当前位置： SCI文献检索 > MOLECULAR BIOLOGY REPORTS期刊下所有文献 > Differential expression of TRPC channels in the left ventricle of spontaneously hypertensive rats.

Differential expression of TRPC channels in the left ventricle of spontaneously hypertensive rats.

Abstract：

:This study was designed to identify the differential expression of the canonical transient receptor potential (TRPC) channels in the left ventricle of spontaneously hypertensive rats (SHR). Echocardiography studies were performed to compare the left ventricular function in SHR vs. Wistar-Kyoto rats (WKY), and the mRNA level of the TRPC channels was determined by quantitative real-time RT-PCR (qRT-PCR). Western blots were performed to examine whether the mRNA expression corresponded with the protein expression. Compared with the WKY, the mRNA expression of TRPC4 and TRPC5 was significantly increased in the 10-week-old SHR (P = 0.032 for TRPC4 and P = 0.043 for TRPC5), so did the TRPC4/5 protein content. The midwall fractional shortening (mFS) of SHR was lower than WKY (P = 0.016). Furthermore, increased expression of TRPC4/5 was correlated with both increased blood pressure and decreased mFS. These findings suggest that TRPC4 and 5 seem to be the main subtypes expressed in the heart of the SHR at the beginning period of hypertension. Theses channels may participate in the development of left ventricular systolic dysfunction.

journal_name

Mol Biol Rep

journal_title

Molecular biology reports

authors

Liu FF,Ma ZY,Li DL,Feng JB,Zhang K,Wang R,Zhang W,Li L,Zhang Y

doi

10.1007/s11033-009-9792-z

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

2645-51

issue

6

eissn

0301-4851

issn

1573-4978

journal_volume

37

pub_type

杂志文章

相关文献

MOLECULAR BIOLOGY REPORTS文献大全
  • CTLA-4 exon 1 +49 polymorphism alone and in a haplotype with -318 promoter polymorphism may confer susceptibility to chronic HBV infection in Chinese Han patients.

    abstract：:Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) plays a pivotal role in regulating T cell activation, which is believably critical for the outcome of hepatitis B virus (HBV) infection. The expression and function of CTLA-4 may be affected by gene polymorphisms. This study investigated the influence of CTLA-4 poly...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-010-0660-7

    authors： Duan S,Zhang G,Han Q,Li Z,Liu Z,Chen J,Lv Y,Li N,Wang Y,Li M,Lou S,Yang M,Zhu Q,Xing F

    更新日期：2011-11-01 00:00:00

  • Identification of a new potential native Indian cattle breed by population differentiation based on microsatellite markers.

    abstract：:India has a rich heritage of rearing cattle where farmers selected native cattle suitable to their local agro-ecological conditions for centuries. It is reflected in 50 indigenous breeds of cattle, besides many lesser known populations not explored so far. It is the need of the hour to characterize such populations to...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-020-05639-5

    authors： Sharma R,Ahlawat S,Sharma H,Bhagat RL,Singh PK,Tantia MS

    更新日期：2020-08-01 00:00:00

  • Association study of ACE polymorphisms and systemic lupus erythematosus in Northern Chinese Han population.

    abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease, with multiple genetic and environmental factors involving in its etiology. Angiotensin converting enzyme (ACE) gene was reported to have important roles in the development and progression of SLE. In this study, a case-control study was carried out to investi...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-012-1813-7

    authors： Gong AM,Li XY,Wang YQ,Yan HX,Xu ZX,Feng Z,Xie YQ,Yin DH,Yang SZ

    更新日期：2012-10-01 00:00:00

  • Computational analysis of human N-acetylgalactosamine-6-sulfate sulfatase enzyme: an update in genotype-phenotype correlation for Morquio A.

    abstract：:Mucopolysaccharidosis IV A (MPS IV A) is a lysosomal storage disease produced by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme. Although genotype-phenotype correlations have been reported, these approaches have not enabled to establish a complete genotype-phenotype correlation, and they ha...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-014-3383-3

    authors： Olarte-Avellaneda S,Rodríguez-López A,Alméciga-Díaz CJ,Barrera LA

    更新日期：2014-11-01 00:00:00

  • Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display.

