Abstract:
:The suppressors of cytokine signaling (SOCS) proteins are originally identified as negative regulators of cytokine-activated Janus kinase/signal transducers and activators of transcription signaling pathway, but increasing evidence reveals that SOCS proteins play an important role in the development of type 2 diabetes involving regulation of the insulin signaling and pancreatic β-cell function, and that SOCS are promising to be the targets for the treatment of type 2 diabetes. In this review, we focus on the emerging role for SOCS and the potential drugs targeting SOCS for type 2 diabetes.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Feng X,Tang H,Leng J,Jiang Qdoi
10.1007/s11033-014-3079-8subject
Has Abstractpub_date
2014-01-01 00:00:00pages
2265-74issue
4eissn
0301-4851issn
1573-4978journal_volume
41pub_type
杂志文章,评审abstract::Molecular detection of Giardia duodenalis by polymerase chain reaction (PCR) is difficult in faecal samples due to inhibitors that contaminate DNA preparations, or due to low cyst concentrations. In order to eliminate inhibitors, improve cyst recovery and molecular detection of G. duodenalis, different types of water,...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05224-5
更新日期:2020-02-01 00:00:00
abstract::Chrysanthemum indicum L. is a traditional oriental medicinal herb prepared as a tea from flowers that have been used in China and South Korea since ancient times. It has a long history in the treatment of hypertension, inflammation, and respiratory diseases. Among Chrysanthemum species, C. indicum has more active chem...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05844-2
更新日期:2020-10-01 00:00:00
abstract::The Cichlid fish Sarotherodon melanotheron is typically found in West and Central African estuaries and lagoons. It represents a good candidate for promoting tilapia farming in brackish waters. Understanding the genetic diversity in its populations from the hydrographical basins of Southern Benin is primordial before ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4354-x
更新日期:2018-12-01 00:00:00
abstract::Scytovirin is a lectin isolated from the cyanobacterium Scytonema varium that has shown activity against HIV, SARS coronavirus and Zaire Ebola virus. Its 95 amino acids are divided into two structural domains (SD), the first spanning amino acids 1-48 (SD1) and the second 49-95 (SD2). Interestingly, the domains are nea...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-017-4116-1
更新日期:2017-08-01 00:00:00
abstract::Fusarium head blight (FHB), predominantly caused by Fusarium graminearum, is a destructive disease that poses a serious threat to wheat (Triticum aestivum L.) production around the world. A suppression subtractive hybridization (SSH) cDNA library was constructed from F. graminearum infected spikes of a resistant Belgi...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1823-5
更新日期:2012-10-01 00:00:00
abstract::Membrane-bound Δ9 desaturase perform oxygenated desaturation reactions to insert the first double bonds within fatty acyl chains between C9 and C10 positions of most saturated substrates. Arthrospira platensis, a blue green microalga, is an important source of polyunsaturated fatty acids (PUFA) such as oleic, linoleic...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4333-2
更新日期:2018-12-01 00:00:00
abstract::Nowadays, lower post-release survivorship of hatchery-reared fish in natural aquatic bodies has attained great attention and research is in progress to determine the reasons for their higher mortality. It is assumed that hatchery rearing environments negatively affect the physiological stress response of the fish. Thu...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05574-5
更新日期:2020-07-01 00:00:00
abstract::Hereditary hearing loss is a genetically heterogeneous disorder. Mutations in connexin 26 (CX26), are a major cause in many countries and are largely dependent on ethnic groups. The purpose of our study was to evaluate the prevalence of GJB2 mutations among affected individuals from south of Iran. Fifty patients prese...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1929-9
更新日期:2012-12-01 00:00:00
abstract::It has been suggested that the estrogen receptor alpha (ERα) and vitamin D receptor (VDR) genes as possibly implicated in reduced bone mineral density (BMD) in osteoporosis. The present study investigated the relation of ERα PvuII/XbaI polymorphisms and VDR FokI/TaqI polymorphisms with BMD in Turkish postmenopausal wo...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1496-0
更新日期:2012-06-01 00:00:00
abstract::Melanotransferrin (MTf), a member of the transferrin families, plays an important role in immune response. But the research about MTf in sea cucumber is limited till now. In this study, the Melanotransferrin (Aj-MTf) gene was firstly cloned and characterized from the sea cucumber Apostichoupus japonicus by reverse tra...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3243-1
更新日期:2014-06-01 00:00:00
abstract::Experiments with 5'-azacytidine and hematopoietic growth factor approved for the transformation of human mesenchymal cells into hematopoietic cells have demonstrated that cell fate can be dramatically altered by changing the epigenetic state of cells. Here, we demonstrate that umbilical cord-derived human mesenchymal ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3351-y
更新日期:2014-07-01 00:00:00
abstract::Proton beam therapy is widely used for treating brain tumor. Despite the efficacy of treatment, the use of this therapy has met some limitations associated with possible damage to normal brain tissues located beyond the tumor site. In this context, the exploration of the harmful effects of protons on the normal brain ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05491-7
更新日期:2020-06-01 00:00:00
abstract::The present study aimed to obtain analgesic-antitumor peptide (AGAP) gene expression in plants. The analgesic-antitumor peptide (AGAP) gene was from the venom of Buthus martensii Karsch. Previous studies showed that AGAP has both analgesic and antitumor activities, suggesting that AGAP would be useful in clinical situ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-008-9277-5
更新日期:2009-05-01 00:00:00
abstract::Birch (Betula platyphylla), an eminent tree species in Northeast and Inner Mongolia of China, has been widely used in architecture, furniture, and paper making in recent years. In order to retrieve genes involved in early development of B. platyphylla male inflorescence, RNA populations extracted from early and late d...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0818-y
