Association between two genetic polymorphisms of the renin-angiotensin-aldosterone system and diabetic nephropathy: a meta-analysis.

Abstract:

:The widely studied candidate genes of the renin-angiotensin-aldosterone system, angiotensinogen (AGT), and angiotensin II receptor type 1 (AGTR1), are implicated in the development of diabetic nephropathy (DN). A number of studies have evaluated the association between the functional polymorphisms, AGT M235T and AGTR1 A1166C, and DN risk with conflicting results. The present meta-analysis was performed to estimate the overall risk of these polymorphisms associated with DN on 4,377 DN cases and 4,905 controls from 34 published case-control studies by searching electronic databases and reference lists of relevant articles. We examined the association between each polymorphism and the risk of DN by odds ratio (OR) with 95% confidence intervals (95% CI) and calculated the ORs for different genetic model. In addition, stratification analysis by ethnicity and diabetes mellitus (DM) type was conducted. In this meta-analysis, we failed to find any significant main effects in both overall analysis and stratified analysis for the AGT M235T. However, the overall analysis detected a significant association between the AGTR1 A1166C and the risk of DN for the CC compared with the AA and dominant genetic model (CC vs. AA: OR = 2.10, 95% CI: 1.00-4.44; dominant model: OR = 2.11, 95% CI: 1.06-4.23). In subgroup analysis, only patients with T2DM showed significant association for CC vs. AA model and dominant model (CC vs. AA: OR = 3.31, 95% CI: 1.21-9.08; dominant model: OR = 3.50, 95% CI: 1.41-8.69). This study suggests that the AGTR1 A1166C polymorphism may contribute to DN development, particularly in T2DM patients.

journal_name

Mol Biol Rep

authors

Ding W,Wang F,Fang Q,Zhang M,Chen J,Gu Y

doi

10.1007/s11033-011-0862-7

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

1293-303

issue

2

eissn

0301-4851

issn

1573-4978

journal_volume

39

pub_type

杂志文章,meta分析
  • Overexpression of AtDREB1D transcription factor improves drought tolerance in soybean.

    abstract::Drought is one of the major abiotic stresses that affect productivity in soybean (Glycine max L.) Several genes induced by drought stress include functional genes and regulatory transcription factors. The Arabidopsis thaliana DREB1D transcription factor driven by the constitutive and ABA-inducible promoters was introd...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-014-3695-3

    authors: Guttikonda SK,Valliyodan B,Neelakandan AK,Tran LS,Kumar R,Quach TN,Voothuluru P,Gutierrez-Gonzalez JJ,Aldrich DL,Pallardy SG,Sharp RE,Ho TH,Nguyen HT

    更新日期:2014-12-01 00:00:00

  • Different mitochondrial DNA copy number in liver and mammary gland of lactating cows with divergent genetic background for milk production.

    abstract::Adequate metabolic adaptation of key tissues playing an essential role for bioenergetic homeostasis and lactogenesis is critical in cows to adapt to changes in energy requirements and physiological processes during the lactation period. Mitochondria are recognized as central to meet energy needs and maintaining of met...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-018-4273-x

    authors: Weikard R,Kuehn C

    更新日期:2018-10-01 00:00:00

  • Effect of ketamine administration on memory consolidation, p-CREB and c-fos expression in the hippocampal slices of minor rats.

    abstract::To investigate the effect of ketamine administration on memory consolidation, p-CREB and c-fos expression in hippocampus of infant rats and the possible mechanism. Ninety-six SD rats of 21 days old were divided into seven groups, Y-maze was used to test the ability of learning and memory for minor rats. p-CREB and c-f...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-010-0374-x

    authors: Peng S,Zhang Y,Ren B,Zhang J,Wang H

    更新日期:2011-04-01 00:00:00

  • Molecular cloning and characterisation of a pattern recognition protein, lipopolysaccharide and beta-1,3-glucan binding protein (LGBP) from Chinese shrimp Fenneropenaeus chinensis.

