当前位置： SCI文献检索 > MOLECULAR BIOLOGY REPORTS期刊下所有文献 > LNX (Ligand of Numb-protein X) interacts with RhoC, both of which regulate AP-1-mediated transcriptional activation.

LNX (Ligand of Numb-protein X) interacts with RhoC, both of which regulate AP-1-mediated transcriptional activation.

Abstract：

:LNX (Ligand of Numb-protein X) was originally isolated as a binding partner to the cell-fate Determinant Numb during development, and then identified to act as a RING finger-type E3 ubiquitin ligase for the ubiquitylation and degradation of Numb. LNX contains 4 PDZ domains which are proved to play a central role in organizing diverse cell signaling assemblies. A yeast two-hybrid screening was used to identify LNX as a potential binding partner for RhoC. RhoC, a member of the Ras family of small GTPases, promotes reorganization of the actin cytoskeleton and regulation of cell shape, attachment, and motility. The interaction between LNX and RhoC in mammalian cells was identified by co-immunoprecipitation assays, and the efficient binding required the first PDZ domain of LNX. LNX and RhoC were further colocalized with each other in mammalian cells, in which RhoC changed its sublocalization from cytoplasm to nucleus when co-transferred with LNX. Furthermore, co-expression of RhoC reduced the transcriptional activity of AP-1, which was up-regulated by over-expression of LNX alone. These results suggest that LNX and RhoC might be part of a larger protein complex that would have important functions in signaling transduction about regulating the transcriptional activities of AP-1.

journal_name

Mol Biol Rep

journal_title

Molecular biology reports

authors

Zheng D,Sun Y,Gu S,Ji C,Zhao W,Xie Y,Mao Y

doi

10.1007/s11033-009-9754-5

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

2431-7

issue

5

eissn

0301-4851

issn

1573-4978

journal_volume

37

pub_type

杂志文章

相关文献

MOLECULAR BIOLOGY REPORTS文献大全
  • Assessment of the expression level of miRNA molecules using a semi-quantitative RT-PCR approach.

    abstract：:Type 2 diabetes is one of the most prevalent diseases, which increases resistance to insulin in target tissues. The measurement of miRNAs quantity is a molecular approach for diagnosis of diabetes. miRNAs are small non-coding RNA strings of 21-23 long nucleotides that act as inhibitors in proteins translation. Several...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-04959-5

    authors： Andoorfar S,Hosseini Tafreshi SA,Rezvani Z

    更新日期：2019-10-01 00:00:00

  • Blocking P2X7 receptor ameliorates oxidized LDL-mediated podocyte apoptosis.

    abstract：:The purpose of our research is to elucidate whether oxLDL activates P2X7R in cultured human podocytes and if the activation of P2X7R leads to podocyte apoptosis. Additionally, we explore the underlying mechanism involved in podocyte apoptosis. Immortalized human podocytes were incubated with oxLDL (80 µg/ml), P2X7R an...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-04823-6

    authors： Zhu Y,Li Q,Xun W,Chen Y,Zhang C,Sun S

    更新日期：2019-08-01 00:00:00

  • Combined effects of niacin and chromium treatment on vascular endothelial dysfunction in hyperlipidemic rats.

    abstract：:Combined treatment with niacin and chromium has been found to have a protective effect against oxidative damage to different tissues of hyperlipidemic rats. But its effects on vascular endothelial dysfunction are less clear. This study was performed to investigate the effect of combined treatment with niacin and chrom...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-008-9309-1

    authors： Niu N,Yu YH,Wang Y,Wang LJ,Li Q,Guo LM

    更新日期：2009-07-01 00:00:00

  • Studies on the interaction between benzophenone and bovine serum albumin by spectroscopic methods.

