The drug-transporter gene MDR1 C3435T and G2677T/A polymorphisms and the risk of multidrug-resistant epilepsy in Turkish children.

Abstract:

:One-third of all individuals with epilepsy are resistant to antiepileptic drug (AED) treatment. Antiepileptic treatment response has been suggested to be modulated by genetic polymorphisms of drug efflux transporters. Several polymorphic variants within the multidrug resistance 1 (MDR1) gene, which encodes the major transmembrane efflux transporter P-glycoprotein, have been proposed to be associated with AED resistance in epilepsy patients. The aim of this study was to evaluate the effect of C3435T and G2677T/A polymorphisms of MDR1 on AED resistance in Turkish children with epilepsy. MDR1 C3435T and G2677T/A were genotyped in 152 patients with epilepsy, classified as drug-resistant in 69 and drug-responsive in 83. Genotypes of the C3435T and G2677T/A polymorphisms were determined by polymerase chain reaction followed by restriction fragment length polymorphism. Genotype and allele frequencies of C3435T and G2677T/A polymorphisms of the MDR1 gene did not differ between drug-resistant and drug-responsive epilepsy patients. Our results suggest that MDR1 C3435T and G2677T/A polymorphisms are not associated with AED resistance in Turkish epileptic patients. To clarify the exact clinical implication of the MDR1 polymorphisms on the multidrug resistance in epilepsy, further investigations in various ethnic populations would be necessary.

journal_name

Mol Biol Rep

authors

Seven M,Batar B,Unal S,Yesil G,Yuksel A,Guven M

doi

10.1007/s11033-013-2866-y

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

331-6

issue

1

eissn

0301-4851

issn

1573-4978

journal_volume

41

pub_type

杂志文章
  • Characterization of Betula platyphylla gene transcripts associated with early development of male inflorescence.

    abstract::Birch (Betula platyphylla), an eminent tree species in Northeast and Inner Mongolia of China, has been widely used in architecture, furniture, and paper making in recent years. In order to retrieve genes involved in early development of B. platyphylla male inflorescence, RNA populations extracted from early and late d...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-011-0818-y

    authors: Xing L,Liu XM

    更新日期:2012-02-01 00:00:00

  • Temporal and spatial expression analysis of PRGL in Gerbera hybrida.

    abstract::GASA-like genes form multigene families in diverse plant species and encode the proteins with a unique cysteine-rich domain (GASA domain). In our previously work, we cloned a GASA-like gene PRGL (Proline-rich GASA-like) from gerbera. Here we report the expression profiles of PRGL and the subcellular localization of PR...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-009-9917-4

    authors: Peng J,Lai L,Wang X

    更新日期:2010-10-01 00:00:00

  • Effects of aqueous extract of Portulaca oleracea L. on oxidative stress and liver, spleen leptin, PARα and FAS mRNA expression in high-fat diet induced mice.

    abstract::We reported that an aqueous extract of Portulaca oleracea L. inhibited high-fat-diet-induced oxidative injury in a dose-dependent manner. Male kunming mice (5-weeks-old, 24 g) were used in this experiment. After a 4-day adaptation period, animals were randomly divided into four groups (n = 10 in each group); Group 1: ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-012-1644-6

    authors: Chen B,Zhou H,Zhao W,Zhou W,Yuan Q,Yang G

    更新日期:2012-08-01 00:00:00

  • Studies on protein organization of nucleosomes using cross-linking.

    abstract::When chromosomal proteins in chromatin or in mononucleosomes were extensively cross-linked with an imido ester, the H1-containing nonameric histone complex was revealed. In this complex, histone H1 is connected with the octamer of core histones. The cross-linking of H1 of the octamer is realized preferentially through...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/BF00805754

    authors: Bakayev VV,Bakayeva TG,Domansky NN

    更新日期:1981-08-14 00:00:00

  • An insight on Drosophila myogenesis and its assessment techniques.

    abstract::Movement assisted by muscles forms the basis of various behavioural traits seen in Drosophila. Myogenesis involves developmental processes like cellular specification, differentiation, migration, fusion, adherence to tendons and neuronal innervation in a series of coordinated event well defined in body space and time....

    journal_title:Molecular biology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11033-020-06006-0

    authors: Dubey M,Ain U,Firdaus H

    更新日期:2020-12-01 00:00:00

  • Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension.

    abstract::Hypertension is a risk factor for the cardiovascular diseases. Although, several drugs are used to treat hypertension, the success of the antihypertensive therapy is limited. Resveratrol decreases blood pressure in animal models of hypertension. This study researched the mechanisms behind the effects of resveratrol on...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-014-3737-x

    authors: Han S,Uludag MO,Usanmaz SE,Ayaloglu-Butun F,Akcali KC,Demirel-Yilmaz E

    更新日期:2015-01-01 00:00:00

  • PON1 Q192R polymorphism (rs662) is associated with childhood embryonal tumors.

    abstract::Genetic susceptibility and environment exposures are associated risk factors in carcinogenesis. Gene polymorphisms that decrease the activity of detoxifying carcinogen substances may modify the effect of exposures. We investigated whether the polymorphisms PON1 rs662 (Q192R), and PON1 rs854560 (L55M) would be associat...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-014-3489-7

    authors: Vasconcelos GM,Gonçalves BA,Montalvão-de-Azevedo R,Thuler LC,Braga FH,Pombo-de-Oliveira MS,de Camargo B,Brazilian Embryonal Tumor Group.

