TLR3 plays significant roles against hepatitis B virus.

abstract：:Correct classification of genomic variants causing potentially aberrant splicing is of utmost importance for patient management, especially in clinically actionable genes such as BRCA1/2. In this article, we report molecular evaluation of the BRCA1 c.439T>C (rs794727800, p.Leu147=) variant based on RNA of a patient su...

journal_title：Molecular biology reports

authors： Minucci A,Mazzuccato G,D'Indinosante M,Di Nardo L,Concolino P,De Bonis M,Urbani A,Scambia G,Fagotti A,Capoluongo E

更新日期：2020-02-01 00:00:00

abstract：:Previous report showed that Estrogen related receptor α (ERRα) knockout mice had a significant reduction in adipose tissue deposition. Although it was reported that ERRα could promote adipogenesis in several immortalized preadipocytes cell lines, the mechanism behind which is still unclear to date. Besides, the expres...

journal_title：Molecular biology reports

authors： Ju D,He J,Zhao L,Zheng X,Yang G

更新日期：2012-03-01 00:00:00

abstract：:Potato (Solanum tubersosum L.) is relatively vulnerable to abiotic stress conditions such as drought, but the tolerance mechanisms to such stress in potato are largely unknown. To gain insight into the transcriptome dynamics that are associated with drought stress, genome-wide gene expression profile was conducted by ...

journal_title：Molecular biology reports

authors： Zhang N,Liu B,Ma C,Zhang G,Chang J,Si H,Wang D

更新日期：2014-01-01 00:00:00

abstract：:The purpose of this study was to identify genomic regions, quantitative trait loci (QTL), affecting carcass traits on chromosome 1 in an F2 population of Japanese quail. For this purpose, two white and wild strains of Japanese quail (16 birds) were crossed reciprocally and F1 generation (34 birds) was created. The F2 ...

journal_title：Molecular biology reports

authors： Moradian H,Esmailizadeh AK,Sohrabi SS,Nasirifar E,Askari N,Mohammadabadi MR,Baghizadeh A

更新日期：2014-07-01 00:00:00

abstract：:HSG1 (Heat shock-induced gene 1) is one of the high-temperature-induced proteins in grapevine. Sequence analysis has demonstrated that HSG1 is a grape Bcl-2-associated athanogene (BAG) that contains IQ and BAG domains in its sequence. HSG1 expression was not detected in leaves without heat treatment, while tendrils, s...

journal_title：Molecular biology reports

authors： Kobayashi M,Takato H,Fujita K,Suzuki S

更新日期：2012-04-01 00:00:00

abstract：:Deprivation of cytokines induces cell cycle arrest and apoptosis in cytokine-dependent hematopoietic progenitors. Previous studies have indicated that in Baf-3, interleukin (IL)-3-dependent cells, apoptosis is caused predominantly by Bim, a BH3-only cell death activator that belongs to the Bcl-2 superfamily. Because B...

journal_title：Molecular biology reports

authors： Matsui H,Shinjyo T,Inaba T

更新日期：2005-06-01 00:00:00

abstract：:Chromatin from guinea pig hepatocytes has been studied by electron microscopy using the spreading technique. Among DNP fibers with nucleosomal organization numerous structures with different organization have been observed. The structures consist of the main axial fiber from which the lateral fibrils branch off normal...

journal_title：Molecular biology reports

authors： Bandrina IN,Manteifel VM,Zelenin AV

更新日期：1980-10-31 00:00:00

abstract：:Generation of induced pluripotent stem cells from endangered cattle breeds makes a significant contribution to the establishment of embryonic stem cell line, conservation and utilization of genetic resources in endangered cattle. In our study, we are trying to construct recombinant proteins of transcription factors Oc...

journal_title：Molecular biology reports

authors： Hu PF,Guan WJ,Li XC,Ma YH

更新日期：2012-06-01 00:00:00

abstract：:AP2/ERF transcription factors play an important role in regulation of the cross-talk between ethylene and jasmonate signaling pathways mediating defense responses of plants to biotic and abiotic stresses. In this study, an AP2/ERF transcription factor gene was isolated and characterized from laticifers of rubber tree ...

journal_title：Molecular biology reports

authors： Chen YY,Wang LF,Dai LJ,Yang SG,Tian WM

更新日期：2012-04-01 00:00:00

abstract：:Whole-exome sequencing (WES) is an ideal method for the diagnosis of autosomal recessive diseases. The aim of this study was to evaluate the diagnostic power of WES in patients with autosomal recessive inheritance and to determine the relationship between genotype and phenotype. Retrospective screenings of 24 patients...

journal_title：Molecular biology reports

authors： Elmas M,Yıldız H,Erdoğan M,Gogus B,Avcı K,Solak M

更新日期：2019-02-01 00:00:00

abstract：:This meta-analysis was performed to evaluate the relationships between promoter DNA methylation in tumor suppressor gene p16 and gastric carcinogenesis. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library and CBM databases were searched for relevant articles published before November 1s...

