Bax releases cytochrome c preferentially from a complex between porin and adenine nucleotide translocator. Hexokinase activity suppresses this effect.

abstract：:The stem cells in freshwater flatworms (planarian) are called neoblasts. Neoblasts are capable of proliferation and differentiation into every cell type, including the gametes. For the investigation of the mechanisms of stem cells proliferation and differentiation the proper evaluation of changes in the cell cycle of ...

journal_title：Molecular biology reports

authors： Ermakov AM,Ermakova ON,Kudravtsev AA,Kreshchenko ND

更新日期：2012-03-01 00:00:00

abstract：:Micro-RNAs (miRNAs) play key roles in regulating genes of the immune system. The aim of this study was to examine the expression of miR-1, 21 and 125a in the immune cells taken from the peripheral blood of patients suffering from chronic HBV infection (CHB). This cross-sectional study was performed on 60 CHB patients ...

journal_title：Molecular biology reports

authors： Momeni M,Hassanshahi G,Arababadi MK,Kennedy D

更新日期：2014-07-01 00:00:00

abstract：:Hypertension is a risk factor for the cardiovascular diseases. Although, several drugs are used to treat hypertension, the success of the antihypertensive therapy is limited. Resveratrol decreases blood pressure in animal models of hypertension. This study researched the mechanisms behind the effects of resveratrol on...

journal_title：Molecular biology reports

authors： Han S,Uludag MO,Usanmaz SE,Ayaloglu-Butun F,Akcali KC,Demirel-Yilmaz E

更新日期：2015-01-01 00:00:00

abstract：:Scytovirin is a lectin isolated from the cyanobacterium Scytonema varium that has shown activity against HIV, SARS coronavirus and Zaire Ebola virus. Its 95 amino acids are divided into two structural domains (SD), the first spanning amino acids 1-48 (SD1) and the second 49-95 (SD2). Interestingly, the domains are nea...

journal_title：Molecular biology reports

authors： Siqueira AS,Lima ARJ,de Souza RC,Santos AS,Vianez Júnior JLDSG,Gonçalves EC

更新日期：2017-08-01 00:00:00

abstract：:Berberine (BBR), an effective compound of Chinese traditional herbal medicine, has preventive effects on diabetes and its complications. In this study, we investigated the therapeutic effects and underlying molecular mechanisms of BBR in rats with high-fat diet and streptozotocin (STZ)-induced diabetic nephropathy mod...

journal_title：Molecular biology reports

authors： Wang FL,Tang LQ,Yang F,Zhu LN,Cai M,Wei W

更新日期：2013-03-01 00:00:00

abstract：:The full-length MECPS cDNA sequence (designated as Chmecps, GenBank Accession No.: DQ415658) was isolated by rapid amplification of cDNA ends (RACE) for the first time from Cephalotaxus harringtonia. The full-length cDNA of Chmecps was 1,146 bp containing a 753 bp open reading frame (ORF) encoding a polypeptide of 250...

journal_title：Molecular biology reports

authors： Chen J,Xiao Y,Di P,Yu X,Chen W,Zhang L

更新日期：2009-09-01 00:00:00

abstract：:The present study aimed to obtain analgesic-antitumor peptide (AGAP) gene expression in plants. The analgesic-antitumor peptide (AGAP) gene was from the venom of Buthus martensii Karsch. Previous studies showed that AGAP has both analgesic and antitumor activities, suggesting that AGAP would be useful in clinical situ...

journal_title：Molecular biology reports

authors： Lai L,Huang T,Wang Y,Liu Y,Zhang J,Song Y

更新日期：2009-05-01 00:00:00

abstract：:Flavonoids are the main flavor components and functional ingredients in tea, and the shikimic acid pathway is considered as one of the most important pathways in flavonoid biosynthesis, but little was known about the function of regulatory genes in the metabolism phenolic compounds in tea plant (Camellia sinensis), es...

journal_title：Molecular biology reports

authors： Zhu XJ,Zhao Z,Xin HH,Wang ML,Wang WD,Chen X,Li XH

更新日期：2016-10-01 00:00:00

abstract：:An improvement in the detection by nucleic acid hybridization of size-fractionated RNA immobilized to nylon-based membranes is described. Electrophoretic transfer of RNA to nylon membranes permits a quantitative determination of different RNA transcripts on the same membrane after sequential hybridization using differ...

journal_title：Molecular biology reports

authors： Khandjian EW

更新日期：1986-01-01 00:00:00

abstract：:Nijmegen Breakage Syndrome protein 1 (NBS1) is one of the most important DNA repair proteins playing important roles in maintaining the genomic stability of NDA. Previous studies regarding the association between NBS1 8360G>C (Glu185Gln) polymorphism and lung cancer reported conflicting results. To derive a more preci...

