Abstract:
:Lipoprotein-associated phospholipase A2 (LP-PLA2) may play an important role in the pathophysiology of coronary heart disease (CHD). The polymorphism of LP-PLA2 gene caused LP-PLA2 enzyme activity depressing or lost. But there is not a definite conclusion for the association of between the LP-PLA2 gene polymorphism and CHD risk. To assess the relationship between LP-PLA2 gene V279F polymorphism and CHD, a comprehensive Meta-analysis was performed. All the case-control studies evaluating the association of between the LP-PLA2 gene V279F polymorphism and CHD risk were identified. Seven case-control studies involving 3,614 patients with CHD and 4,334 controls were included. The crude odds ratios (ORs) of meta-analysis under the different gene model were not significant. But in the stratified analysis by study size, ethnicity, cases definition, and source of controls under the additive model, the association was evident in ethnicity for Japanese group (OR=1.38, 95%CI=1.22-1.56), cases definition for MI (OR=1.22, 95%CI=1.01-1.49), source of controls for the based-hospital (OR=1.42, 95%CI=1.24-1.59). These data suggested that the V279F polymorphism in LP-PLA2 gene may contribute to CHD development. But there is necessary that more well-designed large studies are required for the validation of this association.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Zheng GH,Chen HY,Xiong SQ,Chu JFdoi
10.1007/s11033-010-0529-9subject
Has Abstractpub_date
2011-08-01 00:00:00pages
4089-99issue
6eissn
0301-4851issn
1573-4978journal_volume
38pub_type
杂志文章,meta分析abstract::The aim of this study was to describe the microbial communities in the distal gut of wild wolves (Canis lupus). Fecal samples were collected from three healthy unrelated adult wolves captured at the nearby of Dalai Lake Nature Reserve in Inner Mongolia of China. The diversity of fecal bacteria was investigated by cons...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0060-z
更新日期:2010-12-01 00:00:00
abstract::The widely studied candidate genes of the renin-angiotensin-aldosterone system, angiotensinogen (AGT), and angiotensin II receptor type 1 (AGTR1), are implicated in the development of diabetic nephropathy (DN). A number of studies have evaluated the association between the functional polymorphisms, AGT M235T and AGTR1...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-011-0862-7
更新日期:2012-02-01 00:00:00
abstract::Studies of the refractive properties of Gramicidin A in absolute ethanol and in ethanol water mixtures showed that this peptide in solution undergoes a conformational transition resulting in species with different refractivity. Accordingly, the folded form of this peptide shows a lower specific refractive index increm...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00357540
更新日期:1975-07-01 00:00:00
abstract::Long terminal repeat (LTR)-retrotransposons are mobile genetic elements that are ubiquitous in plants and constitute a major portion of their nuclear genomes. LTR- retrotransposons possess unique properties that make them appropriate for investigating relationships between populations, varieties and closely related sp...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1112-8
更新日期:2012-04-01 00:00:00
abstract::Maize is one of the world's most important crops and a model for grass genome research. Long terminal repeat (LTR) retrotransposons comprise most of the maize genome; their ability to produce new copies makes them efficient high-throughput genetic markers. Inter-retrotransposon-amplified polymorphisms (IRAPs) were use...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05246-4
更新日期:2020-03-01 00:00:00
abstract::Geranylgeranyl diphosphate synthase (GGPPS) [EC 2.5.1.29] catalyzes the biosynthesis of geranylgeranyl diphosphate (GGPP), which is a key precursor for diterpenes such as taxol. Herein, a full-length cDNA encoding GGPPS (designated as CgGGPPS) was cloned and characterized from hazel (Corylus avellana L. Gasaway), a ta...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9935-2
更新日期:2010-10-01 00:00:00
abstract::HSG1 (Heat shock-induced gene 1) is one of the high-temperature-induced proteins in grapevine. Sequence analysis has demonstrated that HSG1 is a grape Bcl-2-associated athanogene (BAG) that contains IQ and BAG domains in its sequence. HSG1 expression was not detected in leaves without heat treatment, while tendrils, s...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1224-1
更新日期:2012-04-01 00:00:00
abstract::Growth-regulating factor (GRF) is an important protein in GA-mediated response, with key roles in plant growth and development. However, it is not known whether or how the GRF proteins in citrus to regulate organ size. In this study, nine citrus GRF genes (CsGRF1-9) were validated from the 'Anliu' sweet orange (AL, Ci...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-016-4048-1
