MicroRNAs in brain development and degeneration.

abstract：:Free cytoplasmic 40S mRNP particles from rat liver were treated with EDTA and separated into two populations of RNP particles with sedimentation maxima of 20S and 35S, respectively. A characteristic set of distinct scRNAs is found for 20S and 35S RNP particles. The sequences of two of the most abundant scRNAs from 20S...

journal_title：Molecular biology reports

authors： Villringer A,Kühn B,Schneider K,Andus T,Michels K,Northemann W,Krupp G,Walckhof B,Gross HJ,Klump H,Kroll A,Branlant C,Heinrich PC

更新日期：1983-05-01 00:00:00

abstract：:High glycemic index diet can induce multiple diseases. Many research indicated that oxidative stress played important role in many pathological conditions. However, the impact of gene expression and dietary habit on oxidation process are still less clear. We used high-glucose diet to feed C57BL/6J mice for 4 weeks, me...

journal_title：Molecular biology reports

authors： Du D,Shi YH,Le GW

更新日期：2010-12-01 00:00:00

abstract：:Through the process of alternative splicing, proteins with distinct biological functions and localisations are generated from a single gene. The mitochondrial folate metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) has been receiving attention in recent years as one of the most frequently upregulat...

journal_title：Molecular biology reports

authors： Nicolaidou V,Papaneophytou C,Koufaris C

更新日期：2020-09-01 00:00:00

abstract：:A pattern recognition protein (PRP), lipopolysaccharide and beta-1,3-glucan binding protein (LGBP) cDNA was cloned from the haemocyte of Chinese shrimp Fenneropenaeus chinensis by the techniques of homology cloning and RACE. Analysis of nucleotide sequence revealed that the full-length cDNA of 1,275 bp has an open rea...

journal_title：Molecular biology reports

authors： Liu F,Li F,Dong B,Wang X,Xiang J

更新日期：2009-03-01 00:00:00

abstract：:Two new thermophilic type II restriction endonucleases, which we designated as Bsu2413I and Bfi2411I, have been isolated from gram-positive thermophilic bacteria Bacillus subtilis strain 2413 and Bacillus firmus strain 2411 respectively and partially purified. The restriction endonucleases were extracted from cell ext...

journal_title：Molecular biology reports

authors： Jutur PP,Hoti SL,Reddy AR

更新日期：2004-06-01 00:00:00

abstract：:Eukaryotic initiation factors are found in the post-ribosomal subunits. We have analyzed the factor activities from the supernatant by means of zonal centrifugation followed by Sepharose-heparin affinity chromatography. They exist both as free factors, sedimenting in a broad range from 4 to 7S, and complexed with othe...

journal_title：Molecular biology reports

authors： Amesz H,Haubrich T,Voorma HO

更新日期：1979-05-31 00:00:00

abstract：:The myocyte enhancer factor 2C (MEF2C) is a member of the MEF2 family of transcription factors, involved in skeletal muscle development. In this study we report the cDNA sequence and isolate the 5' upstream region of the mef2c gene from porcine genomic DNA using PCR-based GenomeWalker. The open reading frame of porcin...

journal_title：Molecular biology reports

authors： Liu M,Xu DQ,Peng J,Zheng R,Li F,Jiang SW

更新日期：2011-10-01 00:00:00

abstract：:Among the bacteria groups, most of them are known to be beneficial to human being whereas only a minority is being recognized as harmful. The pathogenicity of bacteria is due, in part, to their rapid adaptation in the presence of selective pressures exerted by the human host. In addition, through their genomes, bacter...

journal_title：Molecular biology reports

authors： Alibayov B,Baba-Moussa L,Sina H,Zdeňková K,Demnerová K

更新日期：2014-08-01 00:00:00

abstract：:Hypertension is a risk factor for the cardiovascular diseases. Although, several drugs are used to treat hypertension, the success of the antihypertensive therapy is limited. Resveratrol decreases blood pressure in animal models of hypertension. This study researched the mechanisms behind the effects of resveratrol on...

journal_title：Molecular biology reports

authors： Han S,Uludag MO,Usanmaz SE,Ayaloglu-Butun F,Akcali KC,Demirel-Yilmaz E

更新日期：2015-01-01 00:00:00

abstract：:A copper(II) complex containing aspartame (APM) as ligand, Cu(APM)2Cl2·2H2O, was synthesized and characterized. In vitro binding interaction of this complex with human serum albumin (HSA) was studied at physiological pH. Binding studies of this complex with HSA are useful for understanding the Cu(APM)2Cl2·2H2O-HSA int...

journal_title：Molecular biology reports

authors： Shahabadi N,Khodaei MM,Kashanian S,Kheirdoosh F,Filli SM

更新日期：2014-05-01 00:00:00

abstract：:We tried to study the possible effects of lipoic acid (LA) on adhesion molecule expression and its underlying mechanism in the prevention and treatment of cardiovascular disorders. Intercellular adhesion molecule-1 (ICAM-1) expression and endothelial nitric oxide synthase (eNOS) activity were determined after endothel...

