Molecular mechanisms of hormone controlled gene expression in the breast.

abstract：:In the present study, we investigated the differentially expressed proteins associated with ulcerative colitis (UC) using proteomic methods. Two-dimensional electrophoresis (2-DE) technology was performed to separate the total proteins of ulcerative tissues from those of the normal tissues of UC patients. PDQuest soft...

journal_title：Molecular biology reports

authors： Li N,Wang X,Zhang Y,Zhai J,Zhang T,Wei K

更新日期：2012-05-01 00:00:00

abstract：:Phosphomannose isomerase (PMI) is an enzyme that catalyses the first step of the L-galactose pathway for ascorbic acid (AsA) biosynthesis in plants. To clarify the physiological roles of PMI in AsA biosynthesis, the cDNA sequence of PMI was cloned from non-heading Chinese cabbage (Brassica campestris ssp. chinensis Ma...

journal_title：Molecular biology reports

authors： Wang X,Zhang S,Hu D,Zhao X,Li Y,Liu T,Wang J,Hou X,Li Y

更新日期：2014-01-01 00:00:00

abstract：:The tertiary structure of nucleic acids results from an equilibrium between electrostatic interactions of phosphates, stacking interactions of bases, hydrogen bonds between polar atoms and water molecules. Water interactions with ribonucleic acid play a key role in its structure formation, stabilization and dynamics. ...

journal_title：Molecular biology reports

authors： Giel-Pietraszuk M,Barciszewski J

更新日期：2012-05-01 00:00:00

abstract：:The study was done to identify the candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms that contribute to Parkinson's disease (PD) susceptibility and to generate a SNP to ene to pathway hypothesis using an analytical pathway-based approach. We used a PD genome-wide association study...

journal_title：Molecular biology reports

authors： Song GG,Lee YH

更新日期：2013-03-01 00:00:00

abstract：:The two predominant forms of arginase, cytosolic Arginase-I and mitochondrial Arginase-II, catalyze hydrolysis of arginine into ornithine and urea. Based on presence of arginase activity in extracts using potassium chloride (KCl), mitochondrial membrane-bound arginase has also been suggested. However, the activity of ...

journal_title：Molecular biology reports

authors： Mishra S,Mishra R

更新日期：2016-05-01 00:00:00

abstract：:The glycosylation of UDP-glucosyltransferases (UGTs) is of great importance in the control and elimination of both endogenous and exogenous toxins. Bm-UGT10286 (UGT86) is the sole provider of UGT activity against the 5-O position of quercetin and directly influences the formation of green pigment in the Bombyx cocoon....

journal_title：Molecular biology reports

authors： Xu X,Wang M,Wang Y,Sima Y,Zhang D,Li J,Yin W,Xu S

更新日期：2013-05-01 00:00:00

abstract：:Fusarium head blight (FHB), predominantly caused by Fusarium graminearum, is a destructive disease that poses a serious threat to wheat (Triticum aestivum L.) production around the world. A suppression subtractive hybridization (SSH) cDNA library was constructed from F. graminearum infected spikes of a resistant Belgi...

journal_title：Molecular biology reports

authors： Muhovski Y,Batoko H,Jacquemin JM

更新日期：2012-10-01 00:00:00

abstract：:Human Papillomavirus infection is considered as the main etiological factor of cervical cancer (ICC), although, the role of host genetic factors in ICC susceptibility has been increasing. Immunological response is crucial for the prevention of viral associated diseases. Interleukin 1 receptor antagonist (IL-1RN) is co...

journal_title：Molecular biology reports

authors： Sousa H,Santos AM,Catarino R,Pinto D,Moutinho J,Canedo P,Machado JC,Medeiros R

更新日期：2012-12-01 00:00:00

abstract：:Prkar1b gene encodes regulatory type I, beta subunit (RIβ) of cAMP dependent protein kinase A in mouse. Among the various isoforms of regulatory and catalytic subunits that comprise mammalian PKA, RIβ subunit is considered to be one of the important subunits for neuronal functions. This is involved in multiple forms o...

journal_title：Molecular biology reports

authors： Banday AR,Azim S,Tabish M

更新日期：2012-04-01 00:00:00

abstract：:We reported previously that TspGWI, a prototype enzyme of a new Thermus sp. family of restriction endonucleases-methyltransferases (REases-MTases), undergoes the novel phenomenon of sinefungin (SIN)-caused specificity transition. Here we investigated mutant TspGWI N473A, containing a single amino acid (aa) substitutio...

journal_title：Molecular biology reports

authors： Zylicz-Stachula A,Jeżewska-Frąckowiak J,Skowron PM

更新日期：2014-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease, with multiple genetic and environmental factors involving in its etiology. Angiotensin converting enzyme (ACE) gene was reported to have important roles in the development and progression of SLE. In this study, a case-control study was carried out to investi...

