Association of SERPINE2 gene with the risk of chronic obstructive pulmonary disease and spirometric phenotypes in northern Han Chinese population.

abstract：:The influence of peptidyl-tRNA on the dissociation of yeast 80 S ribosomes into subunits was studied. For this purpose temperature-sensitive (ts) suppressor strain of yeast Saccharomyces cervisiae carrying a defect in peptide chain termination was used. It was found that peptidyl-tRNA did not influence the dissociatio...

journal_title：Molecular biology reports

authors： Surguchov AP,Fominykch ES,Lyzlova LV

更新日期：1978-06-16 00:00:00

abstract：:Ribonuclease P (RNase P) is a key enzyme involved in tRNA biosynthesis. It catalyses the endonucleolytic cleavage of nearly all tRNA precursors to produce 5'-end matured tRNA. RNase P activity has been found in all organisms examined, from bacteria to mammals. Eubacterial RNase RNA is the only known RNA enzyme which f...

journal_title：Molecular biology reports

authors： Drainas D

更新日期：1995-01-01 00:00:00

abstract：:Glioma is the most aggressive primary brain tumor. We have previously provided evidence that IFITM3 promoted glioma cells migration. However, the mechanism of how IFITM3 regulates glioma cells invasion and whether IFITM3 participates in TGF-β-mediated glioma invasion are still unknown. In this paper, we proved that IF...

journal_title：Molecular biology reports

authors： Wang H,Tang F,Bian E,Zhang Y,Ji X,Yang Z,Zhao B

更新日期：2020-01-01 00:00:00

abstract：:A full length spermidine synthase (PgSPD) cDNA was isolated and characterized from the root of Panax ginseng C. A. Meyer. The cDNA was 1,188 nucleotides long and had an open reading frame of 1,002 bp with a deduced amino acid sequence of 333 residues. The calculated molecular mass of the matured protein is approximate...

journal_title：Molecular biology reports

authors： Parvin S,Kim YJ,Pulla RK,Sathiyamoorthy S,Miah MG,Kim YJ,Wasnik NG,Yang DC

更新日期：2010-02-01 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) are non-coding RNAs. The potential roles of lncRNAs in type 2 diabetes mellitus (T2DM) are not well-known. In this study, we aim to assess the expression levels of LY86-AS1 and HCG27_201 in T2DM patients and a healthy control group. We obtained whole blood and serum samples from 100 T2DM...

journal_title：Molecular biology reports

authors： Saeidi L,Ghaedi H,Sadatamini M,Vahabpour R,Rahimipour A,Shanaki M,Mansoori Z,Kazerouni F

更新日期：2018-12-01 00:00:00

abstract：:We studied the distribution of the D/D, I/D, and I/I genotypes of the angiotensin-converting enzyme (ACE) in a sample of healthy Lebanese individuals to assess their prevalence and compare them with other populations. ACE genotypes were determined using the Cardiovascular Disease (CVD) StripAssay, which is based on a ...

journal_title：Molecular biology reports

authors： Sabbagh AS,Otrock ZK,Mahfoud ZR,Zaatari GS,Mahfouz RA

更新日期：2007-03-01 00:00:00

abstract：:Iron may be implicated in the generation of oxidative stress by the catalyzing the Haber-Weiss or Fenton reaction. On the other hand, oxidative stress has been implicated in the pathogenesis of age-related macular degeneration (AMD) and heme oxygenase-1 (HO-1), encoded by the HMOX1 gene and heme oxygenase-2 (HO-2), en...

journal_title：Molecular biology reports

authors： Synowiec E,Szaflik J,Chmielewska M,Wozniak K,Sklodowska A,Waszczyk M,Dorecka M,Blasiak J,Szaflik JP

更新日期：2012-03-01 00:00:00

abstract：:Macrophage activation is modulated by both environmental cues and endogenous programs. In the present study, we investigated the role of a PAQR family protein, monocyte to macrophage differentiation-associated (MMD), in macrophage activation and unveiled its underlying molecular mechanism. Our results showed that whil...

journal_title：Molecular biology reports

authors： Liu Q,Zheng J,Yin DD,Xiang J,He F,Wang YC,Liang L,Qin HY,Liu L,Liang YM,Han H

更新日期：2012-05-01 00:00:00

abstract：:Published data on the association of vascular endothelial growth factor (VEGF) -1154G>A polymorphism with cancer risk is inconclusive. To derive a more precise estimation of association between VEGF -1154G>A polymorphism and the risk of cancer, we performed a meta-analysis of 7,071 cancer cases and 7,693 controls from...

journal_title：Molecular biology reports

authors： Hong TT,Zhang RX,Wu XH,Hua D

更新日期：2012-05-01 00:00:00

abstract：:Rice production in recent years is highly affected by rapidly increasing temperatures in the tropical and sub-tropical countries, which threatens the sustainable production in near future. Hence, understanding the heat tolerance mechanism and evolving tolerant varieties is an immense need in the staple crop rice. An e...

