Abstract:
:The response of the respiratory subsystem of oxidative phosphorylation to the environmental pollutant, 2,2',5,5'-tetrachlorobiphenyl (2,2',5,5'-TCB) was investigated by modular kinetic approach. The effects of 20 microM 2,2',5,5'-TCB on the activity of the respiratory chain modules in rat liver mitochondria oxidizing succinate (+ rotenone) in state 3 were assessed. The toxin inhibited the rate of respiration by 23%. Analysis around cytochrome c revealed that 2,2',5,5'-TCB inhibited both cytochrome c-oxidizing and reducing modules. The toxin inhibited also CoQ-oxidizing module, however it did not affect the kinetics of CoQ-reducing module. Taken together, these data indicated that 2,2',5,5'-TCB inhibited cytochrome bc1 but had no effect on succinate dehydrogenase.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Mildaziene V,Nauciene Z,Krab Kdoi
10.1023/a:1020394016372keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
31-4issue
1-2eissn
0301-4851issn
1573-4978journal_volume
29pub_type
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