Abstract:
:Statins have shown pleiotropic effects, many of them independent of their impact on lipids. Angiogenesis can be beneficial in the acute myocardial infarction to improve circulation. However, it also can be harmful due to worsening of atherosclerosis. Here, we established a new minimal invasive rabbit model to study ischemic myocardium and atherosclerosis together to mimic clinical scenario. We demonstrated that simvastatin has the effect of pro-angiogenesis and further improve cardiac function in ischemic myocardium, as well as the effect of anti-angiogenesis to improve atherosclerosis in aorta vessels.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Shen W,Shi HM,Fan WH,Luo XP,Jin B,Li Ydoi
10.1007/s11033-010-0497-0subject
Has Abstractpub_date
2011-08-01 00:00:00pages
3821-8issue
6eissn
0301-4851issn
1573-4978journal_volume
38pub_type
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