Abstract:
:We tried to study the possible effects of lipoic acid (LA) on adhesion molecule expression and its underlying mechanism in the prevention and treatment of cardiovascular disorders. Intercellular adhesion molecule-1 (ICAM-1) expression and endothelial nitric oxide synthase (eNOS) activity were determined after endothelial cells were exposed to high glucose in the absence and presence of LA. Coincubation of endothelial cells with high glucose for 24 h resulted in a significant increase of monocyte-endothelial cell adhesion and the expression of ICAM-1 (P < 0.01). These effects were abolished by LA and LA significantly increased eNOS activities (P < 0.01). These findings suggested that LA may play a role in inhibiting expression of adhesion molecules by increasing eNOS activities.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Jin HB,Yang YB,Song YL,Zhang YC,Li YRdoi
10.1007/s11033-012-2071-4subject
Has Abstractpub_date
2013-01-01 00:00:00pages
377-82issue
1eissn
0301-4851issn
1573-4978journal_volume
40pub_type
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