The effect of tunicamycin on the protease activity of GP63 from Leishmania major.

abstract：:Osteocytic potentiality of human CD34+ stem cells explored in the present study by generating in vitro agarose gel 3D model to understand the bone ossification process. The G-CSF and IL-3 mobilized human CD34+ stem cells isolated apheretically from donor peripheral blood and purity of the cells was assessed by FACS an...

journal_title：Molecular biology reports

authors： Srikanth L,Sunitha MM,Kumar PS,Chandrasekhar C,Vengamma B,Sarma PV

更新日期：2016-11-01 00:00:00

abstract：:One-third of all individuals with epilepsy are resistant to antiepileptic drug (AED) treatment. Antiepileptic treatment response has been suggested to be modulated by genetic polymorphisms of drug efflux transporters. Several polymorphic variants within the multidrug resistance 1 (MDR1) gene, which encodes the major t...

journal_title：Molecular biology reports

authors： Seven M,Batar B,Unal S,Yesil G,Yuksel A,Guven M

更新日期：2014-01-01 00:00:00

abstract：:One of the major limitations when attempting to obtain detailed biochemical, biophysical and immunological characterization of plant DNA mismatch repair proteins is their extremely low abundance in vivo under normal growth conditions. An initial analysis of PMS1 transcript level in various Arabidopsis thaliana tissues...

journal_title：Molecular biology reports

authors： Galles C,Gomez RL,Spampinato CP

更新日期：2011-02-01 00:00:00

abstract：:Complementary DNA to mouse globin mRNA was prepared using viral reverse transcriptase. Molecular hybridisation of this cDNA to Friend virus RNA demonstrates the absence of globin gene sequences. ...

journal_title：Molecular biology reports

authors： Pragnell IB,Gilmour RS

更新日期：1973-12-01 00:00:00

abstract：:Various efforts made to stop the deadly epidemic of HIV since its discovery in 1983 remain unsuccessful and this virus still continues to claim the lives of millions of individuals every year. The viral effect in the cell is complicated and the overall disease outcome is the result of interaction between a few viral p...

journal_title：Molecular biology reports

authors： Sobti RC,Berhane N,Mehedi SA,Kler R,Hosseini SA,Kuttiat V,Wanchu A

更新日期：2010-01-01 00:00:00

abstract：:Regulation of the sumoylation system at the level of gene expression has not yet been explored. To begin to define transcriptional regulatory features, the promoter region for the SUMO1 gene was cloned from human genomic DNA and characterized. Initially, a 532 base pair fragment upstream of and including the predicted...

journal_title：Molecular biology reports

authors： Nanos-Webb A,Deyrieux A,Bian XL,Rosas-Acosta G,Wilson VG

更新日期：2010-03-01 00:00:00

abstract：:Endometriosis is a polygenic and multifactorial gynecology situation which might be associated with angiogenesis. In the current study we assess the role of vascular endothelial growth factor (VEGF) - 2578 A/C, and + 936 C/T polymorphisms in susceptibility to endometriosis and checking the expression of VEGF mRNA in e...

journal_title：Molecular biology reports

authors： Rashidi BH,Sarhangi N,Aminimoghaddam S,Haghollahi F,Naji T,Amoli MM,Shahrabi-Farahani M

更新日期：2019-06-01 00:00:00

abstract：:Putatively functional polymorphisms of one-carbon and xenobiotic metabolic pathways influence susceptibility for wide spectrum of diseases. The current study was aimed to explore gene-gene interactions among these two metabolic pathways in four diseases i.e. breast cancer, systemic lupus erythematosus (SLE), coronary ...

journal_title：Molecular biology reports

authors： Naushad SM,Vijayalakshmi SV,Rupasree Y,Kumudini N,Sowganthika S,Naidu JV,Ramaiah MJ,Rao DN,Kutala VK

更新日期：2015-07-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is considered as a long-term autoimmune disorder. Gene polymorphism and oxidative stress might be involved in the pathogenesis of the disease. We aimed to determine the association between PON-1L55M polymorphism and its effects on inflammatory markers such as anti-cytroline circulated-peptide...

journal_title：Molecular biology reports

authors： Tanhapour M,Shahmohamadnejad S,Vaisi-Raygani A,Kiani A,Shakiba Y,Rahimi Z,Bahrehmand F,Shakiba E,Vaisi-Raygani AA,Alibakhshi R,Eivazi A,Pourmotabbed T

更新日期：2019-02-01 00:00:00

abstract：:The differentially expressed genes in the chickpea pod wall have been identified for the first time using a forward suppression subtractive hybridization (SSH) library. In all, 226 clones of SSH library were sequenced and analyzed. A total of 179 high-quality expressed sequence tags (ESTs) were generated and based on ...

journal_title：Molecular biology reports

authors： Vasantrao JM,Baruah IK,Panda D,Bhattacharjee M,Acharjee S,Sarmah BK

更新日期：2019-12-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) could infect porcine alveolar macrophages (PAM), and the CD169 and CD163 are identified as critical receptors on the surface of PAM, but whether the single nucleotide polymorphisms (SNPs) of these genes could influence the infection is remain unclear. In this...

