Abstract:
:Glioma is the most aggressive primary brain tumor. We have previously provided evidence that IFITM3 promoted glioma cells migration. However, the mechanism of how IFITM3 regulates glioma cells invasion and whether IFITM3 participates in TGF-β-mediated glioma invasion are still unknown. In this paper, we proved that IFITM3 was notably up-regulated in glioma tissues. Knockdown of IFITM3 suppressed STAT3 phosphorylation in vitro, and a specific STAT3 inhibitor AG490 reversed IFITM3-induced invasion of glioma cells. Furthermore, IFITM3 expression was induced by TGF-β in glioma and IFITM3 knockdown abolished TGF-β-mediated glioma cells invasion. Collectively, the results indicate that IFITM3/STAT3 axis may promote TGF-β-induced glioma cells invasion. This study provided some suggestions for the clinical treatment of the brain tumor.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Wang H,Tang F,Bian E,Zhang Y,Ji X,Yang Z,Zhao Bdoi
10.1007/s11033-019-05146-2subject
Has Abstractpub_date
2020-01-01 00:00:00pages
433-441issue
1eissn
0301-4851issn
1573-4978pii
10.1007/s11033-019-05146-2journal_volume
47pub_type
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