journal_title：Molecular biology reports

authors： Jin HB,Yang YB,Song YL,Zhang YC,Li YR

更新日期：2013-01-01 00:00:00

abstract：:DNA-, RNA- and protein synthesis have been studied in Mycobacterium smegmatis cells infected with phage I3. The macromolecular synthesis continued until the end of latent period. Early RNA and protein synthesis were necessary prior to the commencement of DNA replication. The infecting phage DNA sedimented as larger th...

journal_title：Molecular biology reports

authors： Nagaraja V,Gopinathan KP

更新日期：1981-11-30 00:00:00

abstract：:Relying on the regulation of transcription factors, plants resist to various abiotic and biotic stresses. NAC (NAM, ATAF1/2, CUC2) are one of the largest families of plant-specific transcription factors and known to play important roles in plant development and response to environmental stresses. A new NAC gene was cl...

journal_title：Molecular biology reports

authors： Wang YX

更新日期：2013-11-01 00:00:00

abstract：:The rapid progress made over the last 10 years in the identification of individual autoantigens and in the localization of the epitopes involved, has resulted in a parallel reduction in the complexity of the antigen required for the detection of autoantibodies. The ability to use synthetic peptides as antigens is a re...

journal_title：Molecular biology reports

authors： Elkon KB

更新日期：1992-06-01 00:00:00

abstract：:To investigate mechanisms of rat glutathione S-transferase P1 gene (rGSTP1) expression regulation during chemical carcinogenesis. we studied enhancer elements located in the region between -2.5 kb to -2.2 kb. The region was upstream from the start site of transcription and was divided into two major fragments, GPEI an...

journal_title：Molecular biology reports

authors： Liu D,Liao M,Zuo J,Henner WD,Fan F

更新日期：2001-03-01 00:00:00

abstract：:It is widely accepted that protein phosphorylation is a major control event in regulating cell cycle. In the present study, a novel M-phase phosphoprotein 6 (MPP6) was identified from black tiger shrimp Penaeus monodon (designated as PmMPP6) by cDNA library and RACE approaches. The full-length cDNA of PmMPP6 was of 69...

journal_title：Molecular biology reports

authors： Zhou J,Qiu L,Jiang S,Zhou F,Huang J,Yang L,Su T,Zhang D

更新日期：2013-02-01 00:00:00

abstract：:The human COX-2 promoter contains a direct repeat 1 (DR1) which was shown to confer responsiveness to PPARs. We found that in AN(3)CA and F9 cells, this hCOX-2 DR1 mediates responsiveness to all-trans-retinoic acid (tRA) or 9-cis-retinoic acid (9cRA), but this effect was suppressed by PPARδ. Truncated PPARδ lacking th...

journal_title：Molecular biology reports

authors： Han K,Moon I,Lim HJ

更新日期：2011-02-01 00:00:00

abstract：:Membrane-bound Δ9 desaturase perform oxygenated desaturation reactions to insert the first double bonds within fatty acyl chains between C9 and C10 positions of most saturated substrates. Arthrospira platensis, a blue green microalga, is an important source of polyunsaturated fatty acids (PUFA) such as oleic, linoleic...

journal_title：Molecular biology reports

authors： Ben Amor F,Ben Hlima H,Abdelkafi S,Fendri I

更新日期：2018-12-01 00:00:00

abstract：:Spermiogenesis is a developmental process undergoing continuous differentiation to drive a diploid spermatogonium towards a haploid sperm cell. This striking transformation from spermatogonium to spermatozoa is made possible by the stage-specific adaption of cytoskeleton and associated molecular motor proteins. KIFC1 ...

journal_title：Molecular biology reports

authors： Wang YT,Mao H,Hou CC,Sun X,Wang DH,Zhou H,Yang WX

更新日期：2012-07-01 00:00:00

abstract：:Stats are latent transcription factors involved in normal cellular signaling in response to cytokine or growth factor stimulation. Constitutive activation of Stats (primarily Stat3 and Stat5) has been implicated in growth dysregulation and oncogenesis. Furthermore, increased activation of Stats has been observed in se...

journal_title：Molecular biology reports

authors： Barboza JA,Wang S,Schaefer TS

更新日期：2004-03-01 00:00:00

abstract：:Mollusks lack an adaptive immune system and rely solely on the innate immune response. The nuclear factor-kappa B (NF-κB) signaling pathway is one of the most important components of the innate immune system and its activity is regulated by physical interaction with the inhibitor of NF-κB (IκB) protein. The manila cla...

