当前位置： SCI文献检索 > MOLECULAR BIOLOGY REPORTS期刊下所有文献 > Characterization of a novel splicing variant of KLHL5, a member of the kelch protein family.

Characterization of a novel splicing variant of KLHL5, a member of the kelch protein family.

Abstract：

:The kelch-repeat protein family is a recently found new kind of actin-binding protein. It is characterized by tandemly arranged motifs of about 50 amino acids. Previous study showed that most members of the kelch-repeat family were cytoskeletal proteins implicated in various cellular processes, such as actin cytoskeleton interaction, cytoplasmic sequestration of transcription factors and cell morphology. And some of the family members play important roles in tissue development, such as human ENC-1, NRP/B, etc. Another characteristic of the kelch family is that most members have another conserved BTB domain at the extreme amino terminus. The BTB domain is also found at the N-terminus of 5-10% of zinc-finger transcription factor types and is a conserved protein-protein interaction motif. During the large-scale sequencing analysis of a human fetal brain cDNA library we found a novel kelch-like protein gene 5, KLHL5, KLHL5 has high identity with Drosophila kelch protein and many other family members. Here we report a novel splicing variants of KLHL5, named KLHL5b and the expression pattern of KLHL5b in many tissues.

journal_name

Mol Biol Rep

journal_title

Molecular biology reports

authors

Xu J,Gu S,Wang S,Dai J,Ji C,Jin Y,Qian J,Wang L,Ye X,Xie Y,Mao Y

doi

10.1023/a:1026372901766

keywords:

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

239-42

issue

4

eissn

0301-4851

issn

1573-4978

journal_volume

30

pub_type

杂志文章

相关文献

MOLECULAR BIOLOGY REPORTS文献大全
  • Different methylation patterns in BWS/SRS cases clarified by MS-MLPA.

    abstract：:Molecular abnormalities in the 11p15.5 imprinted gene cluster lead to two different growth diseases: Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS). They are mainly caused by epigenetic alterations in one of the two imprinting 11p15 control regions (ICR1 and ICR2). These CpG-rich regions are diffe...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-012-2057-2

    authors： Lukova M,Todorova A,Todorov T,Mitev V

    更新日期：2013-01-01 00:00:00

  • Common genetic variation in CYP1B1 is associated with concentrations of T₄, FT₃ and FT₄ in the sera of polycystic ovary syndrome patients.

    abstract：:CYP1B1 encodes an estrogen enzyme that oxidizes 17β-estradiol to 4-hydroxyestradiol. The evidence demonstrates there may be a relationship between CYP1B1 and thyroid function. To date, no study has evaluated if genetic polymorphisms that regulate concentrations of serum FT3 and FT4 contribute to Polycyctic Ovary Syndr...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-012-2406-1

    authors： Zou S,Sang Q,Wang H,Feng R,Li Q,Zhao X,Xing Q,Jin L,He L,Wang L

    更新日期：2013-04-01 00:00:00

  • Sensitivity of ortho- and paramyxovirus replication to human interferon alpha.

    abstract：:Replication of the influenza virus strains Influenza Ao/WSN (H0N1), fowl plague (Hav1N1) and B-Lee/40 (ATCC) and the paramyxovirus, New Castle disease virus (Victoria) are highly sensitive to human interferon type alpha in Madin Darby bovine kidney cells. Pretreatment of cells with human interferon type alpha resulted...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/BF00775982

    authors： Strube M,Bodo G,Jungwirth C

    更新日期：1985-10-01 00:00:00

  • Identification, characterization and mapping of differentially expressed genes in a winter wheat cultivar (Centenaire) resistant to Fusarium graminearum infection.

    abstract：:Fusarium head blight (FHB), predominantly caused by Fusarium graminearum, is a destructive disease that poses a serious threat to wheat (Triticum aestivum L.) production around the world. A suppression subtractive hybridization (SSH) cDNA library was constructed from F. graminearum infected spikes of a resistant Belgi...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-012-1823-5

    authors： Muhovski Y,Batoko H,Jacquemin JM

    更新日期：2012-10-01 00:00:00

  • Expression analysis of turkey (Meleagris gallopavo) toll-like receptors and molecular characterization of avian specific TLR15.