journal_title：Molecular biology reports

authors： Gong AM,Li XY,Wang YQ,Yan HX,Xu ZX,Feng Z,Xie YQ,Yin DH,Yang SZ

更新日期：2012-10-01 00:00:00

abstract：:The quantitative changes of double-stranded RNA components of nuclear ribonucleo-protein particles containing pre-mRNA was investigated in the course of incubation of particles at 37 degrees C. The incubation of purified nuclear particles revealed the fragmentation of long double-stranded RNA sequences into shorter st...

journal_title：Molecular biology reports

authors： Molnar J,Samarina OP

更新日期：1976-11-01 00:00:00

abstract：:Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) plays a pivotal role in regulating T cell activation, which is believably critical for the outcome of hepatitis B virus (HBV) infection. The expression and function of CTLA-4 may be affected by gene polymorphisms. This study investigated the influence of CTLA-4 poly...

journal_title：Molecular biology reports

authors： Duan S,Zhang G,Han Q,Li Z,Liu Z,Chen J,Lv Y,Li N,Wang Y,Li M,Lou S,Yang M,Zhu Q,Xing F

更新日期：2011-11-01 00:00:00

abstract：:The suppressors of cytokine signaling (SOCS) proteins are originally identified as negative regulators of cytokine-activated Janus kinase/signal transducers and activators of transcription signaling pathway, but increasing evidence reveals that SOCS proteins play an important role in the development of type 2 diabetes...

journal_title：Molecular biology reports

authors： Feng X,Tang H,Leng J,Jiang Q

更新日期：2014-01-01 00:00:00

abstract：:Ribosomes were isolated from baby hamster kidney fibroblasts, either 20 min or 2 days after labelling with radioactive amino acids, and their proteins subjected to two-dimensional polyacrylamide gel electrophoresis. No significant differences were observed between the amounts of radioactivity associated with the posit...

journal_title：Molecular biology reports

authors： Kennedy IM,Leader DP

更新日期：1980-12-31 00:00:00

abstract：:The modified base queuine is a nutrient factor for lower and higher eukaryotes except yeast. It is synthesized in eubacteria and inserted into the wobble position of specific tRNAs (tRNA(GUN)) in exchange of guanine at position 34. The tRNAs of Q family are completely modified in terminally differentiated somatic cell...

journal_title：Molecular biology reports

authors： Pathak C,Vinayak M

更新日期：2005-09-01 00:00:00

abstract：:Myocardial ischemia and reperfusion (MI/R) is associated with an intense inflammatory reaction, which may lead to myocyte injury. In this study, we investigated the effect of quercetin, an inhibitor of c-Jun N-terminal kinase on ischemia/reperfusion injury in isolated rat hearts. Rat models of MI/R were induced by cor...

journal_title：Molecular biology reports

authors： Jin HB,Yang YB,Song YL,Zhang YC,Li YR

更新日期：2012-12-01 00:00:00

abstract：:Initially, we isolated the caffeic acid O-methyltransferase (COMT) gene from Miscanthus sinensis (accession number HM062766.1). Next, we produced transgenic tobacco plants with down-regulated COMT gene expression to study its control of total phenol and lignin content and to perform morphological analysis. These trans...

journal_title：Molecular biology reports

authors： Seong ES,Yoo JH,Lee JG,Kim HY,Hwang IS,Heo K,Kim JK,Lim JD,Sacks EJ,Yu CY

更新日期：2013-02-01 00:00:00

abstract：:In jasmonate biosynthetic pathway, allene oxide synthase (AOS, EC 4.2.1.92), which is a cytochrome P450 (CYP74A), catalyzes the first committed step. We herein cloned a novel cDNA from Lonicera japonica Thunb., named LjAOS (GenBank accession: DQ303120), which was homologous to other AOSs. Southern blot analysis reveal...

journal_title：Molecular biology reports

authors： Jiang K,Pi Y,Hou R,Zeng H,Huang Z,Zhang Z,Sun X,Tang K

更新日期：2009-03-01 00:00:00

abstract：:Maize is one of the world's most important crops and a model for grass genome research. Long terminal repeat (LTR) retrotransposons comprise most of the maize genome; their ability to produce new copies makes them efficient high-throughput genetic markers. Inter-retrotransposon-amplified polymorphisms (IRAPs) were use...

journal_title：Molecular biology reports

authors： Ghonaim M,Kalendar R,Barakat H,Elsherif N,Ashry N,Schulman AH

更新日期：2020-03-01 00:00:00

abstract：:We report the characterization of VvIAA9, an auxin/indole-3-acetic acid (Aux/IAA) protein, in grapevine (Vitis vinifera L.). VvIAA9 was expressed abundantly in leaves and berries. VvIAA9 transcription was drastically upregulated from anthesis to onset of ripening (termed véraison), in which berry diameter rapidly incr...