journal_title：Molecular biology reports

authors： Wahab MMS,Akkareddy S,Shanthi P,Latha P

更新日期：2020-03-01 00:00:00

abstract：:In the Eastern province of Saudi Arabia, thalassemia is highly common. Data on the effect of alpha globin gene variation on the concentration of iron on transfusion dependent Saudis are scanty. A total of 166 transfusions dependent β-thalassemia were included in this study to understand association between the alpha g...

journal_title：Molecular biology reports

authors： AbdulAzeez S,Almandil NB,Naserullah ZA,Al-Jarrash S,Al-Suliman AM,ElFakharay HI,Borgio JF

更新日期：2020-01-01 00:00:00

abstract：:ERBB2/HER2/NEU, a member of the epidermal growth factor receptor family, is overexpressed in more than 25 % of non-small cell lung cancer and is considered to be a significant and independent prognostic factor in lung cancer. Here we generated a lung specific HER2 overexpressing transgenic mouse model. In this model, ...

journal_title：Molecular biology reports

authors： Zeng S,Yang Y,Tan Y,Lu C,Pan Y,Chen L,Lu G

更新日期：2012-08-01 00:00:00

abstract：:JAK/STAT signaling pathway is involved in many diseases, including autoimmune diseases, which are characterized by a close interconnection between immune and bone system. JAK/STAT pathway is involved in bone homeostasis and plays an important role in proliferation and differentiation of some cell types, including oste...

journal_title：Molecular biology reports

authors： Sanpaolo ER,Rotondo C,Cici D,Corrado A,Cantatore FP

更新日期：2020-11-01 00:00:00

abstract：:P73 is a structural and functional homologue of p53, and plays an important role in regulating cell cycle and apoptosis. A potentially functional polymorphism (designated as p73 G4C14-to-A4T14) has been identified in a region in exon 2 of the p73 gene, which may theoretically form a stem-loop structure and thereby aff...

journal_title：Molecular biology reports

authors： Wang L,Gao R,Yu L

更新日期：2012-02-01 00:00:00

abstract：:The complete coding sequences of three porcine genes-SDHB, SNRPA and CRYBB1 were amplified using the reverse transcriptase polymerase chain reaction (RT-PCR) based on the conserved coding sequence information of the mouse or other mammals and highly homologous pig ESTs. These three genes were then deposited into GenBa...

journal_title：Molecular biology reports

authors： An QC,Liu GY

更新日期：2009-04-01 00:00:00

abstract：:This meta-analysis was performed to assess the relationships between the PON1 Q192R (rs662 T>C) polymorphism and the clinical outcome of antiplatelet treatment after percutaneous coronary intervention (PCI). A range of electronic databases were searched: Web of Science (1945-2013), the Cochrane Library Database (Issue...

journal_title：Molecular biology reports

authors： Li P,Bu SH,Lu XT,Li LX,Xu AJ,Tang YN,Zhang J

更新日期：2014-09-01 00:00:00

abstract：:The rapid progress made over the last 10 years in the identification of individual autoantigens and in the localization of the epitopes involved, has resulted in a parallel reduction in the complexity of the antigen required for the detection of autoantibodies. The ability to use synthetic peptides as antigens is a re...

journal_title：Molecular biology reports

authors： Elkon KB

更新日期：1992-06-01 00:00:00

abstract：:The lysyl oxidase-like 2 (LOXL2) protein is a human paralogue of lysyl oxidase (LOX) that functions as an amine oxidase for formation of lysine-derived cross-links found in collagen and elastin. In addition to the C-terminal domains characteristic to the LOX family members, LOXL2 contains four scavenger receptor cyste...

journal_title：Molecular biology reports

authors： Kim YM,Kim EC,Kim Y

更新日期：2011-01-01 00:00:00

abstract：:Cytokinin oxidases are involved in the regulation of plant cytokinin levels, which are important in regulating plant growth and development, and may affect the yield of cereals. Here, we report the isolation and characterization of two putative cytokinin oxidase genes, TaCKX2.1 and TaCKX2.2, from wheat. Both TaCKX2.1 ...

journal_title：Molecular biology reports

authors： Zhang J,Liu W,Yang X,Gao A,Li X,Wu X,Li L

更新日期：2011-04-01 00:00:00

abstract：:The degeneration of retinal pigment epithelium (RPE) cells in the sub retinal pigment epithelial space and choroid is an initial pathological characteristic for the age-related macular degeneration which is the leading cause of severe vision loss in old people. Moreover, oxidative stress is implicated as a major induc...

