Abstract:
:Haemoglobin meseenger RNA was isolated from spleen erythroïd cells of anaemic rabbits. The mRNA fraction looks quite homogeneous when analyzed by sucrose gradient centrifugation; it sediments in the 9S region. When added to an ascites cell free system, spleen 9S RNA stimulates the incorporation of radioactive leucine into protein. The synthesized product has been characterized and identified as α and β chains of rabbit globin.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Nokin P,Gautier Edoi
10.1007/BF00357405subject
Has Abstractpub_date
1973-06-01 00:00:00pages
47-53issue
1eissn
0301-4851issn
1573-4978journal_volume
1pub_type
杂志文章abstract::Diabetic retinopathy (DR) is a multifactorial disease with complex pathophysiology. It is the main cause of blindness among the people in productive age. The purpose of this literature review is to highlight recent achievements in the genetics of diabetic retinopathy with particular focus on candidate gene studies. We...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1007/s11033-016-4075-y
更新日期:2016-12-01 00:00:00
abstract::Using a membrane filter retention technique we have studied the interaction between DNA and lysine rich histone H5 in vitro. It is found that, depending on the ionic conditions, H5 can bind DNA in a random or cooperative manner and exhibits a preference to DNA with high molecular weight and/or high A + T content, as a...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00775749
更新日期:1980-03-31 00:00:00
abstract::The objective of present study was to screen the effect of methyl jasmonate (MJ) in lipopolysaccharide (LPS) induced in vivo and in vitro arthritis. Arthritis was induced in wistar rats by intraplantar administration of LPS (1 mg/Kg) and effect of MJ was screened in two doses (20, 40 mg/Kg, IP), indomethacin (30 mg/Kg...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4520-1
更新日期:2019-02-01 00:00:00
abstract::Ku70 plays an important role in the DSBR (DNA double-strand breaks repair) and maintenance of genomic integrity. Genetic variations within human Ku70 have been demonstrated to be associated with increased risk of several types of cancers. In this hospital-based case-control study, we aimed to investigate whether a sin...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0773-7
更新日期:2012-01-01 00:00:00
abstract::Latexin, a carboxypeptidase A inhibitor, is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat. It is used as a molecular marker for the regional specification of the neocortex. In this study, a cDNA was isolated from a human fetal brain cDNA library. The cDNA (LXN) cont...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/a:1010971219806
更新日期:2000-01-01 00:00:00
abstract::To investigate mechanisms of rat glutathione S-transferase P1 gene (rGSTP1) expression regulation during chemical carcinogenesis. we studied enhancer elements located in the region between -2.5 kb to -2.2 kb. The region was upstream from the start site of transcription and was divided into two major fragments, GPEI an...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/a:1011993604051
更新日期:2001-03-01 00:00:00
abstract::Previous data on association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk were controversial. To investigate the association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk. We performed a meta-analysis to assess the relationship between oral cancer and genotype with English language until...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-011-0777-3
更新日期:2012-01-01 00:00:00
abstract::A meta-analysis of randomized trials was performed to compare the efficacy of toremifene (TOR) with tamoxifen (TAM) in patients with breast cancer. A total of 4,768 intention-to-treat patients from nine randomized trials were identified, with 2,587 patients in TOR group and 2,181 patients in TAM group. The primary out...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-013-2914-7
更新日期:2014-02-01 00:00:00
abstract::Complementary DNA to mouse globin mRNA was prepared using viral reverse transcriptase. Molecular hybridisation of this cDNA to Friend virus RNA demonstrates the absence of globin gene sequences. ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00357645
更新日期:1973-12-01 00:00:00
abstract::Apolipoprotein AV (apoAV) modulates plasma triglyceride levels, which is an independent risk factor for cardiovascular disease. ApoAV is also involved in atherosclerosis lesion formation. In order to systematically evaluate the apolipoprotein-related gene profile in tree shrew, a model for its insusceptibility to athe...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2641-0
更新日期:2013-09-01 00:00:00
abstract::The modified base queuine is a nutrient factor for lower and higher eukaryotes except yeast. It is synthesized in eubacteria and inserted into the wobble position of specific tRNAs (tRNA(GUN)) in exchange of guanine at position 34. The tRNAs of Q family are completely modified in terminally differentiated somatic cell...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-004-6941-2
更新日期:2005-09-01 00:00:00
abstract::The current study represents the first molecular characterization of freshwater fish species in Egypt from two major fish resources; the River Nile and Lake Nasser. A total of 160 DNA barcodes using a 655-bp-long fragment of the mitochondrial cytochrome oxidase subunit I (COI) gene were generated from 37 species belon...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05657-3
更新日期:2020-08-01 00:00:00
abstract::Previous report showed that Estrogen related receptor α (ERRα) knockout mice had a significant reduction in adipose tissue deposition. Although it was reported that ERRα could promote adipogenesis in several immortalized preadipocytes cell lines, the mechanism behind which is still unclear to date. Besides, the expres...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1104-8
更新日期:2012-03-01 00:00:00
abstract::The objective of this study was to analyze possible associations between single nucleotide polymorphisms (SNPs) in the Myf5 gene with chicken growth and reproductive traits. SNPs in Myf5 of the Jinghai yellow chicken were detected by the polymerase chain reaction single-strand conformation polymorphism method and the ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3569-8
更新日期:2014-10-01 00:00:00
abstract::PaeI, a new restriction endonuclease from Pseudomonas aeruginosa clinical strain was isolated and characterized. It recognizes and cleaves the sequence 5'-GCATG reduced C-3' generating DNA fragments with 3'-tetranucleotide sticky ends. DNAs of pBR322, SV40 and bacteriophage lambda have one, two and six PaeI recognitio...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00778522
更新日期:1985-04-01 00:00:00
abstract::Cardiomyocytes possess the ability to respond to mechanical stimuli by reprogramming their gene expression. This study investigated the effects of different loading protocols on signaling and expression responses of myogenic, anabolic, inflammatory, atrophy and pro-apoptotic genes in cardiomyocyte-like H9C2 cells. Dif...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-06112-z
更新日期:2021-01-04 00:00:00
abstract::Because of the importance of androgens to prostate cancer (PCa) development, several candidate genes along androgen pathway have been under intensive study. Given the role of the molecular chaperone HSP70 in the regulation of the androgen receptor (AR) transactivation function, we first chose to explore the associatio...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-007-9107-1
更新日期:2008-09-01 00:00:00
abstract::We reported that an aqueous extract of Portulaca oleracea L. inhibited high-fat-diet-induced oxidative injury in a dose-dependent manner. Male kunming mice (5-weeks-old, 24 g) were used in this experiment. After a 4-day adaptation period, animals were randomly divided into four groups (n = 10 in each group); Group 1: ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1644-6
更新日期:2012-08-01 00:00:00
abstract::The present meta-analysis of relevant case-control studies was conducted to investigate the possible relationships between genetic variations in the killer cell immunoglobulin-like receptor (KIR) gene clusters of the human KIR gene family and susceptibility to ankylosing spondylitis (AS). The following electronic data...