journal_title：Molecular biology reports

authors： Wang HL,Zhou PY,Liu P,Zhang Y

更新日期：2014-07-01 00:00:00

abstract：:The purpose of this study was to assess the value of cytokeratin 19 (CK19) and matrix metalloproteinase 2 (MMP-2) in predicting lymph node metastasis (LNM) and survival after curative resection in hepatocellular carcinoma (HCC) patients. Expression of CK19 and MMP-2 in tumor tissue was assessed through immunohistochem...

journal_title：Molecular biology reports

authors： Xiang ZL,Zeng ZC,Tang ZY,Fan J,Sun HC,Tan YS

更新日期：2011-06-01 00:00:00

abstract：:The purpose of this study is to investigate the effect of H2O2 on the aging of melanogenesis in human melanocytes. The staining of SA-β-galactosidase, an aging marker, was remarkably increased in the cells aged with H2O2 at 62.5 µM or more compared with young cells. The intracellular H2O2 level and melanin synthesis w...

journal_title：Molecular biology reports

authors： Ko H,Kim MM

更新日期：2019-04-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) located at the cell surface and in the extracellular matrix of most animal tissues are proteoglycan coreceptors that carry heparan sulfate chains, and play a vital role in infections of many diseases. HSPGs are classified as glypican, syndecan, perlecan and agrin according to diff...

journal_title：Molecular biology reports

authors： Wang W,Tao C,Zhou P,Zhou X,Zhang Q,Liu B

更新日期：2013-03-01 00:00:00

abstract：:Membrane-bound ribosomes were isolated from a post-mitochondrial supernatant fraction of mouse liver homogenate by sedimentation in a sucrose density gradient, Loose ribosomes were released from the membrane fragments with 0.5 M KCl, while tight bound ribosomes were not released. After purification of the loose and ti...

journal_title：Molecular biology reports

authors： Hoffman WL,Dowben RM

更新日期：1980-07-31 00:00:00

abstract：:The oligochaete earthworm, Eudrilus eugeniae is capable of regenerating both anterior and posterior segments. The present study focuses on the transcriptome analysis of earthworm E. eugeniae to identify and functionally annotate the key genes supporting the anterior blastema formation and regulating the anterior regen...

journal_title：Molecular biology reports

authors： Paul S,Balakrishnan S,Arumugaperumal A,Lathakumari S,Syamala SS,Arumugaswami V,Sivasubramaniam S

更新日期：2020-12-11 00:00:00

abstract：:Overexpression of ATP-binding cassette (ABC) transporters causing multidrug resistance (MDR) in cancer cells is one of the major obstacles in cancer chemotherapy. The 5-FU resistant subclone (HL-60/5FU) of the human HL-60 promyelocytic leukemia cell line was selected by the conventional method of continuous exposure o...

journal_title：Molecular biology reports

authors： Długosz-Pokorska A,Pięta M,Janecki T,Janecka A

更新日期：2019-12-01 00:00:00

abstract：:Molecular DNA markers are used for detection of polymorphisms in individuals. As they are independent of developmental stage of the plant and environmental influences, they can be useful tools in taxonomy. The alleles of simple sequence repeat (SSR) markers (or microsatellites) are traditionally used to identify taxon...

journal_title：Molecular biology reports

authors： Tuler AC,Carrijo TT,Nóia LR,Ferreira A,Peixoto AL,da Silva Ferreira MF

更新日期：2015-11-01 00:00:00

abstract：:Cerebral aneurysm affects 2-5% of the population and posterior inferior cerebellar artery (PICA) aneurysms account for 1-3% of all intracranial aneurysms. Oxidative stress is known to contribute to the progression of cerebrovascular disease and it may be increased by inflammation, a key contributor to cerebral aneurys...

journal_title：Molecular biology reports

authors： Šćepanović V,Tasić G,Repac N,Nikolić I,Janićijević A,Todorović D,Stojanović M,Šćepanović R,Mitrović D,Šćepanović T,Borozan S,Šćepanović L

更新日期：2018-12-01 00:00:00

abstract：:Methylenetetrahydrofolate reductase (MTHFR) polymorphism may play an important role in the pathophysiology of obesity and diabetes accompanied by obesity due to its influence on plasma homocysteine levels. There are significant and sometimes very strong relationship between levels of homocysteine and several multi-sys...

journal_title：Molecular biology reports

authors： Tavakkoly Bazzaz J,Shojapoor M,Nazem H,Amiri P,Fakhrzadeh H,Heshmat R,Parvizi M,Hasani Ranjbar S,Amoli MM

