PON1 Q192R polymorphism (rs662) is associated with childhood embryonal tumors.

abstract：:Recently genetics and epigenetics alterations have been found to be characteristic of malignancy and hence can be used as targets for detection of neoplasia. RAS association domain family protein 1A (RASSF1A) gene hypermethylation has been a subject of interest in recent researches on cancer breast patients. The aim o...

journal_title：Molecular biology reports

authors： Hagrass HA,Pasha HF,Shaheen MA,Abdel Bary EH,Kassem R

更新日期：2014-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) may play important roles in SLE, but genetic polymorphisms of miRNAs and their relationships with various autoantibodies present in SLE patients remain unclear. Here, we report that 213 SLE patients and 209 healthy individuals of Chinese had been taken into this case-control studies, which had been ...

journal_title：Molecular biology reports

authors： Zhang J,Yang B,Ying B,Li D,Shi Y,Song X,Cai B,Huang Z,Wu Y,Wang L

更新日期：2011-03-01 00:00:00

abstract：:Methicillin resistant Staphylococcus aureus (MRSA) is one of the challenging bacterial pathogen due to its acquired resistance to the β lactam antibiotics. The Sortase A is an enzyme of Gram-positive bacteria including S. aureus to anchor surface proteins to the cell wall. Sortase A is well studied enzyme and consider...

journal_title：Molecular biology reports

authors： Uddin R,Saeed K

更新日期：2014-08-01 00:00:00

abstract：:Late-embryogenesis abundant (LEA) proteins have been reported to be closely correlated with the acquisition of desiccation tolerance during seed development and response of plant to drought, salinity, and freezing, etc. In this study, a LEA gene, CarLEA4 (GenBank accession no. GU247511), was isolated from chickpea bas...

journal_title：Molecular biology reports

authors： Gu H,Jia Y,Wang X,Chen Q,Shi S,Ma L,Zhang J,Zhang H,Ma H

更新日期：2012-04-01 00:00:00

abstract：:Although it is known that the hybrid male mouse is sterile just like any other animal's heterogametic sex, the reason why only the male germ cells are impaired has yet to be discovered. TdT-mediated dUTP nick end labeling assay using a confocal fluorescence microscope and DNA fragmentation assay of hybrid testis indic...

journal_title：Molecular biology reports

authors： Hayashida K,Kohno S

更新日期：2009-07-01 00:00:00

abstract：:Increases of oxidatively modified protein in the cell have been associated with the aging process. Such an accumulation of damaged protein may be the result of increase in the rate of protein oxidation and/or decrease in the rate of degradation of oxidized protein. The multicatalytic proteinase or proteasome is known ...

journal_title：Molecular biology reports

authors： Conconi M,Friguet B

更新日期：1997-03-01 00:00:00

abstract：:A double-stranded RNA-specific nuclease (ds RNase) has been isolated and partially purified from human placenta by DEAE-cellulose and DNA-cellulose column chromatography. Denatured DNA-cellulose retained most of the single-stranded RNA-specific nuclease (ss RNase) activity, whereas the ds RNase came out in the void vo...

journal_title：Molecular biology reports

authors： Kalyanaraman S,Maran A,Shanmugam G

更新日期：1983-08-01 00:00:00

abstract：:Dengue virus and Zika virus are arthropod-borne flaviviruses that cause millions of infections worldwide. The co-circulation of both viruses makes serological diagnosis difficult as they share high amino acid similarities in viral proteins. Antigens are one of the key reagents in the differential diagnosis of these vi...

journal_title：Molecular biology reports

authors： Lopes-Luz L,Junqueira IC,da Silveira LA,de Melo Pereira BR,da Silva LA,Ribeiro BM,Nagata T

更新日期：2020-10-01 00:00:00

abstract：:Ribonuclease P (RNase P) is a key enzyme involved in tRNA biosynthesis. It catalyses the endonucleolytic cleavage of nearly all tRNA precursors to produce 5'-end matured tRNA. RNase P activity has been found in all organisms examined, from bacteria to mammals. Eubacterial RNase RNA is the only known RNA enzyme which f...

journal_title：Molecular biology reports

authors： Drainas D

更新日期：1995-01-01 00:00:00

abstract：:Generation of induced pluripotent stem cells from endangered cattle breeds makes a significant contribution to the establishment of embryonic stem cell line, conservation and utilization of genetic resources in endangered cattle. In our study, we are trying to construct recombinant proteins of transcription factors Oc...

journal_title：Molecular biology reports

authors： Hu PF,Guan WJ,Li XC,Ma YH

更新日期：2012-06-01 00:00:00

abstract：:Several lines of evidence indicate that inflammatory processes play pivotal role in the development of intracranial aneurysm (IA). Recently, polymorphisms in the interleukin-12 (IL-12) gene were shown to be associated with immune-mediated inflammatory disease. The aim of this study was to investigate the interactions ...

