Abstract:
:HIV/AIDS remains to be one of the killing diseases of mankind. Host genetic response is one of the factor which determine susceptibility to HIV and disease progression to AIDS. The aim of the present study was to evaluate the impact of ERCC2 Lyc ( 751 ) Gln (excision repair cross complementing rodent repair deficiency, complementation group 2) polymorphism on HIV-1 susceptibility and disease progression to AIDS, as this gene has been reported to intervene in degrading retroviral cDNA before it integrates with the host DNA. This case control study included 300 HIV seropositive cases and an equal number of HIV seronegative controls. DNA was isolated from the blood samples of study subjects and genotyping of ERCC2 was conducted by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) method. The Gln/Gln genotype showed a significant variation between cases and controls (P = 0.047, OR 1.71, 95% CI 1.00-2.93), indicating a possible role of susceptibility in reference to controls and disease progression when compared within cases.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Sobti RC,Berhane N,Mahdi SA,Kler R,Hosseini SA,Kuttiat V,Wanchu Adoi
10.1007/s11033-010-9958-8subject
Has Abstractpub_date
2011-06-01 00:00:00pages
2945-52issue
5eissn
0301-4851issn
1573-4978journal_volume
38pub_type
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