Regulation analysis of contractile ATPase flux in skeletal muscle.

Abstract:

:J The [Ca2+] regulation of contractile ATPase flux, Jp, in skeletal muscle was analysed by computation of the Response R(Jp) Ca2+ for a 10 Hz range of electrical stimulation frequencies. Results of our analysis of the kinetic controls in ATP free energy metabolism in a network model of contracting muscle (J.A.L. Jeneson, H.V. Westerhoff and M.J. Kushmerick (2000) Am. J Physiol. 279, C813-C832) formed the basis for the computations of R(Jp) Ca2+. We found that neural regulation of sustained force generation via simple [Ca2+]cyto frequency encoding in the network was robust for frequencies up to 2 Hz. Above 2 Hz, however, this regulation design broke down because of a shift in contractile ATPase flux control from the Ca2+-sensitive contractile filaments to mitochondria with low Ca2+ sensitivity. The role of glyco(geno)lytic ATP production at high contraction workloads is discussed in the context of this result.

journal_name

Mol Biol Rep

authors

Jeneson JA

doi

10.1023/a:1020317610863

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

167-70

issue

1-2

eissn

0301-4851

issn

1573-4978

journal_volume

29

pub_type

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