Interaction between lysine-rich histones and DNA.

abstract：:Ku70 plays an important role in the DSBR (DNA double-strand breaks repair) and maintenance of genomic integrity. Genetic variations within human Ku70 have been demonstrated to be associated with increased risk of several types of cancers. In this hospital-based case-control study, we aimed to investigate whether a sin...

journal_title：Molecular biology reports

authors： He W,Luo S,Huang T,Ren J,Wu X,Shao J,Zhu Q

更新日期：2012-01-01 00:00:00

abstract：:The cytotoxic T lymphocyte-associated antigen 4 gene (CTLA4) has a crucial role in regulation of T cell proliferation and mediates T cell apoptosis by encoding the T cell receptor. Schizophrenia (SCZ) patients often have abnormalities in terms of the function and development of the immune system. The aim of the presen...

journal_title：Molecular biology reports

authors： Kordi-Tamandani DM,Vaziri S,Dahmardeh N,Torkamanzehi A

更新日期：2013-08-01 00:00:00

abstract：:A full length spermidine synthase (PgSPD) cDNA was isolated and characterized from the root of Panax ginseng C. A. Meyer. The cDNA was 1,188 nucleotides long and had an open reading frame of 1,002 bp with a deduced amino acid sequence of 333 residues. The calculated molecular mass of the matured protein is approximate...

journal_title：Molecular biology reports

authors： Parvin S,Kim YJ,Pulla RK,Sathiyamoorthy S,Miah MG,Kim YJ,Wasnik NG,Yang DC

更新日期：2010-02-01 00:00:00

abstract：:Small ubiquitin-like modifier (SUMO) participates in post-translational modification of various target proteins. SUMOylation is an important molecular regulatory mechanism for plants to respond to abiotic stress. In the present study, GmSUMO2 gene was isolated from soybean seedlings for further study because of the hi...

journal_title：Molecular biology reports

authors： Guo J,Wang S,Wang G,Lu R,Wang Y,Guo Y,Ji W

更新日期：2020-05-01 00:00:00

abstract：:MAPK kinase 1 interacting protein 1 (MAP2K1ip1) is an important scaffold proteins of the mitogen-activated protein kinase (MAPK) pathway that form an active signaling module and enhance the specificity and spatiality of MAPK signaling. In the present study, we identified and characterized a MAP2K1ip1 cDNA from tiger s...

journal_title：Molecular biology reports

authors： Yang L,Liu X,Huang J,Yang Q,Qiu L,Liu W,Jiang S

更新日期：2012-05-01 00:00:00

abstract：:The aim of the present study was construction of mammary gland specific expression vector for high level of human insulin (hINS) expression in transgenic buffalo for therapeutic use. We have constructed mammary gland specific vector containing human insulin gene and there expression efficiency was checked into in vitr...

journal_title：Molecular biology reports

authors： Kaushik R,Singh KP,Kumari A,Rameshbabu K,Singh MK,Manik RS,Palta P,Singla SK,Chauhan MS

更新日期：2014-09-01 00:00:00

abstract：:A nucleic acid sequence MC, encoding Momordica Chanrantia anti-hyperglycaemic peptide MC6 (accession: AAX06814) synthesized according to Escherichia coli preferred codons, was cloned and expressed in E. coli. Recombinant protein pQE8-MC (about 3.5 kDa) was purified and analyzed by 20% SDS-PAGE and western blot. It rev...

journal_title：Molecular biology reports

authors： Liu SX,Fu ZP,Mu RM,Hu ZB,Wang FJ,Wang XR

更新日期：2010-04-01 00:00:00

abstract：:A meta-analysis of randomized trials was performed to compare the efficacy of toremifene (TOR) with tamoxifen (TAM) in patients with breast cancer. A total of 4,768 intention-to-treat patients from nine randomized trials were identified, with 2,587 patients in TOR group and 2,181 patients in TAM group. The primary out...

journal_title：Molecular biology reports

authors： Ye QL,Zhai ZM

更新日期：2014-02-01 00:00:00

abstract：:RNase MRP is a ribonucleoprotein enzyme with a structure similar to RNase P. It is required for normal processing of precursor rRNA, cleaving it in the Internal Transcribed Spacer 1. ...

journal_title：Molecular biology reports

authors： Lindahl L,Zengel JM

更新日期：1995-01-01 00:00:00

abstract：:The majority of the genomic DNA sequence in mammalian and other higher organisms can be transcribed into abundant functional RNA transcripts, especially regulatory non-coding RNAs (ncRNAs) that are expressed in a developmentally and species-specific regulated manner. Here, we review various regulatory non-coding RNAs,...