    abstract::A pattern recognition protein (PRP), lipopolysaccharide and beta-1,3-glucan binding protein (LGBP) cDNA was cloned from the haemocyte of Chinese shrimp Fenneropenaeus chinensis by the techniques of homology cloning and RACE. Analysis of nucleotide sequence revealed that the full-length cDNA of 1,275 bp has an open rea...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-007-9203-2

    authors: Liu F,Li F,Dong B,Wang X,Xiang J

    更新日期:2009-03-01 00:00:00

  • UV crosslinking of RNA to nylon membrane enhances hybridization signals.

    abstract::An improvement in the detection by nucleic acid hybridization of size-fractionated RNA immobilized to nylon-based membranes is described. Electrophoretic transfer of RNA to nylon membranes permits a quantitative determination of different RNA transcripts on the same membrane after sequential hybridization using differ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/BF00364822

    authors: Khandjian EW

    更新日期:1986-01-01 00:00:00

  • Genome-wide analysis of BURP domain-containing genes in maize and sorghum.

    abstract::BURP domain-containing genes comprise a large plant-specific family, yet the functions are very poorly understood, especially in maize (Zea mays) and sorghum (Sorghum vulgare). In this study, 26 BURP family genes in maize (ZmBURP01-15) and sorghum (SbBURP01-11) were identified including the gene structure, phylogeneti...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-010-0587-z

    authors: Gan D,Jiang H,Zhang J,Zhao Y,Zhu S,Cheng B

    更新日期:2011-10-01 00:00:00

  • Isolation of DNA polymerase alpha from germinated wheat embryos.

    abstract::DNA polymerase alpha from germinated wheat embryos was purified by ammonium sulphate fractionation, chromatography on DEAE-Toyopearl, followed by phosphocellulose and heparin Sepharose columns. The specific activity of the purified enzyme was more than 60,000 units/mg. It belongs to the alpha-type according to the lar...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/BF00788748

    authors: Balmukhanov TS,Erekenov AM,Ajtkhozhina NA

    更新日期:1992-02-01 00:00:00

  • Sequence polymorphisms at the growth hormone GH1/GH2-N and GH2-Z gene copies and their relationship with dairy traits in domestic sheep (Ovis aries).

    abstract::The purpose was to analyze the growth hormone GH1/GH2-N and GH2-Z gene copies and to assess their possible association with milk traits in Sarda sheep. Two hundred multiparous lactating ewes were monitored. The two gene copies were amplified separately and each was used as template for a nested PCR, to investigate sin...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-013-2629-9

    authors: Vacca GM,Dettori ML,Balia F,Luridiana S,Mura MC,Carcangiu V,Pazzola M

    更新日期:2013-09-01 00:00:00

  • Long-term ketamine abuse induces cystitis in rats by impairing the bladder epithelial barrier.

    abstract::Long-term ketamine abuse is known to affect the lower urinary tract and produce symptoms of cystitis. However, the pathophysiology and causative mechanism of the changes in bladder function remain unclear. The present study aimed to investigate the existence of ketamine-induced cystitis in a rat model and characterize...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-014-3616-5

    authors: Gu D,Huang J,Yin Y,Shan Z,Zheng S,Wu P

    更新日期:2014-11-01 00:00:00

  • Aragonite shells are more ancient than calcite ones in bivalves: new evidence based on omics.

    abstract::Two calcium carbonate crystal polymorphs, aragonite and calcite, are the main inorganic components of mollusk shells. Some fossil evidences suggest that aragonite shell is more ancient than calcite shell for the Bivalvia. But, the molecular biology evidence for the above deduction is absent. In this study, we searched...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-014-3620-9

    authors: Wang X,Li L,Zhu Y,Song X,Fang X,Huang R,Que H,Zhang G

    更新日期:2014-11-01 00:00:00

  • Development and characterization of genomic microsatellite markers in the tree species, Rhodoleia championii, R. parvipetala, and R. forrestii (Hamamelidaceae).