更新日期:2016-10-01 00:00:00
abstract::Our previous study revealed that CRB3 protein expression was reduced in clear cell renal cell carcinoma (ccRCC) and was associated with TNM stage, pathological grade, and poor prognosis of ccRCC. This study aimed to investigate if DNA methylation of CRB3 decreases its expression, subsequently leading to the progressio...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04892-7
更新日期:2019-08-01 00:00:00
abstract::Macrophage activation is modulated by both environmental cues and endogenous programs. In the present study, we investigated the role of a PAQR family protein, monocyte to macrophage differentiation-associated (MMD), in macrophage activation and unveiled its underlying molecular mechanism. Our results showed that whil...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1370-5
更新日期:2012-05-01 00:00:00
abstract::The glycosylation of UDP-glucosyltransferases (UGTs) is of great importance in the control and elimination of both endogenous and exogenous toxins. Bm-UGT10286 (UGT86) is the sole provider of UGT activity against the 5-O position of quercetin and directly influences the formation of green pigment in the Bombyx cocoon....
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2437-7
更新日期:2013-05-01 00:00:00
abstract::Stable inheritance and expression of transgene are important parameters for successful use of a transgenic crop. We previously transformed a Bt cry1Ba3 gene into cabbage inbred line CA21-3. To evaluate the stability of our Bt cabbage lineages, transgene inheritance and expression were examined in four successive gener...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05344-3
更新日期:2020-04-01 00:00:00
abstract::Stats are latent transcription factors involved in normal cellular signaling in response to cytokine or growth factor stimulation. Constitutive activation of Stats (primarily Stat3 and Stat5) has been implicated in growth dysregulation and oncogenesis. Furthermore, increased activation of Stats has been observed in se...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/b:mole.0000013503.16301.82
更新日期:2004-03-01 00:00:00
abstract::Methylenetetrahydrofolate reductase (MTHFR) polymorphism may play an important role in the pathophysiology of obesity and diabetes accompanied by obesity due to its influence on plasma homocysteine levels. There are significant and sometimes very strong relationship between levels of homocysteine and several multi-sys...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9545-z
更新日期:2010-01-01 00:00:00
abstract::70S RNA has been prepared from mouse mammary tumor virus (MMTV) produced by the GR tumor cell line. After denaturation for 3 min at 60 degrees C the RNA was applied to a sucrose gradient and molecules sedimenting between 10-16S were selected and passed over an oligo-dT cellulose column. The poly A containing RNA fract...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00778742
更新日期:1981-05-22 00:00:00
abstract::Various case-control studies have shown association of single nucleotide polymorphism rs12303764(G/T) in ULK1 with crohn's disease. The techniques used in these studies were time consuming, complicated and require sophisticated/expensive instruments. Therefore, in order to overcome these problems, we have developed a ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-016-4087-7
更新日期:2017-02-01 00:00:00
abstract::The aim of this study was to identify molecular markers to be applied to marker-assisted selection. Three SNPs of the FASN gene were studied. PCR-RFLP was used for genotyping. The SNPs g.17924A>G, g.17860C>T and g.15603A>G all in the FASN gene were genotyped using the enzymes MscI, DdeI and Hae III, respectively. The ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1883-6
更新日期:2012-12-01 00:00:00
abstract::Osteoporosis is a common health problem in Mexico, so it is essential to investigate the status of different gene polymorphisms that could serve as genetic susceptibility markers in the Mexican population. Genes with a role in bone metabolism are excellent candidates for association studies. In this study were determi...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2357-6
更新日期:2013-03-01 00:00:00
abstract::TCF7L2 and SLC30A8 have been found to be associated with type 2 diabetes mellitus (T2DM) as well as with impaired proinsulin processing recently, enzymes encoded by PCSK1 and PCSK2 are reported to play an important role in the process of proinsulin conversion. To investigate whether the single nucleotide polymorphisms...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0705-6