更新日期：2010-01-01 00:00:00

abstract：:High Mobility Group Box 1 (HMGB1) is a nuclear protein participating in chromatin architecture and transcriptional regulation. Recently, there is increasing evidence that HMGB1 contributes to the pathogenesis of chronic inflammatory and autoimmune diseases due to its pro-inflammatory and immunostimulatory properties. ...

journal_title：Molecular biology reports

authors： Pan HF,Wu GC,Li WP,Li XP,Ye DQ

更新日期：2010-03-01 00:00:00

abstract：:In the present study, root cell suspension cultures of W. somnifera were elicited with mycelial extract (1% w/v) and culture filtrate (5% v/v) of their native endophytic fungus Aspergillus terreus 2aWF in shake flask. Culture filtrate of A. terreus 2aWF significantly elicits withanolide A at 6H (12.20 ± 0.52 µg/g FCB)...

journal_title：Molecular biology reports

authors： Kushwaha RK,Singh S,Pandey SS,Kalra A,Vivek Babu CS

更新日期：2019-04-01 00:00:00

abstract：:The binding of acridine orange and ethidium bromide to rat liver chromatin increases by 30% one hour after partial hepatectomy, returns to the control level by the second hour and increases again by the sixth hour. The changes described were found in investigations carried out on whole cells, on isolated nuclei, and o...

journal_title：Molecular biology reports

authors： Sondore OY,Fedoseeva GE,Kadyckov VA,Zelenin AV

更新日期：1978-10-16 00:00:00

abstract：:The Italian National Reference Center for Echinococcosis (CeNRE, Sassari, Italy) set up a diagnostic protocol of "one-step-PCR" useful for the detection of E. granulosus sensu stricto (E.g.s.s.) and the identification of its genotype (G1-G3). The purpose of this work was to perform the validation of the "PCR E.g.s.s."...

journal_title：Molecular biology reports

authors： Santucciu C,Masu G,Mura A,Peruzzu A,Piseddu T,Bonelli P,Masala G

更新日期：2019-04-01 00:00:00

abstract：:Flavonoids are the main flavor components and functional ingredients in tea, and the shikimic acid pathway is considered as one of the most important pathways in flavonoid biosynthesis, but little was known about the function of regulatory genes in the metabolism phenolic compounds in tea plant (Camellia sinensis), es...

journal_title：Molecular biology reports

authors： Zhu XJ,Zhao Z,Xin HH,Wang ML,Wang WD,Chen X,Li XH

更新日期：2016-10-01 00:00:00

abstract：:Adipose differentiation-related protein gene (ADP) plays an important role in controlling lipid accumulation in mammals. It may also affect lipid deposition in birds. However, the molecular mechanism of its actions in birds remains unknown. In the present study, the coding sequence of ADP cDNA for Chinese native breed...

journal_title：Molecular biology reports

authors： Zhao X,Zhu Q,Wang Y,Yang Z,Liu Y

更新日期：2010-07-01 00:00:00

abstract：:Mucor circinelloides is a dimorphic fungal model for studying several biological processes including cell differentiation (yeast-mold transitions) as well as biodiesel and carotene production. The recent release of the first draft sequence of the M. circinelloides genome, combined with the availability of analytical m...

journal_title：Molecular biology reports

authors： Valle-Maldonado MI,Jácome-Galarza IE,Gutiérrez-Corona F,Ramírez-Díaz MI,Campos-García J,Meza-Carmen V

更新日期：2015-03-01 00:00:00

abstract：:Plant microRNAs have shown the capacity to regulate mammalian systems. The potential bioactivity of miR171vr, an isoform of the plant miR171, on human embryonic kidney 293 (HEK293) cells was investigated. Bioinformatics simulations revealed that human G protein subunit alpha 12 (GNA12) transcript could represent an ex...

journal_title：Molecular biology reports

authors： Gismondi A,Nanni V,Monteleone V,Colao C,Di Marco G,Canini A

更新日期：2021-01-01 00:00:00

abstract：:Based on the internal transcribed spacer and inter-simple sequence repeats (ISSR), the phylogenetic relationship and genetic diversity of Metarhizium spp., pathogens found in Chinese burrower bugs, Schiodtella formosana, were analyzed. The results showed that the causative agents of the epizootic green muscardine dise...

journal_title：Molecular biology reports

authors： Luan F,Zhang S,Wang B,Huang B,Li Z

更新日期：2013-01-01 00:00:00

abstract：:Spermiogenesis is a developmental process undergoing continuous differentiation to drive a diploid spermatogonium towards a haploid sperm cell. This striking transformation from spermatogonium to spermatozoa is made possible by the stage-specific adaption of cytoskeleton and associated molecular motor proteins. KIFC1 ...

journal_title：Molecular biology reports

authors： Wang YT,Mao H,Hou CC,Sun X,Wang DH,Zhou H,Yang WX

更新日期：2012-07-01 00:00:00