    abstract：:Toll-like receptors (TLRs) constitute a multi-gene family, which plays a pivotal role in sensing invading pathogens by virtue of conserved microbial patterns. TLR repertoire of chicken and zebra finch has been well studied. However TLR family of other avian species is yet to be characterized. In the present study, we ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-012-1709-6

    authors： Ramasamy KT,Reddy MR,Verma PC,Murugesan S

    更新日期：2012-08-01 00:00:00

  • Green cocoons in silkworm Bombyx mori resulting from the quercetin 5-O-glucosyltransferase of UGT86, is an evolved response to dietary toxins.

    abstract：:The glycosylation of UDP-glucosyltransferases (UGTs) is of great importance in the control and elimination of both endogenous and exogenous toxins. Bm-UGT10286 (UGT86) is the sole provider of UGT activity against the 5-O position of quercetin and directly influences the formation of green pigment in the Bombyx cocoon....

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-012-2437-7

    authors： Xu X,Wang M,Wang Y,Sima Y,Zhang D,Li J,Yin W,Xu S

    更新日期：2013-05-01 00:00:00

  • Molecular mechanisms of hormone controlled gene expression in the breast.

    abstract：:In a meritorious effort H. de Rothschild compiled in 1899 all publications on mammary gland development and milk--a grand total of 8375 [1]. In the preface to this publication Duclaux states: 'Such a discrepancy between the tremendous efforts and the paltriness of the results--hundreds of scientists and thousands of r...

    journal_title：Molecular biology reports

    pub_type： 杂志文章,评审

    doi：10.1023/a:1006851531360

    authors： Hennighausen L

    更新日期：1997-08-01 00:00:00

  • Macromolecular synthesis in mycobacteriophage I3 infected cells.

    abstract：:DNA-, RNA- and protein synthesis have been studied in Mycobacterium smegmatis cells infected with phage I3. The macromolecular synthesis continued until the end of latent period. Early RNA and protein synthesis were necessary prior to the commencement of DNA replication. The infecting phage DNA sedimented as larger th...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/BF00798378

    authors： Nagaraja V,Gopinathan KP

    更新日期：1981-11-30 00:00:00

  • The importance of the multiplex ligation-dependent probe amplification in the identification of a novel two-exon deletion of the NR5A1 gene in a patient with 46,XY differences of sex development.

    abstract：:Gonadal dysgenesis (GD) is a rare cause of differences of sex development (DSD) with highly variable clinical and genetic conditions. Although identification of the causative genetic alterations can offer a clearer prognosis and personalized management to patients, more than 50% of the DSD cases still do not have an a...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-04980-8

    authors： Nagy O,Kárteszi J,Hartwig M,Bertalan R,Jávorszky E,Erhardt É,Patócs A,Tornóczky T,Balogh I,Ujfalusi A

    更新日期：2019-10-01 00:00:00

  • Cardioprotective role of FA against isoproterenol induced cardiac toxicity.

    abstract：:The present study was designed to investigate the protective effect of ferulic acid (FA) against isoproterenol (ISO)-induced cardiac toxicity in rats. Isoproterenol challenged in a dose of 85 mg/kg body weight (b.w.) subcutaneously for two consecutive days in the experimental group resulted in acute cardiac toxicity a...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-018-4297-2

    authors： Jain PG,Mahajan UB,Shinde SD,Surana SJ

    更新日期：2018-10-01 00:00:00

  • CTLA-4 exon 1 +49 polymorphism alone and in a haplotype with -318 promoter polymorphism may confer susceptibility to chronic HBV infection in Chinese Han patients.