    abstract：:The interaction between benzophenone (BP) and bovine serum albumin (BSA) was investigated by the methods of fluorescence spectroscopy combined with UV-Vis absorption and circular dichroism (CD) measurements under simulative physiological conditions. The experiment results showed that the fluorescence quenching of BSA ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-010-0380-z

    authors： Zhang YZ,Zhang J,Li FF,Xiang X,Ren AQ,Liu Y

    更新日期：2011-04-01 00:00:00

  • PMS1 from Arabidopsis thaliana: optimization of protein overexpression in Escherichia coli.

    abstract：:One of the major limitations when attempting to obtain detailed biochemical, biophysical and immunological characterization of plant DNA mismatch repair proteins is their extremely low abundance in vivo under normal growth conditions. An initial analysis of PMS1 transcript level in various Arabidopsis thaliana tissues...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-010-0203-2

    authors： Galles C,Gomez RL,Spampinato CP

    更新日期：2011-02-01 00:00:00

  • An integrated pathway system modeling of Saccharomyces cerevisiae HOG pathway: a Petri net based approach.

    abstract：:Biochemical networks comprise many diverse components and interactions between them. It has intracellular signaling, metabolic and gene regulatory pathways which are highly integrated and whose responses are elicited by extracellular actions. Previous modeling techniques mostly consider each pathway independently with...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-012-2153-3

    authors： Tomar N,Choudhury O,Chakrabarty A,De RK

    更新日期：2013-02-01 00:00:00

  • Vector-free in vivo trans-determination of adult hepatic stem cells to insulin-producing cells.

    abstract：:A reduction in the number of functional β-cells is the central pathological event in diabetes. Liver and ventral pancreas differentiates simultaneously in the same general domain of cells within embryonic endoderm. In addition, the precursor cell population being bi-potential may be targeted for either pancreas or liv...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-04870-z

    authors： Sarkar S,Munshi C,Chatterjee S,Mukherjee S,Bhattacharya S

    更新日期：2019-10-01 00:00:00

  • Optimization of conditions for expression of recombinant interferon-γ in E.coli.

    abstract：:Interferon gamma (IFN-γ) is an important immunoregulatory cytokine that has a central role against viral and bacterial infections. In this study, the cDNA encoding 141 amino acids of mature IFN-γ from mice splenocytes was cloned in a prokaryotic expression vector pQE 30. Optimization of expression conditions resulted ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-014-3537-3

    authors： Kumar M,Singh M,Singh SB

    更新日期：2014-10-01 00:00:00

  • Ultrasound-mediated microbubble destruction facilitates gene transfection in rat C6 glioma cells.

    abstract：:The goal of this study was to determine whether ultrasound (US) exposure combined with microbubble destruction could be used to enhance non-viral gene delivery in rat C6 glioma cells. Microbubbles were prepared and gently mixed with plasmid DNA. The mixture of the DNA and microbubbles was administered to cultured C6 c...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-008-9307-3

    authors： Wang JF,Wu CJ,Zhang CM,Qiu QY,Zheng M

    更新日期：2009-07-01 00:00:00

  • Structure and structure formation of the 20S proteasome.

    abstract：:Eukaryotic 20S proteasomes are complex oligomeric proteins. The maturation process of the 14 different alpha- and beta-subunits has to occur in a highly coordinate manner. In addition beta-subunits are synthesized as proproteins and correct processing has to be guaranteed during complex maturation. The structure forma...

    journal_title：Molecular biology reports

    pub_type： 杂志文章,评审

    doi：10.1023/a:1006826725056

    authors： Schmidt M,Schmidtke G,Kloetzel PM

    更新日期：1997-03-01 00:00:00

  • Genome-wide analysis of the MATE gene family in potato.

    abstract：:The multidrug and toxic compound extrusion (MATE) protein family is a newly discovered family of secondary transporters that extrude metabolic waste and a variety of antibiotics out of the cell using an electrochemical gradient of H+ or Na+ across the membrane. The main function of MATE gene family is to participate i...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-018-4487-y

    authors： Li Y,He H,He LF

    更新日期：2019-02-01 00:00:00

  • Estradiol regulates the expression of CD45 splicing isoforms in lymphocytes.