journal_title：Molecular biology reports

authors： Li LJ,Pan XM,Sima X,Li ZH,Zhang LS,Sun H,Zhu Y,Liang WB,Gao LB,Zhang L

更新日期：2012-12-01 00:00:00

abstract：:To determine the plasma lipid and lipoprotein profiles and their possible association with the type of β-thalassemia mutation we studied 103 major β-thalassemia patients including 71 children and 32 young adults compared to 102 healthy subjects consisted of 90 children and 12 young healthy adults. The plasma lipid and...

journal_title：Molecular biology reports

authors： Madani H,Rahimi Z,Manavi-Shad M,Mozafari H,Akramipour R,Vaisi-Raygani A,Rezaei M,Malek-Khosravi S,Shakiba E,Parsian A

更新日期：2011-04-01 00:00:00

abstract：:The aim of this work was to study β-defensin 1 (SBD1) and β-defensin 2 (SBD2) genes in Valle del Belice dairy sheep in order to identify polymorphisms that can be utilized as markers of the analyzed genes, and search for the functional effects and roles of the identified polymorphisms (variation of the amino acid sequ...

journal_title：Molecular biology reports

authors： Monteleone G,Calascibetta D,Scaturro M,Galluzzo P,Palmeri M,Riggio V,Portolano B

更新日期：2011-11-01 00:00:00

abstract：:The MinION is a miniaturized high-throughput next generation sequencing platform of novel conception. The use of nucleic acids derived from formalin-fixed paraffin-embedded samples is highly desirable, but their adoption for molecular assays is hurdled by the high degree of fragmentation and by the chemical-induced mu...

journal_title：Molecular biology reports

authors： Vacca D,Cancila V,Gulino A,Lo Bosco G,Belmonte B,Di Napoli A,Florena AM,Tripodo C,Arancio W

更新日期：2018-02-01 00:00:00

abstract：:The modified base queuine is a nutrient factor for lower and higher eukaryotes except yeast. It is synthesized in eubacteria and inserted into the wobble position of specific tRNAs (tRNA(GUN)) in exchange of guanine at position 34. The tRNAs of Q family are completely modified in terminally differentiated somatic cell...

journal_title：Molecular biology reports

authors： Pathak C,Vinayak M

更新日期：2005-09-01 00:00:00

abstract：:Recent Genome-Wide Association Studies have identified several single nucleotide polymorphisms (SNPs) associated with breast cancer (BC) among women of Asian, European, and African-American ancestry. Nevertheless, the contribution of these variants in the South American population is unknown. Furthermore, there is lit...

journal_title：Molecular biology reports

authors： Elematore I,Gonzalez-Hormazabal P,Reyes JM,Blanco R,Bravo T,Peralta O,Gomez F,Waugh E,Margarit S,Ibañez G,Romero C,Pakomio J,Roizen G,Di Capua GA,Jara L

更新日期：2014-06-01 00:00:00

abstract：:The complete coding sequences of three porcine genes-SDHB, SNRPA and CRYBB1 were amplified using the reverse transcriptase polymerase chain reaction (RT-PCR) based on the conserved coding sequence information of the mouse or other mammals and highly homologous pig ESTs. These three genes were then deposited into GenBa...

journal_title：Molecular biology reports

authors： An QC,Liu GY

更新日期：2009-04-01 00:00:00

abstract：:As-NUPR1, a stress-related protein, plays an important role in post-diapause during embryonic development in the brine shrimp Artemia sinica. In the present study, successful expression of As-NUPR1 from the cDNA sequence isolated from A. sinica was demonstrated using a prokaryotic expression system. The recombinant pr...

journal_title：Molecular biology reports

authors： Zhang R,Yao F,Cheng C,Chen Y,Lv Y,Li Z,Zhao N,Wang T,Xin W,Zou X,Hou L

更新日期：2014-05-01 00:00:00

abstract：:We tried to study the possible effects of lipoic acid (LA) on adhesion molecule expression and its underlying mechanism in the prevention and treatment of cardiovascular disorders. Intercellular adhesion molecule-1 (ICAM-1) expression and endothelial nitric oxide synthase (eNOS) activity were determined after endothel...

journal_title：Molecular biology reports

authors： Jin HB,Yang YB,Song YL,Zhang YC,Li YR

更新日期：2013-01-01 00:00:00

abstract：:The majority of familial breast and ovarian cancers arise from mutations in the BRCA1 and BRCA2 genes. Amplification at the 11q13.5 locus is commonly observed in breast and ovarian cancers. In 2003, Hughes-Davies et al. identified a novel gene (EMSY) at this locus which binds BRCA2 within a region deleted in some canc...