    更新日期:2014-09-01 00:00:00

  • Vector-free in vivo trans-determination of adult hepatic stem cells to insulin-producing cells.

    abstract::A reduction in the number of functional β-cells is the central pathological event in diabetes. Liver and ventral pancreas differentiates simultaneously in the same general domain of cells within embryonic endoderm. In addition, the precursor cell population being bi-potential may be targeted for either pancreas or liv...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-019-04870-z

    authors: Sarkar S,Munshi C,Chatterjee S,Mukherjee S,Bhattacharya S

    更新日期:2019-10-01 00:00:00

  • Investigation of LDHA and COPB1 as candidate genes for muscle development in the MYOD1 region of pig chromosome 2.

    abstract::Porcine MYOD1 gene has been mapped to swine chromosome (SSC) 2p14-p17, which is involved in the regulation of the proliferation and differentiation of skeletal muscle cells. The LDHA (lactate dehydrogenase A) and COPB1 (coatomer protein complex, subunit beta 1) genes, which map close to MYOD1, are involved in energy m...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-009-9882-y

    authors: Qiu H,Xu X,Fan B,Rothschild MF,Martin Y,Liu B

    更新日期:2010-01-01 00:00:00

  • The Cdx-2 polymorphism in the VDR gene is associated with increased risk of cancer: a meta-analysis.

    abstract::The Cdx-2 polymorphism in VDR gene has been extensively investigated for association with cancer risk, however, results of different studies have been inconsistent. The objective of this study is to assess the relationship of the Cdx-2 polymorphism in VDR and cancer risk by meta-analysis. All eligible case-control stu...

    journal_title:Molecular biology reports

    pub_type: 杂志文章,meta分析

    doi:10.1007/s11033-013-2503-9

    authors: Huang J,Huang J,Ma Y,Wang H,Yang J,Xiong T,Du L

    更新日期:2013-07-01 00:00:00

  • Multiplex minisequencing screening for PTC genotype associated with bitter taste perception.

    abstract::Sensitivity to phenylthiocarbamide (PTC) has a bimodal distribution pattern and the genotype of the TAS2R38 gene, which is composed of combinations of three coding single nucleotide polymorphisms (SNPs), p.A49P (c.145G>C), p.V262A (c.785T>C) and p.I296 V (c.886A>G), determines the ability or inability to taste PTC. In...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-013-3002-8

    authors: Sagong B,Bae JW,Rhyu MR,Kim UK,Ye MK

    更新日期:2014-03-01 00:00:00

  • Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus.

    abstract::MicroRNAs (miRNAs) may play important roles in SLE, but genetic polymorphisms of miRNAs and their relationships with various autoantibodies present in SLE patients remain unclear. Here, we report that 213 SLE patients and 209 healthy individuals of Chinese had been taken into this case-control studies, which had been ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-010-0252-6

    authors: Zhang J,Yang B,Ying B,Li D,Shi Y,Song X,Cai B,Huang Z,Wu Y,Wang L

    更新日期:2011-03-01 00:00:00

  • Salvia lachnostachys Benth has antitumor and chemopreventive effects against solid Ehrlich carcinoma.

    abstract::Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the right pelvic member (...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-019-04931-3

    authors: Corso CR,Stipp MC,Adami ER,da Silva LM,Mariott M,de Andrade SF,de Souza Ramos EA,Klassen G,Beltrame OC,Queiroz-Telles JE,de Oliveira CS,Stefanello MÉA,Acco A

    更新日期:2019-10-01 00:00:00

  • Isolation and functional characterization of DgZFP: a gene encoding a Cys2/His2-type zinc finger protein in chrysanthemum.

    abstract::A Cys2/His2-type zinc finger protein gene, DgZFP, was isolated from chrysanthemum by rapid amplification of cDNA ends (RACE) approach. The DgZFP encodes a protein of 211 amino acids residues with a calculated molecular mass of 22.9 kDa and theoretical isoelectric point is 8.59. DgZFP contains two Cys2/His2-type zinc f...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-009-9886-7

    authors: Liu QL,Xu KD,Ma N,Zeng L,Zhao LJ

    更新日期:2010-02-01 00:00:00

  • Regulation of GSK-3 beta in the proliferation and apoptosis of human thyrocytes investigated using a GSK-3 beta-targeting RNAi adenovirus expression vector: involvement the Wnt/beta-catenin pathway.