journal_title：Molecular biology reports

authors： Lee Y,Wickamarachchi WD,Whang I,Oh M,Umasuthan N,De Zoysa M,Oh C,Kang DH,Lee J

更新日期：2013-02-01 00:00:00

abstract：:Here, we document changes in cell motility and organization of the contractile apparatus of human umbilical cord Wharton's jelly mesenchymal stem cells (MSCWJ-1) in the process of replicative senescence. Colocalization dynamics of F-actin and actin-binding proteins (myosin-9, α-actinin-4, RhoA) were examined in the MS...

journal_title：Molecular biology reports

authors： Bobkov D,Polyanskaya A,Musorina A,Lomert E,Shabelnikov S,Poljanskaya G

更新日期：2020-05-01 00:00:00

abstract：:The mouse double minute 2 (MDM2) gene encodes a phosphoprotein that interacts with P53 and negatively regulates its activity. SNP309 polymorphism (T-G) in the promoter of MDM2 gene has been reported to be associated with enhanced MDM2 expression and tumor development. Many published studies have evaluated the associat...

journal_title：Molecular biology reports

authors： Zhao E,Cui D,Yuan L,Lu W

更新日期：2012-04-01 00:00:00

abstract：:Approximately 90% of patients with advanced breast cancer develop bone metastases; an event that results in severe decrease of quality of life and a drastic deterioration in prognosis. Therefore, to increase the survival of breast cancer patients, the development of new therapeutic strategies to impair metastatic proc...

journal_title：Molecular biology reports

authors： Vashum Y,Premsingh R,Kottaiswamy A,Soma M,Padmanaban A,Kalaiselvan P,Samuel S

更新日期：2020-12-08 00:00:00

abstract：:Experimental evidence highlights the importance of dietetic factors on breast cancer. In this work we aimed to analyze the effects two oils, corn oil (rich in n-6 polyunsaturated fatty acids -PUFA-) and extra virgin olive oil (EVOO), on oxidative stress in an animal model of breast carcinogenesis. Female rats were fed...

journal_title：Molecular biology reports

authors： Escrich R,Vela E,Solanas M,Moral R

更新日期：2020-07-01 00:00:00

abstract：:Combined treatment with niacin and chromium has been found to have a protective effect against oxidative damage to different tissues of hyperlipidemic rats. But its effects on vascular endothelial dysfunction are less clear. This study was performed to investigate the effect of combined treatment with niacin and chrom...

journal_title：Molecular biology reports

authors： Niu N,Yu YH,Wang Y,Wang LJ,Li Q,Guo LM

更新日期：2009-07-01 00:00:00

abstract：:We have chosen to test the safety of human intracerebroventricular (ICV) brain injections of autologous non-genetically-modified adipose-derived stromal vascular fraction (ADSVF). In this IRB-approved trial, 24 patients received ICV ADSVF via an implanted reservoir between 5/22/14 and 5/22/17. Seven others were inject...

journal_title：Molecular biology reports

authors： Duma C,Kopyov O,Kopyov A,Berman M,Lander E,Elam M,Arata M,Weiland D,Cannell R,Caraway C,Berman S,Scord K,Stemler L,Chung K,Khoudari S,McRory R,Duma C,Farmer S,Bravo A,Yassa C,Sanathara A,Singh E,Rapaport B

更新日期：2019-10-01 00:00:00

abstract：:Several lines of evidence indicate that inflammatory processes play pivotal role in the development of intracranial aneurysm (IA). Recently, polymorphisms in the interleukin-12 (IL-12) gene were shown to be associated with immune-mediated inflammatory disease. The aim of this study was to investigate the interactions ...

journal_title：Molecular biology reports

authors： Li LJ,Pan XM,Sima X,Li ZH,Zhang LS,Sun H,Zhu Y,Liang WB,Gao LB,Zhang L

更新日期：2012-12-01 00:00:00

abstract：:Three members of Brassica napus TRANSPARENT TESTA 2 (BnTT2) gene family encoding potential R2R3-MYB regulatory proteins of proanthocyanidin biosynthesis were isolated. BnTT2-1, BnTT2-2, and BnTT2-3 are 1102 bp with two introns, and have a 938-bp full-length cDNA with a 260 amino acid open reading frame. They share 98....

journal_title：Molecular biology reports

authors： Wei YL,Li JN,Lu J,Tang ZL,Pu DC,Chai YR

更新日期：2007-06-01 00:00:00

abstract：:Adipocyte death is important in obesity development. Understanding and prevention of adipocyte deaths may be a molecular approach in the treatment. In the study, we aimed to understand role of Niban gene, which acts as an anti-apoptotic molecule as a response to stress conditions, in adipocytes. 3T3-L1 adipocytes were...

journal_title：Molecular biology reports

authors： Cevik M,Gunduz MK,Deliorman G,Susleyici B

更新日期：2020-12-01 00:00:00