journal_title：Molecular biology reports

authors： Altinisik J,Karateke A,Coksuer H,Ulutin T,Buyru N

更新日期：2011-01-01 00:00:00

abstract：:Porcine MYOD1 gene has been mapped to swine chromosome (SSC) 2p14-p17, which is involved in the regulation of the proliferation and differentiation of skeletal muscle cells. The LDHA (lactate dehydrogenase A) and COPB1 (coatomer protein complex, subunit beta 1) genes, which map close to MYOD1, are involved in energy m...

journal_title：Molecular biology reports

authors： Qiu H,Xu X,Fan B,Rothschild MF,Martin Y,Liu B

更新日期：2010-01-01 00:00:00

abstract：:Male Breast Cancer (MBC) is a rare and aggressive disease that is associated with genetic factors. Mutations in BRCA1 and BRCA2 account for 10% of all MBC cases suggesting that other genetic factors are involved. The aim of the present study is to screen whole BRCA1 and BRCA2 exons using the Ampliseq BRCA panel in Tun...

journal_title：Molecular biology reports

authors： Ben Kridis-Rejeb W,Ben Ayed-Guerfali D,Ammous-Boukhris N,Ayadi W,Kifagi C,Charfi S,Saguem I,Sellami-Boudawara T,Daoud J,Khanfir A,Mokdad-Gargouri R

更新日期：2020-09-01 00:00:00

abstract：:Melanotransferrin (MTf), a member of the transferrin families, plays an important role in immune response. But the research about MTf in sea cucumber is limited till now. In this study, the Melanotransferrin (Aj-MTf) gene was firstly cloned and characterized from the sea cucumber Apostichoupus japonicus by reverse tra...

journal_title：Molecular biology reports

authors： Qiu X,Li D,Cui J,Liu Y,Wang X

更新日期：2014-06-01 00:00:00

abstract：:Neuroinflammation affects millions of people around the world as a result of injury or stress. Neuroinflammation represents almost all types of neurological diseases such as multiple sclerosis and Alzheimer's disease. Neurodegenerative diseases comprise demyelination and synaptic loss. The inflammatory response is fur...

journal_title：Molecular biology reports

authors： Siddiqui S,Kamal A,Khan F,Jamali KS,Saify ZS

更新日期：2019-02-01 00:00:00

abstract：:HIV/AIDS remains to be one of the killing diseases of mankind. Host genetic response is one of the factor which determine susceptibility to HIV and disease progression to AIDS. The aim of the present study was to evaluate the impact of ERCC2 Lyc ( 751 ) Gln (excision repair cross complementing rodent repair deficiency...

journal_title：Molecular biology reports

authors： Sobti RC,Berhane N,Mahdi SA,Kler R,Hosseini SA,Kuttiat V,Wanchu A

更新日期：2011-06-01 00:00:00

abstract：:To gain genetic insights into the protein-rich microalga, the transcriptome of Arthrospira platensis was sequenced using Illumina technology and de novo assembly was carried out. A total of 6023 transcripts were present in the transcriptome among which 4616 transcripts were annotated with specific functions. Gene onto...

journal_title：Molecular biology reports

authors： Kumaresan V,Sannasimuthu A,Arasu MV,Al-Dhabi NA,Arockiaraj J

更新日期：2018-10-01 00:00:00

abstract：:Various case-control studies have shown association of single nucleotide polymorphism rs12303764(G/T) in ULK1 with crohn's disease. The techniques used in these studies were time consuming, complicated and require sophisticated/expensive instruments. Therefore, in order to overcome these problems, we have developed a ...

journal_title：Molecular biology reports

authors： Randhawa R,Duseja A,Changotra H

更新日期：2017-02-01 00:00:00

abstract：:Berberine (BBR), an effective compound of Chinese traditional herbal medicine, has preventive effects on diabetes and its complications. In this study, we investigated the therapeutic effects and underlying molecular mechanisms of BBR in rats with high-fat diet and streptozotocin (STZ)-induced diabetic nephropathy mod...

journal_title：Molecular biology reports

authors： Wang FL,Tang LQ,Yang F,Zhu LN,Cai M,Wei W

更新日期：2013-03-01 00:00:00

abstract：:The purpose was to analyze the growth hormone GH1/GH2-N and GH2-Z gene copies and to assess their possible association with milk traits in Sarda sheep. Two hundred multiparous lactating ewes were monitored. The two gene copies were amplified separately and each was used as template for a nested PCR, to investigate sin...

journal_title：Molecular biology reports

authors： Vacca GM,Dettori ML,Balia F,Luridiana S,Mura MC,Carcangiu V,Pazzola M

更新日期：2013-09-01 00:00:00

abstract：:The aim of this work was to sequence the promoter region of β-lactoglobulin (BLG) gene in four sheep breeds, in order to identify polymorphisms, infer and analyze haplotypes, and phylogenetic relationship among the Valle del Belice breed and the other three breeds considered as ancestors. Sequencing analysis and align...

journal_title：Molecular biology reports

authors： Mastrangelo S,Sardina MT,Riggio V,Portolano B

更新日期：2012-01-01 00:00:00