Suppressors of cytokine signaling (SOCS) and type 2 diabetes.

Abstract:

:The suppressors of cytokine signaling (SOCS) proteins are originally identified as negative regulators of cytokine-activated Janus kinase/signal transducers and activators of transcription signaling pathway, but increasing evidence reveals that SOCS proteins play an important role in the development of type 2 diabetes involving regulation of the insulin signaling and pancreatic β-cell function, and that SOCS are promising to be the targets for the treatment of type 2 diabetes. In this review, we focus on the emerging role for SOCS and the potential drugs targeting SOCS for type 2 diabetes.

journal_name

Mol Biol Rep

authors

Feng X,Tang H,Leng J,Jiang Q

doi

10.1007/s11033-014-3079-8

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

2265-74

issue

4

eissn

0301-4851

issn

1573-4978

journal_volume

41

pub_type

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