    abstract：:Phage display procedure was applied to the N-terminal domain of human topoisomerase I. The consensus sequence identified for clones binding to the N-terminal domain was found in 35 human proteins that are either permanently or temporarily located in the nucleus. They are in majority involved in the DNA repair, transcr...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1023/a:1021237021338

    authors： Trzcińska AM,Girstun A,Piekiełko A,Kowalska-Loth B,Staroń K

    更新日期：2002-12-01 00:00:00

  • Multiplex minisequencing screening for PTC genotype associated with bitter taste perception.

    abstract：:Sensitivity to phenylthiocarbamide (PTC) has a bimodal distribution pattern and the genotype of the TAS2R38 gene, which is composed of combinations of three coding single nucleotide polymorphisms (SNPs), p.A49P (c.145G>C), p.V262A (c.785T>C) and p.I296 V (c.886A>G), determines the ability or inability to taste PTC. In...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-013-3002-8

    authors： Sagong B,Bae JW,Rhyu MR,Kim UK,Ye MK

    更新日期：2014-03-01 00:00:00

  • Protective roles of quercetin in acute myocardial ischemia and reperfusion injury in rats.

    abstract：:Myocardial ischemia and reperfusion (MI/R) is associated with an intense inflammatory reaction, which may lead to myocyte injury. In this study, we investigated the effect of quercetin, an inhibitor of c-Jun N-terminal kinase on ischemia/reperfusion injury in isolated rat hearts. Rat models of MI/R were induced by cor...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-012-2002-4

    authors： Jin HB,Yang YB,Song YL,Zhang YC,Li YR

    更新日期：2012-12-01 00:00:00

  • Molecular characterization, polymorphism and association of porcine SPATA19 gene.

    abstract：:Spermatogenesis associated 19 (SPATA19) is an important reproduction related gene. In this study, we cloned the full-length cDNA sequence of porcine SPATA19 gene through the rapid amplification of cDNA ends (RACE) method. The porcine SPATA19 gene encodes a protein of 154 amino acids which shares high homology with the...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-012-1839-x

    authors： Wang JY,Lan J,Zhao J,Chen L,Liu Y

    更新日期：2012-10-01 00:00:00

  • Effects of the polymorphisms of Mx1, BAT2 and CXCL12 genes on immunological traits in pigs.

    abstract：:It is necessary that genetic markers or biomarkers can be used to predict resistance towards a wide range of infectious diseases. In the present study, we estimated the potential markers and measured their relationship with heritabilities of a wide range of immune traits. Polymorphisms in exon 13 of Mx1, intron 25 of ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-011-0992-y

    authors： Wang SJ,Liu WJ,Sargent CA,Zhao SH,Liu HB,Liu XD,Wang C,Hua GH,Yang LG,Affara NA,Zhang SJ

    更新日期：2012-03-01 00:00:00

  • The targets of 2,2',5,5'-tetrachlorobiphenyl in the respiratory chain of rat liver mitochondria revealed by modular kinetic analysis.

    abstract：:The response of the respiratory subsystem of oxidative phosphorylation to the environmental pollutant, 2,2',5,5'-tetrachlorobiphenyl (2,2',5,5'-TCB) was investigated by modular kinetic approach. The effects of 20 microM 2,2',5,5'-TCB on the activity of the respiratory chain modules in rat liver mitochondria oxidizing ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1023/a:1020394016372

    authors： Mildaziene V,Nauciene Z,Krab K

    更新日期：2002-01-01 00:00:00

  • Functional characterization of a Δ5-like fatty acyl desaturase and its expression during early embryogenesis in the noble scallop Chlamys nobilis Reeve.

