Abstract：
:20S proteasomes are large (700 kDa) proteinase complexes which form the central catalytic core of larger complexes (26S proteasomes or PA28-20S complexes) formed by association with regulatory particles. These larger complexes are involved in diverse regulatory processes in the cell including cyclin breakdown, proteolytic control of transcription factors and other short-lived regulatory proteins, and antigen presentation. In order to carry out these diverse functions the proteasome complexes must be held under tight regulatory control. The early recognition of potential phosphorylation sites in a number of core and regulatory subunits suggested that some control of the complexes activities may be via phosphorylation. We have investigated the role of phosphorylation in determining proteasome localization, activities and association with regulatory complexes.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Bose S,Mason GG,Rivett AJdoi
10.1023/a:1006969517958keywords:
subject
Has Abstractpub_date
1999-04-01 00:00:00pages
11-4issue
1-2eissn
0301-4851issn
1573-4978journal_volume
26pub_type
杂志文章,评审abstract：:The aim of this study was to determine whether the Fcγ receptors (FCGRs) polymorphisms confer susceptibility to periodontitis in ethnically different populations. We did a literature search using PubMed and Embase, and conducted a meta-analysis on the associations between the FCGR2A H131R (rs1801274), FCGR3A F158V (rs...
journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11033-013-2599-y
更新日期：2013-08-01 00:00:00
abstract：:Ribonuclease P (RNase P) is a key enzyme involved in tRNA biosynthesis. It catalyses the endonucleolytic cleavage of nearly all tRNA precursors to produce 5'-end matured tRNA. RNase P activity has been found in all organisms examined, from bacteria to mammals. Eubacterial RNase RNA is the only known RNA enzyme which f...
journal_title：Molecular biology reports
pub_type： 杂志文章,评审
doi：10.1007/BF00988718
更新日期：1995-01-01 00:00:00
abstract：:The aim of this study was to explore whether the cytotoxic T lymphocyte antigen-4 (CTLA-4) +49 A/G polymorphism confers susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted on the associations between CTLA-4 +49 A/G polymorphism and RA using; 1) allele contrast, 2) the recessive model, 3) the dom...
journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11033-011-1364-3
更新日期：2012-05-01 00:00:00
abstract：:Growing data supported that epigenetic modifications, including altered DNA methylation have a potential role in the pathogenesis of autoimmune thyroid diseases (AITD). In the present study we aimed to investigate the methylation status of ICAM-1 gene promoter in patients with AITD. Forty patients with Graves' disease...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-019-04990-6
更新日期：2019-10-01 00:00:00
abstract：:An improvement in the detection by nucleic acid hybridization of size-fractionated RNA immobilized to nylon-based membranes is described. Electrophoretic transfer of RNA to nylon membranes permits a quantitative determination of different RNA transcripts on the same membrane after sequential hybridization using differ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/BF00364822
更新日期：1986-01-01 00:00:00
abstract：:Maize (Zea mays L.) is an important model plant with an important role in agriculture and national economies all over the world. The optimum growth temperature of maize is between 25 and 28 °C. At temperatures below 12 °C, maize is vulnerable to damage by chilling stress. MYB transcription factors play important roles...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-019-04840-5
更新日期：2019-08-01 00:00:00
abstract：:Chemerin, as a new member of adipokines family, is highly expressed in adipose tissue in rodent and its expression increases with obesity. Moreover, chemerin has been reported to have significant relationship with metabolic syndrome and insulin sensitivity. Here, the gene encoding chemerin from Xiang pig was cloned. T...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-0934-8
更新日期：2012-02-01 00:00:00
abstract：:Because of the importance of androgens to prostate cancer (PCa) development, several candidate genes along androgen pathway have been under intensive study. Given the role of the molecular chaperone HSP70 in the regulation of the androgen receptor (AR) transactivation function, we first chose to explore the associatio...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-007-9107-1
更新日期：2008-09-01 00:00:00
