Abstract：
:Testis development is a highly regulated sequence of developmental process that spans from the establishment of germ cell lineage during embryonic development to the periodic wave of spermatogenesis in adulthood. The normal development of testes and the fertility of male animals require specific cell types to respond correctly at a specific time point, the process of which is precisely regulated by various factors. Several members of the transforming growth factor-β superfamily are shown to be the key mediators. They act as the extracellular ligand of signaling transduction that regulates the proliferation, differentiation, apoptosis and other cell behaviors to help coordinate the physiology of the cells to the overall development of the testis and the organism. This paper reviews the current understanding of some of TGF-βs' major regulatory roles in the overall process of testis development, analyzes the current studies and their limitations and points out the research areas that need further investigation.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Fan YS,Hu YJ,Yang WXdoi
10.1007/s11033-011-1265-5subject
Has Abstractpub_date
2012-04-01 00:00:00pages
4727-41issue
4eissn
0301-4851issn
1573-4978journal_volume
39pub_type
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,meta分析
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更新日期：2010-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：Molecular biology reports
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Molecular biology reports
pub_type： 杂志文章
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journal_title：Molecular biology reports
pub_type： 杂志文章
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