    abstract::Disorders in the proliferation and apoptosis of thyrocytes may induce goitre, adenoma and carcinoma in the thyroid. The Wnt/beta-catenin pathway has been demonstrated to be involved in the regulation of cell proliferation, differentiation and apoptosis in various cell lines. The regulatory mechanism on the proliferati...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-009-9819-5

    authors: Chen G,Jiang Q,You Z,Yao J,Mou L,Lin X,Shen X,You T,Lin Q,Wen J,Lin L

    更新日期:2010-07-01 00:00:00

  • Construction of recombinant proteins for reprogramming of endangered Luxi cattle fibroblast cells.

    abstract::Generation of induced pluripotent stem cells from endangered cattle breeds makes a significant contribution to the establishment of embryonic stem cell line, conservation and utilization of genetic resources in endangered cattle. In our study, we are trying to construct recombinant proteins of transcription factors Oc...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-012-1549-4

    authors: Hu PF,Guan WJ,Li XC,Ma YH

    更新日期:2012-06-01 00:00:00

  • Evaluation of polymorphism, hypermethylation and expression pattern of CTLA4 gene in a sample of Iranian patients with schizophrenia.

    abstract::The cytotoxic T lymphocyte-associated antigen 4 gene (CTLA4) has a crucial role in regulation of T cell proliferation and mediates T cell apoptosis by encoding the T cell receptor. Schizophrenia (SCZ) patients often have abnormalities in terms of the function and development of the immune system. The aim of the presen...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-013-2614-3

    authors: Kordi-Tamandani DM,Vaziri S,Dahmardeh N,Torkamanzehi A

    更新日期:2013-08-01 00:00:00

  • Molecular and morphological discrimination of Chrysanthemum indicum using allele-specific PCR and T-shaped trichome.

    abstract::Chrysanthemum indicum L. is a traditional oriental medicinal herb prepared as a tea from flowers that have been used in China and South Korea since ancient times. It has a long history in the treatment of hypertension, inflammation, and respiratory diseases. Among Chrysanthemum species, C. indicum has more active chem...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-020-05844-2

    authors: Abid S,Kaliraj L,Arif MH,Hurh J,Ahn JC,Yang DC,Jung SK

    更新日期:2020-10-01 00:00:00

  • BcPMI2, isolated from non-heading Chinese cabbage encoding phosphomannose isomerase, improves stress tolerance in transgenic tobacco.

    abstract::Phosphomannose isomerase (PMI) is an enzyme that catalyses the first step of the L-galactose pathway for ascorbic acid (AsA) biosynthesis in plants. To clarify the physiological roles of PMI in AsA biosynthesis, the cDNA sequence of PMI was cloned from non-heading Chinese cabbage (Brassica campestris ssp. chinensis Ma...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-014-3072-2

    authors: Wang X,Zhang S,Hu D,Zhao X,Li Y,Liu T,Wang J,Hou X,Li Y

    更新日期:2014-01-01 00:00:00

  • Molecular characterization and genetic structure of Quercus acutissima germplasm in China using microsatellites.

    abstract::Quercus acutissima is native to eastern Asia. It has a wide distribution in China and China is an important component in understanding the ecology and genetic structure of this species. Q. acutissima attained high economic value for hardwood product and can be managed as an energy tree species. To investigate the gene...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-013-2486-6

    authors: Zhang YY,Fang YM,Yu MK,Li XX,Xia T

    更新日期:2013-06-01 00:00:00

  • Effect of mechanical stretch on the expressions of elastin, LOX and Fibulin-5 in rat BMSCs with ligament fibroblasts co-culture.

    abstract::The occurrence of PFD is closely related with elasticity, toughness, and functional changes of the connective tissue of the pelvic support tissue. This study aims to evaluate the effect of mechanical stretch on the differentiation of BMSCs with a co-culture with pelvic ligament fibroblasts. BMSCs was isolated and iden...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-011-1422-x

    authors: Bing Z,Linlin L,Jianguo Y,Shenshen R,Ruifang R,Xi Z

    更新日期:2012-05-01 00:00:00

  • Characterization of HbEREBP1, a wound-responsive transcription factor gene in laticifers of Hevea brasiliensis Muell. Arg.

    abstract::AP2/ERF transcription factors play an important role in regulation of the cross-talk between ethylene and jasmonate signaling pathways mediating defense responses of plants to biotic and abiotic stresses. In this study, an AP2/ERF transcription factor gene was isolated and characterized from laticifers of rubber tree ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-011-1146-y

    authors: Chen YY,Wang LF,Dai LJ,Yang SG,Tian WM

    更新日期:2012-04-01 00:00:00

  • Comparative proteomics analysis of serum proteins in ulcerative colitis patients.

