Sensitivity of ortho- and paramyxovirus replication to human interferon alpha.

abstract：:Changes in host immunity and parasite resistance to drugs are among the factors that contribute to decreased efficacy of antiparasitic drugs such as the antimonial compounds pentamidine, amphotericin (AMP B) and miltefosine. Bioactive natural products could be alternatives for the development of new drugs to treat neg...

journal_title：Molecular biology reports

authors： de Figueiredo Peloso E,Merli RJ,Espuri PF,Nunes JB,Colombo FA,Sierra EJT,de Paulo DC,Dos Santos MH,Carvalho DT,Marques MJ

更新日期：2020-11-01 00:00:00

abstract：:Chromatin from guinea pig hepatocytes has been studied by electron microscopy using the spreading technique. Among DNP fibers with nucleosomal organization numerous structures with different organization have been observed. The structures consist of the main axial fiber from which the lateral fibrils branch off normal...

journal_title：Molecular biology reports

authors： Bandrina IN,Manteifel VM,Zelenin AV

更新日期：1980-10-31 00:00:00

abstract：:The big advantage of using molecular biomarkers to monitor oxygen levels in aquatic systems is that responses at the molecular level tend to be more sensitive, and usually occur earlier than those at higher levels of biological organization Aquatic hypoxia is a frequent event, which can occur naturally in a variety of...

journal_title：Molecular biology reports

authors： Rimoldi S,Terova G,Ceccuzzi P,Marelli S,Antonini M,Saroglia M

更新日期：2012-04-01 00:00:00

abstract：:One of the most crucial steps for preventing viral pandemics is the early detection of the causative virus on site. Various molecular and immunological approaches have been developed for virus detection. In this study, we investigated the utility of the recently introduced convection polymerase chain reaction (cPCR) p...

journal_title：Molecular biology reports

authors： Lee MH,Song KY,Hwang HJ,Kim JH,Hwang I

更新日期：2019-10-01 00:00:00

abstract：:The aim of this work was to study β-defensin 1 (SBD1) and β-defensin 2 (SBD2) genes in Valle del Belice dairy sheep in order to identify polymorphisms that can be utilized as markers of the analyzed genes, and search for the functional effects and roles of the identified polymorphisms (variation of the amino acid sequ...

journal_title：Molecular biology reports

authors： Monteleone G,Calascibetta D,Scaturro M,Galluzzo P,Palmeri M,Riggio V,Portolano B

更新日期：2011-11-01 00:00:00

abstract：:CD40 signaling plays a critical role in the survival rate of gastric cancer patients. Tumour samples were collected from 73 patients with who were diagnosed as gastric cancer in general surgery department in the 1st affiliated hospital of Suzhou University between September 2002 and July 2003. All patients had not rec...

journal_title：Molecular biology reports

authors： Li R,Chen WC,Pang XQ,Tian WY,Wang WP,Zhang XG

更新日期：2012-09-01 00:00:00

abstract：:Metallothioneins are rather ubiquitous metal-binding proteins induced by stressing or physiological stimuli. Two major metallothionein isoforms have been identified in mussel: MT10 and MT20. Nevertheless the high sequence homology, the two isoforms exhibit different expression and inducibility in vivo. We cloned and p...

journal_title：Molecular biology reports

authors： Grattarola M,Carloni M,Dondero F,Viarengo A,Vergani L

更新日期：2006-12-01 00:00:00

abstract：:The aim of this study was to explore candidate single nucleotide polymorphisms (SNPs) and candidate mechanisms of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Two SLE genome-wide association studies (GWASs) datasets were included in this study. Meta-analysis was conducted using 737,984 SNPs in 1,5...

journal_title：Molecular biology reports

authors： Lee YH,Bae SC,Choi SJ,Ji JD,Song GG

更新日期：2012-12-01 00:00:00

abstract：:Two new thermophilic type II restriction endonucleases, which we designated as Bsu2413I and Bfi2411I, have been isolated from gram-positive thermophilic bacteria Bacillus subtilis strain 2413 and Bacillus firmus strain 2411 respectively and partially purified. The restriction endonucleases were extracted from cell ext...

journal_title：Molecular biology reports

authors： Jutur PP,Hoti SL,Reddy AR

更新日期：2004-06-01 00:00:00

abstract：:PNAS-4 is a novel pro-apoptotic protein activated during the early response to DNA damage; however, the molecular mechanisms and pathways regulating PNAS-4 expression in tumors are not well understood. We hypothesized that PNAS-4 is a p53 down-stream target gene and designed this study. We searched online for putative...