    abstract：:Long-chain polyunsaturated fatty acids (LC-PUFAs) are essential in lots of important physiological processes, while, many marine species have no or limited ability of endogenous PUFA biosynthesis, normally due to the lack of key enzymes such as fatty acid desaturase (FAD). In this study, we isolated a scallop Chlamys ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-014-3633-4

    authors： Liu H,Guo Z,Zheng H,Wang S,Wang Y,Liu W,Zhang G

    更新日期：2014-11-01 00:00:00

  • The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin.

    abstract：:The lysyl oxidase-like 2 (LOXL2) protein is a human paralogue of lysyl oxidase (LOX) that functions as an amine oxidase for formation of lysine-derived cross-links found in collagen and elastin. In addition to the C-terminal domains characteristic to the LOX family members, LOXL2 contains four scavenger receptor cyste...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-010-0088-0

    authors： Kim YM,Kim EC,Kim Y

    更新日期：2011-01-01 00:00:00

  • Comparison of the novel dipstick DNA extraction technique with two established techniques for use in biological barcoding.

    abstract：:The novel dipstick DNA extraction method was tested for its reliability and usability for biological barcoding in comparison to a commercial kit and to a simplified isopropanol precipitation method using crayfish gill tissue. Following DNA extraction, the mitochondrial COI-gene was amplified in a PCR-reaction using a ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-05083-0

    authors： Martello A,Lambert B,Johnston C,Cutler J,Stumpf CF

    更新日期：2019-12-01 00:00:00

  • Genetic association of the P-glycoprotein gene ABCB1 polymorphisms with the risk for steroid-induced osteonecrosis of the femoral head in Chinese population.

    abstract：:Steroid administration, which is commonly performed for the treatment of autoimmune inflammatory diseases, cancers or organ transplantation, has been a leading cause of nontraumatic osteonecrosis of the femoral head (ONFH). Single nucleotide polymorphisms (SNPs) of the adenosine triphosphate-binding cassette B1 (ABCB1...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-014-3173-y

    authors： Zhang Y,Kong X,Wang R,Li S,Niu Y,Zhu L,Chen W,Lin N

    更新日期：2014-05-01 00:00:00

  • Identification of novel homologues of three low molecular weight subunits of the mitochondrial bc1 complex.

    abstract：:Large-scale random cDNA sequencing projects have been started for several organisms and are a valuable tool for the analysis of quantitative and qualitative aspects of gene expression. However, the reliability of the obtained data is limited as most of the clones are only partially analysed on one strand. As a consequ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/BF00424432

    authors： Braun HP

    更新日期：1996-01-01 00:00:00

  • iPhosY-PseAAC: identify phosphotyrosine sites by incorporating sequence statistical moments into PseAAC.

    abstract：:Protein phosphorylation is one of the most fundamental types of post-translational modifications and it plays a vital role in various cellular processes of eukaryotes. Among three types of phosphorylation i.e. serine, threonine and tyrosine phosphorylation, tyrosine phosphorylation is one of the most frequent and it i...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-018-4417-z

    authors： Khan YD,Rasool N,Hussain W,Khan SA,Chou KC

    更新日期：2018-12-01 00:00:00

  • Immunity augmentation in Botia dario (Hamilton, 1822) through carotenoid: a dietary approach.

    abstract：:The immunity and health status of ornamental fish is an important aspect, as they are kept in a confined environment and various stressful conditions which lead to depletion of overall colourful appearance and mortality. The carotenoids can act as immunity boosters in captive aquarium system and may be supplemented in...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-05027-8

    authors： Tripathy PS,Khatei A,Parhi J,Choudhury TG,Sahoo L,Mandal SC

    更新日期：2019-12-01 00:00:00

  • Investigation of possible effects of microRNAs involved in regulation of lipid metabolism in the pathogenesis of atherosclerosis.

