Abstract：
:Previous studies from our group have brought forward the concept of angiogenic regeneration during radiotherapy (RT), as a major cause of RT failure. This process was examined herein in rectal cancer patients undergoing preoperative chemo-radiotherapy. Out of 25 patients with stage II/III rectal adenocarcinoma, 15 had incomplete response (pIR) after preoperative chemo-radiotherapy. The MIB1 proliferation index, the vascular density (VD) assessed with the anti-CD31 antibody and the Hypoxia Inducible Factor HIF1α was assessed. High VD before RT was related with poor local relapse free survival LRFS (p = 0.04), in cases with pIR. Pre-RT values of MIB1 and of HIF1α were not related with LRFS. High MIB1 index and intensification of VD beyond pre-treatment levels in post-RT samples, features indicative of angiogenic regeneration, defined poor LRFS (p = 0.04 and p = 0.0008, respectively). Angiogenic regeneration is strongly related to failure of RT and surgery to control loco-regional disease in rectal cancer patients. Addition of anti-angiogenic agents in the preoperative chemo-radiotherapy regimens may prove beneficial in subgroups of patients.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Koukourakis MI,Koukourakis IM,Arelaki S,Kouroupi M,Domoxoudis S,Giatromanolaki Adoi
10.1007/s11033-019-04668-zsubject
Has Abstractpub_date
2019-04-01 00:00:00pages
2147-2152issue
2eissn
0301-4851issn
1573-4978pii
10.1007/s11033-019-04668-zjournal_volume
46pub_type
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