    abstract：:CD45, a common leukocyte antigen expressed on the surface of all nucleated hematopoietic cells, indicates the developmental stage and functional status of lymphocytes by its alternative splicing isoforms. Estrogen is correlated with the immune activity of lymphocytes and is involved in the sex bias of several human au...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-020-05373-y

    authors： Zhang T,Dong Z,Cai H,Rong J,Su Z

    更新日期：2020-04-01 00:00:00

  • Temporal changes in physiological and molecular markers in various brain regions following transient global ischemia in rats.

    abstract：:Several mechanisms are involved in the loss of cellular integrity and tissue destructions in various brain regions during ischemic insult. The affected brain employs various self-repair mechanisms during the poststroke recovery. Therefore, the current study involves time course changes in different brain regions follo...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-05060-7

    authors： Kapoor M,Sharma S,Sandhir R,Nehru B

    更新日期：2019-12-01 00:00:00

  • 3-Deoxyglucosone interferes with insulin signaling and attenuates insulin action on glucose-induced GLP-1 secretion in the enteroendocrine L cell line STC-1.

    abstract：:Maintenance of glucose homeostasis is reciprocally regulated by insulin and glucagon-like peptide-1 (GLP-1). We previously reported that GLP-1 secretion in response to an oral glucose load was impaired following an administration of 3-deoxyglucosone (3DG), an independent factor associated with the development of pre-d...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-04926-0

    authors： Song X,Zhou L,Xu H,Wang F,Liang G,Zhang L,Huang F,Jiang G

    更新日期：2019-10-01 00:00:00

  • Genetic association of the P-glycoprotein gene ABCB1 polymorphisms with the risk for steroid-induced osteonecrosis of the femoral head in Chinese population.

    abstract：:Steroid administration, which is commonly performed for the treatment of autoimmune inflammatory diseases, cancers or organ transplantation, has been a leading cause of nontraumatic osteonecrosis of the femoral head (ONFH). Single nucleotide polymorphisms (SNPs) of the adenosine triphosphate-binding cassette B1 (ABCB1...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-014-3173-y

    authors： Zhang Y,Kong X,Wang R,Li S,Niu Y,Zhu L,Chen W,Lin N

    更新日期：2014-05-01 00:00:00

  • Co-Inheritance of alpha-thalassemia and sickle cell disease in a cohort of Angolan pediatric patients.

    abstract：:The aim of this study was to explore the association between alpha-thalassemia, fetal hemoglobin, hematological indices, and clinical adverse events in Angolan sickle cell disease pediatric patients. A total of 200 sickle cell disease (SCD) children were sampled in Luanda and Caxito. A venous blood sample was collecte...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-020-05628-8

    authors： Santos B,Delgadinho M,Ferreira J,Germano I,Miranda A,Arez AP,Faustino P,Brito M

    更新日期：2020-07-01 00:00:00

  • Polymorphisms in the HPC/ELAC-2 and alpha 1-antitrypsin genes that correlate with human diseases in a North Indian population.

    abstract：:Two genes HPC/ELAC-2 and AAT were studied in north Indian population. HPC/ELAC-2 was studied in prostate cancer cases and AAT was studied in COPD patients. HPC/ELAC-2 is considered as an important cancer-susceptibility gene in prostate cancer. There are two common polymorphisms of this gene, i.e., Ser217Leu and Ala541...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-010-9984-6

    authors： Sobti RC,Thakur H,Gupta L,Janmeja AK,Seth A,Singh SK

    更新日期：2011-06-01 00:00:00

  • Novel cis-acting regulatory elements in wild Oryza species impart improved rice bran quality by lowering the expression of phospholipase D alpha1 enzyme (OsPLDα1).