    abstract：:Due to being stable in the circulatory system plasma miRNAs have been detected in various diseases including coronary artery disease (CAD) which is the major cause of mortality and morbidity worldwide. Atherosclerosis is the major cause of CAD. The first and most important event in the progression of atherosclerosis i...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-018-4547-3

    authors： Gorur A,Celik A,Yildirim DD,Gundes A,Tamer L

    更新日期：2019-02-01 00:00:00

  • Cytotoxic and anti-angiogenic effects of zoledronic acid in DU-145 and PC-3 prostate cancer cell lines.

    abstract：:This study aims to investigate the apoptotic and anti-angiogenic effect of Zoledronic acid on hormone-refractory prostate cancer cell lines. XTT cell proliferation assay used to assess cytotoxicity. Caspase 3/7 activity and DNA fragmentation were measured to verify apoptosis. Angiogenic cytokine profiles investigated ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-020-05840-6

    authors： Gokalp C

    更新日期：2020-10-01 00:00:00

  • The expression and activation of ERK/MAPK pathway in human esophageal cancer cell line EC9706.

    abstract：:While there have been more and more studies concerning mitogen-activated protein kinases (MAPKs) signaling pathways, which control many cellular complex programmes, such as cell proliferation, differentiation, cell death and embryogenesis. However, few studies are carried out about expression and activation of classic...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-010-0178-z

    authors： Zheng ST,Huo Q,Tuerxun A,Ma WJ,Lv GD,Huang CG,Liu Q,Wang X,Lin RY,Sheyhidin I,Lu XM

    更新日期：2011-02-01 00:00:00

  • Identification and characterization of a LEA family gene CarLEA4 from chickpea (Cicer arietinum L.).

    abstract：:Late-embryogenesis abundant (LEA) proteins have been reported to be closely correlated with the acquisition of desiccation tolerance during seed development and response of plant to drought, salinity, and freezing, etc. In this study, a LEA gene, CarLEA4 (GenBank accession no. GU247511), was isolated from chickpea bas...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-011-1130-6

    authors： Gu H,Jia Y,Wang X,Chen Q,Shi S,Ma L,Zhang J,Zhang H,Ma H

    更新日期：2012-04-01 00:00:00

  • Novel cis-acting regulatory elements in wild Oryza species impart improved rice bran quality by lowering the expression of phospholipase D alpha1 enzyme (OsPLDα1).

    abstract：:Rice bran oil is good quality edible oil, rich in antioxidants and comprised typically of oleic-linoleic type fatty acids. However, presence of a highly lipolytic enzyme Phospholipase D alpha1 (OsPLDα1) increases free fatty acid content in the oil which further leads to stale flavor and rancidity of the oil, making it...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-05144-4

    authors： Kaur A,Neelam K,Kitazumi A,Kaur K,Sharma P,Mangat GS,de Los Reyes BG,Brar DS,Singh K

    更新日期：2020-01-01 00:00:00

  • Mitochondrial activity in different regions of the brain at the onset of streptozotocin-induced diabetes in rats.

    abstract：:Diabetes affects a variety of tissues including the central nervous system; moreover, some evidence indicates that memory and learning processes are disrupted. Also, oxidative stress triggers alterations in different tissues including the brain. Recent studies indicate mitochondria dysfunction is a pivotal factor for ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-018-4233-5

    authors： Osorio-Paz I,Ramírez-Pérez G,Hernández-Ramírez JE,Uribe-Carvajal S,Salceda R

    更新日期：2018-10-01 00:00:00

  • Identification and transcript profiles of citrus growth-regulating factor genes involved in the regulation of leaf and fruit development.

    abstract：:Growth-regulating factor (GRF) is an important protein in GA-mediated response, with key roles in plant growth and development. However, it is not known whether or how the GRF proteins in citrus to regulate organ size. In this study, nine citrus GRF genes (CsGRF1-9) were validated from the 'Anliu' sweet orange (AL, Ci...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-016-4048-1

    authors： Liu X,Guo LX,Jin LF,Liu YZ,Liu T,Fan YH,Peng SA

    更新日期：2016-10-01 00:00:00

  • NHE1 gene associated with avian leukosis virus subgroup J infection in chicken.

