Abstract：
:Myocardial ischemia and reperfusion (MI/R) is associated with an intense inflammatory reaction, which may lead to myocyte injury. In this study, we investigated the effect of quercetin, an inhibitor of c-Jun N-terminal kinase on ischemia/reperfusion injury in isolated rat hearts. Rat models of MI/R were induced by coronary occlusion followed by reperfusion, treatment of rats with quercetin (1.0 mg/kg, i.v.) induced a significant reduction of infarct volume and improvements in baseline hemodynamic abnormalities (P < 0.05). Quercetin treatment also attenuated the expression of both TNF-alpha (TNF-α) and interleukin-10 (IL-10) and lowered the serum levels of inflammatory cytokine (P < 0.05). These findings suggested that quercetin treatment significantly attenuated MI/R injury primarily through anti-inflammatory effects.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Jin HB,Yang YB,Song YL,Zhang YC,Li YRdoi
10.1007/s11033-012-2002-4subject
Has Abstractpub_date
2012-12-01 00:00:00pages
11005-9issue
12eissn
0301-4851issn
1573-4978journal_volume
39pub_type
杂志文章abstract：:Published data on the association of vascular endothelial growth factor (VEGF) -1154G>A polymorphism with cancer risk is inconclusive. To derive a more precise estimation of association between VEGF -1154G>A polymorphism and the risk of cancer, we performed a meta-analysis of 7,071 cancer cases and 7,693 controls from...
journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
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abstract：:MAPK cascade is an important intracellular signaling module and function as a convergent point for crosstalk during abiotic stress signaling. In this study SbMAPKK gene has been isolated from Salicornia brachiata, a highly salt tolerant plant growing in costal marshes of Gujarat, India. The SbMAPKK gene is 1,023 bp lo...
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abstract：:Circular RNA (circRNA), a novel type of non-coding RNA that consists of a circular loop, has been demonstrated to act as a "sponge" for microRNAs (miRNAs). However, the role of circRNAs in keloid remains unknown. In this study, we investigated circRNA expression profiles in keloid to identify potential diagnostic and ...
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abstract：:The epidermal growth factor receptor (EGFR) is an important receptor tyrosine kinase member in animals, which plays versatile functions in development, growth, tissue regeneration etc. Current knowledge on EGFR is poor in bivalve mollusks. In this study, we cloned and analyzed an EGFR gene from the Pacific oyster Cras...
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pub_type： 杂志文章,meta分析
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s11033-013-2640-1
更新日期：2013-09-01 00:00:00
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pub_type： 杂志文章
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/BF00357585
更新日期：1973-08-01 00:00:00
