Abstract:
:Mouse U26 has been defined as a 2-aminoadipic 6-semialdehyde dehydrogenase. It was speculated to be a PQQ-dependent AAS dehydrogenase due to the research of demonstrating PQQ as a new B vitamin. We isolated a novel human cDNA from the human fetal brain cDNA library we constructed. Its deduced protein was most related to mouse U26. Thus, we termed it human U26. This putative protein contains an AMP-binding domain, a Phosphopantetheine-binding domain and six PQQ-binding motifs. Human U26 mRNA is ubiquitously expressed in adult tissues and is highly expressed in colon adenocarcinoma (CX-1) and colon adenocarcinoma (GI-112) cell lines. Further study should be made to clarify the precise function of human U26.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Wang L,Jil C,Xu Y,Xu J,Dai J,Wu Q,Wu M,Zou X,Sun L,Gu S,Xie Y,Mao Ydoi
10.1007/s11033-003-2716-4keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
47-53issue
1eissn
0301-4851issn
1573-4978journal_volume
32pub_type
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