更新日期:2012-01-01 00:00:00
abstract::Development of a rapid and accurate quantification method for the detection of microRNAs (miRNAs) has been desired, in particular, when they are differently expressed in normal and pathological conditions. However, various methods for the quantification of small non-coding RNAs as well as miRNAs have been described. T...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2442-x
更新日期:2013-05-01 00:00:00
abstract::Azotobacter chroococcum and A. salinestris do not possess significant and distinct morphological and physiological differences and are often mistaken with each other in microbiological research. In this study, 12 isolates of Azotobacter isolated by standard protocol from soils were identified morphologically and physi...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05133-7
更新日期:2020-01-01 00:00:00
abstract::Mitochondria are highly specialized in function, but mitochondrial and, therefore, cellular integrity is maintained through their dynamic nature. Through the frequent processes of fusion and fission, mitochondria continuously change in shape and adjust function to meet cellular requirements. Abnormalities in fusion/fi...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1007/s11033-014-3663-y
更新日期:2014-11-01 00:00:00
abstract::To investigate the influence of NF-κB antisense oligonucleotide on transdifferentiation of fibroblast in the pathological process of bleomycin-induced pulmonary fibrosis in mice. 6 h before molding of C57BL/6 model of pulmonary fibrosis in mice, NF-κB antisense oligonucleotide was injected from caudal vein. Then the l...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3273-8
更新日期:2014-06-01 00:00:00
abstract::The two predominant forms of arginase, cytosolic Arginase-I and mitochondrial Arginase-II, catalyze hydrolysis of arginine into ornithine and urea. Based on presence of arginase activity in extracts using potassium chloride (KCl), mitochondrial membrane-bound arginase has also been suggested. However, the activity of ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-016-3965-3
更新日期:2016-05-01 00:00:00
abstract::We investigated phenotypic variations for pod shattering, pod length and number of seeds per pod in large germplasm collections of Brassica juncea (2n = 36; AABB) and its progenitor species, B. rapa (2n = 20; AA) and B. nigra (2n = 16; BB). Pod shatter resistance was measured as energy required for rupturing a mature ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05384-9
更新日期:2020-04-01 00:00:00
abstract::Dendropoma petraeum, considered the primary vermetid reef-building species in the Mediterranean, has recently been shown to be a species complex of at least four cryptic species. These species have highly restricted, non-overlapping distributions, causing concern for their conservation status. To better study the gene...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4346-x
更新日期:2018-12-01 00:00:00
abstract::Circadian rhythms are endogenous and self-sustained oscillations of multiple biological processes with approximately 24-h rhythmicity. Circadian genes and their protein products constitute the molecular components of the circadian oscillator that form positive/negative feedback loops and generate circadian rhythms. Th...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2841-7
更新日期:2014-01-01 00:00:00
abstract::The big advantage of using molecular biomarkers to monitor oxygen levels in aquatic systems is that responses at the molecular level tend to be more sensitive, and usually occur earlier than those at higher levels of biological organization Aquatic hypoxia is a frequent event, which can occur naturally in a variety of...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1181-8
更新日期:2012-04-01 00:00:00
abstract::The complete mitochondrial genome of Pseudochauhanea macrorchis was determined and compared with other monogenean mitochondrial genomes from GenBank. The circular genome was 15,031 bp in length and encoded 36 genes (12 protein-coding genes, two ribosomal RNAs, and 22 transfer RNAs) typically found in flatworms. Struct...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1659-z
更新日期:2012-08-01 00:00:00
abstract::Adenylosuccinate lyase (ADSL) is a bifunctional enzyme acting in de novo purine synthesis and purine nucleotide recycling. In the present study, we have constructed a grass carp (Ctenopharyngodon idella) intestinal cDNA library that has over 2.3 × 10(5) primary clones. An expressed sequence tag (EST) of grass carp ade...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0331-8
更新日期:2011-03-01 00:00:00