtb) H37Rv, is annotated as a member of Lip family based on the presence of characteristic consensus esterase motif ‘GXSXG’. In vitro culture studies of Mtb H37Ra indicated that expression of Rv3203 gene was up-regulated during acidic stress as compared to normal wherea...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2861-3
更新日期:2014-01-01 00:00:00
abstract::Proto-oncogen Ahi-1 is closely related to a lot of human and mouse diseases. Ahi-1 mutation will lead to leukemia in mice and Joubert syndrome in human beings. We have cloned the full cDNA sequence of Ahi-1 homologous in zebrafish, and RT-PCR results of ZAhi-1 in different tissues reveal that ZAhi-1 expressed highest ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-006-0005-8
更新日期:2006-06-01 00:00:00
abstract::Expressed sequence tags (ESTs) provide valuable tools that can be used to predict the genes involved in primary and secondary metabolite synthesis. To the best of our knowledge, ESTs have not yet been developed for Codonopsis. lanceolata, and therefore, the EST referenced in this report is the first transcript for C. ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0464-9
更新日期:2011-06-01 00:00:00
abstract::The mechanism by which external Bax releases cytochrome c is still controversial and may also depend on the type of mitochondria and the actual localisation of cytochrome c. Outer membrane porin acquires high binding affinity for hexokinase by interacting with the adenine nucleotide translocator (ANT) in the contact s...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/a:1020383108620
更新日期:2002-01-01 00:00:00
abstract::The plasticity of the central nervous system helps form the basis for the neurobiology of learning and memory. Long-term potentiation (LTP) is the main form of synaptic plasticity, reflecting the activity level of the synaptic information storage process, and provides a good model to study the underlying mechanisms of...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1007/s11033-010-0128-9
更新日期:2011-01-01 00:00:00
abstract::HMG proteins were extracted with 5% PCA or 0.35 M NaCl from whole tissue, nuclei or chromatin of the liver of young (19 weeks) and old (118 weeks) male rats. They were resolved on acetic acid-urea polyacrylamide gel. The electrophoretic patterns of the major HMG proteins 1, 2, 14 and 17 of both ages are similar. The i...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00369896
更新日期:1991-02-01 00:00:00
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journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1786-6
更新日期:2012-09-01 00:00:00
abstract::Biochemical networks comprise many diverse components and interactions between them. It has intracellular signaling, metabolic and gene regulatory pathways which are highly integrated and whose responses are elicited by extracellular actions. Previous modeling techniques mostly consider each pathway independently with...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2153-3
更新日期:2013-02-01 00:00:00
abstract::Phosphomannose isomerase (PMI) is an enzyme that catalyses the first step of the L-galactose pathway for ascorbic acid (AsA) biosynthesis in plants. To clarify the physiological roles of PMI in AsA biosynthesis, the cDNA sequence of PMI was cloned from non-heading Chinese cabbage (Brassica campestris ssp. chinensis Ma...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3072-2
更新日期:2014-01-01 00:00:00
abstract::Human Papillomavirus infection is considered as the main etiological factor of cervical cancer (ICC), although, the role of host genetic factors in ICC susceptibility has been increasing. Immunological response is crucial for the prevention of viral associated diseases. Interleukin 1 receptor antagonist (IL-1RN) is co...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1979-z
更新日期:2012-12-01 00:00:00
abstract::A number of regions designated as RD1-RD16 (region of difference) and encompassing 129 open reading frames have been identified between Mycobacterium tuberculosis and Mycobacterium bovis on the one hand and Bacillus Calmette-Guérin on the other. Identification of T cell epitopes from this set of proteins may serve to ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9613-4
更新日期:2010-04-01 00:00:00
abstract::We tried to study the possible effects of lipoic acid (LA) on adhesion molecule expression and its underlying mechanism in the prevention and treatment of cardiovascular disorders. Intercellular adhesion molecule-1 (ICAM-1) expression and endothelial nitric oxide synthase (eNOS) activity were determined after endothel...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2071-4
更新日期:2013-01-01 00:00:00
abstract::Cytokinin oxidases are involved in the regulation of plant cytokinin levels, which are important in regulating plant growth and development, and may affect the yield of cereals. Here, we report the isolation and characterization of two putative cytokinin oxidase genes, TaCKX2.1 and TaCKX2.2, from wheat. Both TaCKX2.1 ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0367-9
更新日期:2011-04-01 00:00:00
abstract::GASA-like genes form multigene families in diverse plant species and encode the proteins with a unique cysteine-rich domain (GASA domain). In our previously work, we cloned a GASA-like gene PRGL (Proline-rich GASA-like) from gerbera. Here we report the expression profiles of PRGL and the subcellular localization of PR...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9917-4
更新日期:2010-10-01 00:00:00
abstract::Local domestic chicken populations are of paramount importance as a source of protein in developing countries. Bangladesh possesses a large number of native chicken populations which display a broad range of phenotypes well adapted to the extreme wet and hot environments of this region. This and the fact that wild jun...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2522-6
更新日期:2013-06-01 00:00:00
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journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4417-z
更新日期:2018-12-01 00:00:00
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journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1007/s11033-014-3577-8
更新日期:2014-10-01 00:00:00
abstract::This meta-analysis was performed to assess the relationships between the PON1 Q192R (rs662 T>C) polymorphism and the clinical outcome of antiplatelet treatment after percutaneous coronary intervention (PCI). A range of electronic databases were searched: Web of Science (1945-2013), the Cochrane Library Database (Issue...