journal_title:Molecular biology reports
pub_type: 杂志文章,收录出版
doi:10.1007/s11033-014-3402-4
更新日期:2014-08-01 00:00:00
abstract::Evidence is presented to suggest that in chick liver, xanthine dehydrogenase and aldehyde oxidase activities are associated with only one protein species. The results of SDS electrophoresis of the purified material indicate a subunit MW of 120 000. ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00357585
更新日期:1973-08-01 00:00:00
abstract::The purpose of our research is to elucidate whether oxLDL activates P2X7R in cultured human podocytes and if the activation of P2X7R leads to podocyte apoptosis. Additionally, we explore the underlying mechanism involved in podocyte apoptosis. Immortalized human podocytes were incubated with oxLDL (80 µg/ml), P2X7R an...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04823-6
更新日期:2019-08-01 00:00:00
abstract::The complete coding sequences of three porcine genes-SDHB, SNRPA and CRYBB1 were amplified using the reverse transcriptase polymerase chain reaction (RT-PCR) based on the conserved coding sequence information of the mouse or other mammals and highly homologous pig ESTs. These three genes were then deposited into GenBa...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-008-9229-0
更新日期:2009-04-01 00:00:00
abstract::Changes in host immunity and parasite resistance to drugs are among the factors that contribute to decreased efficacy of antiparasitic drugs such as the antimonial compounds pentamidine, amphotericin (AMP B) and miltefosine. Bioactive natural products could be alternatives for the development of new drugs to treat neg...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05887-5
更新日期:2020-11-01 00:00:00
abstract::The immunity and health status of ornamental fish is an important aspect, as they are kept in a confined environment and various stressful conditions which lead to depletion of overall colourful appearance and mortality. The carotenoids can act as immunity boosters in captive aquarium system and may be supplemented in...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05027-8
更新日期:2019-12-01 00:00:00
abstract::Cordyceps sinensis (CS) is an entomogenous fungus used as a tonic food and Chinese medicine to replenish health. This study investigated the protective effects of CS in rats post-renal ischemia-reperfusion (I/R) sequence by analyzing the influence on stromal cell-derived factor-1α (SDF-1α and chemokine (C-X-C motif) r...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2316-2
更新日期:2013-03-01 00:00:00
abstract::We reported earlier about the detection of a chromosomally located arsenic operon (arsRBC) in a gram-negative bacterium Pseudomonas fluorescens strain MSP3, which showed resistance to elevated levels of sodium arsenate and sodium arsenite. The genes for arsenic resistance were cloned into the HindIII site of pBluescri...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/a:1017950207981
更新日期:2001-01-01 00:00:00
abstract::Eukaryotic 20S proteasomes are complex oligomeric proteins. The maturation process of the 14 different alpha- and beta-subunits has to occur in a highly coordinate manner. In addition beta-subunits are synthesized as proproteins and correct processing has to be guaranteed during complex maturation. The structure forma...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1023/a:1006826725056
更新日期:1997-03-01 00:00:00
abstract::Development of a rapid and accurate quantification method for the detection of microRNAs (miRNAs) has been desired, in particular, when they are differently expressed in normal and pathological conditions. However, various methods for the quantification of small non-coding RNAs as well as miRNAs have been described. T...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2442-x
更新日期:2013-05-01 00:00:00
abstract::High glycemic index diet can induce multiple diseases. Many research indicated that oxidative stress played important role in many pathological conditions. However, the impact of gene expression and dietary habit on oxidation process are still less clear. We used high-glucose diet to feed C57BL/6J mice for 4 weeks, me...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0039-9
更新日期:2010-12-01 00:00:00
abstract::Previous studies from our group have brought forward the concept of angiogenic regeneration during radiotherapy (RT), as a major cause of RT failure. This process was examined herein in rectal cancer patients undergoing preoperative chemo-radiotherapy. Out of 25 patients with stage II/III rectal adenocarcinoma, 15 had...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04668-z
更新日期:2019-04-01 00:00:00