journal_title：Molecular biology reports

authors： Wang L,Cheng J,Gao J,Wang J,Liu X,Xiong L

更新日期：2013-03-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease in which numerous cells and mediators affect inflammatory conditions and disease severity. To compare the serum levels of adiponectin, vitamin D, copper, and zinc in patients with RA and to investigate the relationship between these parameters and RA severity...

journal_title：Molecular biology reports

authors： Khajoei S,Hassaninevisi M,Kianmehr N,Seif F,Khoshmirsafa M,Shekarabi M,Samei A,Haghighi A

更新日期：2019-04-01 00:00:00

abstract：:Fascin homologue 1 (FSCN1) has established roles in cell adhesion, motility, and cell-cell interactions. Our LongSAGE analysis suggested that FSCN1 was potentially differentially expressed in prenatal pig skeletal muscle. We have cloned the genomic DNA and mRNA sequence of FSCN1 gene and mapped it to SSC3p16-p17. The ...

journal_title：Molecular biology reports

authors： Tang ZhL,Zhang XJ,Yang ShL,Mu YL,Cui WT,Ao H,Li K

更新日期：2010-06-01 00:00:00

abstract：:ERBB2/HER2/NEU, a member of the epidermal growth factor receptor family, is overexpressed in more than 25 % of non-small cell lung cancer and is considered to be a significant and independent prognostic factor in lung cancer. Here we generated a lung specific HER2 overexpressing transgenic mouse model. In this model, ...

journal_title：Molecular biology reports

authors： Zeng S,Yang Y,Tan Y,Lu C,Pan Y,Chen L,Lu G

更新日期：2012-08-01 00:00:00

abstract：:Xenin is a regulatory peptide first isolated from the human gastric mucosa. Using an open-access protein database MEDLINE (33 million molecules; 11 billion amino acid residues) and our original computer program, we conducted a search for the xenin motifs in the primary structure of proteins across almost the entire ta...

journal_title：Molecular biology reports

authors： Maryanovich AT,Kormilets DY,Polyanovsky AD

更新日期：2018-04-01 00:00:00

abstract：:Heterogeneous nuclear ribonucleoprotein particles (HnRNP) were separated in metrizamide density gradients, into two fractions migrating to 1.31 g ml-1 and 1.18 g ml-1, respectively. Proteins associated with each of these fractions were analysed by SDS-acrylamide gel electrophoresis. It is shown that the whole proteins...

journal_title：Molecular biology reports

authors： Houssais JF

更新日期：1977-03-01 00:00:00

abstract：:Kawasaki disease (KD) is a multi-systemic vasculitis which preferentially affects infants and children. A single nucleotide polymorphism (rs28493229) in the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) was identified to be associated with the increased risk of KD; however, in more recent studies associations have b...

journal_title：Molecular biology reports

authors： Lou J,Xu S,Zou L,Zhong R,Zhang T,Sun Y,Lu X,Liu L,Li C,Wang L,Xiong G,Wang W,Gong F,Wu J

更新日期：2012-12-01 00:00:00

abstract：:Echinococcus granulosus is a parasitic helminth which affects both man and animals. During infection with larval stage of the organism secretory and membrane-bound (S/M) proteins play a meaningful role for evasion of immune system. Antigen B (AgB) is one of them. Present investigation has defined sequence diversity of...

journal_title：Molecular biology reports

authors： Pan D,Bera AK,Bandyopadhyay S,Das S,Rana T,Das SK,Bandyopadhyay S,Manna B,Bhattacharya D

更新日期：2011-03-01 00:00:00

abstract：:In genome engineering, sgRNAs define the genomic target to be modified in CRISPR/Cas9 system. Either for single gene editing or genome-wide screens, sgRNAs are cloned into plasmid vectors. During our performance of CRISPR/Cas9 gene knock out, we found that the central part of a sgRNA was inverted after transformation ...

journal_title：Molecular biology reports

authors： Wang G,Sukumar S

更新日期：2020-08-01 00:00:00

abstract：:Sensitivity to phenylthiocarbamide (PTC) has a bimodal distribution pattern and the genotype of the TAS2R38 gene, which is composed of combinations of three coding single nucleotide polymorphisms (SNPs), p.A49P (c.145G>C), p.V262A (c.785T>C) and p.I296 V (c.886A>G), determines the ability or inability to taste PTC. In...

journal_title：Molecular biology reports

authors： Sagong B,Bae JW,Rhyu MR,Kim UK,Ye MK

更新日期：2014-03-01 00:00:00

abstract：:Published data regarding the association between the apurinic/apyrimidinic endonuclease 1 (APE1) Asp148Glu polymorphism and bladder cancer risk showed inconclusive results. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, ...

