Unfolding Nrf2 in diabetes mellitus.

abstract：:Protein phosphatases type 2C (PP2Cs) from group A, which includes the ABI1/HAB1 and PP2CA branches, are key negative regulators of ABA signaling. HAI-1 gene had been shown to affect both seed and vegetative responses to ABA, which is one of PP2Cs clade A in Arabidopsis thaliana. Transgenic plants containing pHAI-1::GU...

journal_title：Molecular biology reports

authors： Zhang J,Li X,He Z,Zhao X,Wang Q,Zhou B,Yu D,Huang X,Tang D,Guo X,Liu X

更新日期：2013-03-01 00:00:00

abstract：:Antimicrobial resistance is increasing around the world and the search for effective treatment options, such as new antibiotics and combination therapy is urgently needed. The present study evaluates oregano essential oil (OEO) antibacterial activities against reference and multidrug-resistant clinical isolates of Aci...

journal_title：Molecular biology reports

authors： Amaral SC,Pruski BB,de Freitas SB,Allend SO,Ferreira MRA,Moreira C Jr,Pereira DIB,Junior ASV,Hartwig DD

更新日期：2020-12-01 00:00:00

abstract：:Late-embryogenesis abundant (LEA) proteins have been reported to be closely correlated with the acquisition of desiccation tolerance during seed development and response of plant to drought, salinity, and freezing, etc. In this study, a LEA gene, CarLEA4 (GenBank accession no. GU247511), was isolated from chickpea bas...

journal_title：Molecular biology reports

authors： Gu H,Jia Y,Wang X,Chen Q,Shi S,Ma L,Zhang J,Zhang H,Ma H

更新日期：2012-04-01 00:00:00

abstract：:Human Papillomavirus infection is considered as the main etiological factor of cervical cancer (ICC), although, the role of host genetic factors in ICC susceptibility has been increasing. Immunological response is crucial for the prevention of viral associated diseases. Interleukin 1 receptor antagonist (IL-1RN) is co...

journal_title：Molecular biology reports

authors： Sousa H,Santos AM,Catarino R,Pinto D,Moutinho J,Canedo P,Machado JC,Medeiros R

更新日期：2012-12-01 00:00:00

abstract：:The widely studied candidate genes of the renin-angiotensin-aldosterone system, angiotensinogen (AGT), and angiotensin II receptor type 1 (AGTR1), are implicated in the development of diabetic nephropathy (DN). A number of studies have evaluated the association between the functional polymorphisms, AGT M235T and AGTR1...

journal_title：Molecular biology reports

authors： Ding W,Wang F,Fang Q,Zhang M,Chen J,Gu Y

更新日期：2012-02-01 00:00:00

abstract：:Combined treatment with niacin and chromium has been found to have a protective effect against oxidative damage to different tissues of hyperlipidemic rats. But its effects on vascular endothelial dysfunction are less clear. This study was performed to investigate the effect of combined treatment with niacin and chrom...

journal_title：Molecular biology reports

authors： Niu N,Yu YH,Wang Y,Wang LJ,Li Q,Guo LM

更新日期：2009-07-01 00:00:00

abstract：:The swine fatty acid binding protein gene (FABP3) has been screened with 4 primer sets for 270 purebred Yorkshire pigs from National Institute of Animal Science. The selection of primers was based on the swine cDNA sequence (AJ416019), and primer sets (FABP3-2 and FABP3-3) amplified target segments in real time PCR to...

journal_title：Molecular biology reports

authors： Cho KH,Kim MJ,Jeon GJ,Chung HY

更新日期：2011-03-01 00:00:00

abstract：:Latexin, a carboxypeptidase A inhibitor, is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat. It is used as a molecular marker for the regional specification of the neocortex. In this study, a cDNA was isolated from a human fetal brain cDNA library. The cDNA (LXN) cont...

journal_title：Molecular biology reports

authors： Liu Q,Yu L,Gao J,Fu Q,Zhang J,Zhang P,Chen J,Zhao S

更新日期：2000-01-01 00:00:00

abstract：:Folate is crucial for various cellular functions. Several transport mechanisms allow folate to enter the intracellular compartment with folate receptor-α being the major high-affinity receptor. Rare genetic variations in exons of the FR-α gene, FOLR1, were recently shown to cause severe folate deficiency accompanied b...

journal_title：Molecular biology reports

authors： Nilsson TK,Laanpere M,Altmäe S,Serra-Majem L,Salumets A

更新日期：2012-04-01 00:00:00

abstract：:Sulfonamide derivatives, such as sulfadiazine (SD) are used as antibiotics and, very recently, anti-amyloid properties of these have been reported. We have evaluated binding of SD with bovine serum albumin (BSA) followed by unfolding of protein. Studies were accomplished at physiological conditions of temperature (37 ...