    abstract::Rhodoleia Champion ex Hooker is one of the most primitive relict genera of Hamamelidaceae, a key family exploited to understand the origin and early evolution of flowering plants. Genomic simple sequence repeats (SSRs) were developed for R. championii to perform genetic diversity, phylogeographical structure or even s...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-019-05106-w

    authors: Huang Y,Yin Q,Do VT,Meng K,Chen S,Liao B,Fan Q

    更新日期:2019-12-01 00:00:00

  • A novel missense (A79V) mutation of goat PROP1 gene and its association with production traits.

    abstract::As a paired class homeodomain transcription factor, mutations of PROP1 (Prophet of POU1F1) are responsible for deficiencies of GH, PRL, TSH, LH and FSH. Regarding mutations of GH, PRL, and POU1F1 genes significantly associating with different production traits, PROP1 gene is a novel important candidate gene for detect...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-008-9418-x

    authors: Lan X,Pan C,Zhang L,Zhao M,Zhang C,Lei C,Chen H

    更新日期:2009-11-01 00:00:00

  • Expression, purification and characterisation of a novel mutant of the human protein kinase CK2.

    abstract::The recombinant catalytic subunit of human protein kinase CK2 bas been mutagenised at the C-terminal region in an attempt to induce this tail to fold. We suppose in fact that this unstructured C-terminus just might be responsible for the high degradability of the human enzyme. On the basis of theoretical calculations ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1023/a:1023934805326

    authors: Grasselli E,Noviello G,Rando C,Nicolini C,Vergani L

    更新日期:2003-06-01 00:00:00

  • Role of p16 gene promoter methylation in gastric carcinogenesis: a meta-analysis.

    abstract::This meta-analysis was performed to evaluate the relationships between promoter DNA methylation in tumor suppressor gene p16 and gastric carcinogenesis. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library and CBM databases were searched for relevant articles published before November 1s...

    journal_title:Molecular biology reports

    pub_type: 杂志文章,meta分析,收录出版

    doi:10.1007/s11033-014-3319-y

    authors: Wang HL,Zhou PY,Liu P,Zhang Y

    更新日期:2014-07-01 00:00:00

  • ASYMMETRIC LEAVES2 gene, a member of LOB/AS2 family of Arabidopsis thaliana, causes an abaxializing leaves in transgenic cockscomb.

    abstract::The leaf primordium derives from the peripheral zone of shoot apical meristem. During the formation of leaf primordia, they need to establish the proximodistal, mediolateral, and ab/adaxial axes. Among these axes, the ab/adaxial axis might be the most important. ASYMMETRIC LEAVES2 (AS2) gene is a member of AS2/LATERAL...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-011-1288-y

    authors: Sun SB,Song JP,Meng LS

    更新日期:2012-04-01 00:00:00

  • Bax releases cytochrome c preferentially from a complex between porin and adenine nucleotide translocator. Hexokinase activity suppresses this effect.

    abstract::The mechanism by which external Bax releases cytochrome c is still controversial and may also depend on the type of mitochondria and the actual localisation of cytochrome c. Outer membrane porin acquires high binding affinity for hexokinase by interacting with the adenine nucleotide translocator (ANT) in the contact s...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1023/a:1020383108620

    authors: Vyssokikh MY,Zorova L,Zorov D,Heimlich G,Jürgensmeier JJ,Brdiczka D

    更新日期:2002-01-01 00:00:00

  • A site-specific endonuclease from Pseudomonas aeruginosa.

    abstract::PaeI, a new restriction endonuclease from Pseudomonas aeruginosa clinical strain was isolated and characterized. It recognizes and cleaves the sequence 5'-GCATG reduced C-3' generating DNA fragments with 3'-tetranucleotide sticky ends. DNAs of pBR322, SV40 and bacteriophage lambda have one, two and six PaeI recognitio...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/BF00778522

    authors: Sokolov NN,Fitsner AB,Anikeitcheva NV,Choroshoutina YuB,Samko OT,Kolosha VO,Fodor I,Votrin II