journal_title：Molecular biology reports

authors： Liu C,Yin Q,Li L,Zhuang YZ,Zu X,Wang Y

更新日期：2013-01-01 00:00:00

abstract：:The blue swimming crab (Portunus pelagicus) is a valuable marine fishery resource in Indo-West Pacific Ocean. So far, rare genetic resource of this species is available. In this report, the restriction-site associated DNA (RAD) approach was employed to mine the genomic information and identify molecular markers in P. ...

journal_title：Molecular biology reports

authors： Wu Q,Miao G,Li X,Liu W,Ikhwanuddin M,Ma H

更新日期：2018-12-01 00:00:00

abstract：:Recombinant plasmids carrying a highly curved DNA structure are sometimes unstable in Escherichia coli. In order to know the underlying mechanism, several plasmids carrying one or two highly bent DNA segment(s) from the human adenovirus type 2 (Ad2) enhancer and/or origin region of phage lambda replication were system...

journal_title：Molecular biology reports

authors： Ohyama T,Miyano M,Sakuma S

更新日期：1999-12-01 00:00:00

abstract：:F-box proteins are key components of the ubiquitin (Ub)/26S proteasome pathway that mediates selective degradation of regulatory proteins involved in a wide variety of cellular processes affecting eukaryotic cells. In plants, F-box genes form one of the largest multigene superfamilies and control many important biolog...

journal_title：Molecular biology reports

authors： Paquis S,Mazeyrat-Gourbeyre F,Fernandez O,Crouzet J,Clément C,Baillieul F,Dorey S

更新日期：2011-06-01 00:00:00

abstract：:Tall fescue is a perennial cool-season grass with economic importance especially in temperate regions of the northern hemisphere. This study was done to assess the genetic diversity and population structure of 90 tall fescue populations and cultivars using ISSR and EST-SSR markers in order to categorize valuable popul...

journal_title：Molecular biology reports

authors： Shahabzadeh Z,Mohammadi R,Darvishzadeh R,Jaffari M

更新日期：2020-01-01 00:00:00

abstract：:Severe malaria (SM) caused by Plasmodium falciparum (Pf) infection has been associated with life-threatening anemia, metabolic acidosis, cerebral malaria and multiorgan dysfunction. It may lead to death if not treated promptly. RNASE 3 has been linked to Pf growth inhibition and its polymorphisms found associated with...

journal_title：Molecular biology reports

authors： Mukhi B,Gupta H,Wassmer SC,Anvikar AR,Ghosh SK

更新日期：2020-11-01 00:00:00

abstract：:20S proteasomes are large (700 kDa) proteinase complexes which form the central catalytic core of larger complexes (26S proteasomes or PA28-20S complexes) formed by association with regulatory particles. These larger complexes are involved in diverse regulatory processes in the cell including cyclin breakdown, proteol...

journal_title：Molecular biology reports

authors： Bose S,Mason GG,Rivett AJ

更新日期：1999-04-01 00:00:00

abstract：:The Rv3203 (LipV) of Mycobacterium tuberculosis (Mtb) H37Rv, is annotated as a member of Lip family based on the presence of characteristic consensus esterase motif ‘GXSXG’. In vitro culture studies of Mtb H37Ra indicated that expression of Rv3203 gene was up-regulated during acidic stress as compared to normal wherea...

journal_title：Molecular biology reports

authors： Singh G,Arya S,Narang D,Jadeja D,Singh G,Gupta UD,Singh K,Kaur J

更新日期：2014-01-01 00:00:00

abstract：:In jasmonate biosynthetic pathway, allene oxide synthase (AOS, EC 4.2.1.92), which is a cytochrome P450 (CYP74A), catalyzes the first committed step. We herein cloned a novel cDNA from Lonicera japonica Thunb., named LjAOS (GenBank accession: DQ303120), which was homologous to other AOSs. Southern blot analysis reveal...

journal_title：Molecular biology reports

authors： Jiang K,Pi Y,Hou R,Zeng H,Huang Z,Zhang Z,Sun X,Tang K

更新日期：2009-03-01 00:00:00

abstract：:Maize (Zea mays L.) is an important model plant with an important role in agriculture and national economies all over the world. The optimum growth temperature of maize is between 25 and 28 °C. At temperatures below 12 °C, maize is vulnerable to damage by chilling stress. MYB transcription factors play important roles...

journal_title：Molecular biology reports

authors： Li M,Lin L,Zhang Y,Sui N

更新日期：2019-08-01 00:00:00

abstract：:Curcumin is a polyphenolic bioactive compound found in the spice turmeric endowed with diverse pharmacological and biological activities. In this study, fluorescence spectroscopy in combination with UV-Vis absorbance spectroscopy was employed to investigate the high affinity binding of curcumin to herring sperm DNA (h...

journal_title：Molecular biology reports

authors： Li XL,Hu YJ,Mi R,Li XY,Li PQ,Ouyang Y

更新日期：2013-07-01 00:00:00