journal_title：Molecular biology reports

authors： Al-Lohedan HA,Sajih Ali M

更新日期：2013-11-01 00:00:00

abstract：:Bacterial artificial chromosome (BAC) library is an important genomic resource useful in targeted marker development, positional cloning, physical mapping and a substrate for genome sequencing for better understanding the genome organization of a species. The present manuscript elucidates the improvement in protocols ...

journal_title：Molecular biology reports

authors： Kumar R,Baisvar VS,Kushwaha B,Murali S,Singh VK

更新日期：2020-03-01 00:00:00

abstract：:Fascin homologue 1 (FSCN1) has established roles in cell adhesion, motility, and cell-cell interactions. Our LongSAGE analysis suggested that FSCN1 was potentially differentially expressed in prenatal pig skeletal muscle. We have cloned the genomic DNA and mRNA sequence of FSCN1 gene and mapped it to SSC3p16-p17. The ...

journal_title：Molecular biology reports

authors： Tang ZhL,Zhang XJ,Yang ShL,Mu YL,Cui WT,Ao H,Li K

更新日期：2010-06-01 00:00:00

abstract：:Etiological factors for coronary artery disease (CAD) involve a wide range of gene and environmental interactions. One of the systems being implicated in the pathophysiology of CAD is the renin-angiotensin system (RAS). However, the genetic polymorphisms of this system have not been widely studied in Iranian patients ...

journal_title：Molecular biology reports

authors： Firouzabadi N,Tajik N,Bahramali E,Bakhshandeh H,Maadani M,Shafiei M

更新日期：2013-08-01 00:00:00

abstract：:The stem cells in freshwater flatworms (planarian) are called neoblasts. Neoblasts are capable of proliferation and differentiation into every cell type, including the gametes. For the investigation of the mechanisms of stem cells proliferation and differentiation the proper evaluation of changes in the cell cycle of ...

journal_title：Molecular biology reports

authors： Ermakov AM,Ermakova ON,Kudravtsev AA,Kreshchenko ND

更新日期：2012-03-01 00:00:00

abstract：:It has been suggested that the allele frequency of thrombophilic mutations is affected by glucose-6-phosphate dehydrogenase (G6PD) deficiency. The prevalence of thrombophilic mutations were studied in sixty G6PD deficient individuals including 57 males and three females with the mean age of 15 +/- 3.08 and 110 age and...

journal_title：Molecular biology reports

authors： Mozafari H,Rahimi Z,Heidarpour A,Fallahi M,Muniz A

更新日期：2009-11-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) has been investigated extensively at the molecular level. Nevertheless, genome wide study on the temporal and spatial dynamics of the virus is non-existed. To explore this topic, we determined complete coding genome sequences for four PRRSV isolates and analy...

journal_title：Molecular biology reports

authors： Yoon SH,Kim H,Kim J,Lee HK,Park B,Kim H

更新日期：2013-10-12 00:00:00

abstract：:Circulating long noncoding RNAs as biomarkers of diseases have attracted increasing attention recently. However, circulating lncRNAs in hypertension is still unexplored niche. The levels of lncRNAs GAS5, NR024118, MRAK134679, AX765700 and MRNR026574 were measured in the serum and myocardium of hypertensive rats and no...

journal_title：Molecular biology reports

authors： Wu Y,Zhang Z,Ren S,Li K,Ning Q,Jiang X

更新日期：2019-12-01 00:00:00

abstract：:Recent evidence supports a role of Toll-like receptor (TLR) signaling in the development of atherosclerotic lesions. It was confirmed that the presence of functional TLR4 promotes a proinflammatory phenotype and proliferation of vascular smooth muscle cells (VSMCs). Here we tested whether designed TLR4 small interferi...

journal_title：Molecular biology reports

authors： Li H,Xu H,Liu S

更新日期：2011-02-01 00:00:00

abstract：:Wild Solanum species are the important resources for potato improvement. With the availability of potato genome and sequencing progress, knowledge about genomic resources is essential for novel genes discovery. Hence, the aim of this study was to decipher draft genome sequences of unique potato genotypes i.e. somatic ...

journal_title：Molecular biology reports

authors： Tiwari JK,Rawat S,Luthra SK,Zinta R,Sahu S,Varshney S,Kumar V,Dalamu D,Mandadi N,Kumar M,Chakrabarti SK,Rao AR,Rai A

更新日期：2021-01-13 00:00:00

abstract：:One of the most crucial steps for preventing viral pandemics is the early detection of the causative virus on site. Various molecular and immunological approaches have been developed for virus detection. In this study, we investigated the utility of the recently introduced convection polymerase chain reaction (cPCR) p...