    更新日期:1985-04-01 00:00:00

  • Comparative proteomics analysis of serum proteins in ulcerative colitis patients.

    abstract::In the present study, we investigated the differentially expressed proteins associated with ulcerative colitis (UC) using proteomic methods. Two-dimensional electrophoresis (2-DE) technology was performed to separate the total proteins of ulcerative tissues from those of the normal tissues of UC patients. PDQuest soft...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-011-1373-2

    authors: Li N,Wang X,Zhang Y,Zhai J,Zhang T,Wei K

    更新日期:2012-05-01 00:00:00

  • Polymorphisms in twelve candidate genes are associated with growth, muscle lipid profile and meat quality traits in eleven European cattle breeds.

    abstract::Current customers' demands focus on the nutritional and sensory quality of cattle meat. Candidate gene approach allows identification of genetic polymorphisms that have a measurable effect on traits of interest. The aim of this work is to identify new molecular markers for beef production through an association study ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-014-3343-y

    authors: Sevane N,Armstrong E,Wiener P,Pong Wong R,Dunner S,GemQual Consortium.

    更新日期:2014-07-01 00:00:00

  • Expression and characterization of Momordica Chanrantia anti-hyperglycaemic peptide in Escherichia coli.

    abstract::A nucleic acid sequence MC, encoding Momordica Chanrantia anti-hyperglycaemic peptide MC6 (accession: AAX06814) synthesized according to Escherichia coli preferred codons, was cloned and expressed in E. coli. Recombinant protein pQE8-MC (about 3.5 kDa) was purified and analyzed by 20% SDS-PAGE and western blot. It rev...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-009-9609-0

    authors: Liu SX,Fu ZP,Mu RM,Hu ZB,Wang FJ,Wang XR

    更新日期:2010-04-01 00:00:00

  • Green fluorescent protein is superior to blue fluorescent protein as a quantitative reporter of promoter activity in E. coli.

    abstract::Fluorescent proteins related to and derived from green fluorescent protein (GFP) are widely used as tools for investigating a wide range of biological processes. In particular, GFP and its relatives have been used extensively as qualitative reporters of gene expression in many different organisms, but relatively few s...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-008-9285-5

    authors: Lissemore JL,Bayes J,Calvey M,Reineke L,Colagiavanni A,Tscheiner M,Mascotti DP

    更新日期:2009-05-01 00:00:00

  • SSR markers: a tool for species identification in Psidium (Myrtaceae).

    abstract::Molecular DNA markers are used for detection of polymorphisms in individuals. As they are independent of developmental stage of the plant and environmental influences, they can be useful tools in taxonomy. The alleles of simple sequence repeat (SSR) markers (or microsatellites) are traditionally used to identify taxon...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-015-3927-1

    authors: Tuler AC,Carrijo TT,Nóia LR,Ferreira A,Peixoto AL,da Silva Ferreira MF

    更新日期:2015-11-01 00:00:00

  • Effects of aqueous extract of Portulaca oleracea L. on oxidative stress and liver, spleen leptin, PARα and FAS mRNA expression in high-fat diet induced mice.

    abstract::We reported that an aqueous extract of Portulaca oleracea L. inhibited high-fat-diet-induced oxidative injury in a dose-dependent manner. Male kunming mice (5-weeks-old, 24 g) were used in this experiment. After a 4-day adaptation period, animals were randomly divided into four groups (n = 10 in each group); Group 1: ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-012-1644-6

    authors: Chen B,Zhou H,Zhao W,Zhou W,Yuan Q,Yang G

    更新日期:2012-08-01 00:00:00

  • Immune response-related gene expression profile of a novel molluscan IκB protein member from Manila clam (Ruditapes philippinarum).

    abstract::Mollusks lack an adaptive immune system and rely solely on the innate immune response. The nuclear factor-kappa B (NF-κB) signaling pathway is one of the most important components of the innate immune system and its activity is regulated by physical interaction with the inhibitor of NF-κB (IκB) protein. The manila cla...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-012-2196-5

    authors: Lee Y,Wickamarachchi WD,Whang I,Oh M,Umasuthan N,De Zoysa M,Oh C,Kang DH,Lee J