更新日期:2012-02-01 00:00:00
abstract::Prkar1b gene encodes regulatory type I, beta subunit (RIβ) of cAMP dependent protein kinase A in mouse. Among the various isoforms of regulatory and catalytic subunits that comprise mammalian PKA, RIβ subunit is considered to be one of the important subunits for neuronal functions. This is involved in multiple forms o...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1108-4
更新日期:2012-04-01 00:00:00
abstract::Potato (Solanum tubersosum L.) is relatively vulnerable to abiotic stress conditions such as drought, but the tolerance mechanisms to such stress in potato are largely unknown. To gain insight into the transcriptome dynamics that are associated with drought stress, genome-wide gene expression profile was conducted by ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2886-7
更新日期:2014-01-01 00:00:00
abstract::The Italian National Reference Center for Echinococcosis (CeNRE, Sassari, Italy) set up a diagnostic protocol of "one-step-PCR" useful for the detection of E. granulosus sensu stricto (E.g.s.s.) and the identification of its genotype (G1-G3). The purpose of this work was to perform the validation of the "PCR E.g.s.s."...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04625-w
更新日期:2019-04-01 00:00:00
abstract::Myocilin (MYOC) gene is expressed in many ocular tissues, including the trabecular meshwork, a specialized eye tissue essential in regulating intraocular pressure. Many mutations in MYOC have been detected in primary open-angle glaucoma (POAG). We investigated whether MYOC mutations contributed to the susceptibility t...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9667-3
更新日期:2010-01-01 00:00:00
abstract::Cold stress adversely affects the growth and development of seedling of spring soybean. Revealing responses in seedling to cold stress at proteomic level will help us to breed cold-tolerant spring soybean cultivars. In this study, to understand the responses, a proteomic analysis on the leaves of seedlings of one cold...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3803-4
更新日期:2015-03-01 00:00:00
abstract::Evidence indicates that both S-adenosylmethionine (SAMe) metabolism and intramuscular fat are associated with insulin resistance and type II diabetes. However, it is still unknown whether SAMe have effects on intramuscular adipogenesis. The present study investigated the roles of SAMe in the adipogenic differentiation...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9893-8
更新日期:2010-10-01 00:00:00
abstract::Previous studies from our group have brought forward the concept of angiogenic regeneration during radiotherapy (RT), as a major cause of RT failure. This process was examined herein in rectal cancer patients undergoing preoperative chemo-radiotherapy. Out of 25 patients with stage II/III rectal adenocarcinoma, 15 had...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04668-z
更新日期:2019-04-01 00:00:00
abstract::TopBP1 protein displays structural as well as functional similarities to BRCA1 and is involved in DNA replication, DNA damage checkpoint response and transcriptional regulation. Aberrant expression of TopBP1 may lead to genomic instability and can have pathological consequences. In this study we aimed to investigate e...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1622-z
更新日期:2012-07-01 00:00:00
abstract::The aim of this work was to sequence the promoter region of β-lactoglobulin (BLG) gene in four sheep breeds, in order to identify polymorphisms, infer and analyze haplotypes, and phylogenetic relationship among the Valle del Belice breed and the other three breeds considered as ancestors. Sequencing analysis and align...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0794-2
更新日期:2012-01-01 00:00:00
abstract::Caspases have been demonstrated to possess important functions in apoptosis and immune system in vertebrate. But there is less information reported on the oyster larval development. In the present work, two full-length molluscan caspase genes, named Cacaspase-2 and Cacaspase-3, were characterized for the first time fr...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3833-y
更新日期:2015-05-01 00:00:00
abstract::The Fas gene polymorphisms -670A/G (rs1800682) and -1377G/A (rs2234767) have been shown to be associated with systemic lupus erythematosus (SLE), but findings are not consistent. To clarify this point, a meta-analysis was performed. We searched PubMed, CNKI, CBM and Wanfang database. Meta-odds ratios (ORs) and 95 % co...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-012-2075-0
更新日期:2013-01-01 00:00:00
abstract::We characterized a panel of human RNase MRP/RNase P autoantibodies by immunoprecipitation, immunodepletion, immunoaffinity purification and immunoblotting. We report on the protein spectrum that is recognized by RNase MRP/RNase P autoantibodies. We also describe another, related patient serum that based on these assay...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/a:1006878511162
更新日期:1998-03-01 00:00:00
abstract::The Editor-in-Chief has decided to retract this article [1]. The article shows significant overlap with two prior publications by the same authors [2, 3], without providing the due citation and attribution. ...
journal_title:Molecular biology reports
pub_type: 已发布勘误,撤回出版物
doi:10.1007/s11033-019-04760-4
更新日期:2019-10-01 00:00:00
abstract::Large-scale random cDNA sequencing projects have been started for several organisms and are a valuable tool for the analysis of quantitative and qualitative aspects of gene expression. However, the reliability of the obtained data is limited as most of the clones are only partially analysed on one strand. As a consequ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00424432
更新日期:1996-01-01 00:00:00
abstract::Many case-control studies have investigated the role of TGF-β1 gene +869C/T promoter polymorphism in autoimmune diseases, but the results are inconsistent. To clarify this point, we performed a meta-analysis based on all available studies in Pubmed, Elsevier Science Direct, Google Searching, Chinese Biomedical Literat...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-013-2577-4
更新日期:2013-08-01 00:00:00
abstract::Polyomavirus JC (JCPyV) is a ubiquitous human neurotropic virus that can cause progressive multifocal leukoencephalopathy (PML), sometimes as a consequence of drug treatment for disabling diseases, including Multiple Sclerosis. JCPyV expresses microRNAs (miRNAs), and in particular miR-J1-5p, but at now we have limited...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05862-0
更新日期:2020-11-01 00:00:00