journal_title：Molecular biology reports

authors： Zhou B,Yan H,Li Y,Wang R,Chen K,Zhou Z,Sun X

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this study is to investigate the effect of H2O2 on the aging of melanogenesis in human melanocytes. The staining of SA-β-galactosidase, an aging marker, was remarkably increased in the cells aged with H2O2 at 62.5 µM or more compared with young cells. The intracellular H2O2 level and melanin synthesis w...

journal_title：Molecular biology reports

authors： Ko H,Kim MM

更新日期：2019-04-01 00:00:00

abstract：:To explore the relationship of Notch1 mutation in T-ALL with the survival rate of T-ALL patients. The PubMed database, the Cochrane Library, conference proceedings, EMBASE databases, and references of published trials and review articles were searched. Two reviewers independently assessed the quality of the trials and...

journal_title：Molecular biology reports

authors： Ma J,Wu M

更新日期：2012-05-01 00:00:00

abstract：:Berberine (BBR), an effective compound of Chinese traditional herbal medicine, has preventive effects on diabetes and its complications. In this study, we investigated the therapeutic effects and underlying molecular mechanisms of BBR in rats with high-fat diet and streptozotocin (STZ)-induced diabetic nephropathy mod...

journal_title：Molecular biology reports

authors： Wang FL,Tang LQ,Yang F,Zhu LN,Cai M,Wei W

更新日期：2013-03-01 00:00:00

abstract：:Long-chain polyunsaturated fatty acids (LC-PUFAs) are essential in lots of important physiological processes, while, many marine species have no or limited ability of endogenous PUFA biosynthesis, normally due to the lack of key enzymes such as fatty acid desaturase (FAD). In this study, we isolated a scallop Chlamys ...

journal_title：Molecular biology reports

authors： Liu H,Guo Z,Zheng H,Wang S,Wang Y,Liu W,Zhang G

更新日期：2014-11-01 00:00:00

abstract：:It is well-established that an impaired adipose tissue function and morphology caused by a dysregulated gene expression contribute substantially to obesity. Nowadays, animal model studies and in vitro surveys provide evidence for possible roles of HDACs as emerging epigenetic players in the pathogenesis of obesity. Ho...

journal_title：Molecular biology reports

authors： Jannat Ali Pour N,Meshkani R,Toolabi K,Mohassel Azadi S,Zand S,Emamgholipour S

更新日期：2020-05-01 00:00:00

abstract：:Based on the internal transcribed spacer and inter-simple sequence repeats (ISSR), the phylogenetic relationship and genetic diversity of Metarhizium spp., pathogens found in Chinese burrower bugs, Schiodtella formosana, were analyzed. The results showed that the causative agents of the epizootic green muscardine dise...

journal_title：Molecular biology reports

authors： Luan F,Zhang S,Wang B,Huang B,Li Z

更新日期：2013-01-01 00:00:00

abstract：:Purified cucumber mosaic virus (CMV) RNA was reacted with NaIO4 and then [3H]KBH4 to label ends containing exposed 2',3'-hydroxyls. The four major RNA species were then fractionated by polyacrylamide gel electrophoresis. Analysis of digests of these RNAs by ribonucleases T1 plus T2, alkaline phosphatease, snake venom ...

journal_title：Molecular biology reports

authors： Symons RH

更新日期：1975-12-01 00:00:00

abstract：:A nucleic acid sequence MC, encoding Momordica Chanrantia anti-hyperglycaemic peptide MC6 (accession: AAX06814) synthesized according to Escherichia coli preferred codons, was cloned and expressed in E. coli. Recombinant protein pQE8-MC (about 3.5 kDa) was purified and analyzed by 20% SDS-PAGE and western blot. It rev...

journal_title：Molecular biology reports

authors： Liu SX,Fu ZP,Mu RM,Hu ZB,Wang FJ,Wang XR

更新日期：2010-04-01 00:00:00

abstract：:The kelch-repeat protein family is a recently found new kind of actin-binding protein. It is characterized by tandemly arranged motifs of about 50 amino acids. Previous study showed that most members of the kelch-repeat family were cytoskeletal proteins implicated in various cellular processes, such as actin cytoskele...

journal_title：Molecular biology reports

authors： Xu J,Gu S,Wang S,Dai J,Ji C,Jin Y,Qian J,Wang L,Ye X,Xie Y,Mao Y

更新日期：2003-12-01 00:00:00

abstract：:Myopalladin (MYPN) and titin (TTN) play key roles in skeletal muscle structural organisation and for this reason they may be functional candidates for meat production traits in pigs. We analysed by PCR-RFLP two polymorphisms previously identified and described in the 3'UTR of MYPN and TTN genes in a group of Italian L...

journal_title：Molecular biology reports

authors： Braglia S,Davoli R,Zappavigna A,Zambonelli P,Buttazzoni L,Gallo M,Russo V