    abstract：:Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) plays a pivotal role in regulating T cell activation, which is believably critical for the outcome of hepatitis B virus (HBV) infection. The expression and function of CTLA-4 may be affected by gene polymorphisms. This study investigated the influence of CTLA-4 poly...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-010-0660-7

    authors： Duan S,Zhang G,Han Q,Li Z,Liu Z,Chen J,Lv Y,Li N,Wang Y,Li M,Lou S,Yang M,Zhu Q,Xing F

    更新日期：2011-11-01 00:00:00

  • In silico gene expression analysis in Codonopsis lanceolata root.

    abstract：:Expressed sequence tags (ESTs) provide valuable tools that can be used to predict the genes involved in primary and secondary metabolite synthesis. To the best of our knowledge, ESTs have not yet been developed for Codonopsis. lanceolata, and therefore, the EST referenced in this report is the first transcript for C. ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-010-0464-9

    authors： Sathiyamoorthy S,In JG,Lee OR,Lee BS,Devi SR,Yang DC

    更新日期：2011-06-01 00:00:00

  • Association analysis, genetic diversity and structure analysis of tobacco based on AFLP markers.

    abstract：:Knowledge in the area of genetic diversity could aid in providing useful information in the selection of material for breeding such as hybridization programs and quantitative trait loci mapping. To this end, 50 Nicotiana tabacum genotypes were genotyped with 21 primer combination of amplified fragment length polymorph...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-014-3194-6

    authors： Dadras AR,Sabouri H,Nejad GM,Sabouri A,Shoai-Deylami M

    更新日期：2014-05-01 00:00:00

  • Deletion of RBP-J in adult mice leads to the onset of aortic valve degenerative diseases.

    abstract：:Transcription factor RBP-J-mediated Notch signaling has been implicated in several inherited cardiovascular diseases including aortic valve diseases (AVD). But whether Notch signal plays a role in AVD in adults has been unclear. This study aims to test whether the deletion of RBP-J in adult mice would lead to AVD and ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-011-1162-y

    authors： Li Z,Feng L,Wang CM,Zheng QJ,Zhao BJ,Yi W,Zhang JZ,Wang YM,Guo HT,Yi DH,Han H

    更新日期：2012-04-01 00:00:00

  • Cross-priming of microsatellite loci in subfamily cyprininae (family Cyprinidae): their utility in finding markers for population genetic analysis in three Indian major carps.

    abstract：:This study is aimed to identify polymorphic microsatellite markers and establish their potential for population genetics studies in three carp (family cyprinidae; subfamily cyprininae) species, Labeo rohita, Catla catla and Cirrhinus mrigala through use of cyprinid primers. These species have high commercial value and...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-014-3386-0

    authors： Masih P,Luhariya RK,Das R,Gupta A,Mohindra V,Singh RK,Srivastava R,Chauhan UK,Jena JK,Lal KK

    更新日期：2014-08-01 00:00:00

  • Polymorphism Val103Ile of the melanocortin-4 receptor gene in the Serbian population.

    abstract：:The melanocortin-4 receptor (MC4R) plays an important role in weight and energy homeostasis and it is associated with lower risk to develop obesity and lower body mass index. The contribution of MC4R mutation to obesity in Vojvodina (Northern Province of Serbia), known as a region with the largest number of overweight...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-009-9500-z

    authors： Stokić E,Djan M,Vapa Lj,Djan I,Plećas A,Srdić B

    更新日期：2010-01-01 00:00:00

  • Isolation and molecular characterization of MYB60 in Solanum lycopersicum.

    abstract：:Stomatal closure is a common adaptation response of plants to the onset of drought condition and its regulation is controlled by transcription factors. MYB60, a transcription factor involved in the regulation of light-induced stomatal opening, has been characterized in arabidopsis and grapevine. In this work, we studi...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-021-06168-5

    authors： Rodríguez-Hoces de la Guardia A,Ugalde MB,Lobos-Diaz V,Romero-Romero JL,Meyer-Regueiro C,Inostroza-Blancheteau C,Reyes-Diaz M,Aquea F,Arce-Johnson P

    更新日期：2021-01-27 00:00:00

  • Transcription factor 7-like 2 (TCF7L2) gene polymorphism and clinical phenotype in end-stage renal disease patients.

