Abstract:
:Xenin is a regulatory peptide first isolated from the human gastric mucosa. Using an open-access protein database MEDLINE (33 million molecules; 11 billion amino acid residues) and our original computer program, we conducted a search for the xenin motifs in the primary structure of proteins across almost the entire taxonomic range of evolution. Motifs with 40% homology to human xenin are already present in prokaryotes. Homology reaches 84-96% in single-cell algae and plants, becoming complete since bony fishes. We suppose that this regulatory peptide is more ancient and significant than is usually thought.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Maryanovich AT,Kormilets DY,Polyanovsky ADdoi
10.1007/s11033-018-4147-2subject
Has Abstractpub_date
2018-04-01 00:00:00pages
143-150issue
2eissn
0301-4851issn
1573-4978pii
10.1007/s11033-018-4147-2journal_volume
45pub_type
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