abstract：:Interleukin-8 (IL8) polymorphisms have been implicated in several cancers, but their roles in the pathogenesis of hepatocellular carcinoma (HCC) are largely unknown. The present study was designed to explore the association between IL8 polymorphism and the risk of HCC in a Chinese population. Four single nucleotide po...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2993-5
更新日期：2014-03-01 00:00:00
abstract：:Heterogeneous nuclear ribonucleoprotein particles (HnRNP) were separated in metrizamide density gradients, into two fractions migrating to 1.31 g ml-1 and 1.18 g ml-1, respectively. Proteins associated with each of these fractions were analysed by SDS-acrylamide gel electrophoresis. It is shown that the whole proteins...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/BF00643481
更新日期：1977-03-01 00:00:00
abstract：:Common bean is gaining acceptance as one of the most valuable major food consumed worldwide owing to innumerable nutritional and therapeutic benefits. Comparatively less productivity in underdeveloped countries encouraged us to proceed for QTL mining of yield traits in common bean. Heretofore, multiple yield associate...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05735-6
更新日期：2020-09-01 00:00:00
abstract：:Latexin, a carboxypeptidase A inhibitor, is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat. It is used as a molecular marker for the regional specification of the neocortex. In this study, a cDNA was isolated from a human fetal brain cDNA library. The cDNA (LXN) cont...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1023/a:1010971219806
更新日期：2000-01-01 00:00:00
abstract：:The oriental melon (Cucumis melo var. makuwa), called 'chamoe' in Korean, is a popular fruit crop cultivated mainly in Asia and a high-market value crop in Korea. To provide molecular breeding resources for chamoe, we developed and characterized genomic SSR markers from the preliminary Illumina read assemblies of Gotg...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2803-0
更新日期：2013-12-01 00:00:00
abstract：:Telomerase activity is repressed in normal human somatic cells, but is activated in most cancers, suggesting that telomerase may be an important target for cancer therapy. Agents that interact selectively with telomerase are anticipated to exert specific action on cancer cells. In this study, we evaluated maleimide de...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1757-y
更新日期：2012-09-01 00:00:00
abstract：:This experiment was conducted to explore the biological functions of myogenin (MyoG) gene. MyoG gene was cloned from genome of Hu sheep by overlap extension PCR. Then, pEGFP-C1-MyoG and pcDNA3.0-MyoG fusion expression vectors was constructed and pEGFP-C1-MyoG vector had been transfected into NIH-3T3 cells by liposomes...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2945-0
更新日期：2014-02-01 00:00:00
abstract：:In order to extend the knowledge of rabies pathogenesis, a two-dimensional electrophoresis/mass spectrometry based postmortem comparative proteomics analysis was carried out on human brain samples. Alteration in expression profile of several proteins was detected. Proteins related to cytoskeleton, metabolism, proteaso...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2759-0
更新日期：2013-11-01 00:00:00
abstract：:ATP-binding cassette transporter A1 (ABCA1) modulates plasma levels of high density lipoprotein (HDL), a cardiovascular protecting factor. Tree shrew was considered to be an animal protected from atherosclerosis characterized by high proportion of HDL in plasma. The cDNA clones and expression of tree shrew ABCA1 was i...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-007-9199-7
更新日期：2009-03-01 00:00:00
abstract：:HSG1 (Heat shock-induced gene 1) is one of the high-temperature-induced proteins in grapevine. Sequence analysis has demonstrated that HSG1 is a grape Bcl-2-associated athanogene (BAG) that contains IQ and BAG domains in its sequence. HSG1 expression was not detected in leaves without heat treatment, while tendrils, s...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-1224-1
更新日期：2012-04-01 00:00:00
abstract：:The antibacterial and anticancerous properties of EMTAHDCA have already been reported in our previous study. However, mode of action of EMTAHDCA is still elusive. The present study was aimed to investigate the molecular targets in Escherichia coli and spleen of lymphoma-bearing mice in response to cyanocompound 9-ethy...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-019-04659-0
更新日期：2019-06-01 00:00:00
