IFITM3/STAT3 axis promotes glioma cells invasion and is modulated by TGF-β.

Abstract:

:Glioma is the most aggressive primary brain tumor. We have previously provided evidence that IFITM3 promoted glioma cells migration. However, the mechanism of how IFITM3 regulates glioma cells invasion and whether IFITM3 participates in TGF-β-mediated glioma invasion are still unknown. In this paper, we proved that IFITM3 was notably up-regulated in glioma tissues. Knockdown of IFITM3 suppressed STAT3 phosphorylation in vitro, and a specific STAT3 inhibitor AG490 reversed IFITM3-induced invasion of glioma cells. Furthermore, IFITM3 expression was induced by TGF-β in glioma and IFITM3 knockdown abolished TGF-β-mediated glioma cells invasion. Collectively, the results indicate that IFITM3/STAT3 axis may promote TGF-β-induced glioma cells invasion. This study provided some suggestions for the clinical treatment of the brain tumor.

journal_name

Mol Biol Rep

authors

Wang H,Tang F,Bian E,Zhang Y,Ji X,Yang Z,Zhao B

doi

10.1007/s11033-019-05146-2

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

433-441

issue

1

eissn

0301-4851

issn

1573-4978

pii

10.1007/s11033-019-05146-2

journal_volume

47

pub_type

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