journal_title：Molecular biology reports

authors： Fujita K,Horiuchi H,Takato H,Kohno M,Suzuki S

更新日期：2012-07-01 00:00:00

abstract：:Membrane-bound Δ9 desaturase perform oxygenated desaturation reactions to insert the first double bonds within fatty acyl chains between C9 and C10 positions of most saturated substrates. Arthrospira platensis, a blue green microalga, is an important source of polyunsaturated fatty acids (PUFA) such as oleic, linoleic...

journal_title：Molecular biology reports

authors： Ben Amor F,Ben Hlima H,Abdelkafi S,Fendri I

更新日期：2018-12-01 00:00:00

abstract：:Several studies have examined the effects of the tumor necrosis factor-α (TNF-α) -308 A/G and lymphotoxin-α (LT-α) +252 A/G polymorphisms on susceptibility to sarcoidosis, showing mixed results. The purpose of this study was to examine whether the TNF-α -308 A/G and LT-α +252 A/G polymorphisms confer susceptibility to...

journal_title：Molecular biology reports

authors： Song GG,Kim JH,Lee YH

更新日期：2014-01-01 00:00:00

abstract：:Recruitment of inflammatory cells to the arterial wall is an important pathogenic mechanism of atherosclerosis and coronary artery disease (CAD). Functional variability in the genes encoding for chemokines that promote infiltration of atherosclerotic plaques by macrophages and lymphocytes may therefore contribute to t...

journal_title：Molecular biology reports

authors： Stahelova A,Petrkova J,Petrek M,Mrazek F

更新日期：2014-05-01 00:00:00

abstract：:To determine whether methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms are associated with pre-eclampsia susceptibility. Literature searches of the Pubmed, Embase, BIOSIS Previews and Web of Science were conducted to identify all eligible articles up to January 18th, 2013. The pooled odds rati...

journal_title：Molecular biology reports

authors： Li X,Luo YL,Zhang QH,Mao C,Wang XW,Liu S,Chen Q

更新日期：2014-08-01 00:00:00

abstract：:In plants, pathogenesis-related 1 protein (PR1) is considered as important defense protein. The production and accumulation of PR proteins in plants are one of the important responses to several biotic and abiotic stresses. In this regard, PR1 gene was isolated from Triticum turgidum ssp durum and was named as TdPR1.2...

journal_title：Molecular biology reports

authors： Ghorbel M,Zribi I,Missaoui K,Drira-Fakhfekh M,Azzouzi B,Brini F

更新日期：2020-12-13 00:00:00

abstract：:An ORF having a potential to code for a polypeptide of 79 amino acids has been identified within 993 nt sequence of 2 kb EcoRI-W fragment of Spodoptera litura nucleopolyhedrovirus (SpltNPV-I). Nucleotide and deduced amino acid sequence analyses showed its identity with the ubiquitin homologue of eukaryotes (79-80%), M...

journal_title：Molecular biology reports

authors： Jain M,Das RH

更新日期：2004-12-01 00:00:00

abstract：:A secretory high-level expression cloning vector designated as pSBC-20 was constructed by inserting a DNA fragment encoding the signal peptide of ompA protein into pBV 220 vector. Any foreign DNA fragment can be inserted into the polylinker cloning sites located after the secretion signal sequence. The cloned foreign ...

journal_title：Molecular biology reports

authors： Li Y,Yan YC,Guo W,Zhao F,Lai J,Koide SS

更新日期：1995-01-01 00:00:00

abstract：:Mouse U26 has been defined as a 2-aminoadipic 6-semialdehyde dehydrogenase. It was speculated to be a PQQ-dependent AAS dehydrogenase due to the research of demonstrating PQQ as a new B vitamin. We isolated a novel human cDNA from the human fetal brain cDNA library we constructed. Its deduced protein was most related ...

journal_title：Molecular biology reports

authors： Wang L,Jil C,Xu Y,Xu J,Dai J,Wu Q,Wu M,Zou X,Sun L,Gu S,Xie Y,Mao Y

更新日期：2005-03-01 00:00:00

abstract：:Study of retina specific genes would offer insights into retinal diseases and treatment. Based on the information from the gene expression profiles of mouse retinas, we here identified a mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) as one of the highly expressed proteins in retina. Sequence analysis ...

journal_title：Molecular biology reports

authors： Qi S,Wang Y,Zhou M,Ge Y,Yan Y,Wang J,Zhang SS,Zhang S

更新日期：2011-06-01 00:00:00