    abstract：:As a kind of binding protein, the type 1 Na(+)/H(+) exchanger (NHE1) is a receptor for the highly pathogenic Avian leukosis viruses-J subgroup (ALV-J) in chicken. In order to investigate the potential effect of chicken NHE1 gene on leukosis, we compared its expression between ALV-J-affected and -unaffected chicken, sc...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-014-3535-5

    authors： Chen B,Pan W,Zhang L,Liu J,Ouyang H,Nie Q,Zhang X

    更新日期：2014-10-01 00:00:00

  • Amerindians show no association of PPAR-γ2 gene Ala12 allele and obesity: an "unthrifty" variant population genetics.

    abstract：:Obesity is for many scholars the most important starting status that gives rise to Metabolic Syndrome (MS) and Type 2 Diabetes (T2D). In the present paper, a genetically homogeneous Amerindian population, as defined by HLA genes, has been genotyped for one of the MS and T2D predisposing genes: PPAR-γ Ala12 and Pro 12 ...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-012-2230-7

    authors： Arnaiz-Villena A,Fernández-Honrado M,Areces C,Enríquez-de-Salamanca M,Abd-El-Fatah-Khalil S,Coca C,Arribas I,Algora M,Rey D

    更新日期：2013-02-01 00:00:00

  • Molecular cloning, sequence identification, and tissue expression profile analysis of three novel porcine genes: SDHB, SNRPA and CRYBB1.

    abstract：:The complete coding sequences of three porcine genes-SDHB, SNRPA and CRYBB1 were amplified using the reverse transcriptase polymerase chain reaction (RT-PCR) based on the conserved coding sequence information of the mouse or other mammals and highly homologous pig ESTs. These three genes were then deposited into GenBa...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-008-9229-0

    authors： An QC,Liu GY

    更新日期：2009-04-01 00:00:00

  • The Ku70 -1310C/G promoter polymorphism is associated with breast cancer susceptibility in Chinese Han population.

    abstract：:Ku70 plays an important role in the DSBR (DNA double-strand breaks repair) and maintenance of genomic integrity. Genetic variations within human Ku70 have been demonstrated to be associated with increased risk of several types of cancers. In this hospital-based case-control study, we aimed to investigate whether a sin...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-011-0773-7

    authors： He W,Luo S,Huang T,Ren J,Wu X,Shao J,Zhu Q

    更新日期：2012-01-01 00:00:00

  • Potential role of serum fetuin-A in relation with pro-inflammatory, chemokine and adhesion molecules in diabetic kidney disease: a case-control study.

    abstract：:Inflammatory cytokine, adipokine and adhesion molecules are known to play a key role in pathogenesis of diabetic kidney disease (DKD). In this study, our aim was to investigate the role of fetuin-A in relation with pro-inflammatory cytokines (IL-6, IL-18), adipokines (adiponectin, leptin), chemokine (MCP-1), and adhes...

    journal_title：Molecular biology reports

    pub_type： 杂志文章

    doi：10.1007/s11033-019-04592-2

    authors： Nawaz SS,Joy SS,Al Farsi Y,George TP,Siddiqui K

    更新日期：2019-02-01 00:00:00

  • Effects of the interleukin-1β-511 C/T gene polymorphism on the risk of gastric cancer in the context of the relationship between race and H. pylori infection: a meta-analysis of 20,000 subjects.

    abstract：:The interleukin (IL)-1β-511 C/T polymorphism has been shown to be functional and to contribute to the risk of gastric cancer. However, the relationship between the IL-1β-511 C/T polymorphism and gastric carcinogenesis remains inconclusive. A systematical electronic search was conducted of the MEDLINE, EMBASE, and CENT...

    journal_title：Molecular biology reports

    pub_type： 杂志文章,meta分析

    doi：10.1007/s11033-014-3748-7

    authors： Park MJ,Hyun MH,Yang JP,Yoon JM,Park S

    更新日期：2015-01-01 00:00:00