    abstract：:Rice bran oil is good quality edible oil, rich in antioxidants and comprised typically of oleic-linoleic type fatty acids. However, presence of a highly lipolytic enzyme Phospholipase D alpha1 (OsPLDα1) increases free fatty acid content in the oil which further leads to stale flavor and rancidity of the oil, making it...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-05144-4

    authors： Kaur A,Neelam K,Kitazumi A,Kaur K,Sharma P,Mangat GS,de Los Reyes BG,Brar DS,Singh K

    更新日期：2020-01-01 00:00:00

  • Annexin 1 protects against apoptosis induced by serum deprivation in transformed rat retinal ganglion cells.

    abstract：:To investigate whether Annexin 1 can protect a retinal ganglion cells line (RGC-5) from apoptosis as induced by serum deprivation. Annexin 1 location in RGC-5 cells was determined using an indirect immunofluorescent assay. Expression of Annexin 1 in RGC-5 cultures deprived of serum for 0, 2 days was semi-quantified by...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-011-1358-1

    authors： Sun J,Shao Z,Yang Y,Wu D,Zhou X,Yuan H

    更新日期：2012-05-01 00:00:00

  • Gene expression and pathologic response to neoadjuvant chemotherapy in breast cancer.

    abstract：:Pathologic complete response after neoadjuvant systemic treatment appears to be a valid surrogate for better overall survival in breast cancer patients. Currently, together with standard clinicopathologic assessment, novel molecular biomarkers are being exhaustively tested in order to look into the heterogeneity of br...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-012-1576-1

    authors： Kolacinska A,Fendler W,Szemraj J,Szymanska B,Borowska-Garganisz E,Nowik M,Chalubinska J,Kubiak R,Pawlowska Z,Blasinska-Morawiec M,Potemski P,Jeziorski A,Morawiec Z

    更新日期：2012-07-01 00:00:00

  • Glutathione S-transferase M1, T1, and P1 polymorphisms and risk of glioma: a meta-analysis.

    abstract：:The relationship between genetic polymorphisms of glutathione S-transferase (GST) and the development of glioma has been investigated in several epidemiologic studies. However these studies report inconsistent results. In order to quantitatively summarise the evidence for such a relationship, a meta-analysis is conduc...

    journal_title：Molecular biology reports

    pub_type： 杂志文章,meta分析

    doi：10.1007/s11033-012-2213-8

    authors： Fan Z,Wu Y,Shen J,Zhan R

    更新日期：2013-02-01 00:00:00

  • Phenylalanyl-tRNA synthetase from E. coli MRE-600: localization of the phenylalanine binding sites on the subunits by affinity reagents.

    abstract：:The phenylalanine and the phenylalanyl-tRNAPhe binding sites on the subunits of phenylalanyl-tRNA synthetase from E. coli MRE-600 were localized using p-azidoanilidate of [14C]phenylalanine and N-bromoacetyl-[14C]phenylalanyl-tRNAPhe. The phenylalanine recognizing site was shown to be situated on the alpha subunit of ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/BF00778515

    authors： Lavrik OI,Moor NA,Khodyreva SN

    更新日期：1982-03-31 00:00:00

  • Efficiency of RAPD, SSR and cytochrome P450 gene based markers in accessing genetic variability amongst finger millet (Eleusine coracana) accessions.

    abstract：:Finger millet (Eleusine coracana L.) is an important crop used for food, forage, and industrial products. Three DNA marker techniques, random amplified polymorphic DNA (RAPD), simple sequence repeat (SSR) and cytochrome P(450) gene based markers were used for the detection of genetic polymorphism in 83 accessions of f...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-010-0067-5

    authors： Panwar P,Saini RK,Sharma N,Yadav D,Kumar A

    更新日期：2010-12-01 00:00:00

  • Inhibiting UHRF1 expression enhances radiosensitivity in human esophageal squamous cell carcinoma.