journal_title：Molecular biology reports

authors： Lee MH,Song KY,Hwang HJ,Kim JH,Hwang I

更新日期：2019-10-01 00:00:00

abstract：:STAT4 is a transcription factor that has been implicated in the pathogenesis of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Recently, several reports has documented that a STAT4 haplotype is associated with RA, SLE and Sjogren's syndrome. To summarize and review these findings, we conducted a met...

journal_title：Molecular biology reports

authors： Ji JD,Lee WJ,Kong KA,Woo JH,Choi SJ,Lee YH,Song GG

更新日期：2010-01-01 00:00:00

abstract：:Mitochondrial dysfunction plays a crucial role in the central pathogenesis of insulin resistance and type 2 diabetes mellitus. Macrophages play important roles in the pathogenesis of insulin resistance. Lauric acid is a 12-carbon medium chain fatty acid (MCFA) found abundantly in coconut oil or palm kernel oil and it ...

journal_title：Molecular biology reports

authors： Tham YY,Choo QC,Muhammad TST,Chew CH

更新日期：2020-12-01 00:00:00

abstract：:Using degenerate oligodeoxynucleotide primers we previously obtained cDNA fragments from ten different murine protein-tyrosine phosphatases (PTPases). Employing this same primer set, a method was developed to assess the expression levels of these PTPase family members in a fast and simple way. RT-PCR products of sever...

journal_title：Molecular biology reports

authors： Hendriks W,Brugman C,Schepens J,Wieringa B

更新日期：1994-03-01 00:00:00

abstract：:Genetics can provide invaluable tools for management and conservation of bee populations, which are declining worldwide. Among these tools, microsatellite are very useful molecular markers for population analyses. The aim of this study was to isolate and characterize microsatellites for Epicharis (Anepicharis) dejeani...

journal_title：Molecular biology reports

authors： Souza-Shibatta L,Ricardo PC,Pina WC,Flaresso-Neto V,Freiria GA,Kotelok-Diniz T,Gaglianone MC,Arias MC,Sofia SH

更新日期：2021-01-21 00:00:00

abstract：:In clinic, the patients with acute myocardial infarction (AMI) are at high risk to develop ischemia-induced ventricular arrhythmias leading to sudden cardiac death (SCD). Some studies suggest that individual susceptibility to ischemia-induced arrhythmia may be related to the genes encoding ion channels. One of them is...

journal_title：Molecular biology reports

authors： Wan J,Xiong C,Zheng F,Zhou X,Huang C,Jiang H

更新日期：2008-06-01 00:00:00

abstract：:Pathologic complete response after neoadjuvant systemic treatment appears to be a valid surrogate for better overall survival in breast cancer patients. Currently, together with standard clinicopathologic assessment, novel molecular biomarkers are being exhaustively tested in order to look into the heterogeneity of br...

journal_title：Molecular biology reports

authors： Kolacinska A,Fendler W,Szemraj J,Szymanska B,Borowska-Garganisz E,Nowik M,Chalubinska J,Kubiak R,Pawlowska Z,Blasinska-Morawiec M,Potemski P,Jeziorski A,Morawiec Z

更新日期：2012-07-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor-γ (PPARG) is a member of the nuclear hormone receptor superfamily that has attracted considerable attention as a candidate gene for coronary heart disease (CHD) based on its function as a key factor involved in the regulation of lipid and glucose metabolism. In the past d...

journal_title：Molecular biology reports

authors： Xu W,Xu J,Sun B,Chen H,Wang Y,Huang F,Xi P,Jiang J

更新日期：2013-02-01 00:00:00

abstract：:microRNAs are short, non-coding RNAs, that exert a posttranscriptional control on protein synthesis by mRNA interference. They are involved in normal and pathological embryologic development, as well as in adult life pathology, from myocardial infarction to cancer. There are several brain-specific species of microRNA,...

journal_title：Molecular biology reports

authors： Enciu AM,Popescu BO,Gheorghisan-Galateanu A

更新日期：2012-03-01 00:00:00

abstract：:Abnormally protein aggregation and deposition are key pathological features of ALS, which may related with dysfunctional cellular autophagy. In the current study, we found that, compared with wtSOD1 cells, serum starvation treatment resulted in significant higher percentage of apoptosis in mutSOD1 cells; Lithium treat...

journal_title：Molecular biology reports

authors： Yin X,Wang S,Wang X,Yang Y,Jiang H,Wang T,Wang Y,Zhang C,Feng H

更新日期：2019-12-01 00:00:00

abstract：:Molecular DNA markers are used for detection of polymorphisms in individuals. As they are independent of developmental stage of the plant and environmental influences, they can be useful tools in taxonomy. The alleles of simple sequence repeat (SSR) markers (or microsatellites) are traditionally used to identify taxon...

journal_title：Molecular biology reports

authors： Tuler AC,Carrijo TT,Nóia LR,Ferreira A,Peixoto AL,da Silva Ferreira MF

更新日期：2015-11-01 00:00:00