Abstract：
:As an essential signaling modulator, Src gene appears to be necessary for increased expression of the prolactin receptor, normal downstream signaling, and alveolar cell organization. In this study, we detected the polymorphism of Src gene by polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP) and DNA sequencing methods in 985 individuals from three Chinese cattle breeds. Three novel single nucleotide polymorphisms (SNPs) (g.14062C>T ss161151834, g.17302G>A ss161151835, g.18107T>C ss161151836) were detected. Least squares analysis showed that cows with g.14062C>T-CC genotypes and g.18107T>C-TT genotypes had the highest protein rate, while the cows with g.17302G>A-GG genotype had higher 305 d milk yield (p < 0.05), fat yield (p < 0.01) and protein yield (p < 0.01) than the ones with genotypes g.17302G>A-GA. These results revealed the statistical significant effects of three SNPs of the Src gene on the milk production traits in Chinese Holstein. In addition, based on the nine genotypes constructed from 27 combined haplotypes, the association analysis between combined haplotypes and milk production traits was carried out. Statistic results showed that the cows with combined haplotypes H2H4(CCGATT) had the highest fat rate and the highest protein rate and the cows with combined haplotypes H1H8(TCGATC) and H3H7(TCGGCC) had greater 305 d mild yield than H1H2(CCAATC)(P < 0.05). Our finding demonstrated that the Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Liu W,Wang J,Li Q,Ju Z,Huang J,Wang H,Liu S,Li J,Zhong J,Wang Cdoi
10.1007/s11033-010-0031-4subject
Has Abstractpub_date
2010-12-01 00:00:00pages
3771-7issue
8eissn
0301-4851issn
1573-4978journal_volume
37pub_type
杂志文章abstract：:Previous report showed that Estrogen related receptor α (ERRα) knockout mice had a significant reduction in adipose tissue deposition. Although it was reported that ERRα could promote adipogenesis in several immortalized preadipocytes cell lines, the mechanism behind which is still unclear to date. Besides, the expres...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-1104-8
更新日期：2012-03-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-009-9792-z
更新日期：2010-07-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11033-013-2599-y
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pub_type： 杂志文章
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2909-4
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pub_type： 杂志文章
doi：10.1007/s11033-008-9416-z
更新日期：2009-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2009-07-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1007/s11033-012-1915-2
更新日期：2012-12-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-018-4530-z
更新日期：2019-02-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1929-9
更新日期：2012-12-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-005-4536-1
更新日期：2006-09-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-0088-0
更新日期：2011-01-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05458-8
更新日期：2020-05-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05454-y
更新日期：2020-05-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05420-8
更新日期：2020-05-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-2441-y
更新日期：2013-05-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/BF00808381
更新日期：1977-12-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
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更新日期：2010-01-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-005-0887-x
更新日期：2004-12-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/BF01674434
更新日期：1993-10-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-019-04870-z
更新日期：2019-10-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-005-2310-z
更新日期：2005-12-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-0218-8
更新日期：2011-02-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-0067-5
更新日期：2010-12-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05683-1
更新日期：2020-08-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1869-4
更新日期：2012-12-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章,评审
doi：10.1007/s11033-011-0973-1
更新日期：2012-03-01 00:00:00