journal_title：Molecular biology reports

authors： Huang B,Zhang R

更新日期：2014-06-01 00:00:00

abstract：:A cell-free system derived from Dictyostelium discoideum has been used to study the kinetics of inhibition of RNase P by puromycin, amicetin and blasticidin S. Detailed kinetic analysis showed that the type of inhibition of RNase P activity by puromycin is simple competitive, whereas the type of inhibition by amicetin...

journal_title：Molecular biology reports

authors： Kalavrizioti D,Vourekas A,Tekos A,Tsagla A,Stathopoulos C,Drainas D

更新日期：2003-03-01 00:00:00

abstract：:Dipeptidyl peptidase III (DPP III) is an emerging biomarker of human cancers. Expression, specificity, and function of human DPP III (hDPP III) mRNA variant I (V-I), II (V-II), and III (V-III) are poorly understood. Here, we investigated expression of these variants in multiple human tumor derived cell lines. DNA sequ...

journal_title：Molecular biology reports

authors： Prajapati SC,Chauhan SS

更新日期：2016-06-01 00:00:00

abstract：:The relationship between genetic polymorphisms of glutathione S-transferase (GST) and the development of glioma has been investigated in several epidemiologic studies. However these studies report inconsistent results. In order to quantitatively summarise the evidence for such a relationship, a meta-analysis is conduc...

journal_title：Molecular biology reports

authors： Fan Z,Wu Y,Shen J,Zhan R

更新日期：2013-02-01 00:00:00

abstract：:Birch (Betula platyphylla), an eminent tree species in Northeast and Inner Mongolia of China, has been widely used in architecture, furniture, and paper making in recent years. In order to retrieve genes involved in early development of B. platyphylla male inflorescence, RNA populations extracted from early and late d...

journal_title：Molecular biology reports

authors： Xing L,Liu XM

更新日期：2012-02-01 00:00:00

abstract：:The pathogenesis of systemic lupus erythematosus (SLE) is complex, with several susceptibility genes and environmental factors involved in its development and clinical manifestation. Currently, there is a great amount of interest in the identification of biomarkers, as cytokines, that can quantify the susceptibility o...

journal_title：Molecular biology reports

authors： da Silva HD,da Silva AP,da Silva HA,Asano NM,Maia Mde M,de Souza PR

更新日期：2014-01-01 00:00:00

abstract：:The blue swimming crab (Portunus pelagicus) is a valuable marine fishery resource in Indo-West Pacific Ocean. So far, rare genetic resource of this species is available. In this report, the restriction-site associated DNA (RAD) approach was employed to mine the genomic information and identify molecular markers in P. ...

journal_title：Molecular biology reports

authors： Wu Q,Miao G,Li X,Liu W,Ikhwanuddin M,Ma H

更新日期：2018-12-01 00:00:00

abstract：:A number of regions designated as RD1-RD16 (region of difference) and encompassing 129 open reading frames have been identified between Mycobacterium tuberculosis and Mycobacterium bovis on the one hand and Bacillus Calmette-Guérin on the other. Identification of T cell epitopes from this set of proteins may serve to ...

journal_title：Molecular biology reports

authors： Wang J,Zhang H,Wang H

更新日期：2010-04-01 00:00:00

abstract：:In the Eastern province of Saudi Arabia, thalassemia is highly common. Data on the effect of alpha globin gene variation on the concentration of iron on transfusion dependent Saudis are scanty. A total of 166 transfusions dependent β-thalassemia were included in this study to understand association between the alpha g...

journal_title：Molecular biology reports

authors： AbdulAzeez S,Almandil NB,Naserullah ZA,Al-Jarrash S,Al-Suliman AM,ElFakharay HI,Borgio JF

更新日期：2020-01-01 00:00:00

abstract：:We report here a cDNA and its deduced amino acid sequence encoding a cathepsin D-like, aspartic protease from Chlamys farreri (denoted as CfCD) by expressed sequence tag and rapid amplification of cDNA ends techniques. The cDNA of CfCD consisted of 1,810 nucleotides with a canonical polyadenylation signal sequence AAT...

journal_title：Molecular biology reports

authors： Li C,Zhang H,Li L,Song L

更新日期：2010-03-01 00:00:00

abstract：:Various efforts made to stop the deadly epidemic of HIV since its discovery in 1983 remain unsuccessful and this virus still continues to claim the lives of millions of individuals every year. The viral effect in the cell is complicated and the overall disease outcome is the result of interaction between a few viral p...

journal_title：Molecular biology reports

authors： Sobti RC,Berhane N,Mehedi SA,Kler R,Hosseini SA,Kuttiat V,Wanchu A

更新日期：2010-01-01 00:00:00

abstract：:Scytovirin is a lectin isolated from the cyanobacterium Scytonema varium that has shown activity against HIV, SARS coronavirus and Zaire Ebola virus. Its 95 amino acids are divided into two structural domains (SD), the first spanning amino acids 1-48 (SD1) and the second 49-95 (SD2). Interestingly, the domains are nea...