journal_title：Molecular biology reports

authors： Li DD,Zhong BW,Zhang HX,Zhou HY,Luo J,Liu Y,Xu GC,Luan CS,Fang J

更新日期：2016-10-01 00:00:00

abstract：:While there have been more and more studies concerning mitogen-activated protein kinases (MAPKs) signaling pathways, which control many cellular complex programmes, such as cell proliferation, differentiation, cell death and embryogenesis. However, few studies are carried out about expression and activation of classic...

journal_title：Molecular biology reports

authors： Zheng ST,Huo Q,Tuerxun A,Ma WJ,Lv GD,Huang CG,Liu Q,Wang X,Lin RY,Sheyhidin I,Lu XM

更新日期：2011-02-01 00:00:00

abstract：:Lipoprotein-associated phospholipase A2 (LP-PLA2) may play an important role in the pathophysiology of coronary heart disease (CHD). The polymorphism of LP-PLA2 gene caused LP-PLA2 enzyme activity depressing or lost. But there is not a definite conclusion for the association of between the LP-PLA2 gene polymorphism an...

journal_title：Molecular biology reports

authors： Zheng GH,Chen HY,Xiong SQ,Chu JF

更新日期：2011-08-01 00:00:00

abstract：:TCF7L2 and SLC30A8 have been found to be associated with type 2 diabetes mellitus (T2DM) as well as with impaired proinsulin processing recently, enzymes encoded by PCSK1 and PCSK2 are reported to play an important role in the process of proinsulin conversion. To investigate whether the single nucleotide polymorphisms...

journal_title：Molecular biology reports

authors： Zheng X,Ren W,Zhang S,Liu J,Li S,Li J,Yang P,He J,Su S,Li P

更新日期：2012-01-01 00:00:00

abstract：:Maize is one of the world's most important crops and a model for grass genome research. Long terminal repeat (LTR) retrotransposons comprise most of the maize genome; their ability to produce new copies makes them efficient high-throughput genetic markers. Inter-retrotransposon-amplified polymorphisms (IRAPs) were use...

journal_title：Molecular biology reports

authors： Ghonaim M,Kalendar R,Barakat H,Elsherif N,Ashry N,Schulman AH

更新日期：2020-03-01 00:00:00

abstract：:Putatively functional polymorphisms of one-carbon and xenobiotic metabolic pathways influence susceptibility for wide spectrum of diseases. The current study was aimed to explore gene-gene interactions among these two metabolic pathways in four diseases i.e. breast cancer, systemic lupus erythematosus (SLE), coronary ...

journal_title：Molecular biology reports

authors： Naushad SM,Vijayalakshmi SV,Rupasree Y,Kumudini N,Sowganthika S,Naidu JV,Ramaiah MJ,Rao DN,Kutala VK

更新日期：2015-07-01 00:00:00

abstract：:Bud dormancy in perennial plants adapts to environmental and seasonal changes. Bud dormancy is of ecological interest because it affects forest population growth characteristics and is of economical interest because it impacts wood production levels. To understand Pinus sylvestris L. var. mongolica litv. bud-dormancy ...

journal_title：Molecular biology reports

authors： Bi YD,Wei ZG,Shen Z,Lu TC,Cheng YX,Wang BC,Yang CP

更新日期：2011-02-01 00:00:00

abstract：:Uterine leiomyomas (UL) are prevalent benign tumors, especially among women of African ancestry. The disease also has genetic liability and is influenced by risk factors such as hormones and obesity. This study investigates the haplotypes of the Cytochrome P450 1B1 gene (CYP1B1) related to hormones and coiled-coil dom...

journal_title：Molecular biology reports

authors： Alleyne AT,Bideau VS

更新日期：2019-06-01 00:00:00

abstract：:Sulfonamide derivatives, such as sulfadiazine (SD) are used as antibiotics and, very recently, anti-amyloid properties of these have been reported. We have evaluated binding of SD with bovine serum albumin (BSA) followed by unfolding of protein. Studies were accomplished at physiological conditions of temperature (37 ...

journal_title：Molecular biology reports

authors： Al-Lohedan HA,Sajih Ali M

更新日期：2013-11-01 00:00:00

abstract：:One of the major limitations when attempting to obtain detailed biochemical, biophysical and immunological characterization of plant DNA mismatch repair proteins is their extremely low abundance in vivo under normal growth conditions. An initial analysis of PMS1 transcript level in various Arabidopsis thaliana tissues...

journal_title：Molecular biology reports

authors： Galles C,Gomez RL,Spampinato CP

更新日期：2011-02-01 00:00:00

abstract：:Several studies have examined the effects of the tumor necrosis factor-α (TNF-α) -308 A/G and lymphotoxin-α (LT-α) +252 A/G polymorphisms on susceptibility to sarcoidosis, showing mixed results. The purpose of this study was to examine whether the TNF-α -308 A/G and LT-α +252 A/G polymorphisms confer susceptibility to...

journal_title：Molecular biology reports

authors： Song GG,Kim JH,Lee YH

更新日期：2014-01-01 00:00:00