journal_title：Molecular biology reports

authors： Ren YW,Zhang YY,Affara NA,Sargent CA,Yang LG,Zhao JL,Fang LR,Wu JJ,Fang R,Tong Q,Xiao J,Li JL,Jiang YB,Chen HC,Zhang SJ

更新日期：2012-11-01 00:00:00

abstract：:1-aminocyclopropane-1-carboxylic acid oxidase (ACO) enzyme is a member of the Fe II-dependent family of oxidases/oxygenases which require Fe(2+) as a cofactor, ascorbate as a cosubstrate and CO(2) as an activator. This enzyme catalyses the terminal step in the plant signaling of ethylene biosynthetic pathway. A 948 bp...

journal_title：Molecular biology reports

authors： Jafari Z,Haddad R,Hosseini R,Garoosi G

更新日期：2013-02-01 00:00:00

abstract：:Resistin is an obesity-related adipokine which has also been implicated in bone metabolism. Therefore, we designed a study to investigate the possible role of resistin gene variation in both obesity and bone mineral density. We included 1,155 individuals from the Odense Androgen Study (663 young subjects and 492 older...

journal_title：Molecular biology reports

authors： Beckers S,Zegers D,Van Camp JK,Boudin E,Nielsen TL,Brixen K,Andersen M,Van Hul W

更新日期：2013-03-01 00:00:00

abstract：:Spermatogenesis associated 19 (SPATA19) is an important reproduction related gene. In this study, we cloned the full-length cDNA sequence of porcine SPATA19 gene through the rapid amplification of cDNA ends (RACE) method. The porcine SPATA19 gene encodes a protein of 154 amino acids which shares high homology with the...

journal_title：Molecular biology reports

authors： Wang JY,Lan J,Zhao J,Chen L,Liu Y

更新日期：2012-10-01 00:00:00

abstract：:Pathologic complete response after neoadjuvant systemic treatment appears to be a valid surrogate for better overall survival in breast cancer patients. Currently, together with standard clinicopathologic assessment, novel molecular biomarkers are being exhaustively tested in order to look into the heterogeneity of br...

journal_title：Molecular biology reports

authors： Kolacinska A,Fendler W,Szemraj J,Szymanska B,Borowska-Garganisz E,Nowik M,Chalubinska J,Kubiak R,Pawlowska Z,Blasinska-Morawiec M,Potemski P,Jeziorski A,Morawiec Z

更新日期：2012-07-01 00:00:00

abstract：:microRNAs (miRNAs) are a new class of small non-coding RNAs that function as tumor suppressors or oncogenes. Single nucleotide polymorphisms (SNPs) in miRNA may contribute to cancer development. We hypothesized that genetic variations of the miRNA could be associated with the risk of hepatitis B virus (HBV)-related he...

journal_title：Molecular biology reports

authors： Xiang Y,Fan S,Cao J,Huang S,Zhang LP

更新日期：2012-06-01 00:00:00

abstract：:CREB-regulated transcription coactivator 3 (CRTC3) was a recently identified protein which played an important role in glucose and lipid metabolism. Previous research showed that the polymorphisms of CRTC3 were associated with obesity in Mexican-Americans. Data on that relationship in Chinese was unavailable so far. S...

journal_title：Molecular biology reports

authors： Ou Z,Wang G,Li Q,Ma Z,Dai M,Zou F

更新日期：2014-01-01 00:00:00

abstract：:A double-stranded RNA-specific nuclease (ds RNase) has been isolated and partially purified from human placenta by DEAE-cellulose and DNA-cellulose column chromatography. Denatured DNA-cellulose retained most of the single-stranded RNA-specific nuclease (ss RNase) activity, whereas the ds RNase came out in the void vo...

journal_title：Molecular biology reports

authors： Kalyanaraman S,Maran A,Shanmugam G

更新日期：1983-08-01 00:00:00

abstract：:Macroautophagy is a regulated bulk degradation process of cellular components, mainly long-lived proteins or cytoplasmic organelles. Nutrient depletion is a classic inducer of macroautophagy. In this report, we have induced heat-mediated macroautophagy in several cell lines in the absence of nutrient depletion. Heat t...

journal_title：Molecular biology reports

authors： Zhao Y,Gong S,Shunmei E,Zou J

更新日期：2009-11-01 00:00:00

abstract：:Using a membrane filter retention technique we have studied the interaction between DNA and lysine rich histone H5 in vitro. It is found that, depending on the ionic conditions, H5 can bind DNA in a random or cooperative manner and exhibits a preference to DNA with high molecular weight and/or high A + T content, as a...

journal_title：Molecular biology reports

authors： Iovcheva C,Dessev GN

更新日期：1980-03-31 00:00:00

abstract：:Maintenance of glucose homeostasis is reciprocally regulated by insulin and glucagon-like peptide-1 (GLP-1). We previously reported that GLP-1 secretion in response to an oral glucose load was impaired following an administration of 3-deoxyglucosone (3DG), an independent factor associated with the development of pre-d...