abstract：:Our previous study revealed that CRB3 protein expression was reduced in clear cell renal cell carcinoma (ccRCC) and was associated with TNM stage, pathological grade, and poor prognosis of ccRCC. This study aimed to investigate if DNA methylation of CRB3 decreases its expression, subsequently leading to the progressio...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-019-04892-7
更新日期：2019-08-01 00:00:00
abstract：:Growth-regulating factor (GRF) is an important protein in GA-mediated response, with key roles in plant growth and development. However, it is not known whether or how the GRF proteins in citrus to regulate organ size. In this study, nine citrus GRF genes (CsGRF1-9) were validated from the 'Anliu' sweet orange (AL, Ci...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-016-4048-1
更新日期：2016-10-01 00:00:00
abstract：:Cellular cholesterol homeostasis is controlled by the sterol-regulatory element binding transcription factors (SREBFs) that are activated by an SREBF cleavage-activating protein (SCAP). SREBF-2 1784G > C single nucleotide polymorphism (SNP, rs2228314) and SCAP 2386A > G variant (rs12487736) are associated with early o...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-9951-2
更新日期：2011-06-01 00:00:00
abstract：:The Great-billed Seed-finch, Sporophila maximiliani, is a threatened neotropical bird that has declined mainly due to illegal trapping, with very few records in the wild in the last two decades. Despite the existence of a considerable captive population that could be used for reintroductions into the wild, many indivi...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-018-4377-3
更新日期：2018-12-01 00:00:00
abstract：:Matrix metalloproteinases (MMPs) are implicated in atherosclerosis evolution into a coronary artery disease (CAD). They could be used as biomarkers for a predictive approach when they are studied simultaneously. We aim in our study to demonstrate prospectively in patients with history of CAD that MMPs level is linked ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-019-04914-4
更新日期：2019-10-01 00:00:00
abstract：:Sustainable agriculture requires management of insect pests through resistance development. The biological potential of Cry toxins and Vip protein, derived from Bacillus species, is widely recognized in this context. The identification, evaluation of new insecticidal protein genes with different mode of action and ent...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05355-0
更新日期：2020-04-01 00:00:00
abstract：:An ORF having a potential to code for a polypeptide of 79 amino acids has been identified within 993 nt sequence of 2 kb EcoRI-W fragment of Spodoptera litura nucleopolyhedrovirus (SpltNPV-I). Nucleotide and deduced amino acid sequence analyses showed its identity with the ubiquitin homologue of eukaryotes (79-80%), M...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-005-0887-x
更新日期：2004-12-01 00:00:00
abstract：:LNX (Ligand of Numb-protein X) was originally isolated as a binding partner to the cell-fate Determinant Numb during development, and then identified to act as a RING finger-type E3 ubiquitin ligase for the ubiquitylation and degradation of Numb. LNX contains 4 PDZ domains which are proved to play a central role in or...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-009-9754-5
更新日期：2010-06-01 00:00:00
abstract：:The suppressors of cytokine signaling (SOCS) proteins are originally identified as negative regulators of cytokine-activated Janus kinase/signal transducers and activators of transcription signaling pathway, but increasing evidence reveals that SOCS proteins play an important role in the development of type 2 diabetes...
journal_title：Molecular biology reports
pub_type： 杂志文章,评审
doi：10.1007/s11033-014-3079-8
更新日期：2014-01-01 00:00:00
abstract：:The GRAS gene family is a family of transcription factors that regulates plant growth and development. Despite being well-studied in many plant species, little is known about this gene family in orchardgrass (Dactylis glomerata L.), one of the top four economically important perennial forage grasses cultivated worldwi...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05279-9
更新日期：2020-03-01 00:00:00
abstract：:Mitochondrial dysfunction plays a crucial role in the central pathogenesis of insulin resistance and type 2 diabetes mellitus. Macrophages play important roles in the pathogenesis of insulin resistance. Lauric acid is a 12-carbon medium chain fatty acid (MCFA) found abundantly in coconut oil or palm kernel oil and it ...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-06019-9
更新日期：2020-12-01 00:00:00