    abstract::In the present study, we investigated the differentially expressed proteins associated with ulcerative colitis (UC) using proteomic methods. Two-dimensional electrophoresis (2-DE) technology was performed to separate the total proteins of ulcerative tissues from those of the normal tissues of UC patients. PDQuest soft...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-011-1373-2

    authors: Li N,Wang X,Zhang Y,Zhai J,Zhang T,Wei K

    更新日期:2012-05-01 00:00:00

  • HLA genes in Amerindian immigrants to Madrid (Spain): epidemiology and a virtual transplantation waiting list: Amerindians in Madrid (Spain).

    abstract::Amerindians immigrated to Madrid (Spain) region are about 10% of the present day population. Amerindians are believed to be the first American inhabitants, before Na-Dene speakers, Aleuts and Eskimo. They may initially have arrived to America from Siberia and also from other parts of Pacific Sea (South Asia, Polynesia...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-010-0357-y

    authors: Parga-Lozano C,Rey-Medrano D,Gomez-Prieto P,Areces C,Moscoso J,Abd-El-Fatah-Khalil S,Moreno E,Arnaiz-Villena A

    更新日期:2011-04-01 00:00:00

  • Unfolding Nrf2 in diabetes mellitus.

    abstract::In spite of much awareness, diabetes mellitus continues to remain one of major reasons for mortality and morbidity rate all over the globe. Free radicals cause oxidative stress which is responsible for causing diabetes. The recent advancements in elucidation of ARE/keap1/Nrf2 pathway can help in better understanding o...

    journal_title:Molecular biology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11033-020-06081-3

    authors: Behl T,Kaur I,Sehgal A,Sharma E,Kumar A,Grover M,Bungau S

    更新日期:2021-01-03 00:00:00

  • The relationship between vascular endothelial growth factor and spermatogenesis disturbance in an experimentally-induced unilateral cryptorchidism murine model.

    abstract::This study is to explore the relationship between vascular endothelial growth factor (VEGF) and pathological changes in cryptorchidism by using murine model of intraperitoneal cryptorchidism with surgical operation. To investigate the relationship between the changes of VEGF expression and heat stress inducing germ ce...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-020-05454-y

    authors: Gao P,Gao J,Dou X,Peng D,Zhang Y,Li H,Zhu T,Jiang H,Zhang X

    更新日期:2020-05-01 00:00:00

  • Molecular cloning of a novel gene ZAhi-1 and its expression analysis during zebrafish gametogenesis.

    abstract::Proto-oncogen Ahi-1 is closely related to a lot of human and mouse diseases. Ahi-1 mutation will lead to leukemia in mice and Joubert syndrome in human beings. We have cloned the full cDNA sequence of Ahi-1 homologous in zebrafish, and RT-PCR results of ZAhi-1 in different tissues reveal that ZAhi-1 expressed highest ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-006-0005-8

    authors: Zhou W,Song P

    更新日期:2006-06-01 00:00:00

  • Pre and post cloning characterization of a beta-1,4-endoglucanase from Bacillus sp.

    abstract::Consistent with its precloning characterization from the cellulolytic Bacillus sp., beta-1,4-endoglucanase purified from the recombinant E. coli exhibited maximum activity at 60 degrees C and pH 7.0. It was highly specific for CMC hydrolysis, with stability up to 70 degrees C and over a pH range of 6.0-8.0. The K(m) a...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-009-9592-5

    authors: Afzal S,Saleem M,Yasmin R,Naz M,Imran M

    更新日期:2010-04-01 00:00:00

  • Identification of differentially expressed genes under heat stress conditions in rice (Oryza sativa L.).

    abstract::Rice production in recent years is highly affected by rapidly increasing temperatures in the tropical and sub-tropical countries, which threatens the sustainable production in near future. Hence, understanding the heat tolerance mechanism and evolving tolerant varieties is an immense need in the staple crop rice. An e...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-020-05291-z

    authors: Wahab MMS,Akkareddy S,Shanthi P,Latha P

    更新日期:2020-03-01 00:00:00

  • Rapid assessment of protein-tyrosine phosphatase expression levels by RT-PCR with degenerate primers.

    abstract::Using degenerate oligodeoxynucleotide primers we previously obtained cDNA fragments from ten different murine protein-tyrosine phosphatases (PTPases). Employing this same primer set, a method was developed to assess the expression levels of these PTPase family members in a fast and simple way. RT-PCR products of sever...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/BF00997155

    authors: Hendriks W,Brugman C,Schepens J,Wieringa B

    更新日期:1994-03-01 00:00:00