journal_title：Molecular biology reports

authors： Song X,Zhou L,Xu H,Wang F,Liang G,Zhang L,Huang F,Jiang G

更新日期：2019-10-01 00:00:00

abstract：:To gain genetic insights into the protein-rich microalga, the transcriptome of Arthrospira platensis was sequenced using Illumina technology and de novo assembly was carried out. A total of 6023 transcripts were present in the transcriptome among which 4616 transcripts were annotated with specific functions. Gene onto...

journal_title：Molecular biology reports

authors： Kumaresan V,Sannasimuthu A,Arasu MV,Al-Dhabi NA,Arockiaraj J

更新日期：2018-10-01 00:00:00

abstract：:Adenylosuccinate lyase (ADSL) is a bifunctional enzyme acting in de novo purine synthesis and purine nucleotide recycling. In the present study, we have constructed a grass carp (Ctenopharyngodon idella) intestinal cDNA library that has over 2.3 × 10(5) primary clones. An expressed sequence tag (EST) of grass carp ade...

journal_title：Molecular biology reports

authors： Yuan T,Gu JR,Gu WB,Wu J,Ge SR,Xu H

更新日期：2011-03-01 00:00:00

abstract：:The full length cDNA sequence of the Tpt1/TCTP (Tumor protein, Translationally-controlled1) gene was identified from Common Carp (Cyprinus carpio, Cyprinidae), and was designated as CcTpt1 gene. The CDS is 510 bp and encodes a 170-amino acid peptide with a typical Tpt1 signature 2 domain, and is a typical Tpt1 protein...

journal_title：Molecular biology reports

authors： Jiang L,Wang Y,Cheng A,Zhang B,Ma L,Liu Y,Sun X

更新日期：2013-10-13 00:00:00

abstract：:Altered expression and methylation pattern of tumor suppressor and DNA repair genes, in particular involved in mismatch repair (MMR) pathway, frequently occur in primary colorectal (CRC) tumors. However, little is known about (epi)genetic changes of these genes in precancerous and early stages of CRC. The aim of this ...

journal_title：Molecular biology reports

authors： Polakova Vymetalkova V,Vannucci L,Korenkova V,Prochazka P,Slyskova J,Vodickova L,Rusnakova V,Bielik L,Burocziova M,Rossmann P,Vodicka P

更新日期：2013-10-01 00:00:00

abstract：:Potato (Solanum tubersosum L.) is relatively vulnerable to abiotic stress conditions such as drought, but the tolerance mechanisms to such stress in potato are largely unknown. To gain insight into the transcriptome dynamics that are associated with drought stress, genome-wide gene expression profile was conducted by ...

journal_title：Molecular biology reports

authors： Zhang N,Liu B,Ma C,Zhang G,Chang J,Si H,Wang D

更新日期：2014-01-01 00:00:00

abstract：:Allelic variation of BAT-25 (a 25-repeat quasimonomorphic poly T) and BAT-26 (a 26-repeat quasimonomorphic polyA) loci as two mononucleotide microsatellite markers, were analyzed with high-performance liquid chromatography (HPLC) compared with Real-Time PCR using hybridization probes. BAT-26 and BAT-25 markers were us...

journal_title：Molecular biology reports

authors： Mokarram P,Rismanchi M,Alizadeh Naeeni M,Mirab Samiee S,Paryan M,Alipour A,Honardar Z,Kavousipour S,Naghibalhossaini F,Mostafavi-Pour Z,Monabati A,Hosseni SV,Shamsdin SA

更新日期：2014-05-01 00:00:00

abstract：:Common bacterial blight (CBB), incited by Xanthomonas axonopodis pv. phaseoli (Xap), is a serious seed-borne disease of common bean (Phaseolus vulgaris L.) in both temperate and tropical production zones. The line HR45 is highly resistant to Xap infection on leaves and pods in both field and greenhouse. To understand ...

journal_title：Molecular biology reports

authors： Shi C,Chaudhary S,Yu K,Park SJ,Navabi A,McClean PE

更新日期：2011-01-01 00:00:00

abstract：:LNX (Ligand of Numb-protein X) was originally isolated as a binding partner to the cell-fate Determinant Numb during development, and then identified to act as a RING finger-type E3 ubiquitin ligase for the ubiquitylation and degradation of Numb. LNX contains 4 PDZ domains which are proved to play a central role in or...

journal_title：Molecular biology reports

authors： Zheng D,Sun Y,Gu S,Ji C,Zhao W,Xie Y,Mao Y

更新日期：2010-06-01 00:00:00

abstract：:Cartilage has a limited self-repair capability and the repair of large cartilage defects remains a challenge in clinic. This study aimed to investigate the effect of mesenchymal stem cells (MSCs) loaded three-dimensional bilayer collagen scaffold for cartilage repair. Cross-linked three-dimensional bilayer collagen sc...

journal_title：Molecular biology reports

authors： Qi Y,Zhao T,Xu K,Dai T,Yan W

更新日期：2012-02-01 00:00:00