更新日期：2013-12-01 00:00:00

abstract：:The RNA-binding protein Arabidopsis thaliana glycine-rich RNA-binding protein 7 (AtGRP7) regulates the steady-state abundance of numerous target transcripts in A. thaliana. Here we show that the GA1 and GA2 transcripts encoding the first enzymes of the gibberellin biosynthetic pathway are expressed at reduced levels i...

journal_title：Molecular biology reports

authors： Löhr B,Streitner C,Steffen A,Lange T,Staiger D

更新日期：2014-01-01 00:00:00

abstract：:Several mechanisms are involved in the loss of cellular integrity and tissue destructions in various brain regions during ischemic insult. The affected brain employs various self-repair mechanisms during the poststroke recovery. Therefore, the current study involves time course changes in different brain regions follo...

journal_title：Molecular biology reports

authors： Kapoor M,Sharma S,Sandhir R,Nehru B

更新日期：2019-12-01 00:00:00

abstract：:Hepatitis B virus (HBV) as the main prevalent infectious agent, play important roles in inducing severe liver diseases. Previous studies demonstrated that during prolonged forms of hepatitis B infection including chronic, asymptomatic and occult forms, patients are unable to eradicate HBV from hepatocytes completely. ...

journal_title：Molecular biology reports

authors： Karimi-Googheri M,Arababadi MK

更新日期：2014-05-01 00:00:00

abstract：:An RNA polymerase III transcript, 7SK nuclear RNA, was found to bear sequence homology to the B2 class of highly repeated elements in the mouse genome. Northern blot hybridizations between the small RNAs and two B2 clones showed that only one of them (p49C8) hybridized to 7SK RNA. Both clones, however, hybridized to 4...

journal_title：Molecular biology reports

authors： Gallant J,Lovely J,Krause M

更新日期：1987-01-01 00:00:00

abstract：:Folate is crucial for various cellular functions. Several transport mechanisms allow folate to enter the intracellular compartment with folate receptor-α being the major high-affinity receptor. Rare genetic variations in exons of the FR-α gene, FOLR1, were recently shown to cause severe folate deficiency accompanied b...

journal_title：Molecular biology reports

authors： Nilsson TK,Laanpere M,Altmäe S,Serra-Majem L,Salumets A

更新日期：2012-04-01 00:00:00

abstract：:To determine the plasma lipid and lipoprotein profiles and their possible association with the type of β-thalassemia mutation we studied 103 major β-thalassemia patients including 71 children and 32 young adults compared to 102 healthy subjects consisted of 90 children and 12 young healthy adults. The plasma lipid and...

journal_title：Molecular biology reports

authors： Madani H,Rahimi Z,Manavi-Shad M,Mozafari H,Akramipour R,Vaisi-Raygani A,Rezaei M,Malek-Khosravi S,Shakiba E,Parsian A

更新日期：2011-04-01 00:00:00

abstract：:The aim of this work was to sequence the promoter region of β-lactoglobulin (BLG) gene in four sheep breeds, in order to identify polymorphisms, infer and analyze haplotypes, and phylogenetic relationship among the Valle del Belice breed and the other three breeds considered as ancestors. Sequencing analysis and align...

journal_title：Molecular biology reports

authors： Mastrangelo S,Sardina MT,Riggio V,Portolano B

更新日期：2012-01-01 00:00:00

abstract：:Adequate metabolic adaptation of key tissues playing an essential role for bioenergetic homeostasis and lactogenesis is critical in cows to adapt to changes in energy requirements and physiological processes during the lactation period. Mitochondria are recognized as central to meet energy needs and maintaining of met...

journal_title：Molecular biology reports

authors： Weikard R,Kuehn C

更新日期：2018-10-01 00:00:00

abstract：:Recently genetics and epigenetics alterations have been found to be characteristic of malignancy and hence can be used as targets for detection of neoplasia. RAS association domain family protein 1A (RASSF1A) gene hypermethylation has been a subject of interest in recent researches on cancer breast patients. The aim o...

journal_title：Molecular biology reports

authors： Hagrass HA,Pasha HF,Shaheen MA,Abdel Bary EH,Kassem R

更新日期：2014-01-01 00:00:00

abstract：:The association between vitamin D receptor (VDR) gene polymorphisms and risk of benign prostatic hyperplasia (BPH) has been investigated in numerous publications, but published results remain inconclusive. Hence, we conducted this meta-analysis to derive a more precise conclusion. Four polymorphisms (Taq-I, Bsm-I, Apa...

journal_title：Molecular biology reports

authors： Zeng XT,Yao QS,Weng H,Li S,Huang JY,Wang XH

更新日期：2014-10-01 00:00:00