    abstract：:Variants of the transcription factor 7-like 2 gene (TCF7L2) have been associated with type 2 diabetes and cardiovascular disease in different populations. Here we investigated the potential association of the rs7903146 polymorphism in the TCF7L2 gene with clinical profile of end-stage renal disease (ESRD) patients. We...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-014-3275-6

    authors： Buraczynska M,Zukowski P,Ksiazek P,Kuczmaszewska A,Janicka J,Zaluska W

    更新日期：2014-06-01 00:00:00

  • Studies on protein organization of nucleosomes using cross-linking.

    abstract：:When chromosomal proteins in chromatin or in mononucleosomes were extensively cross-linked with an imido ester, the H1-containing nonameric histone complex was revealed. In this complex, histone H1 is connected with the octamer of core histones. The cross-linking of H1 of the octamer is realized preferentially through...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/BF00805754

    authors： Bakayev VV,Bakayeva TG,Domansky NN

    更新日期：1981-08-14 00:00:00

  • Methyl jasmonate a stress phytohormone attenuates LPS induced in vivo and in vitro arthritis.

    abstract：:The objective of present study was to screen the effect of methyl jasmonate (MJ) in lipopolysaccharide (LPS) induced in vivo and in vitro arthritis. Arthritis was induced in wistar rats by intraplantar administration of LPS (1 mg/Kg) and effect of MJ was screened in two doses (20, 40 mg/Kg, IP), indomethacin (30 mg/Kg...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-018-4520-1

    authors： Gunjegaonkar SM,Shanmugarajan TS

    更新日期：2019-02-01 00:00:00

  • Spliceogenic analysis of BRCA1 c.439T>C (rs794727800) variant by High Resolution Melting Analysis.

    abstract：:Correct classification of genomic variants causing potentially aberrant splicing is of utmost importance for patient management, especially in clinically actionable genes such as BRCA1/2. In this article, we report molecular evaluation of the BRCA1 c.439T>C (rs794727800, p.Leu147=) variant based on RNA of a patient su...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-05199-3

    authors： Minucci A,Mazzuccato G,D'Indinosante M,Di Nardo L,Concolino P,De Bonis M,Urbani A,Scambia G,Fagotti A,Capoluongo E

    更新日期：2020-02-01 00:00:00

  • ASYMMETRIC LEAVES2 gene, a member of LOB/AS2 family of Arabidopsis thaliana, causes an abaxializing leaves in transgenic cockscomb.

    abstract：:The leaf primordium derives from the peripheral zone of shoot apical meristem. During the formation of leaf primordia, they need to establish the proximodistal, mediolateral, and ab/adaxial axes. Among these axes, the ab/adaxial axis might be the most important. ASYMMETRIC LEAVES2 (AS2) gene is a member of AS2/LATERAL...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-011-1288-y

    authors： Sun SB,Song JP,Meng LS

    更新日期：2012-04-01 00:00:00

  • The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms.

    abstract：:Cerebral aneurysm affects 2-5% of the population and posterior inferior cerebellar artery (PICA) aneurysms account for 1-3% of all intracranial aneurysms. Oxidative stress is known to contribute to the progression of cerebrovascular disease and it may be increased by inflammation, a key contributor to cerebral aneurys...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-018-4374-6

    authors： Šćepanović V,Tasić G,Repac N,Nikolić I,Janićijević A,Todorović D,Stojanović M,Šćepanović R,Mitrović D,Šćepanović T,Borozan S,Šćepanović L

    更新日期：2018-12-01 00:00:00

  • HIF-1α mRNA levels in Eurasian perch (Perca fluviatilis) exposed to acute and chronic hypoxia.

