Abstract：
:Micro-RNAs (miRNAs) play key roles in regulating genes of the immune system. The aim of this study was to examine the expression of miR-1, 21 and 125a in the immune cells taken from the peripheral blood of patients suffering from chronic HBV infection (CHB). This cross-sectional study was performed on 60 CHB patients and 60 healthy controls and expression of miR-1, 21 and 125a was evaluated using quantitative Real-Time PCR. The results showed that expression of miR-1, 21 and 125a was significantly increased in CHB patients in comparison to healthy controls. Based on our results it may be concluded that increased expression of miR-1, 21 and 125a is significantly associated with CHB and may play key roles in the induction of impaired immune responses in CHB patients.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Momeni M,Hassanshahi G,Arababadi MK,Kennedy Ddoi
10.1007/s11033-014-3355-7subject
Has Abstractpub_date
2014-07-01 00:00:00pages
4833-7issue
7eissn
0301-4851issn
1573-4978journal_volume
41pub_type
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