    更新日期:2013-02-01 00:00:00

  • Molecular characterization and expression profile of MAP2K1ip1/MP1 gene from tiger shrimp, Penaeus monodon.

    abstract::MAPK kinase 1 interacting protein 1 (MAP2K1ip1) is an important scaffold proteins of the mitogen-activated protein kinase (MAPK) pathway that form an active signaling module and enhance the specificity and spatiality of MAPK signaling. In the present study, we identified and characterized a MAP2K1ip1 cDNA from tiger s...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-011-1391-0

    authors: Yang L,Liu X,Huang J,Yang Q,Qiu L,Liu W,Jiang S

    更新日期:2012-05-01 00:00:00

  • The relationship between vascular endothelial growth factor and spermatogenesis disturbance in an experimentally-induced unilateral cryptorchidism murine model.

    abstract::This study is to explore the relationship between vascular endothelial growth factor (VEGF) and pathological changes in cryptorchidism by using murine model of intraperitoneal cryptorchidism with surgical operation. To investigate the relationship between the changes of VEGF expression and heat stress inducing germ ce...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-020-05454-y

    authors: Gao P,Gao J,Dou X,Peng D,Zhang Y,Li H,Zhu T,Jiang H,Zhang X

    更新日期:2020-05-01 00:00:00

  • microRNA 338-3p exhibits tumor suppressor role and its down-regulation is associated with adverse clinical outcome in prostate cancer patients.

    abstract::MicroRNAs (miRNAs) are small non-coding RNAs that function in transcriptional and post-transcriptional regulation of gene expression. Several miRNAs have been implicated in regulating prostate cancer (PCa) progression. Deregulations of miRNA regulatory networks have been reported in ERG positive PCa, which accounts fo...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-016-3948-4

    authors: Bakkar A,Alshalalfa M,Petersen LF,Abou-Ouf H,Al-Mami A,Hegazy SA,Feng F,Alhajj R,Bijian K,Alaoui-Jamali MA,Bismar TA

    更新日期:2016-04-01 00:00:00

  • Cloning and expression of peroxisomal ascorbate peroxidase gene from wheat.

    abstract::A full-length cDNA encoding wheat peroxisomal ascorbate peroxidase (pAPX) was cloned by Suppression Subtractive Hybridization (SSH) and in silico approach. The cDNA was 1027 bp in length and contained a complete ORF of 876 bp, which encodes a protein of 292 amino acid residues. Its deduced amino acids sequence had 84%...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-005-4536-1

    authors: Chen Y,Wang H,Wang X,Cao A,Chen P

    更新日期:2006-09-01 00:00:00

  • Genetic variants in transforming growth factor-β gene (TGFB1) affect susceptibility to schizophrenia.

    abstract::Immense body of evidence indicates that dysfunction of immune system is implicated in the etiology of schizophrenia. The immune theory of schizophrenia is supported by alterations in cytokine profile in the brain and peripheral blood. Given the strong genetic background of schizophrenia, it might be assumed that aberr...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-013-2662-8

    authors: Frydecka D,Misiak B,Beszlej JA,Karabon L,Pawlak-Adamska E,Tomkiewicz A,Partyka A,Jonkisz A,Kiejna A

    更新日期:2013-10-01 00:00:00

  • Comparative properties of rat liver chromatin in situ and in vitro at early stages after partial hepatectomy.

    abstract::The binding of acridine orange and ethidium bromide to rat liver chromatin increases by 30% one hour after partial hepatectomy, returns to the control level by the second hour and increases again by the sixth hour. The changes described were found in investigations carried out on whole cells, on isolated nuclei, and o...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/BF00777513

    authors: Sondore OY,Fedoseeva GE,Kadyckov VA,Zelenin AV

    更新日期:1978-10-16 00:00:00