    abstract：:The big advantage of using molecular biomarkers to monitor oxygen levels in aquatic systems is that responses at the molecular level tend to be more sensitive, and usually occur earlier than those at higher levels of biological organization Aquatic hypoxia is a frequent event, which can occur naturally in a variety of...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-011-1181-8

    authors： Rimoldi S,Terova G,Ceccuzzi P,Marelli S,Antonini M,Saroglia M

    更新日期：2012-04-01 00:00:00

  • Association of the interleukin-10 1082G/A, 819C/T and 3575T/A gene polymorphisms with systemic sclerosis: a meta-analysis.

    abstract：:Many environmental and genetic factors have been contributed to the development of systemic sclerosis (SSc). To determine whether IL-10 gene polymorphisms are associated with SSc, we conducted a meta-analysis approach. A total of eight studies involving 1,034 SSc cases and 1,815 controls were obtained by electronic da...

    journal_title：Molecular biology reports

    pub_type： 杂志文章,meta分析

    doi：10.1007/s11033-012-1510-6

    authors： Peng WJ,Wang BX,Pan HF,Tao JH,Zhang JQ,He Q,Xiao CC,Wang J

    更新日期：2012-06-01 00:00:00

  • Identification of a new potential native Indian cattle breed by population differentiation based on microsatellite markers.

    abstract：:India has a rich heritage of rearing cattle where farmers selected native cattle suitable to their local agro-ecological conditions for centuries. It is reflected in 50 indigenous breeds of cattle, besides many lesser known populations not explored so far. It is the need of the hour to characterize such populations to...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-020-05639-5

    authors： Sharma R,Ahlawat S,Sharma H,Bhagat RL,Singh PK,Tantia MS

    更新日期：2020-08-01 00:00:00

  • Differential regulation of the durum wheat Pathogenesis-related protein (PR1) by Calmodulin TdCaM1.3 protein.

    abstract：:In plants, pathogenesis-related 1 protein (PR1) is considered as important defense protein. The production and accumulation of PR proteins in plants are one of the important responses to several biotic and abiotic stresses. In this regard, PR1 gene was isolated from Triticum turgidum ssp durum and was named as TdPR1.2...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-020-06053-7

    authors： Ghorbel M,Zribi I,Missaoui K,Drira-Fakhfekh M,Azzouzi B,Brini F

    更新日期：2020-12-13 00:00:00

  • Potential role of serum fetuin-A in relation with pro-inflammatory, chemokine and adhesion molecules in diabetic kidney disease: a case-control study.

    abstract：:Inflammatory cytokine, adipokine and adhesion molecules are known to play a key role in pathogenesis of diabetic kidney disease (DKD). In this study, our aim was to investigate the role of fetuin-A in relation with pro-inflammatory cytokines (IL-6, IL-18), adipokines (adiponectin, leptin), chemokine (MCP-1), and adhes...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-04592-2

    authors： Nawaz SS,Joy SS,Al Farsi Y,George TP,Siddiqui K

    更新日期：2019-02-01 00:00:00

  • In vitrocleavage of 45S pre-ribosomal RNA and of giant heterogeneous RNA extracted from human leukemic cells.

    abstract：:45S ribosomal precursor RNA and large heterogeneous RNA molecules (greater than 45S) extracted from human leukemic cells were incubated in vitro with purified RNase III, which specifically attacks double-helical RNA regions. About 50% of the ribosomal precursor was cleaved into two major fragments sedimenting at 28S a...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/BF00808381

    authors： Torelli UL,Ferrari S,Torelli GM,Cadossi R,Ferrari S,Montagnani G,Narni F

    更新日期：1977-12-01 00:00:00

  • Evaluation of circulating Transforming growth factor-beta1, Glypican-3 and Golgi protein-73 mRNAs expression as predictive markers for hepatocellular carcinoma in Egyptian patients.

    abstract：:Hepatocellular carcinoma (HCC) incidence is fast-growing especially in countries highly prevalent with viral hepatitis. Its poor prognosis has driven the research toward the discovery of sensitive markers for early detection. We investigated the usefulness of serum Transforming growth factor-beta1 (TGF-β1), Glypican-3...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-013-2829-3

    authors： Ibrahim GH,Mahmoud MA,Aly NM

    更新日期：2013-12-01 00:00:00