    abstract：:Radiotherapy is an effective treatment for some esophageal cancers, but the molecular mechanisms of radiosensitivity remain unknown. Ubiquitin-like with PHD and ring finger domains 1 (UHRF1) is a novel nuclear protein which is overexpressed in various cancers but not yet examined in esophageal squamous cell carcinoma ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-013-2559-6

    authors： Yang C,Wang Y,Zhang F,Sun G,Li C,Jing S,Liu Q,Cheng Y

    更新日期：2013-09-01 00:00:00

  • Long-term ketamine abuse induces cystitis in rats by impairing the bladder epithelial barrier.

    abstract：:Long-term ketamine abuse is known to affect the lower urinary tract and produce symptoms of cystitis. However, the pathophysiology and causative mechanism of the changes in bladder function remain unclear. The present study aimed to investigate the existence of ketamine-induced cystitis in a rat model and characterize...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-014-3616-5

    authors： Gu D,Huang J,Yin Y,Shan Z,Zheng S,Wu P

    更新日期：2014-11-01 00:00:00

  • Regulation analysis of contractile ATPase flux in skeletal muscle.

    abstract：:J The [Ca2+] regulation of contractile ATPase flux, Jp, in skeletal muscle was analysed by computation of the Response R(Jp) Ca2+ for a 10 Hz range of electrical stimulation frequencies. Results of our analysis of the kinetic controls in ATP free energy metabolism in a network model of contracting muscle (J.A.L. Jenes...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1023/a:1020317610863

    authors： Jeneson JA

    更新日期：2002-01-01 00:00:00

  • Common genetic variation in CYP1B1 is associated with concentrations of T₄, FT₃ and FT₄ in the sera of polycystic ovary syndrome patients.

    abstract：:CYP1B1 encodes an estrogen enzyme that oxidizes 17β-estradiol to 4-hydroxyestradiol. The evidence demonstrates there may be a relationship between CYP1B1 and thyroid function. To date, no study has evaluated if genetic polymorphisms that regulate concentrations of serum FT3 and FT4 contribute to Polycyctic Ovary Syndr...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-012-2406-1

    authors： Zou S,Sang Q,Wang H,Feng R,Li Q,Zhao X,Xing Q,Jin L,He L,Wang L

    更新日期：2013-04-01 00:00:00

  • Haplotypes of CYP1B1 and CCDC57 genes in an Afro-Caribbean female population with uterine leiomyoma.

    abstract：:Uterine leiomyomas (UL) are prevalent benign tumors, especially among women of African ancestry. The disease also has genetic liability and is influenced by risk factors such as hormones and obesity. This study investigates the haplotypes of the Cytochrome P450 1B1 gene (CYP1B1) related to hormones and coiled-coil dom...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-04790-y

    authors： Alleyne AT,Bideau VS

    更新日期：2019-06-01 00:00:00

  • The association of polymorphisms on TGFBR1 and colorectal cancer risk: a meta-analysis.

    abstract：:Epidemiological studies found inconsistent results on the association of two variants on TGFBR1 (TGFBR1*6A and Int7G24A) with colorectal cancer (CRC) risk. The present study was aimed to evaluate the association of these two variants with CRC susceptibility via the meta-analysis methods. For variant TGFBR1*6A, nine re...

    journal_title：Molecular biology reports

    pub_type： 杂志文章,meta分析

    doi：10.1007/s11033-011-1009-6

    authors： Zhang X,Wu L,Sheng Y,Zhou W,Huang Z,Qu J,Gao G,Cai D,Zhang M

    更新日期：2012-03-01 00:00:00

  • Transcriptional profiling and in silico analysis of Dof transcription factor gene family for understanding their regulation during seed development of rice Oryza sativa L.

    abstract：:Seed development is a complex process controlled by temporal and spatial expression of many transcription factors (TF) inside the developing seed. In the present study, transcript profiles of all the 30 members of rice DofTFs from flowering to seed development stages were analyzed. It was found that 16 Dof genes besid...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-010-0429-z

    authors： Gaur VS,Singh US,Kumar A

    更新日期：2011-04-01 00:00:00