journal_title：Molecular biology reports

authors： Siqueira AS,Lima ARJ,de Souza RC,Santos AS,Vianez Júnior JLDSG,Gonçalves EC

更新日期：2017-08-01 00:00:00

abstract：:To investigate whether Annexin 1 can protect a retinal ganglion cells line (RGC-5) from apoptosis as induced by serum deprivation. Annexin 1 location in RGC-5 cells was determined using an indirect immunofluorescent assay. Expression of Annexin 1 in RGC-5 cultures deprived of serum for 0, 2 days was semi-quantified by...

journal_title：Molecular biology reports

authors： Sun J,Shao Z,Yang Y,Wu D,Zhou X,Yuan H

更新日期：2012-05-01 00:00:00

abstract：:Beta(2)-microglobulin (beta(2)m), a protein necessary for proper folding, peptide binding, and surface display of class I antigens plays an important role in immune response. The full-length cDNA containing beta(2)m was cloned from the spleen cDNA library of large yellow croaker Pseudosciaena crocea (Pscr-beta ( 2 ) m...

journal_title：Molecular biology reports

authors： Yu S,Chen X,Ao J

更新日期：2009-09-01 00:00:00

abstract：:Geranylgeranyl diphosphate synthase (GGPPS) [EC 2.5.1.29] catalyzes the biosynthesis of geranylgeranyl diphosphate (GGPP), which is a key precursor for diterpenes such as taxol. Herein, a full-length cDNA encoding GGPPS (designated as CgGGPPS) was cloned and characterized from hazel (Corylus avellana L. Gasaway), a ta...

journal_title：Molecular biology reports

authors： Wang Y,Miao Z,Tang K

更新日期：2010-10-01 00:00:00

abstract：:The leaf primordium derives from the peripheral zone of shoot apical meristem. During the formation of leaf primordia, they need to establish the proximodistal, mediolateral, and ab/adaxial axes. Among these axes, the ab/adaxial axis might be the most important. ASYMMETRIC LEAVES2 (AS2) gene is a member of AS2/LATERAL...

journal_title：Molecular biology reports

authors： Sun SB,Song JP,Meng LS

更新日期：2012-04-01 00:00:00

abstract：:One of the most crucial steps for preventing viral pandemics is the early detection of the causative virus on site. Various molecular and immunological approaches have been developed for virus detection. In this study, we investigated the utility of the recently introduced convection polymerase chain reaction (cPCR) p...

journal_title：Molecular biology reports

authors： Lee MH,Song KY,Hwang HJ,Kim JH,Hwang I

更新日期：2019-10-01 00:00:00

abstract：:The treatment of anaplastic astrocytoma (AA) is controversial. New chemotherapeutic approaches are needed for AA treatment. Temozolomide (TMZ) is one of the chemotherapeutic drugs for the treatment of AA. The cytotoxic effects of TMZ can be removed by the MGMT (O(6)-methylguanine-DNA methyltransferase) enzyme. Then, c...

journal_title：Molecular biology reports

authors： Ugur HC,Taspinar M,Ilgaz S,Sert F,Canpinar H,Rey JA,Castresana JS,Sunguroglu A

更新日期：2014-02-01 00:00:00

abstract：:The multidrug and toxic compound extrusion (MATE) protein family is a newly discovered family of secondary transporters that extrude metabolic waste and a variety of antibiotics out of the cell using an electrochemical gradient of H+ or Na+ across the membrane. The main function of MATE gene family is to participate i...

journal_title：Molecular biology reports

authors： Li Y,He H,He LF

更新日期：2019-02-01 00:00:00

abstract：:Acute and chronic viral hepatitis infections are corresponding to increase the risk of different types of hematological malignancies especially with leukemia. In this study the serological and molecular markers of hepatitis viruses were evaluated in patients with different types of leukemia in comparing with control g...

journal_title：Molecular biology reports

authors： Mirzaee M,Yaghobi R,Ramzi M,Roshan Nia M

更新日期：2012-02-01 00:00:00

abstract：:Regulation of the sumoylation system at the level of gene expression has not yet been explored. To begin to define transcriptional regulatory features, the promoter region for the SUMO1 gene was cloned from human genomic DNA and characterized. Initially, a 532 base pair fragment upstream of and including the predicted...

journal_title：Molecular biology reports

authors： Nanos-Webb A,Deyrieux A,Bian XL,Rosas-Acosta G,Wilson VG

更新日期：2010-03-01 00:00:00