journal_title:Molecular biology reports
pub_type: 撤回出版物,收录出版
doi:10.1007/s11033-014-3509-7
更新日期:2014-09-01 00:00:00
abstract::Olanzapine, an atypical antipsychotic medication, has been associated with weight gain and metabolic toxicity, especially in long term usage. Carnosic acid (CA), a major constituent of rosemary extract, has been shown to improve metabolic abnormalities. In this experiment, the effect of CA on olanzapine-induced obesit...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05825-5
更新日期:2020-10-01 00:00:00
abstract::This study was aimed to evaluate the regulation mechanism of cortactin (CTTN) on matrix metalloproteinases 9 (MMP-9) and its relations with Exo70 in invasion of hepatoma carcinoma (HCC) cells. The expression levels of CTTN, Exo70 and MMP-9 were detected in normal hepatocytes and various HCC cells by real-time PCR. The...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-016-3972-4
更新日期:2016-05-01 00:00:00
abstract::This study was designed to identify the differential expression of the canonical transient receptor potential (TRPC) channels in the left ventricle of spontaneously hypertensive rats (SHR). Echocardiography studies were performed to compare the left ventricular function in SHR vs. Wistar-Kyoto rats (WKY), and the mRNA...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9792-z
更新日期:2010-07-01 00:00:00
abstract::Abnormally protein aggregation and deposition are key pathological features of ALS, which may related with dysfunctional cellular autophagy. In the current study, we found that, compared with wtSOD1 cells, serum starvation treatment resulted in significant higher percentage of apoptosis in mutSOD1 cells; Lithium treat...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05071-4
更新日期:2019-12-01 00:00:00
abstract::The relationship between genetic polymorphisms of glutathione S-transferase (GST) and the development of glioma has been investigated in several epidemiologic studies. However these studies report inconsistent results. In order to quantitatively summarise the evidence for such a relationship, a meta-analysis is conduc...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-012-2213-8
更新日期:2013-02-01 00:00:00
abstract::Macroautophagy is a regulated bulk degradation process of cellular components, mainly long-lived proteins or cytoplasmic organelles. Nutrient depletion is a classic inducer of macroautophagy. In this report, we have induced heat-mediated macroautophagy in several cell lines in the absence of nutrient depletion. Heat t...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9451-4
更新日期:2009-11-01 00:00:00
abstract::In this study we are presenting the development of technetium-99m (99mTc) labeled ibuprofen for the imaging of aseptic inflammation. 99mTc-Ibuprofen complex was developed by optimizing the radiolabeling conditions such as reaction time, ligand and reducing agent concentration, pH, reaction time and temperature. Follow...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04762-2
更新日期:2019-06-01 00:00:00
abstract::Hepatitis B virus X protein (HBx) is closely involved in the development of hepatocellular carcinoma (HCC). Tumor suppressor p53 was reported to induce HBx degradation and repress its oncogenic function recently, but the molecular mechanism is unknown. In this study, we attempted to identify the underlying mechanism. ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9855-1
更新日期:2010-07-01 00:00:00
abstract::A full length spermidine synthase (PgSPD) cDNA was isolated and characterized from the root of Panax ginseng C. A. Meyer. The cDNA was 1,188 nucleotides long and had an open reading frame of 1,002 bp with a deduced amino acid sequence of 333 residues. The calculated molecular mass of the matured protein is approximate...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9725-x
更新日期:2010-02-01 00:00:00